{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T18:31:41Z","timestamp":1772649101241,"version":"3.50.1"},"reference-count":102,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Br J Cancer"],"published-print":{"date-parts":[[2026,3,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Oral squamous cell carcinoma (OSCC) is increasingly common, with over 380,000 new cases annually. Despite its high incidence (6.0 per 100,000 males; 2.3 per 100,000 females) and poor prognosis, no molecular biomarkers exist for early detection. Non-invasive sampling could improve diagnosis and patient outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This pilot study used RNA sequencing to identify significantly upregulated mRNA targets in swab samples from oral and oropharyngeal SCC patients and healthy probands. After filtering, four potential biomarkers were further validated in 79 samples using RT-qPCR. CombiROC analysis assessed diagnostic performance. Additional RT-qPCR on tumour and normal tissues and fluorescence staining in FFPE tumour sections evaluated expression at mRNA and protein levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A panel of three markers (c-JUN, SFN, HSP90AB1) showed high diagnostic accuracy: 92.3% specificity, 92.3% sensitivity, and AUC of 0.91. Fluorescence staining confirmed significantly higher protein expression in tumour tissues, supporting RNA findings. The panel showed stronger diagnostic performance in men than in women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study presents a promising non-invasive biomarker panel for oral and oropharyngeal SCC detection. Further validation in larger cohorts is needed to confirm diagnostic value and clarify sex specificity. The approach is adaptable to other tumour types and sample materials, supporting molecular diagnostics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1038\/s41416-025-03313-w","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T17:30:10Z","timestamp":1767893410000},"page":"961-974","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic accuracy of combinatorial mRNA biomarkers for non-invasive detection and therapy monitoring of oral and oropharyngeal SCC"],"prefix":"10.1038","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5488-0183","authenticated-orcid":false,"given":"Leonie","family":"Hose","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alina Celine","family":"Tekin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart","family":"Verwaaijen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rayoung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9722-4435","authenticated-orcid":false,"given":"Christian","family":"R\u00fcckert-Reed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Hamberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9211-8927","authenticated-orcid":false,"given":"Tobias","family":"Busche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars-Uwe","family":"Scholtz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Brasch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingo","family":"Todt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Goon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Sch\u00fcrmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"3313_CR1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA. 2024;74:229\u201363. https:\/\/doi.org\/10.3322\/caac.21834.","journal-title":"CA"},{"key":"3313_CR2","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1007\/s00103-021-03368-z","volume":"64","author":"L Jansen","year":"2021","unstructured":"Jansen L, Moratin J, Waldmann A, Zaoui K, Holleczek B, Nennecke A, et al. Mundh\u00f6hlen- und Pharynxkarzinome: Inzidenz, Mortalit\u00e4t und \u00dcberleben in Deutschland. Bundesgesundheitsblatt Gesundheitsforsch. Gesundheitsschutz. 2021;64:941\u201350. https:\/\/doi.org\/10.1007\/s00103-021-03368-z.","journal-title":"Bundesgesundheitsblatt Gesundheitsforsch. Gesundheitsschutz"},{"key":"3313_CR3","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1002\/ijc.28811","volume":"135","author":"DS Michaud","year":"2014","unstructured":"Michaud DS, Langevin SM, Eliot M, Nelson HH, Pawlita M, McClean MD, Kelsey KT. High-risk HPV types and head and neck cancer. Int J Cancer. 2014;135:1653\u201361. https:\/\/doi.org\/10.1002\/ijc.28811.","journal-title":"Int J Cancer"},{"issue":"Suppl 1","key":"3313_CR4","doi-asserted-by":"publisher","first-page":"S104","DOI":"10.1007\/s12105-012-0368-1","volume":"6","author":"T Isayeva","year":"2012","unstructured":"Isayeva T, Li Y, Maswahu D, Brandwein-Gensler M. Human papillomavirus in non-oropharyngeal head and neck cancers: a systematic literature review. Head Neck Pathol. 2012;6(Suppl 1):S104\u201320. https:\/\/doi.org\/10.1007\/s12105-012-0368-1.","journal-title":"Head Neck Pathol"},{"key":"3313_CR5","doi-asserted-by":"publisher","first-page":"376","DOI":"10.4103\/jomfp.jomfp_278_22","volume":"26","author":"P Saxena","year":"2022","unstructured":"Saxena P, Prasad S. Evaluation of p16 expression in oral and oropharyngeal squamous cell carcinoma. J Oral Maxillofac Pathol. 2022;26:376\u201381. https:\/\/doi.org\/10.4103\/jomfp.jomfp_278_22.","journal-title":"J Oral Maxillofac Pathol"},{"key":"3313_CR6","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.oraloncology.2016.09.001","volume":"61","author":"N Adhauliya","year":"2016","unstructured":"Adhauliya N, Kalappanavar AN, Ali IM, Annigeri RG. Autophagy: a boon or bane in oral cancer. Oral Oncol. 2016;61:120\u20136. https:\/\/doi.org\/10.1016\/j.oraloncology.2016.09.001.","journal-title":"Oral Oncol"},{"key":"3313_CR7","doi-asserted-by":"publisher","first-page":"1505833","DOI":"10.3389\/froh.2024.1505833","volume":"5","author":"RD Coletta","year":"2024","unstructured":"Coletta RD, Yeudall WA, Salo T. Current trends on prevalence, risk factors and prevention of oral cancer. Front Oral Health. 