{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T08:48:56Z","timestamp":1781426936728,"version":"3.54.1"},"reference-count":72,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:00:00Z","timestamp":1705449600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:00:00Z","timestamp":1705449600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100004410","name":"European Molecular Biology Organization","doi-asserted-by":"publisher","award":["8981"],"award-info":[{"award-number":["8981"]}],"id":[{"id":"10.13039\/100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Gene Ther"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1038\/s41417-024-00725-3","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T11:02:53Z","timestamp":1705489373000},"page":"537-551","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Retinoids and EZH2 inhibitors cooperate to orchestrate anti-oncogenic effects on bladder cancer cells"],"prefix":"10.1038","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6447-1421","authenticated-orcid":false,"given":"Gizem","family":"Ozgun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tutku","family":"Yaras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burcu","family":"Akman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fclden","family":"\u00d6zden-Y\u0131lmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9473-4686","authenticated-orcid":false,"given":"Nick","family":"Landman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6706-1375","authenticated-orcid":false,"given":"G\u00f6khan","family":"Karak\u00fclah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"van Lohuizen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3963-2294","authenticated-orcid":false,"given":"Serif","family":"Senturk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4439-5203","authenticated-orcid":false,"given":"Serap","family":"Erkek-Ozhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,17]]},"reference":[{"key":"725_CR1","doi-asserted-by":"publisher","first-page":"17022","DOI":"10.1038\/nrdp.2017.22","volume":"3","author":"O Sanli","year":"2017","unstructured":"Sanli O, Dobruch J, Knowles MA, Burger M, Alemozaffar M, Nielsen ME, et al. Bladder cancer. Nat Rev Dis Prim. 2017;3:17022.","journal-title":"Nat Rev Dis Prim"},{"key":"725_CR2","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/j.cell.2018.07.036","volume":"174","author":"AG Robertson","year":"2018","unstructured":"Robertson AG, Kim J, Al-Ahmadie H, Bellmunt J, Guo G, Cherniack AD, et al. Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer. Cell. 2018;174:1033.","journal-title":"Cell"},{"key":"725_CR3","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1038\/nature12965","volume":"507","author":"The Cancer Genome Atlas Research Network.","year":"2014","unstructured":"The Cancer Genome Atlas Research Network. Comprehensive molecular characterization of urothelial bladder carcinoma. Nature. 2014;507:315\u201322.","journal-title":"Nature"},{"key":"725_CR4","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.eururo.2019.09.006","volume":"77","author":"A Kamoun","year":"2020","unstructured":"Kamoun A, de Reyni\u00e8s A, Allory Y, Sj\u00f6dahl G, Robertson AG, Seiler R, et al. A consensus molecular classification of muscle-invasive bladder cancer. Eur Urol. 2020;77:420\u201333.","journal-title":"Eur Urol"},{"key":"725_CR5","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18640-0","volume":"11","author":"A Taber","year":"2020","unstructured":"Taber A, Christensen E, Lamy P, Nordentoft I, Prip F, Lindskrog SV, et al. Molecular correlates of cisplatin-based chemotherapy response in muscle invasive bladder cancer by integrated multi-omics analysis. Nat Commun. 