{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T03:12:10Z","timestamp":1793502730551,"version":"4.5.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T00:00:00Z","timestamp":1570752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T00:00:00Z","timestamp":1570752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100009528","name":"Children's Hospital of Michigan Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009528","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Justin\u2019s Gift Charity"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Br J Cancer"],"published-print":{"date-parts":[[2019,11,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n              <jats:p>Fetoplacental neuroblastoma metastasis has been postulated as a mechanism accounting for concordant cases where one twin develops a primary tumour and the second twin manifests the disease without an identifiable primary site. These tumours may originate and spread concomitantly due to the same genetic background shared by monozygotic twins. This study investigated the molecular profile of stage MS neuroblastoma presenting concomitantly in monozygotic twins. Comparative genomic hybridisation (aCGH) was done for each of the twin liver tumour and peripheral blood samples at diagnosis. Comparison of copy-number variation (CNV) regions revealed a set of CNVs that were common to both tumour specimens and not apparent in the blood. The CNV signature in both twins\u2019 tumours was highly similar, suggesting a common clonal origin. Additional findings included large deletion of chromosome 10 and amplification of chromosome 17. Notably, both liver samples had amplification of a short region involving <jats:italic>DEIN<\/jats:italic> (chromosome 4q34.1). Similar CNVs strongly support a common clonal origin and metastatic spread from one twin to the other. <jats:italic>DEIN<\/jats:italic> is a long-coding RNA (IncRNA) that has been found highly expressed in stage MS neuroblastoma and is likely involved in biological processes such as cell migration and metastasis.<\/jats:p>","DOI":"10.1038\/s41416-019-0594-3","type":"journal-article","created":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T23:06:42Z","timestamp":1570748802000},"page":"890-893","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Monozygotic twins with neuroblastoma MS have a similar molecular profile: a case of twin-to-twin metastasis"],"prefix":"10.1038","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5821-6216","authenticated-orcid":false,"given":"Margaret","family":"Shatara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana C.","family":"Xavier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Dombkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Cukovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet M.","family":"Poulik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz","family":"Altinok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubin","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey W.","family":"Taub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,10,11]]},"reference":[{"key":"594_CR1","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1002\/pbc.24906","volume":"61","author":"R Abu-Arja","year":"2014","unstructured":"Abu-Arja, R., Hashem, H., El-Sheikh, A. & Abusin, G. Neuroblastoma in monozygotic twins with distinct presentation pathology and outcome: is it familial or in utero metastasis. Pediatr. Blood Cancer 61, 1124\u20131125 (2014).","journal-title":"Pediatr. Blood Cancer"},{"key":"594_CR2","doi-asserted-by":"publisher","first-page":"2312","DOI":"10.1016\/j.jpedsurg.2010.08.025","volume":"45","author":"T Tajiri","year":"2010","unstructured":"Tajiri, T., Souzaki, R., Kinoshita, Y., Tanaka, S., Koga, Y., Suminoe, A. et al. Concordance for neuroblastoma in monozygotic twins: case report and review of the literature. J. Pediatr Surg. 45, 2312\u20132316 (2010).","journal-title":"J Pediatr Surg."},{"key":"594_CR3","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1016\/S1470-2045(13)70309-7","volume":"14","author":"SG Kreissman","year":"2013","unstructured":"Kreissman, S. G., Seeger, R. C., Matthay, K. K., London, W. B., Sposto, R., Grupp, S. A. et al. Purged versus non-purged peripheral blood stem-cell transplantation for high-risk neuroblastoma (COG A3973): a randomised phase 3 trial. Lancet Oncol. 14, 999\u20131008 (2013).","journal-title":"Lancet Oncol."},{"key":"594_CR4","unstructured":"Agilent Technologies I. Agilent Oligonucleotide Array-Based CGH for Genomic DNA Analysis. ULS Labeling for Blood, Cells, Tissues, or FFPE (with a High Throughput option). Agilent.com. Protocol Version 2015 Aug, 3.5:1\u201394 (2015)."