2024;5:1505833. https:\/\/doi.org\/10.3389\/froh.2024.1505833.","journal-title":"Front Oral Health"},{"key":"3313_CR8","doi-asserted-by":"publisher","unstructured":"Rodr\u00edguez-Molinero J, Miguel\u00e1\u00f1ez-Medr\u00e1n B D C, Puente-Guti\u00e9rrez C, Delgado-Somolinos E, Mart\u00edn Carreras-Presas C, Fern\u00e1ndez-Farhall J. et al. Association between oral cancer and diet: an update. Nutrients. 2021;13: https:\/\/doi.org\/10.3390\/nu13041299.","DOI":"10.3390\/nu13041299"},{"key":"3313_CR9","doi-asserted-by":"publisher","first-page":"414","DOI":"10.18502\/ijph.v53i2.14926","volume":"53","author":"MM Markovic","year":"2024","unstructured":"Markovic MM, Petrovic M, Latas M, Djordjevic I, Milovanovic S, Jovanovic S. Quality of life of patients with oral squamous cell carcinoma. Iran J Public Health. 2024;53:414\u201324. https:\/\/doi.org\/10.18502\/ijph.v53i2.14926.","journal-title":"Iran J Public Health"},{"key":"3313_CR10","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/BF03256330","volume":"13","author":"L Zhang","year":"2009","unstructured":"Zhang L, Xiao H, Wong DT. Salivary biomarkers for clinical applications. Mol Diagn Ther. 2009;13:245\u201359. https:\/\/doi.org\/10.1007\/BF03256330.","journal-title":"Mol Diagn Ther"},{"key":"3313_CR11","doi-asserted-by":"publisher","unstructured":"C\u00edvico-Ortega JL, Gonzalez-Ruiz I, Ramos-Garcia P, Cruz-Granados D, Samayoa-Descamps V. et al. Prognostic and clinicopathological significance of epidermal growth factor receptor (EGFR) expression in oral squamous cell carcinoma: systematic review and meta-analysis. Int J Mol Sci. 2023;24: https:\/\/doi.org\/10.3390\/ijms241511888.","DOI":"10.3390\/ijms241511888"},{"key":"3313_CR12","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.3892\/ol.2013.1627","volume":"6","author":"L Li","year":"2013","unstructured":"Li L, Fukumoto M, Liu D. Prognostic significance of p53 immunoexpression in the survival of oral squamous cell carcinoma patients treated with surgery and neoadjuvant chemotherapy. Oncol Lett. 2013;6:1611\u20135. https:\/\/doi.org\/10.3892\/ol.2013.1627.","journal-title":"Oncol Lett"},{"key":"3313_CR13","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.oraloncology.2018.06.007","volume":"83","author":"P Ramos-Garc\u00eda","year":"2018","unstructured":"Ramos-Garc\u00eda P, Gonz\u00e1lez-Moles M\u00c1, Gonz\u00e1lez-Ruiz L, Ruiz-\u00c1vila I, Ay\u00e9n \u00c1, Gil-Montoya JA. Prognostic and clinicopathological significance of cyclin D1 expression in oral squamous cell carcinoma: a systematic review and meta-analysis. Oral Oncol. 2018;83:96\u2013106. https:\/\/doi.org\/10.1016\/j.oraloncology.2018.06.007.","journal-title":"Oral Oncol"},{"key":"3313_CR14","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1002\/cncr.20480","volume":"101","author":"J Hern\u00e1ndez","year":"2004","unstructured":"Hern\u00e1ndez J, Thompson IM. Prostate-specific antigen: a review of the validation of the most commonly used cancer biomarker. Cancer. 2004;101:894\u2013904. https:\/\/doi.org\/10.1002\/cncr.20480.","journal-title":"Cancer"},{"key":"3313_CR15","doi-asserted-by":"publisher","first-page":"216","DOI":"10.3748\/wjg.v28.i2.216","volume":"28","author":"H Hanif","year":"2022","unstructured":"Hanif H, Ali MJ, Susheela AT, Khan IW, Luna-Cuadros MA, Khan MM, Lau DT. Update on the applications and limitations of alpha-fetoprotein for hepatocellular carcinoma. World J Gastroenterol. 2022;28:216\u201329. https:\/\/doi.org\/10.3748\/wjg.v28.i2.216.","journal-title":"World J Gastroenterol"},{"key":"3313_CR16","doi-asserted-by":"publisher","unstructured":"Charkhchi P, Cybulski C, Gronwald J, Wong FO, Narod SA, Akbari MR. et al. CA125 and ovarian cancer: a comprehensive review. Cancers. 2020;12 https:\/\/doi.org\/10.3390\/cancers12123730.","DOI":"10.3390\/cancers12123730"},{"key":"3313_CR17","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/bs.acr.2021.05.002","volume":"152","author":"GR Bhat","year":"2021","unstructured":"Bhat GR, Hyole RG, Li J. Head and neck cancer: current challenges and future perspectives. Adv Cancer Res. 2021;152:67\u2013102. https:\/\/doi.org\/10.1016\/bs.acr.2021.05.002.","journal-title":"Adv Cancer Res"},{"key":"3313_CR18","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1007\/s40291-024-00743-9","volume":"28","author":"A Qvick","year":"2024","unstructured":"Qvick A, Andersson E, Oldaeus Almer\u00e9n A, Waenerlund M, Stenmark B, Karlsson C, et al. Sensitive and specific droplet digital PCR assays for circulating tumor HPV DNA: development, validation, and clinical application in HPV-associated cancers. Mol Diagn Ther. 2024;28:835\u201345. https:\/\/doi.org\/10.1007\/s40291-024-00743-9.","journal-title":"Mol Diagn Ther"},{"key":"3313_CR19","doi-asserted-by":"publisher","first-page":"107262","DOI":"10.1016\/j.oraloncology.2025.107262","volume":"164","author":"S Chennareddy","year":"2025","unstructured":"Chennareddy S, Chen S, Levinson C, Genden EM, Posner MR, Roof SA. Circulating tumor DNA in human papillomavirus-associated oropharyngeal cancer management: a systematic review. Oral Oncol. 2025;164:107262 https:\/\/doi.org\/10.1016\/j.oraloncology.2025.107262.","journal-title":"Oral Oncol"},{"key":"3313_CR20","doi-asserted-by":"publisher","first-page":"273","DOI":"10.4103\/jomfp.JOMFP_36_19","volume":"23","author":"D Babji","year":"2019","unstructured":"Babji D, Nayak R, Bhat K, Kotrashetti V. Cell-free tumor DNA: emerging reality in oral squamous cell carcinoma. J Oral Maxillofac Pathol. 