{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T03:49:18Z","timestamp":1793418558196,"version":"4.5.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T00:00:00Z","timestamp":1578268800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T00:00:00Z","timestamp":1578268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773957"],"award-info":[{"award-number":["81773957"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2018M642380"],"award-info":[{"award-number":["2018M642380"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Differ"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1038\/s41418-019-0484-5","type":"journal-article","created":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T07:02:46Z","timestamp":1578294166000},"page":"2048-2065","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Dual targeting of SREBP2 and ERR\u03b1 by carnosic acid suppresses RANKL-mediated osteoclastogenesis and prevents ovariectomy-induced bone loss"],"prefix":"10.1038","volume":"27","author":[{"given":"Zu-Guo","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Min","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Ping","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Tong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pyone Myat","family":"Thu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,1,6]]},"reference":[{"key":"484_CR1","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1056\/NEJM199502023320506","volume":"332","author":"SC Manolagas","year":"1995","unstructured":"Manolagas SC, Jilka RL. Bone marrow, cytokines, and bone remodeling\u2014emerging insights into the pathophysiology of osteoporosis. N Engl J Med. 1995;332:305\u201311.","journal-title":"N Engl J Med"},{"key":"484_CR2","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.coph.2016.02.003","volume":"28","author":"M Prideaux","year":"2016","unstructured":"Prideaux M, Findlay DM, Atkins GJ. Osteocytes: the master cells in bone remodelling. Curr Opin Pharmacol. 2016;28:24\u201330.","journal-title":"Curr Opin Pharmacol"},{"key":"484_CR3","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1056\/NEJMra030831","volume":"350","author":"GD Roodman","year":"2004","unstructured":"Roodman GD. Mechanisms of bone metastasis. N Engl J Med. 2004;350:1655\u201364.","journal-title":"N Engl J Med"},{"key":"484_CR4","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.284.5411.143","volume":"284","author":"MF Pittenger","year":"1999","unstructured":"Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, et al. Multilineage potential of adult human mesenchymal stem cells. Science. 1999;284:143\u20137.","journal-title":"Science"},{"key":"484_CR5","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1146\/annurev.genom.9.081307.164437","volume":"9","author":"G Karsenty","year":"2008","unstructured":"Karsenty G. Transcriptional control of skeletogenesis. Annu Rev Genomics Hum Genet. 2008;9:183\u201396.","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"484_CR6","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/s41586-018-0482-7","volume":"561","author":"Y Ikebuchi","year":"2018","unstructured":"Ikebuchi Y, Aoki S, Honma M, Hayashi M, Sugamori Y, Khan M, et al. Coupling of bone resorption and formation by RANKL reverse signalling. Nature. 2018;561:195.","journal-title":"Nature"},{"key":"484_CR7","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/nm1593","volume":"13","author":"M Zaidi","year":"2007","unstructured":"Zaidi M. Skeletal remodeling in health and disease. Nat Med. 2007;13:791.","journal-title":"Nat Med"},{"key":"484_CR8","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.bcp.2016.10.016","volume":"122","author":"Z-G Zheng","year":"2016","unstructured":"Zheng Z-G, Zhou Y-P, Zhang X, Thu PM, Xie Z-S, Lu C, et al. Anhydroicaritin improves diet-induced obesity and hyperlipidemia and alleviates insulin resistance by suppressing SREBPs activation. Biochem Pharmacol. 