2020;11:4858.","journal-title":"Nat Commun"},{"key":"725_CR6","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09624-w","volume":"10","author":"E Lavarone","year":"2019","unstructured":"Lavarone E, Barbieri CM, Pasini D. Dissecting the role of H3K27 acetylation and methylation in PRC2 mediated control of cellular identity. Nat Commun. 2019;10:1679.","journal-title":"Nat Commun"},{"key":"725_CR7","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1038\/s41580-021-00341-1","volume":"22","author":"A Piunti","year":"2021","unstructured":"Piunti A, Shilatifard A. The roles of Polycomb repressive complexes in mammalian development and cancer. Nat Rev Mol Cell Biol. 2021;22:326\u201345.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"725_CR8","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1126\/science.1118947","volume":"310","author":"TL Cha","year":"2005","unstructured":"Cha TL, Zhou BP, Xia W, Wu Y, Yang CC, Chen CT, et al. Molecular biology: Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3. Science (80-). 2005;310:306\u201310.","journal-title":"Science (80-)"},{"key":"725_CR9","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.mrfmmm.2008.07.010","volume":"647","author":"JA Simon","year":"2008","unstructured":"Simon JA, Lange CA. Roles of the EZH2 histone methyltransferase in cancer epigenetics. Mutat Res Mol Mech Mutagen. 2008;647:21\u20139.","journal-title":"Mutat Res Mol Mech Mutagen"},{"key":"725_CR10","doi-asserted-by":"publisher","first-page":"3091","DOI":"10.1158\/0008-5472.CAN-11-3546","volume":"72","author":"G Ren","year":"2012","unstructured":"Ren G, Baritaki S, Marathe H, Feng J, Park S, Beach S, et al. Polycomb protein EZH2 regulates tumor invasion via the transcriptional repression of the metastasis suppressor RKIP in breast and prostate cancer. Cancer Res. 2012;72:3091\u2013104.","journal-title":"Cancer Res"},{"key":"725_CR11","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.gene.2014.01.006","volume":"537","author":"L Zhao","year":"2014","unstructured":"Zhao L, Yu Y, Wu J, Bai J, Zhao Y, Li C, et al. Role of EZH2 in oral squamous cell carcinoma carcinogenesis. Gene. 2014;537:197\u2013202.","journal-title":"Gene"},{"key":"725_CR12","doi-asserted-by":"publisher","first-page":"27107","DOI":"10.3390\/ijms161126000","volume":"16","author":"M Mart\u00ednez-Fern\u00e1ndez","year":"2015","unstructured":"Mart\u00ednez-Fern\u00e1ndez M, Rubio C, Segovia C, L\u00f3pez-Calder\u00f3n FF, Due\u00f1as M, Paramio JM. EZH2 in Bladder Cancer, a Promising Therapeutic Target. Int J Mol Sci. 2015;16:27107\u201332.","journal-title":"Int J Mol Sci"},{"key":"725_CR13","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1200\/JCO.2005.01.5180","volume":"24","author":"IM Bachmann","year":"2006","unstructured":"Bachmann IM, Halvorsen OJ, Collett K, Stefansson IM, Straume O, Haukaas SA, et al. EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast. J Clin Oncol. 2006;24:268\u201373.","journal-title":"J Clin Oncol"},{"key":"725_CR14","doi-asserted-by":"publisher","first-page":"5323","DOI":"10.1093\/emboj\/cdg542","volume":"22","author":"AP Bracken","year":"2003","unstructured":"Bracken AP, Pasini D, Capra M, Prosperini E, Colli E, Helin K. EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer. EMBO J. 2003;22:5323\u201335.","journal-title":"EMBO J"},{"key":"725_CR15","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1016\/j.cell.2008.12.043","volume":"136","author":"E Ezhkova","year":"2009","unstructured":"Ezhkova E, Pasolli HA, Parker JS, Stokes N, Su IH, Hannon G, et al. Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells. Cell. 2009;136:1122\u201335.","journal-title":"Cell"},{"key":"725_CR16","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/nm.4036","volume":"22","author":"KH Kim","year":"2016","unstructured":"Kim KH, Roberts CWM. Targeting EZH2 in cancer. Nat Med. 2016;22:128\u201334.","journal-title":"Nat Med"},{"key":"725_CR17","first-page":"907","volume":"18","author":"Z Chen","year":"2019","unstructured":"Chen Z, Du Y, Liu X, Chen H, Weng X, Guo J, et al. EZH2 inhibition suppresses bladder cancer cell growth and metastasis via the JAK2\/STAT3 signaling pathway. Oncol Lett. 2019;18:907\u201315.","journal-title":"Oncol Lett"},{"key":"725_CR18","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-36164-y","volume":"8","author":"X Zhou","year":"2018","unstructured":"Zhou X, Liu N, Zhang J, Ji H, Liu Y, Yang J, et al. Increased expression of EZH2 indicates aggressive potential of urothelial carcinoma of the bladder in a Chinese population. Sci Rep. 2018;8:17792.","journal-title":"Sci Rep"},{"key":"725_CR19","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.canlet.2016.12.005","volume":"388","author":"D Liu","year":"2017","unstructured":"Liu D, Li Y, Luo G, Xiao X, Tao D, Wu X, et al. LncRNA SPRY4-IT1 sponges miR-101-3p to promote proliferation and metastasis of bladder cancer cells through up-regulating EZH2. Cancer Lett. 2017;388:281\u201391.","journal-title":"Cancer Lett"},{"key":"725_CR20","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/nrd.2016.256","volume":"16","author":"SX Pfister","year":"2017","unstructured":"Pfister SX, Ashworth A. Marked for death: targeting epigenetic changes in cancer. Nat Rev Drug Discov. 2017;16:241\u201363.","journal-title":"Nat Rev Drug Discov"},{"key":"725_CR21","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/nature11606","volume":"492","author":"MT McCabe","year":"2012","unstructured":"McCabe MT, Ott HM, Ganji G, Korenchuk S, Thompson C, Van Aller GS, et al. EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations. Nature. 2012;492:108\u201312.","journal-title":"Nature"},{"key":"725_CR22","doi-asserted-by":"publisher","first-page":"13509","DOI":"10.18632\/oncotarget.14586","volume":"8","author":"K Ihira","year":"2017","unstructured":"Ihira K, Dong P, Xiong Y, Watari H, Konno Y, Hanley SJB, et al. EZH2 inhibition suppresses endometrial cancer progression via miR-361\/Twist axis. Oncotarget. 2017;8:13509\u201320.","journal-title":"Oncotarget"},{"key":"725_CR23","doi-asserted-by":"publisher","first-page":"e0246244","DOI":"10.1371\/journal.pone.0246244","volume":"16","author":"LV Bownes","year":"2021","unstructured":"Bownes LV, Williams AP, Marayati R, Stafman LL, Markert H, Quinn CH, et al. EZH2 inhibition decreases neuroblastoma proliferation and in vivo tumor growth. PLoS One. 2021;16:e0246244.","journal-title":"PLoS One"},{"key":"725_CR24","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1101\/gad.1524107","volume":"21","author":"J Tan","year":"2007","unstructured":"Tan J, Yang X, Zhuang L, Jiang X, Chen W, Lee PL, et al. Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev. 2007;21:1050\u201363.","journal-title":"Genes Dev"},{"key":"725_CR25","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/s41571-019-0267-4","volume":"17","author":"D Morel","year":"2020","unstructured":"Morel D, Jeffery D, Aspeslagh S, Almouzni G, Postel-Vinay S. Combining epigenetic drugs with other therapies for solid tumours \u2014 past lessons and future promise. Nat Rev Clin Oncol. 2020;17:91\u2013107.","journal-title":"Nat Rev Clin Oncol"},{"key":"725_CR26","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1002\/jcp.22417","volume":"226","author":"LJ Gudas","year":"2011","unstructured":"Gudas LJ, Wagner JA. Retinoids regulate stem cell differentiation. J Cell Physiol. 