2019;23:273\u20139. https:\/\/doi.org\/10.4103\/jomfp.JOMFP_36_19.","journal-title":"J Oral Maxillofac Pathol"},{"key":"3313_CR21","doi-asserted-by":"publisher","first-page":"5857","DOI":"10.1158\/1078-0432.CCR-19-2384","volume":"27","author":"E Leung","year":"2021","unstructured":"Leung E, Han K, Zou J, Zhao Z, Zheng Y, Wang TT, et al. HPV sequencing facilitates ultrasensitive detection of hpv circulating tumor DNA. Clin Cancer Res. 2021;27:5857\u201368. https:\/\/doi.org\/10.1158\/1078-0432.CCR-19-2384.","journal-title":"Clin Cancer Res"},{"key":"3313_CR22","doi-asserted-by":"publisher","DOI":"10.1038\/s41525-024-00432-w","volume":"9","author":"G Karlebach","year":"2024","unstructured":"Karlebach G, Steinhaus R, Danis D, Devoucoux M, Anczuk\u00f3w O, Sheynkman G, et al. Alternative splicing is coupled to gene expression in a subset of variably expressed genes. npj Genom Med. 2024;9:54. https:\/\/doi.org\/10.1038\/s41525-024-00432-w.","journal-title":"npj Genom Med"},{"key":"3313_CR23","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1089\/gtmb.2021.0066","volume":"25","author":"H Guo","year":"2021","unstructured":"Guo H, Li C, Su X, Huang X. A five-mRNA expression signature to predict survival in oral squamous cell carcinoma by integrated bioinformatic analyses. Genet Test Mol Biomark. 2021;25:517\u201327. https:\/\/doi.org\/10.1089\/gtmb.2021.0066.","journal-title":"Genet Test Mol Biomark"},{"key":"3313_CR24","doi-asserted-by":"publisher","first-page":"6735","DOI":"10.3892\/ol.2017.7066","volume":"14","author":"R Kitamura","year":"2017","unstructured":"Kitamura R, Toyoshima T, Tanaka H, Kawano S, Matsubara R, Goto Y, et al. Cytokeratin 17 mRNA as a prognostic marker of oral squamous cell carcinoma. Oncol Lett. 2017;14:6735\u201343. https:\/\/doi.org\/10.3892\/ol.2017.7066.","journal-title":"Oncol Lett"},{"key":"3313_CR25","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.32604\/biocell.2023.026704","volume":"47","author":"XI MU","year":"2023","unstructured":"MU XI, HU Y, WU D, YANG H. Differential mRNA expression in peripheral blood is associated with oral squamous cell carcinoma: recent advances and future challenges. Biocell. 2023;47:1449\u201358. https:\/\/doi.org\/10.32604\/biocell.2023.026704.","journal-title":"Biocell"},{"key":"3313_CR26","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-75735-0","volume":"14","author":"K Senevirathna","year":"2024","unstructured":"Senevirathna K, Mahakapuge T, Jayawardana NU, Rajapakse J, Gamage CU, Seneviratne B, et al. Diagnostic potential of salivary IL-1\u03b2, IL-8, SAT, S100P, and OAZ1 in oral squamous cell carcinoma, oral submucous fibrosis, and oral lichen planus based on findings from a Sri Lankan cohort. Sci Rep. 2024;14:27226. https:\/\/doi.org\/10.1038\/s41598-024-75735-0.","journal-title":"Sci Rep"},{"key":"3313_CR27","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1093\/clinchem\/48.8.1178","volume":"48","author":"PS Bernard","year":"2002","unstructured":"Bernard PS, Wittwer CT. Real-time PCR technology for cancer diagnostics. Clin Chem. 2002;48:1178\u201385.","journal-title":"Clin Chem"},{"key":"3313_CR28","doi-asserted-by":"publisher","first-page":"2249","DOI":"10.7150\/jca.24744","volume":"9","author":"S Narrandes","year":"2018","unstructured":"Narrandes S, Xu W. Gene expression detection assay for cancer clinical use. J Cancer. 2018;9:2249\u201365. https:\/\/doi.org\/10.7150\/jca.24744.","journal-title":"J Cancer"},{"key":"3313_CR29","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/s1471-4914(03)00047-9","volume":"9","author":"S Mocellin","year":"2003","unstructured":"Mocellin S, Rossi CR, Pilati P, Nitti D, Marincola FM. Quantitative real-time PCR: a powerful ally in cancer research. Trends Mol Med. 2003;9:189\u201395. https:\/\/doi.org\/10.1016\/s1471-4914(03)00047-9.","journal-title":"Trends Mol Med"},{"key":"3313_CR30","doi-asserted-by":"publisher","first-page":"101615","DOI":"10.1016\/j.bbrep.2023.101615","volume":"37","author":"HA Awrahman","year":"2024","unstructured":"Awrahman HA, Mohamad D. Advanced breast cancer diagnosis: Multiplex RT-qPCR for precise typing and angiogenesis profiling. Biochem Biophys Rep. 2024;37:101615 https:\/\/doi.org\/10.1016\/j.bbrep.2023.101615.","journal-title":"Biochem Biophys Rep"},{"key":"3313_CR31","doi-asserted-by":"publisher","first-page":"e012799","DOI":"10.1136\/bmjopen-2016-012799","volume":"6","author":"JF Cohen","year":"2016","unstructured":"Cohen JF, Korevaar DA, Altman DG, Bruns DE, Gatsonis CA, Hooft L, et al. STARD 2015 guidelines for reporting diagnostic accuracy studies: explanation and elaboration. BMJ Open. 2016;6:e012799 https:\/\/doi.org\/10.1136\/bmjopen-2016-012799.","journal-title":"BMJ Open"},{"key":"3313_CR32","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/bjc.2014.639","volume":"112","author":"GS Collins","year":"2015","unstructured":"Collins GS, Reitsma JB, Altman DG, Moons KGM. Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD): the TRIPOD statement. Br J Cancer. 2015;112:251\u20139. https:\/\/doi.org\/10.1038\/bjc.2014.639.","journal-title":"Br J Cancer"},{"key":"3313_CR33","doi-asserted-by":"publisher","DOI":"10.1038\/srep45477","volume":"7","author":"S Mazzara","year":"2017","unstructured":"Mazzara S, Rossi RL, Grifantini R, Donizetti S, Abrignani S, Bombaci M. CombiROC: an interactive web tool for selecting accurate marker combinations of omics data. Sci Rep. 2017;7:45477. https:\/\/doi.org\/10.1038\/srep45477.","journal-title":"Sci Rep"},{"key":"3313_CR34","doi-asserted-by":"publisher","first-page":"83","DOI":"10.4103\/1735-3327.150339","volume":"12","author":"R Verma","year":"2015","unstructured":"Verma R, Singh A, Badni M, Chandra A, Gupta S, Verma R. Evaluation of exfoliative cytology in the diagnosis of oral premalignant and malignant lesions: a cytomorphometric analysis. Dent Res J. 2015;12:83\u201388. https:\/\/doi.org\/10.4103\/1735-3327.150339.","journal-title":"Dent Res J"},{"key":"3313_CR35","first-page":"355","volume":"9","author":"M Diniz-Freitas","year":"2004","unstructured":"Diniz-Freitas M, Garc\u00eda-Garc\u00eda A, Crespo-Abelleira A, Martins-Carneiro JL, G\u00e1ndara-Rey JM. Applications of exfoliative cytology in the diagnosis of oral cancer. Med Oral. 2004;9:355\u201361.","journal-title":"Med Oral"},{"key":"3313_CR36","doi-asserted-by":"publisher","unstructured":"Pierfelice TV, D\u2019Amico E, Cinquini C, Iezzi G, D\u2019Arcangelo C, D\u2019Ercole S. et al. The diagnostic potential of non-invasive tools for oral cancer and precancer: a systematic review. Diagnostics. 