{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:40:07Z","timestamp":1788345607895,"version":"build-2803163510"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T00:00:00Z","timestamp":1626307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T00:00:00Z","timestamp":1626307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["R35 CA253185"],"award-info":[{"award-number":["R35 CA253185"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA205406"],"award-info":[{"award-number":["R01 CA205406"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["R21 CA230873"],"award-info":[{"award-number":["R21 CA230873"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["UM1 CA186107"],"award-info":[{"award-number":["UM1 CA186107"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["U01 CA167552"],"award-info":[{"award-number":["U01 CA167552"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["P01 CA87969"],"award-info":[{"award-number":["P01 CA87969"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["P50 CA127003"],"award-info":[{"award-number":["P50 CA127003"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["R35 CA197735"],"award-info":[{"award-number":["R35 CA197735"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["P01 CA 55075"],"award-info":[{"award-number":["P01 CA 55075"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["R03 CA197879"],"award-info":[{"award-number":["R03 CA197879"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["R21 CA222940"],"award-info":[{"award-number":["R21 CA222940"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["R21 CA230873"],"award-info":[{"award-number":["R21 CA230873"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Stuart and Suzanne Steele MGH Research Scholar"},{"name":"U.S. Department of Health & Human Services | National Institutes of Health"},{"name":"U.S. Department of Health & Human Services | National Institutes of Health"},{"name":"U.S. Department of Health & Human Services | National Institutes of Health"},{"name":"U.S. Department of Health & Human Services | National Institutes of Health"},{"name":"U.S. Department of Health & Human Services | National Institutes of Health"},{"name":"U.S. Department of Health & Human Services | National Institutes of Health"},{"name":"U.S. Department of Health & Human Services | National Institutes of Health"},{"name":"U.S. Department of Health & Human Services | National Institutes of Health"},{"name":"U.S. Department of Health & Human Services | National Institutes of Health"},{"name":"U.S. Department of Health & Human Services | National Institutes of Health"},{"name":"U.S. Department of Health & Human Services | National Institutes of Health"},{"DOI":"10.13039\/100000969","name":"American Institute for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000969","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Br J Cancer"],"published-print":{"date-parts":[[2021,9,28]]},"DOI":"10.1038\/s41416-021-01487-7","type":"journal-article","created":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T16:03:24Z","timestamp":1626365004000},"page":"1016-1024","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Sugar-sweetened beverage, artificially sweetened beverage and sugar intake and colorectal cancer survival"],"prefix":"10.1038","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7965-9769","authenticated-orcid":false,"given":"Emilie S.","family":"Zoltick","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie A.","family":"Smith-Warner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles S.","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Meyerhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew T.