{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T23:43:56Z","timestamp":1782344636710,"version":"3.54.5"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470212"],"award-info":[{"award-number":["82470212"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bone Marrow Transplant"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1038\/s41409-025-02666-3","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T07:57:22Z","timestamp":1751615842000},"page":"1316-1324","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Machine learning-based prediction of G-CSF-induced hematopoietic stem cell mobilization outcomes in healthy volunteers"],"prefix":"10.1038","volume":"60","author":[{"given":"Ce","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangjun","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimei","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfei","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7051-219X","authenticated-orcid":false,"given":"Yi","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1852-326X","authenticated-orcid":false,"given":"Jimin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamin","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huarui","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3706-4959","authenticated-orcid":false,"given":"Yishan","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luxin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5431-1133","authenticated-orcid":false,"given":"Yibo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2723-1621","authenticated-orcid":false,"given":"He","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3857-5574","authenticated-orcid":false,"given":"Yanmin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,4]]},"reference":[{"key":"2666_CR1","doi-asserted-by":"publisher","first-page":"599","DOI":"10.6004\/jnccn.2020.0021","volume":"18","author":"A Saad","year":"2020","unstructured":"Saad A, de Lima M, Anand S, Bhatt VR, Bookout R, Chen G, et al. Hematopoietic Cell Transplantation, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Cancer Netw. 2020;18:599\u2013634. https:\/\/doi.org\/10.6004\/jnccn.2020.0021.","journal-title":"J Natl Compr Cancer Netw"},{"key":"2666_CR2","doi-asserted-by":"publisher","first-page":"2641","DOI":"10.1182\/blood-2014-10-570234","volume":"125","author":"LT Vo","year":"2015","unstructured":"Vo LT, Daley GQ. De novo generation of HSCs from somatic and pluripotent stem cell sources. Blood. 2015;125:2641\u20132648. https:\/\/doi.org\/10.1182\/blood-2014-10-570234.","journal-title":"Blood"},{"key":"2666_CR3","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1126\/science.1064081","volume":"294","author":"DE Wright","year":"2001","unstructured":"Wright DE, Wagers AJ, Gulati AP, Johnson FL, Weissman IL. Physiological migration of hematopoietic stem and progenitor cells. Science. 2001;294:1933\u20131936. https:\/\/doi.org\/10.1126\/science.1064081.","journal-title":"Science"},{"key":"2666_CR4","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1182\/blood.V47.6.1031.1031","volume":"47","author":"CM Richman","year":"1976","unstructured":"Richman CM, Weiner RS, Yankee RA. Increase in circulating stem cells following chemotherapy in man. Blood. 1976;47:1031\u20131039.","journal-title":"Blood"},{"issue":"4","key":"2666_CR5","doi-asserted-by":"publisher","first-page":"e0028","DOI":"10.5041\/rmmj.10162","volume":"5","author":"I Henig","year":"2014","unstructured":"Henig I, Zuckerman T. Hematopoietic stem cell transplantation-50 years of evolution and future perspectives. Rambam Maimonides Med J. 2014;5(4):e0028 https:\/\/doi.org\/10.5041\/rmmj.10162.","journal-title":"Rambam Maimonides Med J"},{"key":"2666_CR6","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1200\/jco.2016.69.5395","volume":"35","author":"N Adra","year":"2017","unstructured":"Adra N, Abonour R, Althouse SK, Albany C, Hanna NH, Einhorn LH. High-dose chemotherapy and autologous peripheral-blood stem-cell transplantation for relapsed metastatic germ cell tumors: the Indiana University Experience. J Clin Oncol J Am Soc Clin Oncol. 