2024;14: https:\/\/doi.org\/10.3390\/diagnostics14182033.","DOI":"10.3390\/diagnostics14182033"},{"key":"3313_CR37","doi-asserted-by":"publisher","first-page":"1740","DOI":"10.1038\/sj.bjc.6600953","volume":"88","author":"S Temam","year":"2003","unstructured":"Temam S, Trassard M, Leroux G, Bosq J, Luboinski B, Lenoir G, et al. Cytology vs molecular analysis for the detection of head and neck squamous cell carcinoma in oesopharyngeal brush samples: a prospective study in 56 patients. Br J Cancer. 2003;88:1740\u20135. https:\/\/doi.org\/10.1038\/sj.bjc.6600953.","journal-title":"Br J Cancer"},{"key":"3313_CR38","doi-asserted-by":"publisher","first-page":"51","DOI":"10.3322\/caac.21384","volume":"67","author":"KD Shield","year":"2017","unstructured":"Shield KD, Ferlay J, Jemal A, Sankaranarayanan R, Chaturvedi AK, Bray F, Soerjomataram I. The global incidence of lip, oral cavity, and pharyngeal cancers by subsite in 2012. CA. 2017;67:51\u201364. https:\/\/doi.org\/10.3322\/caac.21384.","journal-title":"CA"},{"key":"3313_CR39","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1038\/sj.bdj.2009.1009","volume":"207","author":"S Warnakulasuriya","year":"2009","unstructured":"Warnakulasuriya S. Causes of oral cancer-an appraisal of controversies. Br Dent J. 2009;207:471\u20135. https:\/\/doi.org\/10.1038\/sj.bdj.2009.1009.","journal-title":"Br Dent J"},{"key":"3313_CR40","doi-asserted-by":"publisher","first-page":"699594","DOI":"10.3389\/fonc.2021.699594","volume":"11","author":"MT Khan","year":"2021","unstructured":"Khan MT, Prajapati B, Lakhina S, Sharma M, Prajapati S, Chosdol K, Sinha S. Identification of gender-specific molecular differences in glioblastoma (GBM) and low-grade glioma (LGG) by the analysis of large transcriptomic and epigenomic datasets. Front Oncol. 2021;11:699594 https:\/\/doi.org\/10.3389\/fonc.2021.699594.","journal-title":"Front Oncol"},{"key":"3313_CR41","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-022-00469-5","volume":"13","author":"J Ma","year":"2022","unstructured":"Ma J, Yao Y, Tian Y, Chen K, Liu B. Advances in sex disparities for cancer immunotherapy: unveiling the dilemma of Yin and Yang. Biol Sex Differ. 2022;13:58. https:\/\/doi.org\/10.1186\/s13293-022-00469-5.","journal-title":"Biol Sex Differ"},{"key":"3313_CR42","doi-asserted-by":"publisher","unstructured":"Kim Z, Lee J, Yoon YE, Yun JW. Unveiling prognostic RNA biomarkers through a multi-cohort study in colorectal cancer. Int J Mol Sci. 2024;25 https:\/\/doi.org\/10.3390\/ijms25063317.","DOI":"10.3390\/ijms25063317"},{"key":"3313_CR43","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/s1471-4914(02)02355-9","volume":"8","author":"D Klein","year":"2002","unstructured":"Klein D. Quantification using real-time PCR technology: applications and limitations. Trends Mol Med. 2002;8:257\u201360. https:\/\/doi.org\/10.1016\/s1471-4914(02)02355-9.","journal-title":"Trends Mol Med"},{"key":"3313_CR44","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/bs.mim.2015.04.005","volume":"42","author":"J Engstrom-Melnyk","year":"2015","unstructured":"Engstrom-Melnyk J, Rodriguez PL, Peraud O, Hein RC. Clinical applications of quantitative real-time PCR in virology. Methods Microbiol. 2015;42:161\u201397. https:\/\/doi.org\/10.1016\/bs.mim.2015.04.005.","journal-title":"Methods Microbiol"},{"key":"3313_CR45","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.clinbiochem.2019.01.005","volume":"66","author":"L Dimitrakopoulos","year":"2019","unstructured":"Dimitrakopoulos L, Prassas I, Sieuwerts AM, Diamandis EP, Martens J, Charames GS. Proteome-wide onco-proteogenomic somatic variant identification in ER-positive breast cancer. Clin Biochem. 2019;66:63\u201375. https:\/\/doi.org\/10.1016\/j.clinbiochem.2019.01.005.","journal-title":"Clin Biochem"},{"key":"3313_CR46","doi-asserted-by":"publisher","first-page":"e63812","DOI":"10.1371\/journal.pone.0063812","volume":"8","author":"S Zeilinger","year":"2013","unstructured":"Zeilinger S, K\u00fchnel B, Klopp N, Baurecht H, Kleinschmidt A, Gieger C, et al. Tobacco smoking leads to extensive genome-wide changes in DNA methylation. PloS ONE. 2013;8:e63812 https:\/\/doi.org\/10.1371\/journal.pone.0063812.","journal-title":"PloS ONE"},{"key":"3313_CR47","doi-asserted-by":"publisher","first-page":"e1651","DOI":"10.1371\/journal.pone.0001651","volume":"3","author":"MT Landi","year":"2008","unstructured":"Landi MT, Dracheva T, Rotunno M, Figueroa JD, Liu H, Dasgupta A, et al. Gene expression signature of cigarette smoking and its role in lung adenocarcinoma development and survival. PloS ONE. 2008;3:e1651 https:\/\/doi.org\/10.1371\/journal.pone.0001651.","journal-title":"PloS ONE"},{"key":"3313_CR48","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-43295-3","volume":"9","author":"K Hijazi","year":"2019","unstructured":"Hijazi K, Malyszko B, Steiling K, Xiao X, Liu G, Alekseyev YO, et al. Tobacco-related alterations in airway gene expression are rapidly reversed within weeks following smoking-cessation. Sci Rep. 2019;9:6978. https:\/\/doi.org\/10.1038\/s41598-019-43295-3.","journal-title":"Sci Rep"},{"key":"3313_CR49","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.biochi.2020.02.015","volume":"173","author":"F Portillo","year":"2020","unstructured":"Portillo F, V\u00e1zquez J, Pajares MA. Protein-protein interactions involving enzymes of the mammalian methionine and homocysteine metabolism. Biochimie. 2020;173:33\u201347. https:\/\/doi.org\/10.1016\/j.biochi.2020.02.015.","journal-title":"Biochimie"},{"key":"3313_CR50","doi-asserted-by":"publisher","first-page":"6297","DOI":"10.1002\/jcp.30298","volume":"236","author":"J-J Zhou","year":"2021","unstructured":"Zhou J-J, Li H, Li L, Li Y, Wang PH, Meng XM, He JG. CYLD mediates human pulmonary artery smooth muscle cell dysfunction in congenital heart disease-associated pulmonary arterial hypertension. J Cell Physiol. 