{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:39:45Z","timestamp":1787002785210,"version":"build-2736575974"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:00:00Z","timestamp":1661299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:00:00Z","timestamp":1661299200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bone Marrow Transplant"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1038\/s41409-022-01786-4","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T11:03:55Z","timestamp":1661339035000},"page":"1689-1697","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Survival and late effects of hematopoietic cell transplantation in patients with thalassemia major"],"prefix":"10.1038","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5037-0515","authenticated-orcid":false,"given":"Stella","family":"Santarone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6720-3564","authenticated-orcid":false,"given":"Stefano","family":"Angelini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Natale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4906-5799","authenticated-orcid":false,"given":"Doriana","family":"Vaddinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Spadano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Casciani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Papola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enza","family":"Di Lembo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Iannetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9019-1821","authenticated-orcid":false,"given":"Paolo","family":"Di Bartolomeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,24]]},"reference":[{"key":"1786_CR1","doi-asserted-by":"publisher","first-page":"741","DOI":"10.3324\/haematol.12413","volume":"93","author":"E Angelucci","year":"2008","unstructured":"Angelucci E, Barosi G, Camaschella C, Cappellini MD, Cazzola M, Galanello R, et al. Italian Society of Hematology practice guidelines for the management of iron over- load in thalassemia major and related disorders. Haematologica. 2008;93:741\u201352.","journal-title":"Haematologica"},{"key":"1786_CR2","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1182\/blood-2018-10-879247","volume":"133","author":"A Piga","year":"2019","unstructured":"Piga A, Perrotta S, Gamberini MP, Voskaridou E, Melpignano A, Filosa A, et al. Luspatercept improves hemoglobin levels and blood transfusion requirements in a study of patients with \u00df-thalassemia. Blood. 2019;133:1279\u201389.","journal-title":"Blood"},{"key":"1786_CR3","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1056\/NEJMoa1910182","volume":"382","author":"MD Cappellini","year":"2020","unstructured":"Cappellini MD, Viprakasit V, Taher AT, Georgiev P, Kuo KHM, Coates T, et al. A Phase 3 Trial of Luspatercept in Patients with Transfusion-Dependent \u00df-Thalassemia. N. Engl J Med. 2020;382:1219\u201331.","journal-title":"N. Engl J Med"},{"key":"1786_CR4","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1038\/nature09328","volume":"467","author":"M Cavazzana-Calvo","year":"2010","unstructured":"Cavazzana-Calvo M, Payen E, Negre O, Wang G, Hehir K, Fusil F, et al. Transfusion independence and HMGA2 activation after gene therapy of human beta-thalassaemia. Nature. 2010;467:318\u201322.","journal-title":"Nature"},{"key":"1786_CR5","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1056\/NEJMoa1705342","volume":"378","author":"AA Thompson","year":"2018","unstructured":"Thompson AA, Walters MC, Kwiatkowski J, Rasko JEL, Ribeil J-A, Hongeng S, et al. Gene Therapy in Patients with Transfusion-Dependent \u00df-Thalassemia. N. Engl J Med. 2018;378:1479\u201393.","journal-title":"N. Engl J Med"},{"key":"1786_CR6","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1056\/NEJMoa2113206","volume":"386","author":"F Locatelli","year":"2022","unstructured":"Locatelli F, Thompson AA, Kwiatkowski JL, Porter JB, Thrasher AJ, Hongeng S, et al. Betibeglogene Autotemcel Gene Therapy for Non- \u00df0\/ \u00df0 Genotype \u00df-Thalassemia. N. Engl J Med. 2022;386:415\u201327.","journal-title":"N. Engl J Med"},{"key":"1786_CR7","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1056\/NEJMe2118580","volume":"386","author":"E Payen","year":"2022","unstructured":"Payen E. Efficacy and Safety of Gene Therapy for \u00df-Thalassemia. N. Engl J Med. 2022;386:488\u201390.","journal-title":"N. Engl J Med"},{"key":"1786_CR8","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/S0140-6736(82)90319-1","volume":"2","author":"ED Thomas","year":"1982","unstructured":"Thomas ED, Buckner CD, Sanders JE, Papayannopoulou T, Borgna-Pignatti C, De Stefano P, et al. Marrow transplantation for thalassaemia. Lancet. 