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimmie","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3909-2323","authenticated-orcid":false,"given":"Shuji","family":"Ogino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meir J.","family":"Stampfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward L.","family":"Giovannucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7300-1694","authenticated-orcid":false,"given":"Kana","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,15]]},"reference":[{"key":"1487_CR1","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s00384-005-0776-8","volume":"21","author":"M Davies","year":"2006","unstructured":"Davies M, Gupta S, Goldspink G, Winslet M. The insulin-like growth factor system and colorectal cancer: clinical and experimental evidence. Int J Colorectal Dis. 2006;21:201\u20138.","journal-title":"Int J Colorectal Dis"},{"key":"1487_CR2","unstructured":"World Cancer Research Fund\/American Institute for Cancer Research. Diet, Nutrition, Physical Activity and Cancer: A Global Perspective. Continuous Update Project Expert Report. 2018. dietandcancerreport.org."},{"key":"1487_CR3","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1093\/jnci\/dji375","volume":"97","author":"SC Larsson","year":"2005","unstructured":"Larsson SC, Orsini N, Wolk A. Diabetes mellitus and risk of colorectal cancer: a meta-analysis. J Natl Cancer Inst. 2005;97:1679\u201387.","journal-title":"J Natl Cancer Inst"},{"key":"1487_CR4","doi-asserted-by":"publisher","first-page":"e0120706","DOI":"10.1371\/journal.pone.0120706","volume":"10","author":"J Lee","year":"2015","unstructured":"Lee J, Meyerhardt JA, Giovannucci E, Jeon JY. Association between body mass index and prognosis of colorectal cancer: a meta-analysis of prospective cohort studies. PLoS ONE. 2015;10:e0120706.","journal-title":"PLoS ONE"},{"key":"1487_CR5","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1093\/annonc\/mdu012","volume":"25","author":"D Schmid","year":"2014","unstructured":"Schmid D, Leitzmann MF. Association between physical activity and mortality among breast cancer and colorectal cancer survivors: a systematic review and meta-analysis. Ann Oncol. 2014;25:1293\u2013311.","journal-title":"Ann Oncol"},{"key":"1487_CR6","doi-asserted-by":"publisher","first-page":"e115377","DOI":"10.1371\/journal.pone.0115377","volume":"9","author":"TT Fung","year":"2014","unstructured":"Fung TT, Kashambwa R, Sato K, Chiuve SE, Fuchs CS, Wu K, et al. Post diagnosis diet quality and colorectal cancer survival in women. PLoS ONE. 2014;9:e115377.","journal-title":"PLoS ONE"},{"key":"1487_CR7","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1001\/jama.298.7.754","volume":"298","author":"JA Meyerhardt","year":"2007","unstructured":"Meyerhardt JA, Niedzwiecki D, Hollis D, Saltz LB, Hu FB, Mayer RJ, et al. Association of dietary patterns with cancer recurrence and survival in patients with stage III colon cancer. JAMA. 2007;298:754\u201364.","journal-title":"JAMA"},{"key":"1487_CR8","doi-asserted-by":"publisher","first-page":"1702","DOI":"10.1093\/jnci\/djs399","volume":"104","author":"JA Meyerhardt","year":"2012","unstructured":"Meyerhardt JA, Sato K, Niedzwiecki D, Ye C, Saltz LB, Mayer RJ, et al. Dietary glycemic load and cancer recurrence and survival in patients with stage III colon cancer: findings from CALGB 89803. J Natl Cancer Inst. 2012;104:1702\u201311.","journal-title":"J Natl Cancer Inst"},{"key":"1487_CR9","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1038\/bjc.2017.272","volume":"117","author":"C Yuan","year":"2017","unstructured":"Yuan C, Bao Y, Sato K, Nimptsch K, Song M, Brand-Miller JC, et al. Influence of dietary insulin scores on survival in colorectal cancer patients. Br J Cancer. 2017;117:1079\u201387.","journal-title":"Br J Cancer"},{"key":"1487_CR10","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1016\/S1470-2045(06)70976-7","volume":"7","author":"LW Jones","year":"2006","unstructured":"Jones LW, Demark-Wahnefried W. Diet, exercise, and complementary therapies after primary treatment for cancer. Lancet Oncol. 