2021;236:6297\u2013311. https:\/\/doi.org\/10.1002\/jcp.30298.","journal-title":"J Cell Physiol"},{"key":"3313_CR51","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1007\/s12672-024-01434-x","volume":"15","author":"J Hu","year":"2024","unstructured":"Hu J, Jiang Q, Mao W, Zhong S, Sun H, Mao K. STARD7 could be an immunological and prognostic biomarker: from pan-cancer analysis to hepatocellular carcinoma validation. Discov Oncol. 2024;15:543 https:\/\/doi.org\/10.1007\/s12672-024-01434-x.","journal-title":"Discov Oncol"},{"key":"3313_CR52","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1002\/mc.23560","volume":"62","author":"YQ Zhao","year":"2023","unstructured":"Zhao YQ, Jin HR, Kim D, Jung SH, Liu S, Wan J, et al. SUMO1 degrader induces ER stress and ROS accumulation through deSUMOylation of TCF4 and inhibition of its transcription of StarD7 in colon cancer. Mol Carcinog. 2023;62:1249\u201362. https:\/\/doi.org\/10.1002\/mc.23560.","journal-title":"Mol Carcinog"},{"key":"3313_CR53","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12671-y","volume":"10","author":"MA Corbett","year":"2019","unstructured":"Corbett MA, Kroes T, Veneziano L, Bennett MF, Florian R, Schneider AL, et al. Intronic ATTTC repeat expansions in STARD7 in familial adult myoclonic epilepsy linked to chromosome 2. Nat Commun. 2019;10:4920. https:\/\/doi.org\/10.1038\/s41467-019-12671-y.","journal-title":"Nat Commun"},{"key":"3313_CR54","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.pneurobio.2006.03.006","volume":"78","author":"G Raivich","year":"2006","unstructured":"Raivich G, Behrens A. Role of the AP-1 transcription factor c-Jun in developing, adult and injured brain. Prog Neurobiol. 2006;78:347\u201363. https:\/\/doi.org\/10.1016\/j.pneurobio.2006.03.006.","journal-title":"Prog Neurobiol"},{"key":"3313_CR55","doi-asserted-by":"publisher","first-page":"537650","DOI":"10.3389\/fcimb.2020.537650","volume":"10","author":"N Aggarwal","year":"2020","unstructured":"Aggarwal N, Yadav J, Thakur K, Bibban R, Chhokar A, Tripathi T, et al. Human papillomavirus infection in head and neck squamous cell carcinomas: transcriptional triggers and changed disease patterns. Front Cell Infect Microbiol. 2020;10:537650 https:\/\/doi.org\/10.3389\/fcimb.2020.537650.","journal-title":"Front Cell Infect Microbiol"},{"key":"3313_CR56","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1177\/1947601913485413","volume":"4","author":"ND Ebelt","year":"2013","unstructured":"Ebelt ND, Cantrell MA, van den Berg CL. c-Jun N-terminal kinases mediate a wide range of targets in the metastatic cascade. Genes Cancer. 2013;4:378\u201387. https:\/\/doi.org\/10.1177\/1947601913485413.","journal-title":"Genes Cancer"},{"key":"3313_CR57","doi-asserted-by":"publisher","first-page":"429","DOI":"10.3892\/ijo.2015.3052","volume":"47","author":"H-F Zhao","year":"2015","unstructured":"Zhao H-F, Wang J, To Tony. S.-S. The phosphatidylinositol 3-kinase\/Akt and c-Jun N-terminal kinase signaling in cancer: alliance or contradiction? (Review). Int J Oncol. 2015;47:429\u201336. https:\/\/doi.org\/10.3892\/ijo.2015.3052.","journal-title":"Int J Oncol"},{"key":"3313_CR58","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1016\/j.jhep.2019.08.011","volume":"71","author":"J K\u00fcmpers","year":"2019","unstructured":"K\u00fcmpers J, Fromme M, Schneider CV, Trautwein C, Denk H, Hamesch K, Strnad P. Assessment of liver phenotype in adults with severe alpha-1 antitrypsin deficiency (Pi*ZZ genotype). J Hepatol. 2019;71:1272\u20134. https:\/\/doi.org\/10.1016\/j.jhep.2019.08.011.","journal-title":"J Hepatol"},{"key":"3313_CR59","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.4103\/jcrt.JCRT_324_16","volume":"14","author":"KS Shraddha","year":"2018","unstructured":"Shraddha KS, Niranjan KC, Hallikeri K. Immunolocalization of c-Jun in normal mucosa, oral submucous fibrosis, epithelial dysplasia, and oral squamous cell carcinoma: a comparative study. J cancer Res Ther. 2018;14:1180\u20133. https:\/\/doi.org\/10.4103\/jcrt.JCRT_324_16.","journal-title":"J cancer Res Ther"},{"key":"3313_CR60","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.oooo.2015.09.003","volume":"121","author":"JS Lima","year":"2016","unstructured":"Lima JS, Correa L, Klingbeil MFG, Sousa SCOM de. c-Jun, pc-Jun, and p27 are differently expressed in oral leukoplakias in smokers and never-smokers. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;121:73\u201380. https:\/\/doi.org\/10.1016\/j.oooo.2015.09.003.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"3313_CR61","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.oraloncology.2008.04.006","volume":"45","author":"K Laimer","year":"2009","unstructured":"Laimer K, Blassnig N, Spizzo G, Kloss F, Rasse M, Obrist P, et al. Prognostic significance of 14-3-3sigma expression in oral squamous cell carcinoma (OSCC). Oral Oncol. 2009;45:127\u201334. https:\/\/doi.org\/10.1016\/j.oraloncology.2008.04.006.","journal-title":"Oral Oncol"},{"key":"3313_CR62","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.cca.2020.09.009","volume":"511","author":"Y Huang","year":"2020","unstructured":"Huang Y, Yang M, Huang W. 14-3-3 \u03c3: a potential biomolecule for cancer therapy. Clin Chim Acta. 2020;511:50\u201358. https:\/\/doi.org\/10.1016\/j.cca.2020.09.009.","journal-title":"Clin Chim Acta"},{"key":"3313_CR63","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1002\/prca.200900091","volume":"3","author":"E Hayashi","year":"2009","unstructured":"Hayashi E, Kuramitsu Y, Fujimoto M, Zhang X, Tanaka T, Uchida K, et al. Proteomic profiling of differential display analysis for human oral squamous cell carcinoma: 14-3-3 \u03c3 Protein is upregulated in human oral squamous cell carcinoma and dependent on the differentiation level. Proteom Clin Appl. 2009;3:1338\u201347. https:\/\/doi.org\/10.1002\/prca.200900091.","journal-title":"Proteom Clin Appl"},{"key":"3313_CR64","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-024-03184-6","volume":"24","author":"N Sakuma","year":"2024","unstructured":"Sakuma N, Abe M, Ishii D, Kawasaki T, Arakawa N, Matsuyama S, et al. Serum stratifin measurement is useful for evaluating disease severity and outcomes in patients with acute exacerbation of interstitial lung disease: a retrospective study. BMC Pulm Med. 2024;24:364. https:\/\/doi.org\/10.1186\/s12890-024-03184-6.","journal-title":"BMC Pulm Med"},{"key":"3313_CR65","doi-asserted-by":"publisher","unstructured":"Maiti S, Picard D. Cytosolic Hsp90 isoform-specific functions and clinical significance. Biomolecules. 