2011;226:322\u201330.","journal-title":"J Cell Physiol"},{"key":"725_CR27","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/35106036","volume":"1","author":"L Altucci","year":"2001","unstructured":"Altucci L, Gronemeyer H. The promise of retinoids to fight against cancer. Nat Rev Cancer. 2001;1:181\u201393.","journal-title":"Nat Rev Cancer"},{"key":"725_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fgene.2022.1065320","volume":"13","author":"S Chen","year":"2022","unstructured":"Chen S, Hu Q, Tao X, Xia J, Wu T, Cheng B, et al. Retinoids in cancer chemoprevention and therapy: Meta-analysis of randomized controlled trials. Front Genet. 2022;13:1\u201314.","journal-title":"Front Genet"},{"key":"725_CR29","first-page":"391","volume":"10","author":"JL Clifford","year":"2001","unstructured":"Clifford JL, Sabichi AL, Zou C, Yang X, Steele VE, Kelloff GJ, et al. Effects of novel phenylretinamides on cell growth and apoptosis in bladder cancer. Cancer Epidemiol Biomark Prev a Publ Am Assoc Cancer Res cosponsored Am Soc Prev Oncol 2001;10:391\u20135.","journal-title":"Cancer Epidemiol Biomark Prev a Publ Am Assoc Cancer Res cosponsored Am Soc Prev Oncol"},{"key":"725_CR30","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.3390\/cells8111392","volume":"8","author":"A le Maire","year":"2019","unstructured":"le Maire A, Teyssier C, Balaguer P, Bourguet W, Germain P. Regulation of RXR-RAR Heterodimers by RXR- and RAR-Specific Ligands and Their Combinations. Cells. 2019;8:1392.","journal-title":"Cells"},{"key":"725_CR31","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.jmb.2007.06.079","volume":"372","author":"RF Gillespie","year":"2007","unstructured":"Gillespie RF, Gudas LJ. Retinoid regulated association of transcriptional co-regulators and the polycomb group protein SUZ12 with the retinoic acid response elements of Hoxa1, RARbeta(2), and Cyp26A1 in F9 embryonal carcinoma cells. J Mol Biol. 2007;372:298\u2013316.","journal-title":"J Mol Biol"},{"key":"725_CR32","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1146\/annurev-pathol-011110-130303","volume":"6","author":"XH Tang","year":"2011","unstructured":"Tang XH, Gudas LJ. Retinoids, retinoic acid receptors, and cancer. Annu Rev Pathol. 2011;6:345\u201364.","journal-title":"Annu Rev Pathol"},{"key":"725_CR33","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25:402\u20138.","journal-title":"Methods"},{"key":"725_CR34","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","volume":"30","author":"AM Bolger","year":"2014","unstructured":"Bolger AM, Lohse M, Usadel B. Trimmomatic: a flexible trimmer for Illumina sequence data. Bioinformatics. 2014;30:2114\u201320.","journal-title":"Bioinformatics"},{"key":"725_CR35","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkz114","volume":"47","author":"Y Liao","year":"2019","unstructured":"Liao Y, Smyth GK, Shi W. The R package Rsubread is easier, faster, cheaper and better for alignment and quantification of RNA sequencing reads. Nucleic Acids Res. 2019;47:e47.","journal-title":"Nucleic Acids Res"},{"key":"725_CR36","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","volume":"25","author":"H Li","year":"2009","unstructured":"Li H, Handsaker B, Wysoker A, Fennell T, Ruan J, Homer N, et al. The Sequence Alignment\/Map format and SAMtools. Bioinformatics. 2009;25:2078\u20139.","journal-title":"Bioinformatics"},{"key":"725_CR37","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","volume":"30","author":"Y Liao","year":"2014","unstructured":"Liao Y, Smyth GK, Shi W. featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Bioinformatics. 