2017;35:1096\u20131102. https:\/\/doi.org\/10.1200\/jco.2016.69.5395.","journal-title":"J Clin Oncol J Am Soc Clin Oncol"},{"key":"2666_CR7","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/s0140-6736(96)90536-x","volume":"347","author":"N Schmitz","year":"1996","unstructured":"Schmitz N, Linch DC, Dreger P, Goldstone AH, Boogaerts MA, Ferrant A, et al. Randomised trial of filgrastim-mobilised peripheral blood progenitor cell transplantation versus autologous bone-marrow transplantation in lymphoma patients. Lancet. 1996;347:353\u2013357. https:\/\/doi.org\/10.1016\/s0140-6736(96)90536-x.","journal-title":"Lancet"},{"key":"2666_CR8","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1200\/jco.1995.13.6.1328","volume":"13","author":"J Beyer","year":"1995","unstructured":"Beyer J, Schwella N, Zingsem J, Strohscheer I, Schwaner I, Oettle H, et al. Hematopoietic rescue after high-dose chemotherapy using autologous peripheral-blood progenitor cells or bone marrow: a randomized comparison. J Clin Oncol J Am Soc Clin Oncol. 1995;13:1328\u20131335. https:\/\/doi.org\/10.1200\/jco.1995.13.6.1328.","journal-title":"J Clin Oncol J Am Soc Clin Oncol"},{"key":"2666_CR9","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1111\/j.1365-2141.1984.tb03987.x","volume":"58","author":"LB To","year":"1984","unstructured":"To LB, Haylock DN, Kimber RJ, Juttner CA. High levels of circulating haemopoietic stem cells in very early remission from acute non-lymphoblastic leukaemia and their collection and cryopreservation. Br J Haematol. 1984;58:399\u2013410. https:\/\/doi.org\/10.1111\/j.1365-2141.1984.tb03987.x.","journal-title":"Br J Haematol"},{"key":"2666_CR10","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1182\/blood.V82.6.1720.1720","volume":"82","author":"RA Briddell","year":"1993","unstructured":"Briddell RA, Hartley CA, Smith KA, McNiece IK. Recombinant rat stem cell factor synergizes with recombinant human granulocyte colony-stimulating factor in vivo in mice to mobilize peripheral blood progenitor cells that have enhanced repopulating potential. Blood. 1993;82:1720\u20131723.","journal-title":"Blood"},{"key":"2666_CR11","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1182\/blood.V70.1.206.206","volume":"70","author":"P Mayer","year":"1987","unstructured":"Mayer P, Lam C, Obenaus H, Liehl E, Besemer J. Recombinant human GM-CSF induces leukocytosis and activates peripheral blood polymorphonuclear neutrophils in nonhuman primates. Blood. 1987;70:206\u2013213.","journal-title":"Blood"},{"key":"2666_CR12","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1182\/blood-2008-10-184721","volume":"114","author":"P Ramirez","year":"2009","unstructured":"Ramirez P, Rettig MP, Uy GL, Deych E, Holt MS, Ritchey JK, et al. BIO5192, a small molecule inhibitor of VLA-4, mobilizes hematopoietic stem and progenitor cells. Blood. 2009;114:1340\u20131343. https:\/\/doi.org\/10.1182\/blood-2008-10-184721.","journal-title":"Blood"},{"key":"2666_CR13","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1203\/pdr.0b013e3180332d36","volume":"61","author":"F Zaldivar","year":"2007","unstructured":"Zaldivar F, Eliakim A, Radom-Aizik S, Leu SY, Cooper DM. The effect of brief exercise on circulating CD34+ stem cells in early and late pubertal boys. Pediatr Res. 2007;61:491\u2013495. https:\/\/doi.org\/10.1203\/pdr.0b013e3180332d36.","journal-title":"Pediatr Res"},{"key":"2666_CR14","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1182\/blood-2011-04-348904","volume":"119","author":"JG Juarez","year":"2012","unstructured":"Juarez JG, Harun N, Thien M, Welschinger R, Baraz R, Pena AD, et al. Sphingosine-1-phosphate facilitates trafficking of hematopoietic stem cells and their mobilization by CXCR4 antagonists in mice. Blood. 