2006;7:1017\u201326.","journal-title":"Lancet Oncol"},{"key":"1487_CR11","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1016\/j.jacc.2015.08.025","volume":"66","author":"VS Malik","year":"2015","unstructured":"Malik VS, Hu FB. Fructose and cardiometabolic health: what the evidence from sugar-sweetened beverages tells us. J Am Coll Cardiol. 2015;66:1615\u201324.","journal-title":"J Am Coll Cardiol"},{"key":"1487_CR12","doi-asserted-by":"publisher","first-page":"e99816","DOI":"10.1371\/journal.pone.0099816","volume":"9","author":"MA Fuchs","year":"2014","unstructured":"Fuchs MA, Sato K, Niedzwiecki D, Ye X, Saltz LB, Mayer RJ, et al. Sugar-sweetened beverage intake and cancer recurrence and survival in CALGB 89803 (Alliance). PLoS ONE. 2014;9:e99816.","journal-title":"PLoS ONE"},{"key":"1487_CR13","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1111\/obr.12040","volume":"14","author":"FB Hu","year":"2013","unstructured":"Hu FB. Resolved: there is sufficient scientific evidence that decreasing sugar-sweetened beverage consumption will reduce the prevalence of obesity and obesity-related diseases. Obes Rev. 2013;14:606\u201319.","journal-title":"Obes Rev"},{"key":"1487_CR14","unstructured":"Fakhouri THI, Kit BK, Ogden CL. Consumption of diet drinks in the United States, 2009\u20122010. NCHS data brief, no 109. Hyattsville, MD: National Center for Health Statistics. 2012."},{"key":"1487_CR15","doi-asserted-by":"publisher","first-page":"e0199244","DOI":"10.1371\/journal.pone.0199244","volume":"13","author":"BJ Guercio","year":"2018","unstructured":"Guercio BJ, Zhang S, Niedzwiecki D, Li Y, Babic A, Morales-Oyarvide V, et al. Associations of artificially sweetened beverage intake with disease recurrence and mortality in stage III colon cancer: Results from CALGB 89803 (Alliance). PLoS ONE. 2018;13:e0199244.","journal-title":"PLoS ONE"},{"key":"1487_CR16","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1001\/jama.2013.6562","volume":"310","author":"DS Ludwig","year":"2013","unstructured":"Ludwig DS. Examining the health effects of fructose. JAMA. 2013;310:33\u201334.","journal-title":"JAMA"},{"key":"1487_CR17","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1007\/s10620-016-4054-0","volume":"61","author":"S Softic","year":"2016","unstructured":"Softic S, Cohen DE, Kahn CR. Role of dietary fructose and hepatic de novo lipogenesis in fatty liver disease. Dig Dis Sci. 2016;61:1282\u201393.","journal-title":"Dig Dis Sci"},{"key":"1487_CR18","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1089\/jwh.1997.6.49","volume":"6","author":"GA Colditz","year":"1997","unstructured":"Colditz GA, Manson JE, Hankinson SE. The Nurses\u2019 Health Study: 20-year contribution to the understanding of health among women. J Women\u2019s Health. 1997;6:49\u201362.","journal-title":"J Women\u2019s Health"},{"key":"1487_CR19","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/0140-6736(91)90542-W","volume":"338","author":"EB Rimm","year":"1991","unstructured":"Rimm EB, Giovannucci EL, Willett WC, Colditz GA, Ascherio A, Rosner B, et al. Prospective study of alcohol consumption and risk of coronary disease in men. Lancet. 1991;338:464\u20138.","journal-title":"Lancet"},{"key":"1487_CR20","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1093\/oxfordjournals.aje.a113804","volume":"119","author":"MJ Stampfer","year":"1984","unstructured":"Stampfer MJ, Willett WC, Speizer FE, Dysert DC, Lipnick R, Rosner B, et al. Test of the National Death Index. Am J Epidemiol. 1984;119:837\u20139.","journal-title":"Am J Epidemiol"},{"key":"1487_CR21","unstructured":"Willet W. Nutritional Epidemiology. 3rd edn. New York: Oxford University Press; 2012."