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Pollutant associations with haematologic cancers are suggestive, but these cancers are aetiologically heterogeneous and sub-type examinations are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The American Cancer Society Cancer Prevention Study-II Nutrition Cohort was used to examine associations of outdoor air pollutants with adult haematologic cancers. Census block group level annual predictions of particulate matter (PM\n                      <jats:sub>2.5<\/jats:sub>\n                      , PM\n                      <jats:sub>10<\/jats:sub>\n                      , PM\n                      <jats:sub>10-2.5<\/jats:sub>\n                      ), nitrogen dioxide (NO\n                      <jats:sub>2<\/jats:sub>\n                      ), ozone (O\n                      <jats:sub>3<\/jats:sub>\n                      ), sulfur dioxide (SO\n                      <jats:sub>2<\/jats:sub>\n                      ), and carbon monoxide (CO) were assigned with residential addresses. Hazard ratios (HR) and 95% confidence intervals (CI) between time-varying pollutants and haematologic subtypes were estimated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 108,002 participants, 2659 incident haematologic cancers were identified from 1992\u20132017. Higher PM\n                      <jats:sub>10-2.5<\/jats:sub>\n                      concentrations were associated with mantle cell lymphoma (HR per 4.1\u2009\u03bcg\/m\n                      <jats:sup>3<\/jats:sup>\n                      \u2009=\u20091.43, 95% CI 1.08\u20131.90). NO\n                      <jats:sub>2<\/jats:sub>\n                      was associated with Hodgkin lymphoma (HR per 7.2 ppb\u2009=\u20091.39; 95% CI 1.01\u20131.92) and marginal zone lymphoma (HR per 7.2 ppb\u2009=\u20091.30; 95% CI 1.01\u20131.67). CO was associated with marginal zone (HR per 0.21 ppm\u2009=\u20091.30; 95% CI 1.04\u20131.62) and T-cell (HR per 0.21 ppm\u2009=\u20091.27; 95% CI 1.00\u20131.61) lymphomas.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The role of air pollutants on haematologic cancers may have been underestimated previously because of sub-type heterogeneity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1038\/s41416-024-02718-3","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T10:04:39Z","timestamp":1716804279000},"page":"149-158","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Outdoor air pollution and risk of incident adult haematologic cancer subtypes in a large US prospective cohort"],"prefix":"10.1038","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5418-9000","authenticated-orcid":false,"given":"W. 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