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Incident primary cancer cases were ascertained by linkage to the New South Wales Cancer Registry to 2013 by the Centre for Health Record Linkage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Over a median of 5.4 years, 17,332 cancers were diagnosed. Increasing levels of alcohol intake were associated with increased risk of cancers of the upper aerodigestive tract (1.19; 1.10\u20131.29), mouth and pharynx (1.18; 1.08\u20131.29), oesophagus (1.22; 1.04\u20131.43), colorectum (1.09; 1.04\u20131.15), colon (1.13; 1.06\u20131.20), liver (1.22; 1.04\u20131.44) and breast (1.11; 1.02\u20131.21). Breast cancer risk was marginally associated with drinking pattern, with higher risk when intake was concentrated on 1\u20133 days\/week compared to the same amount spread over 4\u20137 days (\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>interaction<\/jats:sub>\n                      \u2009=\u20090.049).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Alcohol consumption confers a significant risk of cancer, and drinking pattern may be independently related to breast cancer risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1038\/s41416-020-01101-2","type":"journal-article","created":{"date-parts":[[2020,10,11]],"date-time":"2020-10-11T15:02:31Z","timestamp":1602428551000},"page":"513-523","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Alcohol consumption, drinking patterns and cancer incidence in an Australian cohort of 226,162 participants aged 45 years and over"],"prefix":"10.1038","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9596-6825","authenticated-orcid":false,"given":"Peter","family":"Sarich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Canfell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Egger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Banks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Joshy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Grogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne F.","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,10,11]]},"reference":[{"key":"1101_CR1","unstructured":"Australian Bureau of Statistics. 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All participants consented to participate by signing a consent form that accompanied the questionnaire. All procedures were performed in accordance with the Declaration of Helsinki.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"The data that support the findings of this study are available from the Sax Institute (\n                      \n                      ).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data availability"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Dr. Peter Sarich was funded by a postgraduate research scholarship from Cancer Council NSW, the 45 and Up PhD Scholarship in Cancer Research. Prof. Karen Canfell is co-principal investigator of an unrelated investigator-initiated trial of cervical screening in Australia (Compass; ACTRN12613001207707 and NCT02328872), which is conducted and funded by the VCS Foundation (VCS), a government-funded health promotion charity. She is also an investigator of Compass New Zealand (ACTRN12614000714684), which was conducted and funded by Diagnostic Medlab (DML), now Auckland District Health Board. The VCS Foundation received equipment and a funding contribution from Roche Molecular Systems and Ventana USA and DML received equipment and a funding contribution for Compass from Roche Molecular Systems. However, neither Prof. Canfell nor her institution on her behalf (Cancer Council NSW) receives direct funding from industry for this trial or any other project. Prof. Emily Banks is supported by the National Health and Medical Research Council of Australia (reference: 1136128) and the Government of Australia. The funding source had no role in study design; in the collection, analysis and interpretation of data; in the writing of the report; in the decision to submit the paper for publication.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding information"}}]}}