{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:26:57Z","timestamp":1792787217322,"version":"4.5.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T00:00:00Z","timestamp":1523923200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Differ"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1038\/s41418-018-0099-2","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T08:02:00Z","timestamp":1523952120000},"page":"2023-2036","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["A novel endogenous damage signal, glycyl tRNA synthetase, activates multiple beneficial functions of mesenchymal stem cells"],"prefix":"10.1038","volume":"25","author":[{"given":"Se-Ra","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se-Ran","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan Hum","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwa-Yong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In-Sun","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,4,17]]},"reference":[{"key":"99_CR1","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1146\/annurev.biochem.69.1.617","volume":"69","author":"M Ibba","year":"2000","unstructured":"Ibba M, Soll D. Aminoacyl-tRNA synthesis. Annu Rev Biochem. 2000;69:617\u201350.","journal-title":"Annu Rev Biochem"},{"key":"99_CR2","doi-asserted-by":"publisher","first-page":"14913","DOI":"10.1073\/pnas.0602045103","volume":"103","author":"SG Park","year":"2006","unstructured":"Park SG, Kang YS, Kim JY, Lee CS, Ko YG, Lee WJ, et al. Hormonal activity of AIMP1\/p43 for glucose homeostasis. Proc Natl Acad Sci USA. 2006;103:14913\u20138.","journal-title":"Proc Natl Acad Sci USA"},{"key":"99_CR3","doi-asserted-by":"publisher","first-page":"23028","DOI":"10.1074\/jbc.M101544200","volume":"276","author":"YG Ko","year":"2001","unstructured":"Ko YG, Park H, Kim T, Lee JW, Park SG, Seol W, et al. A cofactor of tRNA synthetase, p43, is secreted to up-regulate proinflammatory genes. J Biol Chem. 2001;276:23028\u201333.","journal-title":"J Biol Chem"},{"key":"99_CR4","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1073\/pnas.012602099","volume":"99","author":"K Wakasugi","year":"2002","unstructured":"Wakasugi K, Slike BM, Hood J, Otani A, Ewalt KL, Friedlander M, et al. A human aminoacyl-tRNA synthetase as a regulator of angiogenesis. Proc Natl Acad Sci USA. 2002;99:173\u20137.","journal-title":"Proc Natl Acad Sci USA"},{"key":"99_CR5","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/S0002-9440(10)62262-6","volume":"166","author":"SG Park","year":"2005","unstructured":"Park SG, Shin H, Shin YK, Lee Y, Choi EC, Park BJ, et al. The novel cytokine p43 stimulates dermal fibroblast proliferation and wound repair. Am J Pathol. 2005;166:387\u201398.","journal-title":"Am J Pathol"},{"key":"99_CR6","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.canlet.2009.06.005","volume":"287","author":"JM Han","year":"2010","unstructured":"Han JM, Myung H, Kim S. Antitumor activity and pharmacokinetic properties of ARS-interacting multi-functional protein 1 (AIMP1\/p43). Cancer Lett. 2010;287:157\u201364.","journal-title":"Cancer Lett"},{"key":"99_CR7","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1086\/375039","volume":"72","author":"A Antonellis","year":"2003","unstructured":"Antonellis A, Ellsworth RE, Sambuughin N, Puls I, Abel A, Lee-Lin SQ, et al. Glycyl tRNA synthetase mutations in Charcot-Marie-Tooth disease type 2D and distal spinal muscular atrophy type V. Am J Hum Genet. 2003;72:1293\u20139.","journal-title":"Am J Hum Genet"},{"key":"99_CR8","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1107\/S1744309106046434","volume":"62","author":"W Xie","year":"2006","unstructured":"Xie W, Schimmel P, Yang XL. Crystallization and preliminary X-ray analysis of a native human tRNA synthetase whose allelic variants are associated with Charcot-Marie-Tooth disease. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006;62:1243\u20136.","journal-title":"Acta Crystallogr Sect F Struct Biol Cryst Commun"},{"key":"99_CR9","doi-asserted-by":"publisher","first-page":"2959","DOI":"10.1016\/j.febslet.2007.05.046","volume":"581","author":"MZ Cader","year":"2007","unstructured":"Cader MZ, Ren J, James PA, Bird LE, Talbot K, Stammers DK. Crystal structure of human wildtype and S581L-mutant glycyl-tRNA synthetase, an enzyme underlying distal spinal muscular atrophy. FEBS Lett. 2007;581:2959\u201364.","journal-title":"FEBS Lett"},{"key":"99_CR10","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1002\/jor.1100090504","volume":"9","author":"AI Caplan","year":"1991","unstructured":"Caplan AI. Mesenchymal stem cells. J Orthop Res. 1991;9:641\u201350.","journal-title":"J Orthop Res"},{"key":"99_CR11","doi-asserted-by":"publisher","first-page":"207","DOI":"10.3727\/096368911X586756","volume":"21","author":"W Gong","year":"2012","unstructured":"Gong W, Han Z, Zhao H, Wang Y, Wang J, Zhong J, et al. Banking human umbilical cord-derived mesenchymal stromal cells for clinical use. Cell Transplant. 2012;21:207\u201316.","journal-title":"Cell Transplant"},{"key":"99_CR12","first-page":"300","volume":"2","author":"C Yellowley","year":"2013","unstructured":"Yellowley C. CXCL12\/CXCR4 signaling and other recruitment and homing pathways in fracture repair. Bone Rep. 2013;2:300.","journal-title":"Bone Rep"},{"key":"99_CR13","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1634\/stemcells.2005-0319","volume":"24","author":"M Honczarenko","year":"2006","unstructured":"Honczarenko M, Le Y, Swierkowski M, Ghiran I, Glodek AM, Silberstein LE. Human bone marrow stromal cells express a distinct set of biologically functional chemokine receptors. Stem Cells. 2006;24:1030\u201341.","journal-title":"Stem Cells"},{"key":"99_CR14","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1002\/jcb.21172","volume":"101","author":"J Ringe","year":"2007","unstructured":"Ringe J, Strassburg S, Neumann K, Endres M, Notter M, Burmester GR, et al. Towards in situ tissue repair: human mesenchymal stem cells express chemokine receptors CXCR1, CXCR2 and CCR2, and migrate upon stimulation with CXCL8 but not CCL2. J Cell Biochem. 2007;101:135\u201346.","journal-title":"J Cell Biochem"},{"key":"99_CR15","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1634\/stemcells.2004-0176","volume":"24","author":"G Forte","year":"2006","unstructured":"Forte G, Minieri M, Cossa P, Antenucci D, Sala M, Gnocchi V, et al. Hepatocyte growth factor effects on mesenchymal stem cells: proliferation, migration, and differentiation. Stem Cells. 2006;24:23\u201333.","journal-title":"Stem Cells"},{"key":"99_CR16","doi-asserted-by":"publisher","first-page":"2789","DOI":"10.1111\/j.1582-4934.2012.01602.x","volume":"16","author":"B Gharibi","year":"2012","unstructured":"Gharibi B, Ghuman MS, Hughes FJ. Akt- and Erk-mediated regulation of proliferation and differentiation during PDGFRbeta-induced MSC self-renewal. J Cell Mol Med. 2012;16:2789\u2013801.","journal-title":"J Cell Mol Med"},{"key":"99_CR17","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1002\/jcp.24114","volume":"228","author":"B Zheng","year":"2013","unstructured":"Zheng B, Wang C, He L, Xu X, Qu J, Hu J, et al. Neural differentiation of mesenchymal stem cells influences chemotactic responses to HGF. J Cell Physiol. 2013;228:149\u201362.","journal-title":"J Cell Physiol"},{"key":"99_CR18","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1159\/000430167","volume":"36","author":"BQ Song","year":"2015","unstructured":"Song BQ, Chi Y, Li X, Du WJ, Han ZB, Tian JJ, et al. Inhibition of notch signaling promotes the adipogenic differentiation of mesenchymal stem cells through autophagy activation and PTEN-PI3K\/AKT\/mTOR pathway. Cell Physiol Biochem. 2015;36:1991\u20132002.","journal-title":"Cell Physiol Biochem"},{"key":"99_CR19","doi-asserted-by":"publisher","first-page":"2704","DOI":"10.1002\/jcb.24148","volume":"113","author":"JM Tang","year":"2012","unstructured":"Tang JM, Yuan J, Li Q, Wang JN, Kong X, Zheng F, et al. Acetylcholine induces mesenchymal stem cell migration via Ca2\u2009+\u2009\/PKC\/ERK1\/2 signal pathway. J Cell Biochem. 