2014;30:923\u201330.","journal-title":"Bioinformatics"},{"key":"725_CR38","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","volume":"26","author":"MD Robinson","year":"2010","unstructured":"Robinson MD, McCarthy DJ, Smyth GK. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 2010;26:139\u201340.","journal-title":"Bioinformatics"},{"key":"725_CR39","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu G, Wang LG, Han Y, He QY. clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS. 2012;16:284\u20137.","journal-title":"OMICS"},{"key":"725_CR40","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1038\/nprot.2007.202","volume":"2","author":"D Shechter","year":"2007","unstructured":"Shechter D, Dormann HL, Allis CD, Hake SB. Extraction, purification and analysis of histones. Nat Protoc. 2007;2:1445\u201357.","journal-title":"Nat Protoc"},{"key":"725_CR41","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2011-12-8-r83","volume":"12","author":"T Liu","year":"2011","unstructured":"Liu T, Ortiz JA, Taing L, Meyer CA, Lee B, Zhang Y, et al. Cistrome: an integrative platform for transcriptional regulation studies. Genome Biol. 2011;12:R83.","journal-title":"Genome Biol"},{"key":"725_CR42","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2008-9-9-r137","volume":"9","author":"Y Zhang","year":"2008","unstructured":"Zhang Y, Liu T, Meyer CA, Eeckhoute J, Johnson DS, Bernstein BE, et al. Model-based Analysis of ChIP-Seq (MACS). Genome Biol. 2008;9:R137.","journal-title":"Genome Biol"},{"key":"725_CR43","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/j.urolonc.2010.09.005","volume":"30","author":"H Wang","year":"2012","unstructured":"Wang H, Albadine R, Magheli A, Guzzo TJ, Ball MW, Hinz S, et al. Increased EZH2 protein expression is associated with invasive urothelial carcinoma of the bladder. Urol Oncol. 2012;30:428\u201333.","journal-title":"Urol Oncol"},{"key":"725_CR44","doi-asserted-by":"publisher","first-page":"e549","DOI":"10.1038\/bcj.2017.27","volume":"7","author":"C Pawlyn","year":"2017","unstructured":"Pawlyn C, Bright MD, Buros AF, Stein CK, Walters Z, Aronson LI, et al. Overexpression of EZH2 in multiple myeloma is associated with poor prognosis and dysregulation of cell cycle control. Blood Cancer J. 2017;7:e549.","journal-title":"Blood Cancer J"},{"key":"725_CR45","doi-asserted-by":"publisher","first-page":"11606","DOI":"10.1073\/pnas.1933744100","volume":"100","author":"CG Kleer","year":"2003","unstructured":"Kleer CG, Cao Q, Varambally S, Shen R, Ota I, Tomlins SA, et al. EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Proc Natl Acad Sci USA. 2003;100:11606\u201311.","journal-title":"Proc Natl Acad Sci USA"},{"key":"725_CR46","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.csbj.2015.09.001","volume":"13","author":"B Yadav","year":"2015","unstructured":"Yadav B, Wennerberg K, Aittokallio T, Tang J. Searching for drug synergy in complex dose-response landscapes using an interaction potency model. Comput Struct Biotechnol J. 2015;13:504\u201313.","journal-title":"Comput Struct Biotechnol J"},{"key":"725_CR47","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.gpb.2022.01.004","volume":"20","author":"S Zheng","year":"2022","unstructured":"Zheng S, Wang W, Aldahdooh J, Malyutina A, Shadbahr T, Tanoli Z, et al. SynergyFinder Plus: toward better interpretation and annotation of drug combination screening datasets. Genomics Proteom Bioinforma. 