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Raised inflammatory markers were the most common abnormality (74\u201379% of tested cases). Rates of blood test use and abnormal results progressively increased from 7 months pre-diagnosis in cancer patients, with relatively small corresponding increases in symptomatic controls. In cancer patients, the largest increases from baseline were raised platelets in males with abdominal pain (increased 33-fold), raised white blood cell count in males with abdominal bloating (increased 37-fold) and low albumin in females with either symptom (increased 22\u201341 fold).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Common blood test abnormalities are early signals of cancer in some individuals with non-specific abdominal symptoms and could support expedited cancer diagnosis.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1038\/s41416-024-02936-9","type":"journal-article","created":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T17:57:34Z","timestamp":1736618254000},"page":"450-461","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A UK population-based case-control study of blood tests before cancer diagnosis in patients with non-specific abdominal symptoms"],"prefix":"10.1038","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1837-1542","authenticated-orcid":false,"given":"Meena","family":"Rafiq","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0643-7890","authenticated-orcid":false,"given":"Becky","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1148-1922","authenticated-orcid":false,"given":"Matthew","family":"Barclay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Abel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3845-9493","authenticated-orcid":false,"given":"Cristina","family":"Renzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2873-7421","authenticated-orcid":false,"given":"Georgios","family":"Lyratzopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,11]]},"reference":[{"key":"2936_CR1","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1038\/bjc.2012.408","volume":"107","author":"L Elliss-Brookes","year":"2012","unstructured":"Elliss-Brookes L, McPhail S, Ives A, Greenslade M, Shelton J, Hiom S, et al. 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