2012;113:2704\u201313.","journal-title":"J Cell Biochem"},{"key":"99_CR20","doi-asserted-by":"publisher","first-page":"E640","DOI":"10.1073\/pnas.1200194109","volume":"109","author":"MC Park","year":"2012","unstructured":"Park MC, Kang T, Jin D, Han JM, Kim SB, Park YJ, et al. Secreted human glycyl-tRNA synthetase implicated in defense against ERK-activated tumorigenesis. Proc Natl Acad Sci USA. 2012;109:E640\u2013647.","journal-title":"Proc Natl Acad Sci USA"},{"key":"99_CR21","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1016\/j.bbamcr.2006.07.001","volume":"1773","author":"H Yamaguchi","year":"2007","unstructured":"Yamaguchi H, Condeelis J. Regulation of the actin cytoskeleton in cancer cell migration and invasion. Biochim Biophys Acta. 2007;1773:642\u201352.","journal-title":"Biochim Biophys Acta"},{"key":"99_CR22","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/nsmb.1706","volume":"17","author":"Q Zhou","year":"2010","unstructured":"Zhou Q, Kapoor M, Guo M, Belani R, Xu X, Kiosses WB, et al. Orthogonal use of a human tRNA synthetase active site to achieve multifunctionality. Nat Struct Mol Biol. 2010;17:57\u201361.","journal-title":"Nat Struct Mol Biol"},{"key":"99_CR23","doi-asserted-by":"publisher","first-page":"1894","DOI":"10.1093\/hmg\/ddl112","volume":"15","author":"L Armstrong","year":"2006","unstructured":"Armstrong L, Hughes O, Yung S, Hyslop L, Stewart R, Wappler I, et al. The role of PI3K\/AKT, MAPK\/ERK and NFkappabeta signalling in the maintenance of human embryonic stem cell pluripotency and viability highlighted by transcriptional profiling and functional analysis. Hum Mol Genet. 2006;15:1894\u2013913.","journal-title":"Hum Mol Genet"},{"key":"99_CR24","doi-asserted-by":"publisher","first-page":"e71283","DOI":"10.1371\/journal.pone.0071283","volume":"8","author":"P Muller","year":"2013","unstructured":"Muller P, Langenbach A, Kaminski A, Rychly J. Modulating the actin cytoskeleton affects mechanically induced signal transduction and differentiation in mesenchymal stem cells. PLoS ONE. 2013;8:e71283.","journal-title":"PLoS ONE"},{"key":"99_CR25","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1007\/s12013-014-0228-6","volume":"71","author":"F Gao","year":"2015","unstructured":"Gao F, Hu X, Xie X, Liu X, Wang J. Heat shock protein 90 stimulates rat mesenchymal stem cell migration via PI3K\/Akt and ERK1\/2 pathways. Cell Biochem Biophys. 2015;71:481\u20139.","journal-title":"Cell Biochem Biophys"},{"key":"99_CR26","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1126\/science.1110364","volume":"309","author":"M Dezawa","year":"2005","unstructured":"Dezawa M, Ishikawa H, Itokazu Y, Yoshihara T, Hoshino M, Takeda S, et al. Bone marrow stromal cells generate muscle cells and repair muscle degeneration. Science. 2005;309:314\u20137.","journal-title":"Science"},{"key":"99_CR27","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1046\/j.0953-816x.2001.01814.x","volume":"14","author":"M Dezawa","year":"2001","unstructured":"Dezawa M, Takahashi I, Esaki M, Takano M, Sawada H. Sciatic nerve regeneration in rats induced by transplantation of in vitro differentiated bone-marrow stromal cells. Eur J Neurosci. 2001;14:1771\u20136.","journal-title":"Eur J Neurosci"},{"key":"99_CR28","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.2337\/db08-0180","volume":"57","author":"R Abdi","year":"2008","unstructured":"Abdi R, Fiorina P, Adra CN, Atkinson M, Sayegh MH. Immunomodulation by mesenchymal stem cells: a potential therapeutic strategy for type 1 diabetes. Diabetes. 2008;57:1759\u201367.","journal-title":"Diabetes"},{"key":"99_CR29","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1126\/science.290.5497.1779","volume":"290","author":"E Mezey","year":"2000","unstructured":"Mezey E, Chandross KJ, Harta G, Maki RA, McKercher SR. Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science. 2000;290:1779\u201382.","journal-title":"Science"},{"key":"99_CR30","first-page":"129","volume":"19","author":"AB Scandurro","year":"2001","unstructured":"Scandurro AB, Weldon CW, Figueroa YG, Alam J, Beckman BS. Gene microarray analysis reveals a novel hypoxia signal transduction pathway in human hepatocellular carcinoma cells. Int J Oncol. 2001;19:129\u201335.","journal-title":"Int J Oncol"},{"key":"99_CR31","doi-asserted-by":"publisher","first-page":"e1002399","DOI":"10.1371\/journal.pgen.1002399","volume":"7","author":"WW Motley","year":"2011","unstructured":"Motley WW, Seburn KL, Nawaz MH, Miers KE, Cheng J, Antonellis A, et al. Charcot-Marie-Tooth-linked mutant GARS is toxic to peripheral neurons independent of wild-type GARS levels. PLoS Genet. 2011;7:e1002399.","journal-title":"PLoS Genet"},{"key":"99_CR32","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1084\/jem.20020186","volume":"196","author":"OM Howard","year":"2002","unstructured":"Howard OM, Dong HF, Yang D, Raben N, Nagaraju K, Rosen A, et al. Histidyl-tRNA synthetase and asparaginyl-tRNA synthetase, autoantigens in myositis, activate chemokine receptors on T lymphocytes and immature dendritic cells. J Exp Med. 2002;196:781\u201391.","journal-title":"J Exp Med"},{"key":"99_CR33","doi-asserted-by":"publisher","first-page":"2213","DOI":"10.1016\/j.yexcr.2010.05.009","volume":"316","author":"AM Hocking","year":"2010","unstructured":"Hocking AM, Gibran NS. Mesenchymal stem cells: paracrine signaling and differentiation during cutaneous wound repair. Exp Cell Res. 2010;316:2213\u20139.","journal-title":"Exp Cell Res"},{"key":"99_CR34","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.yexcr.2009.08.001","volume":"316","author":"AN Smith","year":"2010","unstructured":"Smith AN, Willis E, Chan VT, Muffley LA, Isik FF, Gibran NS, et al. Mesenchymal stem cells induce dermal fibroblast responses to injury. Exp Cell Res. 2010;316:48\u201354.","journal-title":"Exp Cell Res"},{"key":"99_CR35","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1111\/j.1524-475X.2009.00499.x","volume":"17","author":"EY Lee","year":"2009","unstructured":"Lee EY, Xia Y, Kim WS, Kim MH, Kim TH, Kim KJ, et al. Hypoxia-enhanced wound-healing function of adipose-derived stem cells: increase in stem cell proliferation and up-regulation of VEGF and bFGF. Wound Repair Regen. 2009;17:540\u20137.","journal-title":"Wound Repair Regen"},{"key":"99_CR36","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/j.febslet.2009.11.064","volume":"584","author":"M Guo","year":"2010","unstructured":"Guo M, Schimmel P, Yang XL. Functional expansion of human tRNA synthetases achieved by structural inventions. FEBS Lett. 2010;584:434\u201342.","journal-title":"FEBS Lett"},{"key":"99_CR37","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1126\/science.284.5411.147","volume":"284","author":"K Wakasugi","year":"1999","unstructured":"Wakasugi K, Schimmel P. Two distinct cytokines released from a human aminoacyl-tRNA synthetase. Science. 1999;284:147\u201351.","journal-title":"Science"},{"key":"99_CR38","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0031-6997(24)01359-0","volume":"50","author":"AE Aplin","year":"1998","unstructured":"Aplin AE, Howe A, Alahari SK, Juliano RL. Signal transduction and signal modulation by cell adhesion receptors: the role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins. Pharmacol Rev. 1998;50:197\u2013263.","journal-title":"Pharmacol Rev"},{"key":"99_CR39","doi-asserted-by":"crossref","first-page":"445","DOI":"10.18388\/abp.2004_3583","volume":"51","author":"T Okegawa","year":"2004","unstructured":"Okegawa T, Pong RC, Li Y, Hsieh JT. The role of cell adhesion molecule in cancer progression and its application in cancer therapy. Acta Biochim Pol. 2004;51:445\u201357.","journal-title":"Acta Biochim