1982;2:227\u20139.","journal-title":"Lancet"},{"key":"1786_CR9","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1038\/bmt.2015.293","volume":"51","author":"D Baronciani","year":"2016","unstructured":"Baronciani D, Angelucci E, Potschger U, Gaziev J, Yesillipek A, Zecca M, et al. Hemopoietic stem cell transplantation in thalassemia: a report from the European Society for Blood and Bone Marrow Transplantation Hemoglobinopathy Registry, 2000\u20132010. Bone Marrow Transpl. 2016;51:536\u201341.","journal-title":"Bone Marrow Transpl"},{"key":"1786_CR10","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1182\/asheducation-2010.1.456","volume":"2010","author":"E Angelucci","year":"2010","unstructured":"Angelucci E. Hematopoietic stem cell transplantation in Thalassemia. Hematol Am Soc Hematol Educ Program. 2010;2010:456\u201362.","journal-title":"Hematol Am Soc Hematol Educ Program"},{"key":"1786_CR11","doi-asserted-by":"publisher","first-page":"2562","DOI":"10.1182\/bloodadvances.2019000291","volume":"3","author":"C Li","year":"2019","unstructured":"Li C, Mathews V, Kim S, George B, Hebert K, Jiang H, et al. Related and unrelated donor transplantation for \u00df-thalassemia major: results of an international survey. Blood Adv. 2019;3:2562\u201370.","journal-title":"Blood Adv"},{"key":"1786_CR12","doi-asserted-by":"publisher","first-page":"811","DOI":"10.3324\/haematol.2013.099747","volume":"99","author":"E Angelucci","year":"2014","unstructured":"Angelucci E, Matthes-Martin S, Baronciani D, Bernaudin F, Bonanomi S, Cappellini MD, et al. Hematopoietic stem cell transplantation in thalassemia major and sickle cell disease: indications and management recommendations from an international expert panel. Haematologica. 2014;99:811\u201320.","journal-title":"Haematologica"},{"key":"1786_CR13","doi-asserted-by":"publisher","first-page":"2262","DOI":"10.1182\/blood-2013-05-502658","volume":"122","author":"G La Nasa","year":"2013","unstructured":"La Nasa G, Caocci G, Efficace F, Dessi C, Vacca A, Piras E. Long-term health-related quality of life evaluated more than 20 years after hematopoietic stem cell transplantation for thalassemia. Blood. 2013;122:2262\u201370.","journal-title":"Blood"},{"key":"1786_CR14","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.1016\/j.bbmt.2017.06.004","volume":"23","author":"S Chaudhury","year":"2017","unstructured":"Chaudhury S, Ayas M, Rosen C, Ma M, Viqaruddin M, Parikh S, et al. A Multicenter Retrospective Analysis stressing the importance of long-term follow-up after Hematopoietic cell transplantation for \u00df-Thalassemia. Biol Blood Marrow Transpl. 2017;23:1695\u2013700.","journal-title":"Biol Blood Marrow Transpl"},{"key":"1786_CR15","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.3324\/haematol.2017.183467","volume":"103","author":"I Rahal","year":"2018","unstructured":"Rahal I, Galambrun C, Bertrand Y, Garnier N, Paillard C, Frange P, et al. Late effects after hematopoietic stem cell transplantation for \u00df-thalassemia major: the French national experience. Haematologica. 2018;103:1143\u20139.","journal-title":"Haematologica"},{"key":"1786_CR16","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1002\/ajh.24898","volume":"92","author":"G Caocci","year":"2017","unstructured":"Caocci G, Orofino MG, Vacca A, Piroddi A, Piras E, Addari MC, et al. Long-term survival of beta thalassemia major patients treated with hematopoietic stem cell transplantation compared with survival with conventional treatment. Am J Hematol. 2017;92:1303\u201310.","journal-title":"Am J Hematol"},{"key":"1786_CR17","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1038\/bmt.2016.287","volume":"52","author":"S Santarone","year":"2017","unstructured":"Santarone S, Natale A, Olioso P, Onofrillo D, D\u2019Incecco C, Parruti G, et al. Pregnancy outcome following hematopoietic cell transplantation for thalassemia major. Bone Marrow Transpl. 