2012;119:707\u2013716. https:\/\/doi.org\/10.1182\/blood-2011-04-348904.","journal-title":"Blood"},{"key":"2666_CR15","first-page":"186","volume":"5","author":"MJ Cline","year":"1977","unstructured":"Cline MJ, Golde DW. Mobilization of hematopoietic stem cells (CFU-C) into the peripheral blood of man by endotoxin. Exp Hematol. 1977;5:186\u2013190.","journal-title":"Exp Hematol"},{"key":"2666_CR16","doi-asserted-by":"publisher","unstructured":"Karpova D, Rettig MP, DiPersio JF. Mobilized peripheral blood: an updated perspective. F1000Research 2019;8, https:\/\/doi.org\/10.12688\/f1000research.21129.1","DOI":"10.12688\/f1000research.21129.1"},{"key":"2666_CR17","doi-asserted-by":"publisher","first-page":"3020","DOI":"10.1182\/blood-2004-01-0272","volume":"106","author":"CL Semerad","year":"2005","unstructured":"Semerad CL, Christopher MJ, Liu F, Short B, Simmons PJ, Winkler I, et al. G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow. Blood. 2005;106:3020\u20133027. https:\/\/doi.org\/10.1182\/blood-2004-01-0272.","journal-title":"Blood"},{"key":"2666_CR18","doi-asserted-by":"publisher","first-page":"818","DOI":"10.3324\/haematol.2011.056945","volume":"97","author":"O Salvucci","year":"2012","unstructured":"Salvucci O, Jiang K, Gasperini P, Maric D, Zhu J, Sakakibara S, et al. MicroRNA126 contributes to granulocyte colony-stimulating factor-induced hematopoietic progenitor cell mobilization by reducing the expression of vascular cell adhesion molecule 1. Haematologica. 2012;97:818\u2013826. https:\/\/doi.org\/10.3324\/haematol.2011.056945.","journal-title":"Haematologica"},{"key":"2666_CR19","first-page":"595","volume":"4","author":"LB To","year":"1989","unstructured":"To LB, Davy ML, Haylock DN, Dyson PG, Thorp D, Juttner CA. Autotransplantation using peripheral blood stem cells mobilized by cyclophosphamide. Bone Marrow Transplant. 1989;4:595\u2013596.","journal-title":"Bone Marrow Transplant"},{"key":"2666_CR20","doi-asserted-by":"publisher","first-page":"5720","DOI":"10.1182\/blood-2008-08-174946","volume":"113","author":"JF DiPersio","year":"2009","unstructured":"DiPersio JF, Stadtmauer EA, Nademanee A, Micallef IN, Stiff PJ, Kaufman JL, et al. Plerixafor and G-CSF versus placebo and G-CSF to mobilize hematopoietic stem cells for autologous stem cell transplantation in patients with multiple myeloma. Blood. 2009;113:5720\u20135726. https:\/\/doi.org\/10.1182\/blood-2008-08-174946.","journal-title":"Blood"},{"key":"2666_CR21","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/leu.2010.248","volume":"25","author":"AM Greenbaum","year":"2011","unstructured":"Greenbaum AM, Link DC. Mechanisms of G-CSF-mediated hematopoietic stem and progenitor mobilization. Leukemia. 2011;25:211\u2013217. https:\/\/doi.org\/10.1038\/leu.2010.248.","journal-title":"Leukemia"},{"key":"2666_CR22","doi-asserted-by":"publisher","first-page":"4530","DOI":"10.1182\/blood-2011-06-318220","volume":"118","author":"LB To","year":"2011","unstructured":"To LB, Levesque JP, Herbert KE. How I treat patients who mobilize hematopoietic stem cells poorly. Blood. 2011;118:4530\u20134540. https:\/\/doi.org\/10.1182\/blood-2011-06-318220.","journal-title":"Blood"},{"key":"2666_CR23","doi-asserted-by":"publisher","first-page":"2547","DOI":"10.1200\/jco.1995.13.10.2547","volume":"13","author":"W Bensinger","year":"1995","unstructured":"Bensinger W, Appelbaum F, Rowley S, Storb R, Sanders J, Lilleby K, et al. Factors that influence collection and engraftment of autologous peripheral-blood stem cells. J Clin Oncol J Am Soc Clin Oncol. 