{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T16:09:45Z","timestamp":1781712585691,"version":"3.54.5"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bone Marrow Transplant"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1038\/s41409-025-02676-1","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T13:54:51Z","timestamp":1753365291000},"page":"1344-1350","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Outcomes of hematopoietic stem cell transplantation in pediatric acute lymphoblastic leukemia: a multicenter Brazilian cohort study"],"prefix":"10.1038","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5518-1131","authenticated-orcid":false,"given":"Daniela","family":"Morales","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisele","family":"Loth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verg\u00edlio Antonio Rensi","family":"Colturato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9050-7918","authenticated-orcid":false,"given":"Rita Barbosa","family":"Tavares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Lermontov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1971-9299","authenticated-orcid":false,"given":"Adriana Mello","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polliany Roberta Dorini","family":"Pelegrina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cilmara Cristina","family":"Kuwahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalia","family":"Kersting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciliana","family":"Rechenmacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila de Oliveira","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmine","family":"Monteiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9482-0776","authenticated-orcid":false,"given":"Mariana Bohns","family":"Michalowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario Bernardes","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmem","family":"Bonfim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9495-6932","authenticated-orcid":false,"given":"Liane Esteves","family":"Daudt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,24]]},"reference":[{"key":"2676_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pcl.2009.11.005","volume":"57","author":"AS Wayne","year":"2010","unstructured":"Wayne AS, Baird K, Egeler RM. Hematopoietic stem cell transplantation for leukemia. Pediatr Clin North Am. 2010;57:1\u201325.","journal-title":"Pediatr Clin North Am"},{"key":"2676_CR2","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1007\/s10555-019-09834-0","volume":"38","author":"H Inaba","year":"2019","unstructured":"Inaba H, Pui CH. Immunotherapy in pediatric acute lymphoblastic leukemia. Cancer Metastasis Rev. 2019;38:595\u2013610.","journal-title":"Cancer Metastasis Rev"},{"key":"2676_CR3","unstructured":"National Cancer Institute (NIH): Cancer in Children and Adolescents. 2023 Sep. Available from: https:\/\/www.cancer.gov\/types\/childhood-cancers\/child-adolescent-cancers-fact-sheet. [Accessed 2023 Oct 16]."},{"key":"2676_CR4","doi-asserted-by":"publisher","unstructured":"Da Silva FF, De Oliveira Latorre MDRD Survival from acute lymphocytic leukemia in children in the city of S\u00e3o Paulo, Brazil. Public Health J. 2020;36. https:\/\/doi.org\/10.1590\/0102-311X00008019.","DOI":"10.1590\/0102-311X00008019"},{"key":"2676_CR5","first-page":"348","volume":"42","author":"KA Silva","year":"2020","unstructured":"Silva KA, de S, Spagnol F, Farias MG, Alegretti AP, Michalowski MB, et al. Influence of minimal residual disease by multiparametric flow cytometry at day 15 of induction in risk stratification of children with B-cell acute lymphoblastic leukemia treated at a referral hospital in southern Brazil. Hematol Transfus Cell Ther. 2020;42:348\u201355.","journal-title":"Hematol Transfus Cell Ther"},{"key":"2676_CR6","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1111\/bjh.17494","volume":"194","author":"MB Michalowski","year":"2021","unstructured":"Michalowski MB, Cecconello DK, Lins MM, Carvalho MPSS, Silva KA, de S, et al. Influence of different asparaginase formulations in the prognosis of children with acute lymphocytic leukaemia in Brazil: a multicentre, retrospective controlled study. Br J Haematol. 2021;194:168\u201373.","journal-title":"Br J Haematol"},{"key":"2676_CR7","doi-asserted-by":"crossref","unstructured":"Tavares RCB, Bonfim CS, Seber A, Pereira Lermontov S, Coulturato V, Zecchin VG, et al. Hematopoietic cell transplantation in pediatric patients with acute leukemias or myelodysplastic syndrome using unrelated adult or umbilical cord blood donors in Brazil. Pediatr Transplant. 