2017;52:388\u201393.","journal-title":"Bone Marrow Transpl"},{"key":"1786_CR18","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/bmt.2017.214","volume":"53","author":"S Santarone","year":"2018","unstructured":"Santarone S, Pepe A, Meloni A, Natale A, Pistoia L, Olioso P, et al. Secondary solid cancer following hematopoietic cell transplantation in patients with thalassemia major. Bone Marrow Transpl. 2018;53:39\u201343.","journal-title":"Bone Marrow Transpl"},{"key":"1786_CR19","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1002\/ajh.21175","volume":"83","author":"P Di Bartolomeo","year":"2008","unstructured":"Di Bartolomeo P, Santarone S, Di Bartolomeo E, Olioso P, Bavaro P, Papalinetti G, et al. Long-term results of survival in patients with thalassemia major treated with bone marrow transplantation. Am J Hematol. 2008;83:528\u201330.","journal-title":"Am J Hematol"},{"key":"1786_CR20","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1016\/0168-8278(95)80226-6","volume":"22","author":"K Ishak","year":"1995","unstructured":"Ishak K, Baptista A, Bianchi L, Callea F, De Groote J, Gudat F, et al. Histological grading and staging of chronic hepatitis. J Hepatol. 1995;22:696\u20139.","journal-title":"J Hepatol"},{"key":"1786_CR21","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1097\/00007890-197410000-00001","volume":"18","author":"H Glucksberg","year":"1974","unstructured":"Glucksberg H, Storb R, Fefer A, Buckner CD, Neiman PE, Clift RA, et al. Clinical manifestations of graft-versus- host disease in human recipients of marrow from HL-A-matched sibling donors. Transplantation. 1974;18:295\u2013304.","journal-title":"Transplantation"},{"key":"1786_CR22","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1053\/bbmt.2003.50026","volume":"9","author":"SJ Lee","year":"2003","unstructured":"Lee SJ, Vogelsang G, Flowers ME. Chronic graft-versus-host disease. Biol Blood Marrow Transpl. 2003;9:215\u201333.","journal-title":"Biol Blood Marrow Transpl"},{"key":"1786_CR23","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.fsigen.2014.04.013","volume":"12","author":"K Oostdik","year":"2014","unstructured":"Oostdik K, Lenz K, Nye J, Schelling K, Yet D, Bruski S, et al. Developmental validation of the PowerPlex\u00ae Fusion System for analysis of casework and reference samples: A 24-locus multiplex for new database standards. Forensic Sci Int Gent. 2014;12:69\u201376.","journal-title":"Forensic Sci Int Gent"},{"key":"1786_CR24","unstructured":"European Association for the Study of the Liver. EASL recommendations on treatment of hepatitis C: Final update of the series. J Hepatol. 2020;73:1170\u2013218."},{"key":"1786_CR25","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1016\/j.bbmt.2018.04.002","volume":"24","author":"S Shenoy","year":"2018","unstructured":"Shenoy S, Gaziev J, Angelucci E, King A, Bhatia M, Smith A, et al. Late effects screening guidelines after Hematopoietic Cell Transplantation (HCT) for Hemoglobinopathy: Consensus Statement from the Second Pediatric Blood and Marrow Transplant Consortium International Conference on Late Effects after Pediatric HCT. Biol Blood Marrow Transpl. 2018;24:1313\u201321.","journal-title":"Biol Blood Marrow Transpl"},{"key":"1786_CR26","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.bbmt.2012.08.005","volume":"19","author":"C Galambrun","year":"2013","unstructured":"Galambrun C, Pondarr\u00e8 C, Bertrand Y, Loundou A, Bordigoni P, Frange P, et al. French Multicenter 22 Year-Experience in Stem cell Transplantation for Beta-Thalassemia Major: Lessons and Future Directions. Biol Blood Marrow Transpl. 2013;19:62\u20138.","journal-title":"Biol Blood Marrow Transpl"},{"key":"1786_CR27","doi-asserted-by":"publisher","first-page":"3494","DOI":"10.1182\/blood.V87.8.3494.bloodjournal8783494","volume":"87","author":"M Andreani","year":"1996","unstructured":"Andreani M, Manna M, Lucarelli G, Tonucci F, Agostinelli F, Ripalti M, et al. Persistence of Mixed Chimerism in Patients Transplanted for the Treatment of Thalassemia. Blood. 1996;87:3494\u20139.","journal-title":"Blood"},{"key":"1786_CR28","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1038\/bmt.2017.231","volume":"53","author":"NA Fouzia","year":"2017","unstructured":"Fouzia NA, Edison ES, Lakshmi KM, Korula A, Velayudhan SR, Balasubramanian P, et al. Long-term outcome of mixed chimerism after stem cell transplantation for thalassemia major conditioned with busulfan and cyclophosphamide. Bone Marrow Transpl. 