2022;12 https:\/\/doi.org\/10.3390\/biom12091166.","DOI":"10.3390\/biom12091166"},{"key":"3313_CR66","doi-asserted-by":"publisher","first-page":"724192","DOI":"10.3389\/fphar.2021.724192","volume":"12","author":"M Niu","year":"2021","unstructured":"Niu M, Zhang B, Li L, Su Z, Pu W, Zhao C, et al. Targeting HSP90 inhibits proliferation and induces apoptosis through AKT1\/ERK pathway in lung cancer. Front Pharmacol. 2021;12:724192 https:\/\/doi.org\/10.3389\/fphar.2021.724192.","journal-title":"Front Pharmacol"},{"key":"3313_CR67","doi-asserted-by":"publisher","first-page":"448","DOI":"10.3892\/or.2020.7873","volume":"45","author":"N Shiraishi","year":"2021","unstructured":"Shiraishi N, Onda T, Hayashi K, Onidani K, Watanabe K, Sekikawa S, Shibahara T. Heat shock protein 90 as a molecular target for therapy in oral squamous cell carcinoma: inhibitory effects of 17\u2011DMAG and ganetespib on tumor cells. Oncol Rep. 2021;45:448\u201358. https:\/\/doi.org\/10.3892\/or.2020.7873.","journal-title":"Oncol Rep"},{"key":"3313_CR68","doi-asserted-by":"publisher","first-page":"185","DOI":"10.4103\/ccd.ccd_101_18","volume":"10","author":"KP Priyanka","year":"2019","unstructured":"Priyanka KP, Majumdar S, Kotina S, Uppala D, Balla H. Expression of heat shock protein 70 in oral epithelial dysplasia and oral squamous cell carcinoma: an immunohistochemical study. Contemp Clin Dent. 2019;10:185\u201390. https:\/\/doi.org\/10.4103\/ccd.ccd_101_18.","journal-title":"Contemp Clin Dent"},{"key":"3313_CR69","doi-asserted-by":"publisher","first-page":"53","DOI":"10.4103\/0973-029X.157202","volume":"19","author":"P Patil","year":"2015","unstructured":"Patil P, Nandimath K, Prabhu S, Naikmasur VG. Heat shock protein (HSP70) as a marker of epithelial dysplasia in oral dysplastic lesions: a clinicopathological study. J Oral Maxillofac Pathol. 2015;19:53\u201357. https:\/\/doi.org\/10.4103\/0973-029X.157202.","journal-title":"J Oral Maxillofac Pathol"},{"key":"3313_CR70","doi-asserted-by":"publisher","first-page":"514","DOI":"10.14639\/0392-100X-N1450","volume":"41","author":"JK Bar","year":"2021","unstructured":"Bar JK, Cierpikowski P, Lis-Nawara A, Duc P, Ha\u0142o\u0144 A, Radwan-Oczko M. Comparison of p53, HSP90, E-cadherin and HPV in oral lichen planus and oral squamous cell carcinoma. Acta Otorhinolaryngol Ital. 2021;41:514\u201322. https:\/\/doi.org\/10.14639\/0392-100X-N1450.","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"3313_CR71","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.cstres.2024.05.005","volume":"29","author":"S Rastogi","year":"2024","unstructured":"Rastogi S, Joshi A, Sato N, Lee S, Lee MJ, Trepel JB, Neckers L. An update on the status of HSP90 inhibitors in cancer clinical trials. Cell Stress Chaperones. 2024;29:519\u201339. https:\/\/doi.org\/10.1016\/j.cstres.2024.05.005.","journal-title":"Cell Stress Chaperones"},{"key":"3313_CR72","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-13-152","volume":"13","author":"JW Goldman","year":"2013","unstructured":"Goldman JW, Raju RN, Gordon GA, El-Hariry I, Teofilivici F, Vukovic VM, et al. A first in human, safety, pharmacokinetics, and clinical activity phase I study of once weekly administration of the Hsp90 inhibitor ganetespib (STA-9090) in patients with solid malignancies. BMC Cancer. 2013;13:152. https:\/\/doi.org\/10.1186\/1471-2407-13-152.","journal-title":"BMC Cancer"},{"key":"3313_CR73","first-page":"1197","volume":"31","author":"T Okui","year":"2011","unstructured":"Okui T, Shimo T, Hassan NM, Fukazawa T, Kurio N, Takaoka M, et al. Antitumor effect of novel HSP90 inhibitor NVP-AUY922 against oral squamous cell carcinoma. Anticancer Res. 2011;31:1197\u2013204.","journal-title":"Anticancer Res"},{"key":"3313_CR74","doi-asserted-by":"publisher","first-page":"3663","DOI":"10.1126\/sciadv.adk3663","volume":"10","author":"F Chen","year":"2024","unstructured":"Chen F, Tang C, Yang F, Ekpenyong A, Qin R, Xie J, et al. HSP90 inhibition suppresses tumor glycolytic flux to potentiate the therapeutic efficacy of radiotherapy for head and neck cancer. Sci Adv. 2024;10:3663 https:\/\/doi.org\/10.1126\/sciadv.adk3663.","journal-title":"Sci Adv"},{"key":"3313_CR75","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.896","volume":"12","author":"JY Kim","year":"2022","unstructured":"Kim JY, Kim MJ, Lee JS, Son J, Kim DH, Lee JS, et al. Stratifin (SFN) regulates lung cancer progression via nucleating the Vps34-BECN1-TRAF6 complex for autophagy induction. Clin Transl Med. 2022;12:896. https:\/\/doi.org\/10.1002\/ctm2.896.","journal-title":"Clin Transl Med"},{"key":"3313_CR76","doi-asserted-by":"publisher","first-page":"3369","DOI":"10.1007\/s12033-023-00946-1","volume":"66","author":"N Du","year":"2024","unstructured":"Du N, Li D, Zhao W, Liu Y. Stratifin (SFN) regulates cervical cancer cell proliferation, apoptosis, and cytoskeletal remodeling and metastasis progression through LIMK2\/cofilin signaling. Mol Biotechnol. 