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We identify that core-binding factor \u03b2 (Cbf\u03b2) in bone marrow Adipoq\n                    <jats:sup>+<\/jats:sup>\n                    cells (BMACs) is essential for maintaining SSPC number and function. Cbf\u03b2 deletion in BMACs (CKO) leads to SSPC depletion, including periosteal populations, and impairs bicortical fracture healing in mice. Multi-omics (RNA-seq, CUT&amp;Tag-seq, and ATAC-seq) reveal that Cbf\u03b2 preserves chromatin accessibility at DNA repair loci, maintaining genomic stability, preventing BMAC senescence, and mitigating the senescence-associated secretory phenotype (SASP). Senolytic therapy alleviates BMAC senescence, restores SSPC populations, and improves bone repair in CKO mice. In both humans and mice, Cbf\u03b2 expression declines with aging, accompanied by increased BMAC senescence. AAV-mediated Cbf\u03b2 overexpression restores aging-related bone repair and SSPC decline. These findings reveal a novel mechanism in which Cbf\u03b2 in BMACs regulates SSPC maintenance via a senescence\/SASP axis, offering a potential therapeutic strategy for age-related bone repair deficits.\n                  <\/jats:p>","DOI":"10.1038\/s41413-026-00568-8","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T07:41:23Z","timestamp":1786347683000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Youthfulness of marrow Adipoq+ cells maintained by Cbf\u03b2 facilitates stem cell-based bone repair"],"prefix":"10.1038","volume":"14","author":[{"given":"Tiannan","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shali","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erman","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meizhu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenhe","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2188-6958","authenticated-orcid":false,"given":"Yi-Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1059-0916","authenticated-orcid":false,"given":"Mengrui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"568_CR1","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1210\/endrev\/bnac008","volume":"43","author":"D Saul","year":"2022","unstructured":"Saul, D. & Khosla, S. 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