2017;53:169\u201374.","journal-title":"Bone Marrow Transpl"},{"key":"1786_CR29","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1038\/sj.bmt.1703133","volume":"28","author":"T Murdych","year":"2001","unstructured":"Murdych T, Weisdorf DJ. Serious cardiac complications during bone marrow transplantation at the University of Minnesota, 1977\u20131997. Bone Marrow Transpl. 2001;28:283\u20137.","journal-title":"Bone Marrow Transpl"},{"key":"1786_CR30","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.1016\/S0140-6736(00)02357-6","volume":"355","author":"B Modell","year":"2000","unstructured":"Modell B, Khan M, Darlison M. Survival in \u00df-thalassemia major in the UK: data from the UK Thalassemia Register. Lancet. 2000;355:2051\u20132.","journal-title":"Lancet"},{"key":"1786_CR31","doi-asserted-by":"publisher","first-page":"724","DOI":"10.3324\/haematol.2009.018051","volume":"95","author":"I Thuret","year":"2010","unstructured":"Thuret I, Pondarr\u00e8 C, Loundou A, Steschenko D, Girot R, Bachir D, et al. Complications and treatment of patients with \u00df-thalassemia in France: results of the National Registry. Haematologica. 2010;95:724\u20139.","journal-title":"Haematologica"},{"key":"1786_CR32","first-page":"1187","volume":"89","author":"C Borgna-Pignatti","year":"2004","unstructured":"Borgna-Pignatti C, Rugolotto S, De Stefano P, Zhao H, Cappellini MD, Del Vecchio GC, et al. Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine. Haematologica. 2004;89:1187\u201393.","journal-title":"Haematologica"},{"key":"1786_CR33","doi-asserted-by":"publisher","first-page":"3829","DOI":"10.1182\/bloodadvances.2019000966","volume":"3","author":"C Neunert","year":"2019","unstructured":"Neunert C, Terrel DR, Arnold DM, Buchanan G, Cines DB, Cooper N. American Society of Hematology guidelines for immune thrombocytopenia. Blood Adv. 2019;3:3829\u201366.","journal-title":"Blood Adv"},{"key":"1786_CR34","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/ajh.21616","volume":"85","author":"DR Terrel","year":"2010","unstructured":"Terrel DR, Beebe LA, Vesely SK, Neas BR, Segal JB, George JN. The incidence of immune thrombocytopenic purpura in children and adults: a critical review of published report. Am J Hematol. 2010;85:174\u201380.","journal-title":"Am J Hematol"},{"key":"1786_CR35","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3390\/jcm6020016","volume":"6","author":"A Zufferey","year":"2017","unstructured":"Zufferey A, Kapur R, Semple JW. Pathogenesis and Therapeutic Mechanisms in Immune Thrombocytopenia (ITP). J Clin Med. 2017;6:16\u201337.","journal-title":"J Clin Med"},{"key":"1786_CR36","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1111\/nyas.13005","volume":"1368","author":"S Zanella","year":"2016","unstructured":"Zanella S, Garani MC, Borgna-Pignatti C. Malignancies and thalassemia: a review of the literature. Ann N. Y Acad Sci. 2016;1368:140\u20138.","journal-title":"Ann N. Y Acad Sci"},{"key":"1786_CR37","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.jinf.2021.10.024","volume":"84","author":"M Mikulska","year":"2022","unstructured":"Mikulska M, Knelange N, Nicolini LA, Tridello G, Santarone S, Di Bartolomeo P, et al. Efficacy, safety and feasibility of treatment of chronic HCV infection with directly acting agents in hematopoietic stem cell transplant recipients \u2013 Study of infectious disease working party of EBMT. J Infect. 2022;84:71\u20139.","journal-title":"J Infect"}],"container-title":["Bone Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41409-022-01786-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41409-022-01786-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41409-022-01786-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T09:50:25Z","timestamp":1744192225000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41409-022-01786-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,24]]},"references-count":37,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["1786"],"URL":"https:\/\/doi.org\/10.1038\/s41409-022-01786-4","relation":{},"ISSN":["0268-3369","1476-5365"],"issn-type":[{"value":"0268-3369","type":"print"},{"value":"1476-5365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,24]]},"assertion":[{"value":"24 April 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 August 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 August 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}