2024;66:3369\u201381. https:\/\/doi.org\/10.1007\/s12033-023-00946-1.","journal-title":"Mol Biotechnol"},{"key":"3313_CR77","doi-asserted-by":"publisher","first-page":"6787791","DOI":"10.1155\/2022\/6787791","volume":"2022","author":"M Rishehri","year":"2022","unstructured":"Rishehri M, Etemadi T, Pisheh L, Koufigar G, Azadeh M. Quantitative expression of SFN, lncRNA CCDC18-AS1, and lncRNA LINC01343 in human breast cancer as the regulator biomarkers in a novel ceRNA network: based on bioinformatics and experimental analyses. Genet Res. 2022;2022:6787791 https:\/\/doi.org\/10.1155\/2022\/6787791.","journal-title":"Genet Res"},{"key":"3313_CR78","doi-asserted-by":"publisher","first-page":"321","DOI":"10.3892\/ijo.2017.4214","volume":"52","author":"B Rong","year":"2018","unstructured":"Rong B, Yang S. Molecular mechanism and targeted therapy of Hsp90 involved in lung cancer: new discoveries and developments (Review). Int J Oncol. 2018;52:321\u201336. https:\/\/doi.org\/10.3892\/ijo.2017.4214.","journal-title":"Int J Oncol"},{"key":"3313_CR79","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-015-0085-z","volume":"15","author":"T Xu","year":"2015","unstructured":"Xu T, Fang Y, Rong A, Wang J. Flexible combination of multiple diagnostic biomarkers to improve diagnostic accuracy. BMC Med Res Methodol. 2015;15:94. https:\/\/doi.org\/10.1186\/s12874-015-0085-z.","journal-title":"BMC Med Res Methodol"},{"key":"3313_CR80","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1038\/bjc.2017.199","volume":"117","author":"MR Russell","year":"2017","unstructured":"Russell MR, Graham C, D'Amato A, Gentry-Maharaj A, Ryan A, Kalsi JK, et al. A combined biomarker panel shows improved sensitivity for the early detection of ovarian cancer allowing the identification of the most aggressive type II tumours. Br J Cancer. 2017;117:666\u201374. https:\/\/doi.org\/10.1038\/bjc.2017.199.","journal-title":"Br J Cancer"},{"key":"3313_CR81","doi-asserted-by":"publisher","unstructured":"Harlid S, Gunter MJ, van Guelpen B. Risk-predictive and diagnostic biomarkers for colorectal cancer; a systematic review of studies using pre-diagnostic blood samples collected in prospective cohorts and screening settings. Cancers. 2021;13; https:\/\/doi.org\/10.3390\/cancers13174406.","DOI":"10.3390\/cancers13174406"},{"key":"3313_CR82","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1016\/j.jtho.2021.01.1607","volume":"16","author":"EC Bartlett","year":"2021","unstructured":"Bartlett EC, Silva M, Callister ME, Devaraj A. False-negative results in lung cancer screening-evidence and controversies. J Thorac Oncol. 2021;16:912\u201321. https:\/\/doi.org\/10.1016\/j.jtho.2021.01.1607.","journal-title":"J Thorac Oncol"},{"key":"3313_CR83","first-page":"913","volume":"33","author":"C Gei\u00dfler","year":"2013","unstructured":"Gei\u00dfler C, Tahtali A, Diensthuber M, Gassner D, St\u00f6ver T, Wagenblast J. The role of p16 expression as a predictive marker in HPV-positive oral SCCHN-a retrospective single-center study. Anticancer Res. 2013;33:913\u20136.","journal-title":"Anticancer Res"},{"key":"3313_CR84","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1111\/cas.12287","volume":"104","author":"H Wang","year":"2013","unstructured":"Wang H, Sun R, Lin H, Hu W-H. P16INK4A as a surrogate biomarker for human papillomavirus-associated oropharyngeal carcinoma: consideration of some aspects. Cancer Sci. 2013;104:1553\u20139. https:\/\/doi.org\/10.1111\/cas.12287.","journal-title":"Cancer Sci"},{"key":"3313_CR85","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/j.jaad.2020.03.126","volume":"83","author":"TJ Willenbrink","year":"2020","unstructured":"Willenbrink TJ, Ruiz ES, Cornejo CM, Schmults CD, Arron ST, Jambusaria-Pahlajani A. Field cancerization: definition, epidemiology, risk factors, and outcomes. J Am Acad Dermatol. 2020;83:709\u201317. https:\/\/doi.org\/10.1016\/j.jaad.2020.03.126.","journal-title":"J Am Acad Dermatol"},{"key":"3313_CR86","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.oraloncology.2017.03.018","volume":"68","author":"S Tabatabaeifar","year":"2017","unstructured":"Tabatabaeifar S, Larsen MJ, Larsen SR, Kruse TA, Thomassen M, S\u00f8rensen JA. Investigating a case of possible field cancerization in oral squamous cell carcinoma by the use of next-generation sequencing. Oral Oncol. 2017;68:74\u201380. https:\/\/doi.org\/10.1016\/j.oraloncology.2017.03.018.","journal-title":"Oral Oncol"},{"key":"3313_CR87","doi-asserted-by":"publisher","unstructured":"Dikova V, Jantus-Lewintre E, Bagan J. Potential non-invasive biomarkers for early diagnosis of oral squamous cell carcinoma. J Clin Med. 2021;10 https:\/\/doi.org\/10.3390\/jcm10081658.","DOI":"10.3390\/jcm10081658"},{"key":"3313_CR88","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1053\/j.seminoncol.2004.09.012","volume":"31","author":"R Hasina","year":"2004","unstructured":"Hasina R, Lingen MW. Head and neck cancer: the pursuit of molecular diagnostic markers. Semin Oncol. 2004;31:718\u201325. https:\/\/doi.org\/10.1053\/j.seminoncol.2004.09.012.","journal-title":"Semin Oncol"},{"key":"3313_CR89","doi-asserted-by":"publisher","unstructured":"Ranganath K et al. Molecular biomarkers of malignant transformation in head and neck dysplasia. Cancers. 2022;14; https:\/\/doi.org\/10.3390\/cancers14225581.","DOI":"10.3390\/cancers14225581"},{"key":"3313_CR90","doi-asserted-by":"publisher","first-page":"317","DOI":"10.3389\/fonc.2020.00317","volume":"10","author":"X Lin","year":"2020","unstructured":"Lin X, Xiao Z, Chen T, Liang SH, Guo H. Glucose metabolism on tumor plasticity, diagnosis, and treatment. Front Oncol. 