{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:05:56Z","timestamp":1792181156059,"version":"4.4.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Gene Ther"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1038\/s41417-024-00784-6","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T08:02:18Z","timestamp":1716796938000},"page":"1251-1265","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["CircPKN2 promotes ferroptosis in bladder cancer by promoting the ubiquitination of Stearoyl-CoA Desaturase 1"],"prefix":"10.1038","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4459-8271","authenticated-orcid":false,"given":"Changkun","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengming","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1266-278X","authenticated-orcid":false,"given":"Ye","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianbao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangchen","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,27]]},"reference":[{"key":"784_CR1","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.eururo.2023.03.029","volume":"84","author":"I Jubber","year":"2023","unstructured":"Jubber I, Ong S, Bukavina L, Black PC, Comp\u00e9rat E, Kamat AM, et al. Epidemiology of bladder cancer in 2023: A systematic review of risk factors. Eur Urol. 2023;84:176\u201390.","journal-title":"Eur Urol"},{"key":"784_CR2","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.1016\/j.cell.2022.04.021","volume":"185","author":"CX Liu","year":"2022","unstructured":"Liu CX, Chen LL. Circular RNAs: Characterization, cellular roles, and applications. Cell. 2022;185:2016\u201334.","journal-title":"Cell"},{"key":"784_CR3","doi-asserted-by":"publisher","first-page":"100937","DOI":"10.1016\/j.drup.2023.100937","volume":"67","author":"X Guo","year":"2023","unstructured":"Guo X, Gao C, Yang DH, Li S. Exosomal circular RNAs: A chief culprit in cancer chemotherapy resistance. Drug Resist Updat. 2023;67:100937.","journal-title":"Drug Resist Updat"},{"key":"784_CR4","doi-asserted-by":"publisher","first-page":"216023","DOI":"10.1016\/j.canlet.2022.216023","volume":"554","author":"X Meng","year":"2023","unstructured":"Meng X, Xiao W, Sun J, Li W, Yuan H, Yu T, et al. CircPTK2\/PABPC1\/SETDB1 axis promotes EMT-mediated tumor metastasis and gemcitabine resistance in bladder cancer. Cancer Lett. 2023;554:216023.","journal-title":"Cancer Lett"},{"key":"784_CR5","doi-asserted-by":"publisher","first-page":"2239","DOI":"10.1158\/0008-5472.CAN-21-4349","volume":"82","author":"M An","year":"2022","unstructured":"An M, Zheng H, Huang J, Lin Y, Luo Y, Kong Y, et al. Aberrant nuclear export of circNCOR1 underlies SMAD7-mediated lymph node metastasis of bladder cancer. Cancer Res. 2022;82:2239\u201353.","journal-title":"Cancer Res"},{"key":"784_CR6","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","volume":"149","author":"SJ Dixon","year":"2012","unstructured":"Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149:1060\u201372.","journal-title":"Cell"},{"key":"784_CR7","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1038\/s41573-023-00749-8","volume":"22","author":"K Hadian","year":"2023","unstructured":"Hadian K, Stockwell BR. The therapeutic potential of targeting regulated non-apoptotic cell death. Nat Rev Drug Discov. 2023;22:723\u201342.","journal-title":"Nat Rev Drug Discov"},{"key":"784_CR8","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","volume":"185","author":"BR Stockwell","year":"2022","unstructured":"Stockwell BR. Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications. Cell. 2022;185:2401\u201321.","journal-title":"Cell"},{"key":"784_CR9","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1016\/j.cmet.2023.09.004","volume":"35","author":"Y Zhao","year":"2023","unstructured":"Zhao Y, Liu Z, Liu G, Zhang Y, Liu S, Gan D, et al. Neutrophils resist ferroptosis and promote breast cancer metastasis through aconitate decarboxylase 1. Cell Metab. 2023;35:1688\u20131703.e10.","journal-title":"Cell Metab"},{"key":"784_CR10","doi-asserted-by":"crossref","unstructured":"Chang K, Chen Y, Zhang X, Zhang W, Xu N, Zeng B, et al. DPP9 Stabilizes NRF2 to suppress ferroptosis and induce Sorafenib resistance in clear cell renal cell carcinoma. Cancer Res 2023.","DOI":"10.1158\/0008-5472.c.6960528.v1"},{"key":"784_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.102201","volume":"48","author":"WS Wei","year":"2021","unstructured":"Wei WS, Wang N, Deng MH, Dong P, Liu JY, Xiang Z, et al. LRPPRC regulates redox homeostasis via the circANKHD1\/FOXM1 axis to enhance bladder urothelial carcinoma tumorigenesis. Redox Biol. 2021;48:102201.","journal-title":"Redox Biol"},{"key":"784_CR12","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s13046-023-02614-3","volume":"42","author":"J Lv","year":"2023","unstructured":"Lv J, Li K, Yu H, Han J, Zhuang J, Yu R, et al. HNRNPL induced circFAM13B increased bladder cancer immunotherapy sensitivity via inhibiting glycolysis through IGF2BP1\/PKM2 pathway. J Exp Clin Cancer Res. 2023;42:41.","journal-title":"J Exp Clin Cancer Res"},{"key":"784_CR13","doi-asserted-by":"publisher","first-page":"6142","DOI":"10.1158\/0008-5472.CAN-21-1518","volume":"81","author":"W Wei","year":"2021","unstructured":"Wei W, Sun J, Zhang H, Xiao X, Huang C, Wang L, et al. Circ0008399 interaction with WTAP promotes assembly and activity of the m(6)A Methyltransferase complex and promotes cisplatin resistance in bladder cancer. Cancer Res. 2021;81:6142\u201356.","journal-title":"Cancer Res"},{"key":"784_CR14","doi-asserted-by":"crossref","unstructured":"Dong J, Zheng Z, Zhou M, Wang Y, Chen J, Cen J, et al. EGCG-LYS Fibrils-mediated CircMAP2K2 silencing decreases the proliferation and metastasis ability of gastric cancer cells in vitro and in vivo. Adv Sci 2023:e2304075.","DOI":"10.1002\/advs.202304075"},{"key":"784_CR15","doi-asserted-by":"publisher","first-page":"12443","DOI":"10.2147\/OTT.S281713","volume":"13","author":"W Li","year":"2020","unstructured":"Li W, Zhang Y, Li Y, Cao Y, Zhou J, Sun Z, et al. Profiling analysis reveals the crucial role of the endogenous peptides in bladder cancer progression. Oncol Targets Ther. 2020;13:12443\u201355.","journal-title":"Oncol Targets Ther"},{"key":"784_CR16","first-page":"1719","volume":"44","author":"W Li","year":"2019","unstructured":"Li W, Li Y, Sun Z, Zhou J, Cao Y, Ma W, et al. Comprehensive circular RNA profiling reveals the regulatory role of the hsa_circ_0137606\/miR\u20111231 pathway in bladder cancer progression. Int J Mol Med. 2019;44:1719\u201328.","journal-title":"Int J Mol Med"},{"key":"784_CR17","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.752","volume":"12","author":"Y Luo","year":"2022","unstructured":"Luo Y, Huang S, Wei J, Zhou H, Wang W, Yang J, et al. Long noncoding RNA LINC01606 protects colon cancer cells from ferroptotic cell death and promotes stemness by SCD1-Wnt\/\u03b2-catenin-TFE3 feedback loop signalling. Clin Transl Med. 2022;12:e752.","journal-title":"Clin Transl Med"},{"key":"784_CR18","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s13045-023-01452-2","volume":"16","author":"F Zhang","year":"2023","unstructured":"Zhang F, Jiang J, Qian H, Yan Y, Xu W. Exosomal circRNA: emerging insights into cancer progression and clinical application potential. J Hematol Oncol. 