2016;122:42\u201361.","journal-title":"Biochem Pharmacol"},{"key":"484_CR9","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1093\/aje\/kwp043","volume":"169","author":"CA Derby","year":"2009","unstructured":"Derby CA, Crawford SL, Pasternak RC, Sowers M, Sternfeld B, Matthews KA. Lipid changes during the menopause transition in relation to age and weight: the Study of Women's Health Across the Nation. Am J Epidemiol. 2009;169:1352\u201361.","journal-title":"Am J Epidemiol"},{"key":"484_CR10","unstructured":"Jeong T-D, Lee W, Choi S-E, Kim JS, Kim H-K, Bae SJ, et al. Relationship between serum total cholesterol level and serum biochemical bone turnover markers in healthy pre-and postmenopausal women. BioMed Res Int. 2014;2014:398397."},{"key":"484_CR11","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.bone.2008.09.020","volume":"44","author":"J Makovey","year":"2009","unstructured":"Makovey J, Chen JS, Hayward C, Williams FM, Sambrook PN. Association between serum cholesterol and bone mineral density. Bone. 2009;44:208\u201313.","journal-title":"Bone"},{"key":"484_CR12","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1507\/endocrj.49.211","volume":"49","author":"T Yamaguchi","year":"2002","unstructured":"Yamaguchi T, Sugimoto T, Yano S, Yamauchi M, Sowa H, Chen Q, et al. Plasma lipids and osteoporosis in postmenopausal women. Endocr J. 2002;49:211\u20137.","journal-title":"Endocr J"},{"key":"484_CR13","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1001\/jama.2018.7498","volume":"319","author":"SJ Curry","year":"2018","unstructured":"Curry SJ, Krist AH, Owens DK, Barry MJ, Caughey AB, Davidson KW, et al. Screening for osteoporosis to prevent fractures: US Preventive Services Task Force recommendation statement. J Am Med Assoc. 2018;319:2521\u201331.","journal-title":"J Am Med Assoc"},{"key":"484_CR14","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3389\/fendo.2015.00165","volume":"6","author":"CC Mandal","year":"2015","unstructured":"Mandal CC. High cholesterol deteriorates bone health: new insights into molecular mechanisms. Front Endocrinol. 2015;6:165.","journal-title":"Front Endocrinol"},{"key":"484_CR15","doi-asserted-by":"crossref","first-page":"S108","DOI":"10.1038\/sj.cdd.4401399","volume":"11","author":"E Luegmayr","year":"2004","unstructured":"Luegmayr E, Glantschnig H, Wesolowski G, Gentile M, Fisher J, Rodan G, et al. Osteoclast formation, survival and morphology are highly dependent on exogenous cholesterol\/lipoproteins. Cell Death Differ. 2004;11:S108.","journal-title":"Cell Death Differ"},{"key":"484_CR16","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S8756-3282(98)00082-9","volume":"23","author":"T Sato","year":"1998","unstructured":"Sato T, Morita I, Murota S. Involvement of cholesterol in osteoclast-like cell formation via cellular fusion. Bone. 1998;23:135\u201340.","journal-title":"Bone"},{"key":"484_CR17","first-page":"53","volume":"3","author":"W Grasser","year":"2003","unstructured":"Grasser W, Baumann A, Petras S, Harwood H, Devalaraja R, Renkiewicz R, et al. Regulation of osteoclast differentiation by statins. J Musculoskelet Neuronal Interact. 2003;3:53\u201362.","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"484_CR18","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1042\/BSR20110118","volume":"32","author":"F Ruan","year":"2012","unstructured":"Ruan F, Zheng Q, Wang J. Mechanisms of bone anabolism regulated by statins. Biosci Rep. 2012;32:511\u20139.","journal-title":"Biosci Rep"},{"key":"484_CR19","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1126\/science.286.5446.1946","volume":"286","author":"G Mundy","year":"1999","unstructured":"Mundy G, Garrett R, Harris S, Chan J, Chen D, Rossini G, et al. Stimulation of bone formation in vitro and in rodents by statins. Science. 1999;286:1946\u20139.","journal-title":"Science"},{"key":"484_CR20","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.1001\/jama.283.24.3205","volume":"283","author":"CR Meier","year":"2000","unstructured":"Meier CR, Schlienger RG, Kraenzlin ME, Schlegel B, Jick H. HMG-CoA reductase inhibitors and the risk of fractures. J Am Med Assoc. 