2022;20:587\u201396.","journal-title":"Genomics Proteom Bioinforma"},{"key":"725_CR48","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1083\/jcb.200310015","volume":"165","author":"J Hitomi","year":"2004","unstructured":"Hitomi J, Katayama T, Eguchi Y, Kudo T, Taniguchi M, Koyama Y, et al. Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and A\u03b2-induced cell death. J Cell Biol. 2004;165:347\u201356.","journal-title":"J Cell Biol"},{"key":"725_CR49","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-24075-x","volume":"8","author":"S Kleinsimon","year":"2018","unstructured":"Kleinsimon S, Longmuss E, Rolff J, J\u00e4ger S, Eggert A, Delebinski C, et al. GADD45A and CDKN1A are involved in apoptosis and cell cycle modulatory effects of viscumTT with further inactivation of the STAT3 pathway. Sci Rep. 2018;8:5750.","journal-title":"Sci Rep"},{"key":"725_CR50","doi-asserted-by":"publisher","DOI":"10.1186\/s13008-015-0008-8","volume":"10","author":"KS Borges","year":"2015","unstructured":"Borges KS, Arboleda VA, Vilain E. Mutations in the PCNA-binding site of CDKN1C inhibit cell proliferation by impairing the entry into S phase. Cell Div. 2015;10:2.","journal-title":"Cell Div"},{"key":"725_CR51","doi-asserted-by":"publisher","first-page":"27023","DOI":"10.18632\/oncotarget.4809","volume":"6","author":"JC Tiffen","year":"2015","unstructured":"Tiffen JC, Gunatilake D, Gallagher SJ, Gowrishankar K, Heinemann A, Cullinane C, et al. Targeting activating mutations of EZH2 leads to potent cell growth inhibition in human melanoma by derepression of tumor suppressor genes. Oncotarget. 2015;6:27023\u201336.","journal-title":"Oncotarget"},{"key":"725_CR52","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1038\/s41568-019-0143-7","volume":"19","author":"LN Kent","year":"2019","unstructured":"Kent LN, Leone G. The broken cycle: E2F dysfunction in cancer. Nat Rev Cancer. 2019;19:326\u201338.","journal-title":"Nat Rev Cancer"},{"key":"725_CR53","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1038\/s41392-023-01570-w","volume":"8","author":"X Chen","year":"2023","unstructured":"Chen X, Shi C, He M, Xiong S, Xia X. Endoplasmic reticulum stress: molecular mechanism and therapeutic targets. Signal Transduct Target Ther. 2023;8:352.","journal-title":"Signal Transduct Target Ther"},{"key":"725_CR54","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/sj.cdd.4401373","volume":"11","author":"S Oyadomari","year":"2004","unstructured":"Oyadomari S, Mori M. Roles of CHOP\/GADD153 in endoplasmic reticulum stress. Cell Death Differ. 2004;11:381\u20139.","journal-title":"Cell Death Differ"},{"key":"725_CR55","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/s11010-019-03642-4","volume":"463","author":"MDK Zahid","year":"2020","unstructured":"Zahid MDK, Rogowski M, Ponce C, Choudhury M, Moustaid-Moussa N, Rahman SM. CCAAT\/enhancer-binding protein beta (C\/EBP\u03b2) knockdown reduces inflammation, ER stress, and apoptosis, and promotes autophagy in oxLDL-treated RAW264.7 macrophage cells. Mol Cell Biochem. 2020;463:211\u201323.","journal-title":"Mol Cell Biochem"},{"key":"725_CR56","doi-asserted-by":"publisher","first-page":"4308","DOI":"10.3390\/ijms21124308","volume":"21","author":"M Tolomeo","year":"2020","unstructured":"Tolomeo M, Grimaudo S. The \u201cJanus\u201d Role of C\/EBPs family members in cancer progression. Int J Mol Sci. 2020;21:4308.","journal-title":"Int J Mol Sci"},{"key":"725_CR57","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/s41585-022-00693-z","volume":"20","author":"E Grobet-Jeandin","year":"2023","unstructured":"Grobet-Jeandin E, Pinar U, Parra J, Roupr\u00eat M, Seisen T. Health-related quality of life after curative treatment for muscle-invasive bladder cancer. Nat