2020;24.","DOI":"10.1111\/petr.13789"},{"key":"2676_CR8","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/j.beha.2008.10.002","volume":"21","author":"C Anasetti","year":"2008","unstructured":"Anasetti C. What are the most important donor and recipient factors affecting the outcome of related and unrelated allogeneic transplantation? Best Pr Res Clin Haematol. 2008;21:691\u20137.","journal-title":"Best Pr Res Clin Haematol"},{"key":"2676_CR9","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/s41409-018-0221-6","volume":"54","author":"M Kato","year":"2019","unstructured":"Kato M, Kurata M, Kanda J, Kato K, Tomizawa D, Kudo K, et al. Impact of graft-versus-host disease on relapse and survival after allogeneic stem cell transplantation for pediatric leukemia. Bone Marrow Transpl. 2019;54:68\u201375.","journal-title":"Bone Marrow Transpl"},{"key":"2676_CR10","doi-asserted-by":"crossref","unstructured":"Algeri M, Merli P, Locatelli F, Pagliara D The role of allogeneic hematopoietic stem cell transplantation in pediatric leukemia. J Clin Med. 2021;10.","DOI":"10.3390\/jcm10173790"},{"key":"2676_CR11","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1038\/bmt.2008.358","volume":"43","author":"L Silla","year":"2009","unstructured":"Silla L, Fischer GB, Paz A, Daudt LE, Mitto I, Katz B, et al. Patient socioeconomic status as a prognostic factor for allo-SCT. Bone Marrow Transpl. 2009;43:571\u20137. https:\/\/doi.org\/10.1038\/bmt.2008.358. Epub 2008 Nov 3. PMID: 18978820","journal-title":"Bone Marrow Transpl"},{"key":"2676_CR12","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1016\/j.bbmt.2005.09.004","volume":"11","author":"AH Filipovich","year":"2005","unstructured":"Filipovich AH, Weisdorf D, Pavletic S, Socie G, Wingard JR, Lee SJ, et al. National Institutes of Health Consensus Development Project on criteria for clinical trials in chronic graft-versus-host disease: I. diagnosis and staging working group report. Biol Blood Marrow Transpl. 2005;11:945\u201356.","journal-title":"Biol Blood Marrow Transpl"},{"key":"2676_CR13","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1046\/j.1365-2141.1997.1112925.x","volume":"97","author":"PA Rowlings","year":"1997","unstructured":"Rowlings PA, Przepiorka D, Klein JP, Gale RP, Passweg JR, Henslee-Downey PJ, et al. IBMTR Severity Index for grading acute graft-versus-host disease: Retrospective comparison with Glucksberg grade. Br J Haematol. 1997;97:855\u201364.","journal-title":"Br J Haematol"},{"key":"2676_CR14","doi-asserted-by":"publisher","first-page":"3996","DOI":"10.1182\/blood-2015-03-580027","volume":"125","author":"JJM Van Dongen","year":"2015","unstructured":"Van Dongen JJM, Van Der Velden VHJ, Br\u00fcggemann M, Orfao A. Minimal residual disease diagnostics in acute lymphoblastic leukemia: Need for sensitive, fast, and standardized technologies. Blood. 2015;125:3996\u20134009.","journal-title":"Blood"},{"key":"2676_CR15","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1200\/JCO.2014.58.9747","volume":"33","author":"C Peters","year":"2015","unstructured":"Peters C, Matthes-Martin S, Poetschger U, Schrappe M, Schrauder A, Von Stackelberg A, et al. Stem-cell transplantation in children with acute lymphoblastic leukemia: A prospective international multicenter trial comparing sibling donors with matched unrelated donors - The ALL-SCT-BFM-2003 trial. J Clin Oncol. 2015;33:1265\u201374.","journal-title":"J Clin Oncol"},{"key":"2676_CR16","first-page":"83","volume":"64","author":"E Ward","year":"2014","unstructured":"Ward E, DeSantis C, Robbins A, Kohler B, Jemal A. Childhood and adolescent cancer statistics, 2014. CA Cancer J Clin. 2014;64:83\u2013103.","journal-title":"CA Cancer J Clin"},{"key":"2676_CR17","doi-asserted-by":"publisher","unstructured":"Chang JH, Poppe MM, Hua C, Marcus KJ, Esiashvili N Acute lymphoblastic leukemia. Pediatr Blood Cancer. 2021;68. Available from: https:\/\/doi.org\/10.1002\/pbc.28371. [Accessed 2023 Oct 16].","DOI":"10.1002\/pbc.28371"},{"key":"2676_CR18","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1038\/bmt.2008.215","volume":"42","author":"HJ Symons","year":"2008","unstructured":"Symons HJ, Fuchs EJ. Hematopoietic SCT from partially HLA-mismatched (HLA-haploidentical) related donors. Bone Marrow Transpl. 2008;42:365\u201377.","journal-title":"Bone Marrow Transpl"},{"key":"2676_CR19","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1038\/s41409-020-0854-0","volume":"55","author":"AM Willasch","year":"2020","unstructured":"Willasch AM, Peters C, Sedl\u00e1\u010dek P, Dalle JH, Kitra-Roussou V, Yesilipek A, et al. Myeloablative conditioning for allo-HSCT in pediatric ALL: FTBI or chemotherapy? A multicenter EBMT-PDWP study. Bone Marrow Transpl. 