},{"key":"594_CR5","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1002\/gcc.22174","volume":"53","author":"J Theissen","year":"2014","unstructured":"Theissen, J., Oberthuer, A., Hombach, A., Volland, R., Hertwig, F., Fischer, M. et al. Chromosome 17\/17q gain and unaltered profiles in high resolution array-CGH are prognostically informative in neuroblastoma. Genes Chromosomes Cancer 53, 639\u2013649 (2014).","journal-title":"Genes Chromosomes Cancer"},{"key":"594_CR6","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1097\/00043426-199905000-00005","volume":"21","author":"SG DuBois","year":"1999","unstructured":"DuBois, S. G., Kalika, Y., Lukens, J. N., Brodeur, G. M., Seeger, R. C., Atkinson, J. B. et al. Metastatic sites in stage IV and IVS neuroblastoma correlate with age, tumor biology, and survival. J. Pediatr. Hematol. Oncol. 21, 181\u2013189 (1999).","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"594_CR7","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1080\/15592294.2016.1226739","volume":"11","author":"A Decock","year":"2016","unstructured":"Decock, A., Ongenaert, M., De Wilde, B., Brichard, B., Noguera, R., Speleman, F. et al. Stage 4S neuroblastoma tumors show a characteristic DNA methylation portrait. Epigenetics 11, 761\u2013771 (2016).","journal-title":"Epigenetics"},{"key":"594_CR8","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/S0140-6736(71)92705-X","volume":"1","author":"BD Clarkson","year":"1971","unstructured":"Clarkson, B. D. & Boyse, E. A. Possible explanation of the high concoddance for acute leukaemia in monozygotic twins. Lancet 1, 699\u2013701 (1971).","journal-title":"Lancet"},{"key":"594_CR9","doi-asserted-by":"publisher","first-page":"2321","DOI":"10.1182\/blood-2002-12-3817","volume":"102","author":"MF Greaves","year":"2003","unstructured":"Greaves, M. F., Maia, A. T., Wiemels, J. L. & Ford, A. M. Leukemia in twins: lessons in natural history. Blood 102, 2321\u20132333 (2003).","journal-title":"Blood"},{"key":"594_CR10","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1038\/nm.1944","volume":"15","author":"W Liu","year":"2009","unstructured":"Liu, W., Laitinen, S., Khan, S., Vihinen, M., Kowalski, J., Yu, G. et al. Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer. Nat. Med. 15, 559\u2013565 (2009).","journal-title":"Nat. Med."},{"key":"594_CR11","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1373\/clinchem.2014.227785","volume":"60","author":"L Hartmann","year":"2014","unstructured":"Hartmann, L., Stephenson, C. F., Verkamp, S. R., Johnson, K. R., Burnworth, B., Hammock, K. et al. Detection of clonal evolution in hematopoietic malignancies by combining comparative genomic hybridization and single nucleotide polymorphism arrays. Clin. Chem. 60, 1558\u20131568 (2014).","journal-title":"Clin. Chem."},{"key":"594_CR12","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-28941-6","volume":"8","author":"R J Jansen","year":"2018","unstructured":"J Jansen, R., Moehlendick, B., Bartenhagen, C., T\u00f3th, C., Lehwald, N., Stoecklein, N. H. et al. 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Oncol."},{"key":"594_CR17","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.gde.2017.03.008","volume":"42","author":"VP Tolbert","year":"2017","unstructured":"Tolbert, V. P., Coggins, G. E. & Maris, J. M. Genetic susceptibility to neuroblastoma. Curr. Opin. Genet. Dev. 42, 81\u201390 (2017).","journal-title":"Curr. Opin. Genet. Dev."}],"container-title":["British Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41416-019-0594-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41416-019-0594-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41416-019-0594-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:05:52Z","timestamp":1684616752000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41416-019-0594-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,11]]},"references-count":17,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,11,12]]}},"alternative-id":["594"],"URL":"https:\/\/doi.org\/10.1038\/s41416-019-0594-3","relation":{},"ISSN":["0007-0920","1532-1827"],"issn-type":[{"value":"0007-0920","type":"print"},{"value":"1532-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,11]]},"assertion":[{"value":"29 April 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 September 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 October 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study has ethical approval and consent to participate, which was obtained by\u00a0The Wayne State University Institutional Review Board in 2009 (IRB number 017505MP4F). The study was performed in accordance with the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"This study was funded by The Justin\u2019s Gift Charity and the Children\u2019s Hospital of Michigan Foundation.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"Consent was obtained from the mother.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"Data supporting the results are presented at the end of this paper and in Fig.\u00a0. Detailed method is presented at the end of this paper.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data availability"}},{"value":"This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons Attribution 4.0 International (CC BY 4.0).","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Note"}}]}}