{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T12:53:25Z","timestamp":1789131205162,"version":"build-2803163510"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Br J Cancer"],"published-print":{"date-parts":[[2025,9,7]]},"DOI":"10.1038\/s41416-025-03078-2","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T14:29:11Z","timestamp":1749565751000},"page":"574-581","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Intratumoral bacterial abundance confers poor response to adjuvant gemcitabine in resected pancreatic cancer patients which is mitigated by postoperative antibiotics"],"prefix":"10.1038","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5091-5060","authenticated-orcid":false,"given":"Michael","family":"Guenther","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai Agash","family":"Surendran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Hauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Fahrenschon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed Dervis","family":"Arslan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0754-9034","authenticated-orcid":false,"given":"Steffen","family":"Ormanns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,10]]},"reference":[{"key":"3078_CR1","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1002\/ijc.34044","volume":"151","author":"M Guenther","year":"2022","unstructured":"Guenther M, Boeck S, Heinemann V, Werner J, Engel J, Ormanns S. The impact of adjuvant therapy on outcome in UICC stage I pancreatic cancer. Int J Cancer. 2022;151:914\u20139.","journal-title":"Int J Cancer"},{"key":"3078_CR2","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1001\/jama.2021.13027","volume":"326","author":"W Park","year":"2021","unstructured":"Park W, Chawla A, O\u2019Reilly EM. Pancreatic cancer: a review. Jama. 2021;326:851\u201362.","journal-title":"Jama"},{"key":"3078_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2022.100777","volume":"8","author":"M Reni","year":"2023","unstructured":"Reni M, Giommoni E, Bergamo F, Milella M, Cavanna L, Di Marco MC, et al. Guideline Application in Real world: multi-Institutional Based survey of Adjuvant and first-Line pancreatic Ductal adenocarcinoma treatment in Italy. Primary analysis of the GARIBALDI survey. ESMO open. 2023;8:100777.","journal-title":"ESMO open"},{"key":"3078_CR4","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1038\/s41416-020-01029-7","volume":"123","author":"M Guenther","year":"2020","unstructured":"Guenther M, Haas M, Heinemann V, Kruger S, Westphalen CB, von Bergwelt-Baildon M, et al. Bacterial lipopolysaccharide as negative predictor of gemcitabine efficacy in advanced pancreatic cancer\u2013translational results from the AIO-PK0104 Phase 3 study. Br J Cancer. 2020;123:1370\u20136.","journal-title":"Br J Cancer"},{"key":"3078_CR5","doi-asserted-by":"publisher","DOI":"10.1093\/jncics\/pkac039","volume":"6","author":"M Guenther","year":"2022","unstructured":"Guenther M, Gil L, Surendran SA, Palm MA, Heinemann V, von Bergwelt-Baildon M, et al. Bacterial lipopolysaccharide as a negative predictor of adjuvant gemcitabine efficacy in pancreatic cancer. JNCI Cancer Spectr. 2022;6:pkac039.","journal-title":"JNCI Cancer Spectr"},{"key":"3078_CR6","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1126\/science.aah5043","volume":"357","author":"LT Geller","year":"2017","unstructured":"Geller LT, Barzily-Rokni M, Danino T, Jonas OH, Shental N, Nejman D, et al. Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine. Science. 2017;357:1156\u201360.","journal-title":"Science"},{"key":"3078_CR7","doi-asserted-by":"publisher","first-page":"e234254","DOI":"10.1001\/jamanetworkopen.2023.4254","volume":"6","author":"DJ Fulop","year":"2023","unstructured":"Fulop DJ, Zylberberg HM, Wu YL, Aronson A, Labiner AJ, Wisnivesky J, et al. Association of antibiotic receipt with survival among patients with metastatic pancreatic ductal adenocarcinoma receiving chemotherapy. JAMA Netw Open. 2023;6:e234254.","journal-title":"JAMA Netw Open"},{"key":"3078_CR8","doi-asserted-by":"publisher","first-page":"5041","DOI":"10.1002\/cam4.3870","volume":"10","author":"C Mohindroo","year":"2021","unstructured":"Mohindroo C, Hasanov M, Rogers JE, Dong W, Prakash LR, Baydogan S, et al. Antibiotic use influences outcomes in advanced pancreatic adenocarcinoma patients. Cancer Med. 2021;10:5041\u201350.","journal-title":"Cancer Med"},{"key":"3078_CR9","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/S0580-9517(01)30046-6","volume":"30","author":"J Pernthaler","year":"2001","unstructured":"Pernthaler J, Gl\u00f6ckner F-O, Sch\u00f6nhuber W, Amann R. Fluorescence in situ hybridization (FISH) with rRNA-targeted oligonucleotide probes. Methods Microbiol. 