2020;55:1540\u201351.","journal-title":"Bone Marrow Transpl"},{"key":"2676_CR20","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1053\/j.seminoncol.2012.09.005","volume":"39","author":"L Luznik","year":"2012","unstructured":"Luznik L, O\u2019Donnell PV, Fuchs EJ. Post-transplantation cyclophosphamide for tolerance induction in HLA-haploidentical bone marrow transplantation. Semin Oncol. 2012;39:683\u201393.","journal-title":"Semin Oncol"},{"key":"2676_CR21","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1038\/s41409-023-01911-x","volume":"58","author":"MS Massei","year":"2023","unstructured":"Massei MS, Capolsini I, Mastrodicasa E, Perruccio K, Arcioni F, Cerri C, et al. HLA-haploidentical hematopoietic stem cells transplantation with regulatory and conventional T-cell adoptive immunotherapy in pediatric patients with very high-risk acute leukemia. Bone Marrow Transpl. 2023;58:526\u201333.","journal-title":"Bone Marrow Transpl"},{"key":"2676_CR22","doi-asserted-by":"publisher","first-page":"S31","DOI":"10.1038\/bmt.2015.92","volume":"50","author":"EJ Fuchs","year":"2015","unstructured":"Fuchs EJ. HLA-haploidentical blood or marrow transplantation with high-dose, post-transplantation cyclophosphamide. Bone Marrow Transpl. 2015;50:S31\u20136.","journal-title":"Bone Marrow Transpl"},{"key":"2676_CR23","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1200\/JCO.2012.44.3523","volume":"31","author":"A Bashey","year":"2013","unstructured":"Bashey A, Zhang X, Sizemore CA, Manion K, Brown S, Holland HK, et al. T-cell-replete HLA-haploidentical hematopoietic transplantation for hematologic malignancies using post-transplantation cyclophosphamide results in outcomes equivalent to those of contemporaneous HLA-matched related and unrelated donor transplantation. J Clin Oncol. 2013;31:1310\u20136.","journal-title":"J Clin Oncol"},{"key":"2676_CR24","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1016\/j.bbmt.2020.05.001","volume":"26","author":"A Im","year":"2020","unstructured":"Im A, Rashidi A, Wang T, Hemmer M, MacMillan ML, Pidala J, et al. Risk Factors for Graft-versus-Host Disease in Haploidentical Hematopoietic Cell Transplantation Using Post-Transplant Cyclophosphamide. Biol Blood Marrow Transpl. 2020;26:1459\u201368.","journal-title":"Biol Blood Marrow Transpl"},{"key":"2676_CR25","first-page":"985","volume":"11","author":"JM Vase","year":"1993","unstructured":"Vase JM, Reed EC, Pippert GC, Anderson JR, Bierman PJ, Kessinger A, et al. Mesna Compared With Continuous Bladder Irrigation as Uroprotection During High-Dose Chemotherapy and Transplantation: A Randomized Trial. J Clin Oncol. 1993;11:985\u20139.","journal-title":"J Clin Oncol"},{"key":"2676_CR26","first-page":"4674","volume":"103","author":"M El-Zimaity","year":"2004","unstructured":"El-Zimaity M, Saliba R, Chan K, Shahjahan M, Carrasco A, Khorshid O, et al. Hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation: donor type matters. Haematologica. 2004;103:4674\u201380.","journal-title":"Haematologica"},{"key":"2676_CR27","doi-asserted-by":"crossref","unstructured":"Simione AJ, Das Neves HRA, Da Silva CC, Sabaini PMDS, Geraldo BLSS, Otuyama LJ, et al. Current use and outcomes of hematopoietic stem cell transplantation: Brazilian summary slides - 2023. J Bone Marrow Transplant Cell Ther. 2023;4:200.","DOI":"10.46765\/2675-374X.2023v4n2p200"}],"container-title":["Bone Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41409-025-02676-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41409-025-02676-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41409-025-02676-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T18:04:09Z","timestamp":1761847449000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41409-025-02676-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,24]]},"references-count":27,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["2676"],"URL":"https:\/\/doi.org\/10.1038\/s41409-025-02676-1","relation":{},"ISSN":["0268-3369","1476-5365"],"issn-type":[{"value":"0268-3369","type":"print"},{"value":"1476-5365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,24]]},"assertion":[{"value":"23 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study was reviewed and approved by the Local Research Ethics Committee of the Hospital de Cl\u00ednicas de Porto Alegre and other participating centers (CAAE: 42464621.5.1001.5327, #2021-0035). All methods were performed in accordance with relevant guidelines and regulations. Due to the retrospective nature of this study, the requirement for informed consent was waived by the Ethics Committees of the participating institutions.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}]}}