1995;13:2547\u20132555. https:\/\/doi.org\/10.1200\/jco.1995.13.10.2547.","journal-title":"J Clin Oncol J Am Soc Clin Oncol"},{"key":"2666_CR24","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1038\/sj.bmt.1705147","volume":"36","author":"R Goterris","year":"2005","unstructured":"Goterris R, Hern\u00e1ndez-Boluda JC, Teruel A, G\u00f3mez C, Lis MJ, Terol MJ, et al. Impact of different strategies of second-line stem cell harvest on the outcome of autologous transplantation in poor peripheral blood stem cell mobilizers. Bone Marrow Transplant. 2005;36:847\u2013853. https:\/\/doi.org\/10.1038\/sj.bmt.1705147.","journal-title":"Bone Marrow Transplant"},{"key":"2666_CR25","doi-asserted-by":"publisher","first-page":"2331","DOI":"10.1111\/trf.13688","volume":"56","author":"MA Fiala","year":"2016","unstructured":"Fiala MA, Park S, Slade M, DiPersio JF, Stockerl-Goldstein KE. Remobilization of hematopoietic stem cells in healthy donors for allogeneic transplantation. Transfusion. 2016;56:2331\u20132335. https:\/\/doi.org\/10.1111\/trf.13688.","journal-title":"Transfusion"},{"key":"2666_CR26","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/s41591-018-0300-7","volume":"25","author":"EJ Topol","year":"2019","unstructured":"Topol EJ. High-performance medicine: the convergence of human and artificial intelligence. Nat Med. 2019;25:44\u201356. https:\/\/doi.org\/10.1038\/s41591-018-0300-7.","journal-title":"Nat Med"},{"key":"2666_CR27","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-022-04824-6","volume":"23","author":"H Chen","year":"2022","unstructured":"Chen H, Liu J, Hua C, Feng J, Pang B, Cao D, et al. Accurate classification of white blood cells by coupling pre-trained ResNet and DenseNet with SCAM mechanism. BMC Bioinforma. 2022;23:282 https:\/\/doi.org\/10.1186\/s12859-022-04824-6.","journal-title":"BMC Bioinforma"},{"key":"2666_CR28","doi-asserted-by":"publisher","first-page":"3626","DOI":"10.1182\/bloodadvances.2019000934","volume":"3","author":"Y Arai","year":"2019","unstructured":"Arai Y, Kondo T, Fuse K, Shibasaki Y, Masuko M, Sugita J, et al. Using a machine learning algorithm to predict acute graft-versus-host disease following allogeneic transplantation. Blood Adv. 2019;3:3626\u20133634. https:\/\/doi.org\/10.1182\/bloodadvances.2019000934.","journal-title":"Blood Adv"},{"key":"2666_CR29","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1182\/bloodadvances.2021005149","volume":"6","author":"J Xiang","year":"2022","unstructured":"Xiang J, Shi M, Fiala MA, Gao F, Rettig MP, Uy GL, et al. Machine learning-based scoring models to predict hematopoietic stem cell mobilization in allogeneic donors. Blood Adv. 2022;6:1991\u20132000. https:\/\/doi.org\/10.1182\/bloodadvances.2021005149.","journal-title":"Blood Adv"},{"key":"2666_CR30","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1182\/bloodadvances.2019000923","volume":"4","author":"N Farhadfar","year":"2020","unstructured":"Farhadfar N, Hsu JW, Logan BR, Sees JA, Chitphakdithai P, Sugrue MW, et al. Weighty choices: selecting optimal G-CSF doses for stem cell mobilization to optimize yield. Blood Adv. 2020;4:706\u2013716. https:\/\/doi.org\/10.1182\/bloodadvances.2019000923.","journal-title":"Blood Adv"},{"key":"2666_CR31","doi-asserted-by":"publisher","first-page":"eabk0271","DOI":"10.1126\/sciadv.abk0271","volume":"7","author":"J Lengefeld","year":"2021","unstructured":"Lengefeld J, Cheng CW, Maretich P, Blair M, Hagen H, McReynolds MR, et al. Cell size is a determinant of stem cell potential during aging. Sci Adv. 2021;7:eabk0271 https:\/\/doi.org\/10.1126\/sciadv.abk0271.","journal-title":"Sci Adv"},{"key":"2666_CR32","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.cell.2008.01.025","volume":"132","author":"SH Orkin","year":"2008","unstructured":"Orkin SH, Zon LI. Hematopoiesis: an evolving paradigm for stem cell biology. Cell. 2008;132:631\u2013644. https:\/\/doi.org\/10.1016\/j.cell.2008.01.025.","journal-title":"Cell"},{"key":"2666_CR33","doi-asserted-by":"publisher","first-page":"765","DOI":"10.3324\/haematol.2023.282935","volume":"109","author":"S Pagliuca","year":"2024","unstructured":"Pagliuca S, Kulasekararaj AG, Eikema DJ, Piepenbroek B, Iftikhar R, Satti TM, et al. Current use of androgens in bone marrow failure disorders: a report from the Severe Aplastic Anemia Working Party of the European Society for Blood and Marrow Transplantation. Haematologica. 