},{"key":"1487_CR22","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1161\/CIRCULATIONAHA.109.192627","volume":"120","author":"RK Johnson","year":"2009","unstructured":"Johnson RK, Appel LJ, Brands M, Howard BV, Lefevre M, Lustig RH, et al. Dietary sugars intake and cardiovascular health: a scientific statement from the American Heart Association. Circulation. 2009;120:1011\u201320.","journal-title":"Circulation"},{"key":"1487_CR23","doi-asserted-by":"publisher","first-page":"1220S","DOI":"10.1093\/ajcn\/65.4.1220S","volume":"65","author":"WC Willett","year":"1997","unstructured":"Willett WC, Howe GR, Kushi LH. Adjustment for total energy intake in epidemiologic studies. Am J Clin Nutr. 1997;65:1220S\u20131228S.","journal-title":"Am J Clin Nutr"},{"key":"1487_CR24","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1002\/sim.4780080504","volume":"8","author":"S Durrleman","year":"1989","unstructured":"Durrleman S, Simon R. Flexible regression models with cubic splines. Stat Med. 1989;8:551\u201361.","journal-title":"Stat Med"},{"key":"1487_CR25","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1093\/ajcn\/76.6.1261","volume":"76","author":"ML McCullough","year":"2002","unstructured":"McCullough ML, Feskanich D, Stampfer MJ, Giovannucci EL, Rimm EB, Hu FB, et al. Diet quality and major chronic disease risk in men and women: moving toward improved dietary guidance. Am J Clin Nutr. 2002;76:1261\u201371.","journal-title":"Am J Clin Nutr"},{"key":"1487_CR26","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1093\/jnci\/djq107","volume":"102","author":"X Zhang","year":"2010","unstructured":"Zhang X, Albanes D, Beeson WL, van den Brandt PA, Buring JE, Flood A, et al. Risk of colon cancer and coffee, tea, and sugar-sweetened soft drink intake: pooled analysis of prospective cohort studies. J Natl Cancer Inst. 2010;102:771\u201383.","journal-title":"J Natl Cancer Inst"},{"key":"1487_CR27","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1158\/1055-9965.EPI-05-0428","volume":"14","author":"DS Michaud","year":"2005","unstructured":"Michaud DS, Fuchs CS, Liu S, Willett WC, Colditz GA, Giovannucci E. Dietary glycemic load, carbohydrate, sugar, and colorectal cancer risk in men and women. Cancer Epidemiol Biomark Prev. 2005;14:138\u201347.","journal-title":"Cancer Epidemiol Biomark Prev"},{"key":"1487_CR28","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1007\/s10552-012-9918-9","volume":"23","author":"D Aune","year":"2012","unstructured":"Aune D, Chan DS, Lau R, Vieira R, Greenwood DC, Kampman E, et al. Carbohydrates, glycemic index, glycemic load, and colorectal cancer risk: a systematic review and meta-analysis of cohort studies. Cancer Causes Control. 2012;23:521\u201335.","journal-title":"Cancer Causes Control"},{"key":"1487_CR29","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1016\/j.jand.2016.06.003","volume":"116","author":"ES Powell","year":"2016","unstructured":"Powell ES, Smith-Taillie LP, Popkin BM. Added sugars intake across the distribution of US children and adult consumers: 1977-2012. J Acad Nutr Diet. 2016;116:1543\u201350 e1541.","journal-title":"J Acad Nutr Diet"},{"key":"1487_CR30","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1093\/ajcn\/66.5.1264","volume":"66","author":"SH Holt","year":"1997","unstructured":"Holt SH, Miller JC, Petocz P. An insulin index of foods: the insulin demand generated by 1000-kJ portions of common foods. Am J Clin Nutr. 1997;66:1264\u201376.","journal-title":"Am J Clin Nutr"},{"key":"1487_CR31","doi-asserted-by":"publisher","first-page":"e8077","DOI":"10.1136\/bmj.e8077","volume":"346","author":"WC Willett","year":"2013","unstructured":"Willett WC, Ludwig DS. Science souring on sugar. BMJ. 2013;346:e8077.","journal-title":"BMJ"},{"key":"1487_CR32","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1158\/1055-9965.EPI-17-0200","volume":"26","author":"BJ Caan","year":"2017","unstructured":"Caan BJ, Meyerhardt JA, Kroenke CH, Alexeeff S, Xiao J, Weltzien E, et al. Explaining the obesity paradox: the association between body composition and colorectal cancer survival (C-SCANS Study). Cancer Epidemiol Biomark Prev. 2017;26:1008\u201315.","journal-title":"Cancer Epidemiol Biomark Prev"},{"key":"1487_CR33","unstructured":"Noone A. M, Howlader N, Krapcho M, Miller D, Brest A, Yu M, et al. (eds). SEER Cancer Statistics Review, 1975-2015 (based on November 2017 SEER data submission). Bethesda: National Cancer Institute; 2018."