2023;16:67.","journal-title":"J Hematol Oncol"},{"key":"784_CR19","doi-asserted-by":"crossref","unstructured":"Loix M, Zelcer N, Bogie JFJ, Hendriks JJA. The ubiquitous role of ubiquitination in lipid metabolism. Trends Cell Biol 2024;34:416-29.","DOI":"10.1016\/j.tcb.2023.09.001"},{"key":"784_CR20","doi-asserted-by":"publisher","first-page":"e2215132120","DOI":"10.1073\/pnas.2215132120","volume":"120","author":"S Chen","year":"2023","unstructured":"Chen S, Li K, Guo J, Chen HN, Ming Y, Jin Y, et al. circNEIL3 inhibits tumor metastasis through recruiting the E3 ubiquitin ligase Nedd4L to degrade YBX1. Proc Natl Acad Sci USA. 2023;120:e2215132120.","journal-title":"Proc Natl Acad Sci USA"},{"key":"784_CR21","doi-asserted-by":"crossref","unstructured":"Guo Z, Huo X, Li X, Jiang C, Xue L. Advances in regulation and function of stearoyl-CoA desaturase 1 in cancer, from bench to bed. Sci China Life Sci 2023.","DOI":"10.1007\/s11427-023-2352-9"},{"key":"784_CR22","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/j.trecan.2023.03.003","volume":"9","author":"U Sen","year":"2023","unstructured":"Sen U, Coleman C, Sen T. Stearoyl coenzyme A desaturase-1: multitasker in cancer, metabolism, and ferroptosis. Trends Cancer. 2023;9:480\u20139.","journal-title":"Trends Cancer"},{"key":"784_CR23","doi-asserted-by":"publisher","first-page":"5843","DOI":"10.1158\/0008-5472.CAN-12-1329","volume":"72","author":"X Du","year":"2012","unstructured":"Du X, Wang QR, Chan E, Merchant M, Liu J, French D, et al. FGFR3 stimulates stearoyl CoA desaturase 1 activity to promote bladder tumor growth. Cancer Res. 2012;72:5843\u201355.","journal-title":"Cancer Res"},{"key":"784_CR24","doi-asserted-by":"publisher","first-page":"2342","DOI":"10.1242\/jcs.02951","volume":"119","author":"H Kato","year":"2006","unstructured":"Kato H, Sakaki K, Mihara K. Ubiquitin-proteasome-dependent degradation of mammalian ER stearoyl-CoA desaturase. J Cell Sci. 2006;119:2342\u201353.","journal-title":"J Cell Sci"},{"key":"784_CR25","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1038\/s41388-023-02678-7","volume":"42","author":"G Shu","year":"2023","unstructured":"Shu G, Lu X, Pan Y, Cen J, Huang K, Zhou M, et al. Exosomal circSPIRE1 mediates glycosylation of E-cadherin to suppress metastasis of renal cell carcinoma. Oncogene. 2023;42:1802\u201320.","journal-title":"Oncogene"}],"container-title":["Cancer Gene Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41417-024-00784-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41417-024-00784-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41417-024-00784-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T03:05:21Z","timestamp":1723691121000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41417-024-00784-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,27]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["784"],"URL":"https:\/\/doi.org\/10.1038\/s41417-024-00784-6","relation":{},"ISSN":["0929-1903","1476-5500"],"issn-type":[{"value":"0929-1903","type":"print"},{"value":"1476-5500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,27]]},"assertion":[{"value":"20 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 May 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The collection of human tissue samples conformed to the Declaration of Helsinki and gained approval from the Board and Ethics Committee of the Northern Jiangsu People\u2019s Hospital, Yangzhou University. The animal study was conducted in compliance with the regulations and approved by the Experimental Animal Ethics Committee of Yangzhou University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}]}}