{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:29:19Z","timestamp":1790357359944,"version":"4.1.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Br J Cancer"],"published-print":{"date-parts":[[2019,11,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n              <jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The antihypertensive agent hydrochlorothiazide has been associated with increased risks of non-melanoma skin cancer (NMSC) and possibly some melanoma subtypes. Previous studies were, however, conducted in predominantly Caucasian populations. We therefore examined the association between hydrochlorothiazide and skin cancer risk in an Asian population.<\/jats:p>\n              <\/jats:sec>\n              <jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>By using Taiwan\u2019s National Health Insurance Research Database (NHIRD), we conducted three separate case\u2013control studies of lip cancer, non-lip non-melanoma skin cancer and melanoma. Cases (<jats:italic>n<\/jats:italic>\u2009=\u200929,082) with a first-ever skin cancer diagnoses (2008\u20132015) were matched 1:10 to population controls. We estimated odds ratios (ORs) associating hydrochlorothiazide use with skin cancer risk by using conditional logistic regression.<\/jats:p>\n              <\/jats:sec>\n              <jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Hydrochlorothiazide use showed no overall association with any of the three outcomes: ORs for high cumulative use of HCTZ (\u226550,000\u2009mg) were 0.86 (95% CI 0.09\u20137.81) for lip cancer, 1.16 (95% CI 0.98\u20131.37) for non-lip NMSC and 1.07 (95% CI 0.65\u20131.76) for melanoma. There was some evidence of a dose\u2013response pattern for non-lip NMSC, with an OR of 1.66 (95% CI 0.82\u20133.33) for 100,000\u2013149,999\u2009mg of HCTZ. The null findings were robust across subgroup and sensitivity analyses.<\/jats:p>\n              <\/jats:sec>\n              <jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Use of HCTZ appears safe in terms of skin cancer risk in an Asian population.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1038\/s41416-019-0613-4","type":"journal-article","created":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T09:30:41Z","timestamp":1572600641000},"page":"973-978","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Use of hydrochlorothiazide and risk of skin cancer: a nationwide Taiwanese case\u2013control study"],"prefix":"10.1038","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9314-5679","authenticated-orcid":false,"given":"Anton","family":"Potteg\u00e5rd","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7457-9092","authenticated-orcid":false,"given":"Sidsel Arnspang","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrun Alba Johannesdottir","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaw-Ning","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Kai","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu-Chi","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Chieh","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward Chia-Cheng","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,11,1]]},"reference":[{"key":"613_CR1","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1001\/archinternmed.2012.2754","volume":"172","author":"GD Friedman","year":"2012","unstructured":"Friedman, G. 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The remaining authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The study was approved by the Institutional Review Board of National Cheng-Kung University Hospital (B-ER-107-378) that also waived the requirement for informed consent by the participants. We performed the study in accordance with the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"This study was supported in part by a grant from Taiwan\u2019s Ministry of Science and Technology (107-2320-B-006-070-MY3). The funder had no role in the design, conduct, or data interpretation of the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"The data that support the findings of this study are available from Taiwan\u2019s National Health Insurance Research Database (NHIRD). Restrictions apply to the availability of these data, which were used under license for this study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data availability"}},{"value":"This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons Attribution 4.0 International (CC BY 4.0).","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Note"}}]}}