Rev Urol. 2023;20:279\u201393.","journal-title":"Nat Rev Urol"},{"key":"725_CR58","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.ccr.2007.04.009","volume":"11","author":"R Villa","year":"2007","unstructured":"Villa R, Pasini D, Gutierrez A, Morey L, Occhionorelli M, Vir\u00e9 E, et al. Role of the polycomb repressive complex 2 in acute promyelocytic leukemia. Cancer Cell. 2007;11:513\u201325.","journal-title":"Cancer Cell"},{"key":"725_CR59","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1002\/jcp.24224","volume":"228","author":"YD Benoit","year":"2013","unstructured":"Benoit YD, Laursen KB, Witherspoon MS, Lipkin SM, Gudas LJ. Inhibition of PRC2 histone methyltransferase activity increases TRAIL-mediated apoptosis sensitivity in human colon cancer cells. J Cell Physiol. 2013;228:764\u201372.","journal-title":"J Cell Physiol"},{"key":"725_CR60","doi-asserted-by":"publisher","first-page":"3083","DOI":"10.3389\/fimmu.2018.03083","volume":"9","author":"H Hu","year":"2018","unstructured":"Hu H, Tian M, Ding C, Yu S. The C\/EBP Homologous Protein (CHOP) transcription factor functions in endoplasmic reticulum stress-induced apoptosis and microbial infection. Front Immunol. 2018;9:3083.","journal-title":"Front Immunol"},{"key":"725_CR61","doi-asserted-by":"publisher","first-page":"1836","DOI":"10.1038\/cdd.2012.67","volume":"19","author":"F Allagnat","year":"2012","unstructured":"Allagnat F, Fukaya M, Nogueira TC, Delaroche D, Welsh N, Marselli L, et al. C\/EBP homologous protein contributes to cytokine-induced pro-inflammatory responses and apoptosis in \u03b2-cells. Cell Death Differ. 2012;19:1836\u201346.","journal-title":"Cell Death Differ"},{"key":"725_CR62","doi-asserted-by":"publisher","first-page":"5806","DOI":"10.1093\/emboj\/cdg556","volume":"22","author":"E Duprez","year":"2003","unstructured":"Duprez E, Wagner K, Koch H, Tenen DG. C\/EBPbeta: a major PML-RARA-responsive gene in retinoic acid-induced differentiation of APL cells. EMBO J. 2003;22:5806\u201316.","journal-title":"EMBO J"},{"key":"725_CR63","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.3390\/ijms19071918","volume":"19","author":"A Marchwicka","year":"2018","unstructured":"Marchwicka A, Marcinkowska E. Regulation of Expression of CEBP Genes by Variably Expressed Vitamin D Receptor and Retinoic Acid Receptor \u03b1 in Human Acute Myeloid Leukemia Cell Lines. Int J Mol Sci. 2018;19:1918.","journal-title":"Int J Mol Sci"},{"key":"725_CR64","doi-asserted-by":"publisher","first-page":"3911","DOI":"10.1182\/blood-2003-10-3688","volume":"104","author":"S Gery","year":"2004","unstructured":"Gery S, Park DJ, Vuong PT, Chih DY, Lemp N, Koeffler HP. Retinoic acid regulates C\/EBP homologous protein expression (CHOP), which negatively regulates myeloid target genes. Blood. 2004;104:3911\u20137.","journal-title":"Blood"},{"key":"725_CR65","doi-asserted-by":"publisher","first-page":"5391","DOI":"10.1158\/1078-0432.CCR-14-2680","volume":"21","author":"SR Lee","year":"2015","unstructured":"Lee SR, Roh YG, Kim SK, Lee JS, Seol SY, Lee HH, et al. Activation of EZH2 and SUZ12 Regulated by E2F1 Predicts the Disease Progression and Aggressive Characteristics of Bladder Cancer. Clin Cancer Res J Am Assoc Cancer Res. 2015;21:5391\u2013403.","journal-title":"Clin Cancer Res J Am Assoc Cancer Res"},{"key":"725_CR66","doi-asserted-by":"publisher","first-page":"2358","DOI":"10.1182\/blood.2022015668","volume":"140","author":"M Poplineau","year":"2022","unstructured":"Poplineau M, Platet N, Mazuel A, H\u00e9rault L, N\u2019Guyen L, Koide S, et al. Noncanonical EZH2 drives retinoic acid resistance of variant acute promyelocytic leukemias. Blood. 