2020;10:317 https:\/\/doi.org\/10.3389\/fonc.2020.00317.","journal-title":"Front Oncol"},{"key":"3313_CR91","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.cell.2010.06.006","volume":"142","author":"A Babour","year":"2010","unstructured":"Babour A, Bicknell AA, Tourtellotte J, Niwa M. A surveillance pathway monitors the fitness of the endoplasmic reticulum to control its inheritance. Cell. 2010;142:256\u201369. https:\/\/doi.org\/10.1016\/j.cell.2010.06.006.","journal-title":"Cell"},{"key":"3313_CR92","doi-asserted-by":"publisher","first-page":"D1334","DOI":"10.1093\/nar\/gkab970","volume":"50","author":"G Tang","year":"2022","unstructured":"Tang G, Cho M, Wang X. OncoDB: an interactive online database for analysis of gene expression and viral infection in cancer. Nucleic Acids Res. 2022;50:D1334\u2013D1339. https:\/\/doi.org\/10.1093\/nar\/gkab970.","journal-title":"Nucleic Acids Res"},{"key":"3313_CR93","doi-asserted-by":"publisher","unstructured":"Hu Y, Zeng Q, Li C, Xie Y. Expression profile and prognostic value of SFN in human ovarian cancer. Biosci Rep. 2019;39: https:\/\/doi.org\/10.1042\/BSR20190100.","DOI":"10.1042\/BSR20190100"},{"key":"3313_CR94","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1856-y","volume":"15","author":"GM Young","year":"2015","unstructured":"Young GM, Radhakrishnan VM, Centuori SM, Gomes CJ, Martinez JD. Comparative analysis of 14-3-3 isoform expression and epigenetic alterations in colorectal cancer. BMC Cancer. 2015;15:826. https:\/\/doi.org\/10.1186\/s12885-015-1856-y.","journal-title":"BMC Cancer"},{"key":"3313_CR95","doi-asserted-by":"publisher","first-page":"2932","DOI":"10.1158\/0008-5472.CAN-06-4511","volume":"67","author":"E Pick","year":"2007","unstructured":"Pick E, Kluger Y, Giltnane JM, Moeder C, Camp RL, Rimm DL, Kluger HM. High HSP90 expression is associated with decreased survival in breast cancer. Cancer Res. 2007;67:2932\u20137. https:\/\/doi.org\/10.1158\/0008-5472.CAN-06-4511.","journal-title":"Cancer Res"},{"key":"3313_CR96","doi-asserted-by":"publisher","first-page":"2657","DOI":"10.3892\/etm.2019.7228","volume":"17","author":"K Liu","year":"2019","unstructured":"Liu K, Kang M, Li J, Qin W, Wang R. Prognostic value of the mRNA expression of members of the HSP90 family in non-small cell lung cancer. Exp Ther Med. 2019;17:2657\u201365. https:\/\/doi.org\/10.3892\/etm.2019.7228.","journal-title":"Exp Ther Med"},{"key":"3313_CR97","doi-asserted-by":"publisher","first-page":"7822","DOI":"10.1158\/1078-0432.CCR-08-1369","volume":"14","author":"C-F Li","year":"2008","unstructured":"Li C-F, Huang WW, Wu JM, Yu SC, Hu TH, Uen YH, et al. Heat shock protein 90 overexpression independently predicts inferior disease-free survival with differential expression of the alpha and beta isoforms in gastrointestinal stromal tumors. Clin Cancer Res. 2008;14:7822\u201331. https:\/\/doi.org\/10.1158\/1078-0432.CCR-08-1369.","journal-title":"Clin Cancer Res"},{"key":"3313_CR98","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1515\/oncologie-2023-0602","volume":"26","author":"C Jin","year":"2024","unstructured":"Jin C, Xu X, Li T, Zhang C, Peng J, Liu C, et al. The HSP90AB1-mediated upregulation of IDO1 can promote the progression of colorectal cancer. Oncologie. 2024;26:445\u201355. https:\/\/doi.org\/10.1515\/oncologie-2023-0602.","journal-title":"Oncologie"},{"key":"3313_CR99","doi-asserted-by":"publisher","first-page":"E2875","DOI":"10.1073\/pnas.1203659109","volume":"109","author":"L Blau","year":"2012","unstructured":"Blau L, Knirsh R, Ben-Dror I, Oren S, Kuphal S, Hau P, et al. Aberrant expression of c-Jun in glioblastoma by internal ribosome entry site (IRES)-mediated translational activation. Proc Natl Acad Sci USA. 2012;109:E2875\u201384. https:\/\/doi.org\/10.1073\/pnas.1203659109.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3313_CR100","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1093\/carcin\/21.5.313","volume":"21","author":"H Wang","year":"2000","unstructured":"Wang H, Birkenbach M, Hart J. Expression of Jun family members in human colorectal adenocarcinoma. Carcinogenesis. 2000;21:1313\u20137. https:\/\/doi.org\/10.1093\/carcin\/21.5.313.","journal-title":"Carcinogenesis"},{"key":"3313_CR101","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-022-10393-x","volume":"22","author":"P Zhu","year":"2022","unstructured":"Zhu P, Liu G, Wang X, Lu J, Zhou Y, Chen S, et al. Transcription factor c-Jun modulates GLUT1 in glycolysis and breast cancer metastasis. BMC Cancer. 2022;22:1283. https:\/\/doi.org\/10.1186\/s12885-022-10393-x.","journal-title":"BMC Cancer"},{"key":"3313_CR102","doi-asserted-by":"publisher","first-page":"8218","DOI":"10.1074\/jbc.M110.100792","volume":"285","author":"X Jiao","year":"2010","unstructured":"Jiao X, Katiyar S, Willmarth NE, Liu M, Ma X, Flomenberg N, et al. c-Jun induces mammary epithelial cellular invasion and breast cancer stem cell expansion. J Biol Chem. 2010;285:8218\u201326. https:\/\/doi.org\/10.1074\/jbc.M110.100792.","journal-title":"J Biol Chem"}],"container-title":["British Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41416-025-03313-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41416-025-03313-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41416-025-03313-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T16:26:17Z","timestamp":1772641577000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41416-025-03313-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,8]]},"references-count":102,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,3,20]]}},"alternative-id":["3313"],"URL":"https:\/\/doi.org\/10.1038\/s41416-025-03313-w","relation":{},"ISSN":["0007-0920","1532-1827"],"issn-type":[{"value":"0007-0920","type":"print"},{"value":"1532-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,8]]},"assertion":[{"value":"24 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 December 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 January 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study was approved by the Ethics Committee of the university hospital Ruhr-Universit\u00e4t Bochum in Bad Oeynhausen, Germany (2022_060_1). All participants gave written informed consent according to the agreed patient information sheets. All methods were carried out in accordance with relevant guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}