2024;109:765\u2013776. https:\/\/doi.org\/10.3324\/haematol.2023.282935.","journal-title":"Haematologica"},{"key":"2666_CR34","doi-asserted-by":"publisher","first-page":"101132","DOI":"10.1016\/j.blre.2023.101132","volume":"62","author":"A Bosi","year":"2023","unstructured":"Bosi A, Barcellini W, Passamonti F, Fattizzo B. Androgen use in bone marrow failures and myeloid neoplasms: mechanisms of action and a systematic review of clinical data. Blood Rev. 2023;62:101132 https:\/\/doi.org\/10.1016\/j.blre.2023.101132.","journal-title":"Blood Rev"},{"key":"2666_CR35","doi-asserted-by":"publisher","first-page":"986954","DOI":"10.3389\/fpubh.2022.986954","volume":"10","author":"C Cheang","year":"2022","unstructured":"Cheang C, Law S, Ren J, Chan W, Wang C, Dong Z. Prevalence of hyperuricemia in patients with severe obesity and the relationship between serum uric acid and severe obesity: A decade retrospective cross-section study in Chinese adults. Front public health. 2022;10:986954 https:\/\/doi.org\/10.3389\/fpubh.2022.986954.","journal-title":"Front public health"},{"key":"2666_CR36","doi-asserted-by":"publisher","first-page":"1215521","DOI":"10.3389\/fendo.2023.1215521","volume":"14","author":"MY Tan","year":"2023","unstructured":"Tan MY, Mo CY, Li F, Zhao Q. The association between serum uric acid and hypertriglyceridemia: evidence from the National Health and Nutrition Examination Survey (2007-2018). Front Endocrinol. 2023;14:1215521 https:\/\/doi.org\/10.3389\/fendo.2023.1215521.","journal-title":"Front Endocrinol"},{"key":"2666_CR37","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/s0925-5710(97)00590-2","volume":"66","author":"T Yano","year":"1997","unstructured":"Yano T, Katayama Y, Sunami K, Deguchi S, Nawa Y, Hiramatsu Y, et al. G-CSF-induced mobilization of peripheral blood stem cells for allografting: comparative study of daily single versus divided dose of G-CSF. Int J Hematol. 1997;66:169\u2013178. https:\/\/doi.org\/10.1016\/s0925-5710(97)00590-2.","journal-title":"Int J Hematol"},{"key":"2666_CR38","first-page":"761","volume":"111","author":"N Kr\u00f6ger","year":"2000","unstructured":"Kr\u00f6ger N, Renges H, Kr\u00fcger W, Gutensohn K, L\u00f6liger C, Carrero I, et al. A randomized comparison of once versus twice daily recombinant human granulocyte colony-stimulating factor (filgrastim) for stem cell mobilization in healthy donors for allogeneic transplantation. Br J Haematol. 2000;111:761\u2013765.","journal-title":"Br J Haematol"}],"container-title":["Bone Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41409-025-02666-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41409-025-02666-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41409-025-02666-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T18:04:06Z","timestamp":1761847446000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41409-025-02666-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,4]]},"references-count":38,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["2666"],"URL":"https:\/\/doi.org\/10.1038\/s41409-025-02666-3","relation":{},"ISSN":["0268-3369","1476-5365"],"issn-type":[{"value":"0268-3369","type":"print"},{"value":"1476-5365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,4]]},"assertion":[{"value":"20 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}