2022;140:2358\u201370.","journal-title":"Blood"},{"key":"725_CR67","doi-asserted-by":"publisher","first-page":"e01141","DOI":"10.1128\/mBio.01141-17","volume":"8","author":"JH Arbuckle","year":"2017","unstructured":"Arbuckle JH, Gardina PJ, Gordon DN, Hickman HD, Yewdell JW, Pierson TC, et al. Inhibitors of the Histone Methyltransferases EZH2\/1 Induce a Potent Antiviral State and Suppress Infection by Diverse Viral Pathogens. MBio. 2017;8:e01141\u201317.","journal-title":"MBio"},{"key":"725_CR68","doi-asserted-by":"publisher","first-page":"2442","DOI":"10.1016\/j.jid.2020.02.042","volume":"140","author":"J Tiffen","year":"2020","unstructured":"Tiffen J, Gallagher SJ, Filipp F, Gunatilake D, Emran AA, Cullinane C, et al. EZH2 Cooperates with DNA Methylation To Downregulate Key Tumor Suppressors and IFN Gene Signatures in Melanoma. J Invest Dermatol. 2020;140:2442\u201354.e5.","journal-title":"J Invest Dermatol"},{"key":"725_CR69","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1158\/1078-0432.CCR-11-0962","volume":"18","author":"CD Kemp","year":"2012","unstructured":"Kemp CD, Rao M, Xi S, Inchauste S, Mani H, Fetsch P, et al. Polycomb repressor complex-2 is a novel target for mesothelioma therapy. Clin Cancer Res J Am Assoc Cancer Res. 2012;18:77\u201390.","journal-title":"Clin Cancer Res J Am Assoc Cancer Res"},{"key":"725_CR70","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1080\/10428194.2018.1430795","volume":"59","author":"N Gulati","year":"2018","unstructured":"Gulati N, B\u00e9guelin W, Giulino-Roth L. Enhancer of zeste homolog 2 (EZH2) inhibitors. Leuk Lymphoma. 2018;59:1574\u201385.","journal-title":"Leuk Lymphoma"},{"key":"725_CR71","doi-asserted-by":"publisher","first-page":"2100","DOI":"10.1038\/s41418-019-0278-9","volume":"26","author":"S Ramakrishnan","year":"2019","unstructured":"Ramakrishnan S, Granger V, Rak M, Hu Q, Attwood K, Aquila L, et al. Inhibition of EZH2 induces NK cell-mediated differentiation and death in muscle-invasive bladder cancer. Cell Death Differ. 2019;26:2100\u201314.","journal-title":"Cell Death Differ"},{"key":"725_CR72","doi-asserted-by":"publisher","first-page":"eaai8312","DOI":"10.1126\/scitranslmed.aai8312","volume":"9","author":"LD Ler","year":"2017","unstructured":"Ler LD, Ghosh S, Chai X, Thike AA, Heng HL, Siew EY, et al. Loss of tumor suppressor KDM6A amplifies PRC2-regulated transcriptional repression in bladder cancer and can be targeted through inhibition of EZH2. Sci Transl Med. 2017;9:eaai8312.","journal-title":"Sci Transl Med"}],"container-title":["Cancer Gene Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41417-024-00725-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41417-024-00725-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41417-024-00725-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,14]],"date-time":"2024-04-14T23:02:42Z","timestamp":1713135762000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41417-024-00725-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,17]]},"references-count":72,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["725"],"URL":"https:\/\/doi.org\/10.1038\/s41417-024-00725-3","relation":{},"ISSN":["0929-1903","1476-5500"],"issn-type":[{"value":"0929-1903","type":"print"},{"value":"1476-5500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,17]]},"assertion":[{"value":"5 May 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 January 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study was approved by the Non-Interventional Research Ethics Committee of Izmir Biomedicine and Genome Center.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}