2001;30:207\u201326.","journal-title":"Methods Microbiol"},{"key":"3078_CR10","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2021.1874815","volume":"13","author":"K Duncan","year":"2021","unstructured":"Duncan K, Carey-Ewend K, Vaishnava SJGM. Spatial analysis of gut microbiome reveals a distinct ecological niche associated with the mucus layer. Gut Microbes. 2021;13:1874815.","journal-title":"Gut Microbes"},{"key":"3078_CR11","doi-asserted-by":"publisher","first-page":"3661","DOI":"10.1002\/sim.6607","volume":"34","author":"PC Austin","year":"2015","unstructured":"Austin PC, Stuart E. Moving towards best practice when using inverse probability of treatment weighting (IPTW) using the propensity score to estimate causal treatment effects in observational studies. Stat Med. 2015;34:3661\u201379.","journal-title":"Stat Med"},{"key":"3078_CR12","doi-asserted-by":"publisher","first-page":"426","DOI":"10.3390\/biom15030426","volume":"15","author":"M Guenther","year":"2025","unstructured":"Guenther M, Surendran SA, Steinke LM, Liou I, Palm MA, Heinemann V, et al. The prognostic, predictive and clinicopathological implications of KRT81\/HNF1A- and GATA6-based transcriptional subtyping in pancreatic cancer. Biomolecules. 2025;15:426.","journal-title":"Biomolecules"},{"key":"3078_CR13","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1038\/s41388-024-02974-w","volume":"43","author":"GD Sepich-Poore","year":"2024","unstructured":"Sepich-Poore GD, McDonald D, Kopylova E, Guccione C, Zhu Q, Austin G, et al. Robustness of cancer microbiome signals over a broad range of methodological variation. Oncogene. 2024;43:1127\u201348.","journal-title":"Oncogene"},{"key":"3078_CR14","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1038\/s42003-021-02557-5","volume":"4","author":"W Guo","year":"2021","unstructured":"Guo W, Zhang Y, Guo S, Mei Z, Liao H, Dong H, et al. Tumor microbiome contributes to an aggressive phenotype in the basal-like subtype of pancreatic cancer. Commun Biol. 2021;4:1019.","journal-title":"Commun Biol"},{"key":"3078_CR15","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/j.cell.2019.07.008","volume":"178","author":"E Riquelme","year":"2019","unstructured":"Riquelme E, Zhang Y, Zhang L, Montiel M, Zoltan M, Dong W, et al. Tumor microbiome diversity and composition influence pancreatic cancer outcomes. Cell. 2019;178:795\u2013806.e12.","journal-title":"Cell"},{"key":"3078_CR16","doi-asserted-by":"publisher","first-page":"107171","DOI":"10.1016\/j.jbc.2024.107171","volume":"300","author":"L Jiang","year":"2024","unstructured":"Jiang L, Zhang L, Shu Y, Zhang Y, Gao L, Qiu S, et al. Deciphering the role of Enterococcus faecium cytidine deaminase in gemcitabine resistance of gallbladder cancer. J Biol Chem. 2024;300:107171.","journal-title":"J Biol Chem"},{"key":"3078_CR17","doi-asserted-by":"publisher","first-page":"6238","DOI":"10.3748\/wjg.v25.i41.6238","volume":"25","author":"CM Kr\u00fcger","year":"2019","unstructured":"Kr\u00fcger CM, Adam U, Adam T, Kramer A, Heidecke CD, Makowiec F, et al. Bacterobilia in pancreatic surgery-conclusions for perioperative antibiotic prophylaxis. World J Gastroenterol. 2019;25:6238\u201347.","journal-title":"World J Gastroenterol"},{"key":"3078_CR18","first-page":"84","volume":"55","author":"RJ Klement","year":"2019","unstructured":"Klement RJ, Pazienza V. Impact of different types of diet on gut microbiota profiles and cancer prevention and treatment. Medicine. 2019;55:84.","journal-title":"Medicine"}],"container-title":["British Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41416-025-03078-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41416-025-03078-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41416-025-03078-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T19:07:17Z","timestamp":1757185637000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41416-025-03078-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,10]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,9,7]]}},"alternative-id":["3078"],"URL":"https:\/\/doi.org\/10.1038\/s41416-025-03078-2","relation":{},"ISSN":["0007-0920","1532-1827"],"issn-type":[{"value":"0007-0920","type":"print"},{"value":"1532-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,10]]},"assertion":[{"value":"29 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 May 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Due to the observation period of our study (2000\u20132016) and the poor prognosis of the disease, patient informed consent could not be obtained. Considering these circumstances, the ethics committee of the medical faculty of Ludwig-Maximilians-University approved the use of anonymized patient data without obtaining the patients\u2019 informed consent (project 20-081), and the study was carried out according to the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}}]}}