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Bone represents a frequent site for metastasis, where Spindle-shaped N-cadherin\n                    <jats:sup>+<\/jats:sup>\n                    CD45\n                    <jats:sup>\u2212<\/jats:sup>\n                    osteoblasts (SNOs) hold dormant metastatic cells in the endosteal niche with a Notch2-dependent mechanism. In this work, we excluded the involvement of Notch1 in SNO-induced breast cancer cellular dormancy by immunofluorescence\/immunohistochemistry and molecular approaches, using breast cancer tissues and cell lines. RNAdSeq in human bone metastatic MDA-MB231 breast cancer cells sorted for Notch1\n                    <jats:sup>HIGH<\/jats:sup>\n                    and Notch2\n                    <jats:sup>HIGH<\/jats:sup>\n                    expression demonstrated that, compared to their low counterpart, only Notch2\n                    <jats:sup>HIGH<\/jats:sup>\n                    cells expressed enriched pathways relevant for the metastatic process, including pluripotency and Hematopoietic Stem Cell (HSC) gene signatures. They expressed the HSC-associated genes\n                    <jats:italic>CXCR4<\/jats:italic>\n                    ,\n                    <jats:italic>CD34<\/jats:italic>\n                    and\n                    <jats:italic>TIE2<\/jats:italic>\n                    and MDA-MB231 cells enriched in the encoded proteins showed lesser proliferation ability. Reduced incidence of osteolytic lesions was induced by CXCR4\n                    <jats:sup>HIGH<\/jats:sup>\n                    cells intratibially injected in immunocompromised mice, while lower lesion extension was induced by CXCR4\n                    <jats:sup>HIGH<\/jats:sup>\n                    and TIE2\n                    <jats:sup>HIGH<\/jats:sup>\n                    injected cells compared to CXCR4\n                    <jats:sup>LOW<\/jats:sup>\n                    and TIE2\n                    <jats:sup>LOW<\/jats:sup>\n                    cells. Notch2\n                    <jats:sup>HIGH<\/jats:sup>\n                    cells were enriched in endoplasmic reticulum stress and unfolded protein response genes and overexpressed the CD177 protein, while the CD177 ligands, Plaur, Itgam and Ceacam 1, were highly expressed in SNOs. Kaplan-Meier plots showed positive correlation between high expression of CD177, ITGAM and CEACAM 1 - but not PLAUR - and overall survival of patients. CD177\n                    <jats:sup>HIGH<\/jats:sup>\n                    cells were also CXCR4\n                    <jats:sup>HIGH<\/jats:sup>\n                    , CD34\n                    <jats:sup>HIGH<\/jats:sup>\n                    and Notch2\n                    <jats:sup>HIGH<\/jats:sup>\n                    and proliferated less than CD177\n                    <jats:sup>LOW<\/jats:sup>\n                    cells. These results support the relevance of Notch2 in SNO-mediated cellular dormancy and identified new pathways implicated in bone metastatic breast cancer cell quiescence.\n                  <\/jats:p>","DOI":"10.1038\/s41413-026-00535-3","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T06:57:14Z","timestamp":1778741834000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The endosteal niche regulates breast cancer cell dormancy in bone: identification of new molecular determinants"],"prefix":"10.1038","volume":"14","author":[{"given":"Antonio","family":"Maurizi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Salbini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Ciocca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzia","family":"Rea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe D.","family":"Tocchini-Valentini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilde","family":"Merolle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8254-9333","authenticated-orcid":false,"given":"Hanna","family":"Taipaleenm\u00e4ki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2624-5677","authenticated-orcid":false,"given":"Christina M\u00f8ller","family":"Andreasen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Pellegrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5887-4419","authenticated-orcid":false,"given":"Anna","family":"Teti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"535_CR1","doi-asserted-by":"publisher","first-page":"216899","DOI":"10.1016\/j.canlet.2024.216899","volume":"591","author":"R Liu","year":"2024","unstructured":"Liu, R. et al. 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