},{"key":"1487_CR34","first-page":"1013","volume":"5","author":"TT Tran","year":"1996","unstructured":"Tran TT, Medline A, Bruce WR. Insulin promotion of colon tumors in rats. Cancer Epidemiol Biomark Prev. 1996;5:1013\u20135.","journal-title":"Cancer Epidemiol Biomark Prev"},{"key":"1487_CR35","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.cellsig.2007.10.010","volume":"20","author":"J Sun","year":"2008","unstructured":"Sun J, Jin T. Both Wnt and mTOR signaling pathways are involved in insulin-stimulated proto-oncogene expression in intestinal cells. Cell Signal. 2008;20:219\u201329.","journal-title":"Cell Signal"},{"key":"1487_CR36","doi-asserted-by":"crossref","unstructured":"Cooney RV, Chai W, Franke AA, Wilkens LR, Kolonel LN, Le Marchand, L. C-reactive protein, lipid-soluble micronutrients, and survival in colorectal cancer patients. Cancer Epidemiol Biomark Prev. 2013;22:1278\u201388.","DOI":"10.1158\/1055-9965.EPI-13-0199"},{"key":"1487_CR37","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1161\/CIRCULATIONAHA.111.067017","volume":"125","author":"L de Koning","year":"2012","unstructured":"de Koning L, Malik VS, Kellogg MD, Rimm EB, Willett WC, Hu FB. Sweetened beverage consumption, incident coronary heart disease, and biomarkers of risk in men. Circulation. 2012;125:1735\u201341. S1731.","journal-title":"Circulation"},{"key":"1487_CR38","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1093\/ajcn\/49.6.1155","volume":"49","author":"AW Thorburn","year":"1989","unstructured":"Thorburn AW, Storlien LH, Jenkins AB, Khouri S, Kraegen EW. Fructose-induced in vivo insulin resistance and elevated plasma triglyceride levels in rats. Am J Clin Nutr. 1989;49:1155\u201363.","journal-title":"Am J Clin Nutr"},{"key":"1487_CR39","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1093\/ajcn\/33.2.273","volume":"33","author":"H Beck-Nielsen","year":"1980","unstructured":"Beck-Nielsen H, Pedersen O, Lindskov HO. Impaired cellular insulin binding and insulin sensitivity induced by high-fructose feeding in normal subjects. Am J Clin Nutr. 1980;33:273\u20138.","journal-title":"Am J Clin Nutr"},{"key":"1487_CR40","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1093\/ajcn\/80.4.1043","volume":"80","author":"T Wu","year":"2004","unstructured":"Wu T, Giovannucci E, Pischon T, Hankinson SE, Ma J, Rifai N, et al. Fructose, glycemic load, and quantity and quality of carbohydrate in relation to plasma C-peptide concentrations in US women. Am J Clin Nutr. 2004;80:1043\u20139.","journal-title":"Am J Clin Nutr"},{"key":"1487_CR41","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1200\/JCO.2008.17.9945","volume":"27","author":"BM Wolpin","year":"2009","unstructured":"Wolpin BM, Meyerhardt JA, Chan AT, Ng K, Chan JA, Wu K, et al. Insulin, the insulin-like growth factor axis, and mortality in patients with nonmetastatic colorectal cancer. J Clin Oncol. 2009;27:176\u201385.","journal-title":"J Clin Oncol"},{"key":"1487_CR42","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1016\/j.jhep.2018.01.019","volume":"68","author":"T Jensen","year":"2018","unstructured":"Jensen T, Abdelmalek MF, Sullivan S, Nadeau KJ, Green M, Roncal C, et al. Fructose and sugar: a major mediator of non-alcoholic fatty liver disease. J Hepatol. 