Pol"},{"key":"99_CR40","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1242\/jcs.114.10.1829","volume":"114","author":"M Nakagawa","year":"2001","unstructured":"Nakagawa M, Fukata M, Yamaga M, Itoh N, Kaibuchi K. Recruitment and activation of Rac1 by the formation of E-cadherin-mediated cell-cell adhesion sites. J Cell Sci. 2001;114:1829\u201338.","journal-title":"J Cell Sci"},{"key":"99_CR41","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/S0960-9822(02)00661-9","volume":"12","author":"EM Kovacs","year":"2002","unstructured":"Kovacs EM, Goodwin M, Ali RG, Paterson AD, Yap AS. Cadherin-directed actin assembly: E-cadherin physically associates with the Arp2\/3 complex to direct actin assembly in nascent adhesive contacts. Curr Biol. 2002;12:379\u201382.","journal-title":"Curr Biol"},{"key":"99_CR42","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1089\/ten.teb.2012.0672","volume":"19","author":"J Chen","year":"2013","unstructured":"Chen J, Crawford R, Chen C, Xiao Y. The key regulatory roles of the PI3K\/Akt signaling pathway in the functionalities of mesenchymal stem cells and applications in tissue regeneration. Tissue Eng Part B Rev. 2013;19:516\u201328.","journal-title":"Tissue Eng Part B Rev"},{"key":"99_CR43","doi-asserted-by":"publisher","first-page":"4619","DOI":"10.1242\/jcs.01481","volume":"117","author":"C Huang","year":"2004","unstructured":"Huang C, Jacobson K, Schaller MD. MAP kinases and cell migration. J Cell Sci. 2004;117:4619\u201328.","journal-title":"J Cell Sci"},{"key":"99_CR44","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1073\/pnas.012601899","volume":"99","author":"A Otani","year":"2002","unstructured":"Otani A, Slike BM, Dorrell MI, Hood J, Kinder K, Ewalt KL, et al. A fragment of human TrpRS as a potent antagonist of ocular angiogenesis. Proc Natl Acad Sci USA. 2002;99:178\u201383.","journal-title":"Proc Natl Acad Sci USA"},{"key":"99_CR45","doi-asserted-by":"publisher","first-page":"14903","DOI":"10.1073\/pnas.2436330100","volume":"100","author":"E Tzima","year":"2003","unstructured":"Tzima E, Reader JS, Irani-Tehrani M, Ewalt KL, Schwartz MA, Schimmel P. Biologically active fragment of a human tRNA synthetase inhibits fluid shear stress-activated responses of endothelial cells. Proc Natl Acad Sci USA. 2003;100:14903\u20137.","journal-title":"Proc Natl Acad Sci USA"},{"key":"99_CR46","doi-asserted-by":"publisher","DOI":"10.1038\/srep22966","volume":"6","author":"HJ Dong","year":"2016","unstructured":"Dong HJ, Jang GB, Lee HY, Park SR, Kim JY, Nam JS, et al. The Wnt\/beta-catenin signaling\/Id2 cascade mediates the effects of hypoxia on the hierarchy of colorectal-cancer stem cells. Sci Rep. 2016;6:22966.","journal-title":"Sci Rep"},{"key":"99_CR47","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.canlet.2012.09.009","volume":"328","author":"ES Choi","year":"2013","unstructured":"Choi ES, Jung JY, Lee JS, Park JH, Cho NP, Cho SD. Myeloid cell leukemia-1 is a key molecular target for mithramycin A-induced apoptosis in androgen-independent prostate cancer cells and a tumor xenograft animal model. Cancer Lett. 2013;328:65\u201372.","journal-title":"Cancer Lett"}],"container-title":["Cell Death & Differentiation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41418-018-0099-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41418-018-0099-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41418-018-0099-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T18:36:20Z","timestamp":1751567780000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41418-018-0099-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,17]]},"references-count":47,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["99"],"URL":"https:\/\/doi.org\/10.1038\/s41418-018-0099-2","relation":{},"ISSN":["1350-9047","1476-5403"],"issn-type":[{"value":"1350-9047","type":"print"},{"value":"1476-5403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,17]]},"assertion":[{"value":"15 August 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}