{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T01:18:16Z","timestamp":1788311896044,"version":"build-2803163510"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T00:00:00Z","timestamp":1571961600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T00:00:00Z","timestamp":1571961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"NET Patient Foundation 74 Upper Holly Walk Leamington Spa UK CV32 4JL"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Br J Cancer"],"published-print":{"date-parts":[[2019,11,26]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The diagnosis of neuroendocrine neoplasms (NENs) is often delayed. This first UK population-based epidemiological study of NENs compares outcomes with non-NENs to identify any inequalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Age-standardised incidence rate (ASR), 1-year overall survival, hazard ratios and standardised mortality rates (SMRs) were calculated for all malignant NENs diagnosed 2013\u20132015 from UK national Public Health records. Comparison with non-NENs assessed 1-year overall survival (1YS) and association between diagnosis at stage IV and morphology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 15,222 NENs were identified, with an ASR (2013\u20132015 combined) of 8.6 per 100,000 (95% CI 8.5\u20138.7); 4.6 per 100 000 (95% CI, 4.5\u20134.7) for gastro-entero-pancreatic (GEP) NENs. The 1YS was 75% (95% CI, 73.9\u201375.4) varying significantly by sex. Site and morphology were prognostic. NENs (predominantly small cell carcinomas) in the oesophagus, bladder, prostate, and female reproductive organs had a poorer outcome and were three times more likely to be diagnosed at stage IV than non-NENs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Advanced stage at diagnosis with significantly poorer outcomes of some NENs compared with non-NENs at the same anatomical site, highlight the need for improved access to specialist services and targeted service improvement.<\/jats:p><\/jats:sec>","DOI":"10.1038\/s41416-019-0606-3","type":"journal-article","created":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T18:27:10Z","timestamp":1572028030000},"page":"966-972","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Impact of neuroendocrine morphology on cancer outcomes and stage at diagnosis: a UK nationwide cohort study 2013\u20132015"],"prefix":"10.1038","volume":"121","author":[{"given":"Tracey S. 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The Regulation provides the legal context to set aside the common-law duty of confidence to allow data to be collected without direct consent to support core public health functions. It is this permission that enables the UK cancer registries to collect detailed information from all people resident in the UK who have cancer or a reasonable suspicion of cancer.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"This project was funded by the NET Patient Foundation.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"No individual\u2019s personal data was included, only aggregated data is presented.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publish"}},{"value":"Supplementary datasets cited have been made available as supplementary material. Other data for this study is available on request from PHE NCRAS, NHS National Services Scotland, Public Health Wales Welsh Cancer Intelligence & Surveillance Unit and Public Health Agency Queen\u2019s University Belfast.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data availability"}}]}}