2018;68:1063\u201375.","journal-title":"J Hepatol"},{"key":"1487_CR43","doi-asserted-by":"publisher","first-page":"8263","DOI":"10.3748\/wjg.v23.i47.8263","volume":"23","author":"BJ Perumpail","year":"2017","unstructured":"Perumpail BJ, Khan MA, Yoo ER, Cholankeril G, Kim D, Ahmed A. Clinical epidemiology and disease burden of nonalcoholic fatty liver disease. World J Gastroenterol. 2017;23:8263\u201376.","journal-title":"World J Gastroenterol"},{"key":"1487_CR44","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.bbadis.2017.11.026","volume":"1864","author":"P Agosti","year":"2018","unstructured":"Agosti P, Sabba C, Mazzocca A. Emerging metabolic risk factors in hepatocellular carcinoma and their influence on the liver microenvironment. Biochim Biophys Acta Mol Basis Dis. 2018;1864:607\u201317.","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"1487_CR45","doi-asserted-by":"publisher","first-page":"2527","DOI":"10.1002\/ijc.26031","volume":"128","author":"RR Langley","year":"2011","unstructured":"Langley RR, Fidler IJ. The seed and soil hypothesis revisited-the role of tumor-stroma interactions in metastasis to different organs. Int J Cancer. 2011;128:2527\u201335.","journal-title":"Int J Cancer"},{"key":"1487_CR46","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1136\/gut.2004.062745","volume":"54","author":"N Andre","year":"2005","unstructured":"Andre N, Schmiegel W. Chemoradiotherapy for colorectal cancer. Gut. 2005;54:1194\u2013202.","journal-title":"Gut"},{"key":"1487_CR47","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.jhep.2015.03.032","volume":"63","author":"J Ma","year":"2015","unstructured":"Ma J, Fox CS, Jacques PF, Speliotes EK, Hoffmann U, Smith CE, et al. Sugar-sweetened beverage, diet soda, and fatty liver disease in the Framingham Heart Study cohorts. J Hepatol. 2015;63:462\u20139.","journal-title":"J Hepatol"},{"key":"1487_CR48","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1001\/jamainternmed.2013.13563","volume":"174","author":"Q Yang","year":"2014","unstructured":"Yang Q, Zhang Z, Gregg EW, Flanders WD, Merritt R, Hu FB. Added sugar intake and cardiovascular diseases mortality among US adults. JAMA Intern Med. 2014;174:516\u201324.","journal-title":"JAMA Intern Med"},{"key":"1487_CR49","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.3945\/ajcn.113.069369","volume":"99","author":"N Tasevska","year":"2014","unstructured":"Tasevska N, Park Y, Jiao L, Hollenbeck A, Subar AF, Potischman N. Sugars and risk of mortality in the NIH-AARP Diet and Health Study. Am J Clin Nutr. 2014;99:1077\u201388.","journal-title":"Am J Clin Nutr"},{"key":"1487_CR50","doi-asserted-by":"publisher","first-page":"2113","DOI":"10.1161\/CIRCULATIONAHA.118.037401","volume":"139","author":"VS Malik","year":"2019","unstructured":"Malik VS, Li Y, Pan A, De Koning L, Schernhammer E, Willett WC, et al. Long-term consumption of sugar-sweetened and artificially sweetened beverages and risk of mortality in US adults. Circulation. 2019;139:2113\u201325.","journal-title":"Circulation"},{"key":"1487_CR51","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1007\/s11894-017-0602-9","volume":"19","author":"M Pearlman","year":"2017","unstructured":"Pearlman M, Obert J, Casey L. The association between artificial sweeteners and obesity. Curr Gastroenterol Rep. 2017;19:64.","journal-title":"Curr Gastroenterol Rep"},{"key":"1487_CR52","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1016\/0002-8223(93)91754-E","volume":"93","author":"D Feskanich","year":"1993","unstructured":"Feskanich D, Rimm EB, Giovannucci EL, Colditz GA, Stampfer MJ, Litin LB, et al. Reproducibility and validity of food intake measurements from a semiquantitative food frequency questionnaire. J Am Diet Assoc. 1993;93:790\u20136.","journal-title":"J Am Diet Assoc"},{"key":"1487_CR53","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1093\/ije\/18.4.858","volume":"18","author":"S Salvini","year":"1989","unstructured":"Salvini S, Hunter DJ, Sampson L, Stampfer MJ, Colditz GA, Rosner B, et al. Food-based validation of a dietary questionnaire: the effects of week-to-week variation in food consumption. Int J Epidemiol. 1989;18:858\u201367.","journal-title":"Int J Epidemiol"},{"key":"1487_CR54","doi-asserted-by":"publisher","unstructured":"Al-Shaar L, Yuan C, Rosner B, Dean SB, Ivey KL, Clowry CM, et al. Reproducibility and validity of a semi-quantitative food frequency questionnaire in men assessed by multiple methods. Am J Epidemiol. 2020. https:\/\/doi.org\/10.1093\/aje\/kwaa280.","DOI":"10.1093\/aje\/kwaa280"},{"key":"1487_CR55","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1093\/aje\/kww104","volume":"185","author":"C Yuan","year":"2017","unstructured":"Yuan C, Spiegelman D, Rimm EB, Rosner BA, Stampfer MJ, Barnett JB, et al. Validity of a dietary questionnaire assessed by comparison with multiple weighed dietary records or 24-hour recalls. Am J Epidemiol. 2017;185:570\u201384.","journal-title":"Am J Epidemiol"},{"key":"1487_CR56","unstructured":"Zoltick ES. Nutritional and lifestyle factors for cancer incidence and survival. 2016. Preprint at http:\/\/nrs.harvard.edu\/urn-3:HUL.InstRepos:32644537."}],"container-title":["British Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41416-021-01487-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41416-021-01487-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41416-021-01487-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T00:03:01Z","timestamp":1657843381000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41416-021-01487-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,15]]},"references-count":56,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,9,28]]}},"alternative-id":["1487"],"URL":"https:\/\/doi.org\/10.1038\/s41416-021-01487-7","relation":{},"ISSN":["0007-0920","1532-1827"],"issn-type":[{"value":"0007-0920","type":"print"},{"value":"1532-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,15]]},"assertion":[{"value":"10 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 June 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"CSF reports consulting role for Amylin Pharmaceuticals, Astra-Zeneca, Bain Capital, CytomX Therapeutics, Daiichi-Sankyo, Eli Lilly, Entrinsic Health, Evolveimmune Therapeutics, Genentech, Merck, Taiho and Unum Therapeutics. He also serves as a Director for CytomX Therapeutics and owns unexercised stock options for CytomX and Entrinsic Health. He is a co-Founder of Evolveimmune Therapeutics and has equity in this private company. He had provided expert testimony for Amylin Pharmaceuticals and Eli Lilly. CSF is now an employee of Genentech and Roche. JAM received institutional research funding from Boston Biomedical and has served as an advisor\/consultant to Ignyta, Taiho and Cota; though this study was not funded by any of these commercial entities. ATC has received consulting fees from Bayer Pharma AG, Pfizer Inc, and Boehringer Ingelheim for work unrelated to this manuscript. He has also served as an investigator on a trial funded by Zoe Global Ltd. KN has received institutional research funding from Pharmavite, Evergrande Group, Janssen and Revolution Medicines. She has also served on an advisory board for Seattle Genetics, Array Biopharma and BiomX, and has served as a consultant to X-Biotix Therapeutics. The remaining authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The study protocol was approved by the institutional review boards of the Brigham and Women\u2019s Hospital and Harvard T.H. Chan School of Public Health, and those of participating registries as required. Return of questionnaires was considered to imply informed consent. The study was performed in accordance with the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}