2000;283:3205\u201310.","journal-title":"J Am Med Assoc"},{"key":"484_CR21","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1002\/jbmr.2229","volume":"29","author":"K Inoue","year":"2014","unstructured":"Inoue K, Imai Y. Identification of novel transcription factors in osteoclast differentiation using genome\u2010wide analysis of open chromatin determined by Dnase-seq. J Bone Miner Res. 2014;29:1823\u201332.","journal-title":"J Bone Miner Res"},{"key":"484_CR22","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1016\/j.bbadis.2015.08.018","volume":"1852","author":"K Inoue","year":"2015","unstructured":"Inoue K, Imai Y. Fatostatin, an SREBP inhibitor, prevented RANKL-induced bone loss by suppression of osteoclast differentiation. Biochim Biophys Acta. 2015;1852:2432\u201341.","journal-title":"Biochim Biophys Acta"},{"key":"484_CR23","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ejphar.2017.05.017","volume":"809","author":"Z-G Zheng","year":"2017","unstructured":"Zheng Z-G, Zhang X, Zhou Y-P, Lu C, Thu PM, Qian C, et al. Anhydroicaritin, a SREBPs inhibitor, inhibits RANKL-induced osteoclastic differentiation and improves diabetic osteoporosis in STZ-induced mice. Eur J Pharmacol. 2017;809:156\u201362.","journal-title":"Eur J Pharmacol"},{"key":"484_CR24","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.bbadis.2018.10.026","volume":"1865","author":"Z Jie","year":"2019","unstructured":"Jie Z, Xie Z, Xu W, Zhao X, Jin G, Sun X, et al. SREBP-2 aggravates breast cancer associated osteolysis by promoting osteoclastogenesis and breast cancer metastasis. Biochim Biophysa Acta. 2019;1865:115\u201325.","journal-title":"Biochim Biophysa Acta"},{"key":"484_CR25","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.mito.2011.03.121","volume":"11","author":"LJ Eichner","year":"2011","unstructured":"Eichner LJ, Gigu\u00e8re V. Estrogen related receptors (ERRs): a new dawn in transcriptional control of mitochondrial gene networks. Mitochondrion. 2011;11:544\u201352.","journal-title":"Mitochondrion"},{"key":"484_CR26","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.tem.2010.06.008","volume":"21","author":"M Gallet","year":"2010","unstructured":"Gallet M, Vanacker J-M. ERR receptors as potential targets in osteoporosis. Trends Endocrinol Metab. 2010;21:637\u201341.","journal-title":"Trends Endocrinol Metab"},{"key":"484_CR27","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.tem.2010.08.006","volume":"21","author":"Y Wan","year":"2010","unstructured":"Wan Y. PPAR\u03b3 in bone homeostasis. Trends Endocrinol Metab. 2010;21:722\u20138.","journal-title":"Trends Endocrinol Metab"},{"key":"484_CR28","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.cmet.2010.04.015","volume":"11","author":"W Wei","year":"2010","unstructured":"Wei W, Wang X, Yang M, Smith LC, Dechow PC, Wan Y. PGC1\u03b2 mediates PPAR\u03b3 activation of osteoclastogenesis and rosiglitazone-induced bone loss. Cell Metab. 2010;11:503\u201316.","journal-title":"Cell Metab"},{"key":"484_CR29","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/jbmr.1836","volume":"28","author":"E Bonnelye","year":"2013","unstructured":"Bonnelye E, Aubin JE. An energetic orphan in an endocrine tissue: a revised perspective of the function of estrogen receptor\u2010related receptor alpha in bone and cartilage. J Bone Miner Res. 2013;28:225\u201333.","journal-title":"J Bone Miner Res"},{"key":"484_CR30","first-page":"2161","volume":"5","author":"E Bonnelye","year":"2016","unstructured":"Bonnelye E. Estrogen Receptor Related Receptor Alpha (ERR\u03b1) in skeletal tissues. Endocrinol Metab Syndr. 2016;5:2161\u20131017.1000244.","journal-title":"Endocrinol Metab Syndr"},{"key":"484_CR31","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.cmet.2015.12.010","volume":"23","author":"W Wei","year":"2016","unstructured":"Wei W, Schwaid AG, Wang X, Wang X, Chen S, Chu Q, et al. Ligand activation of ERR\u03b1 by cholesterol mediates statin and bisphosphonate effects. Cell Metab. 2016;23:479\u201391.","journal-title":"Cell Metab"},{"key":"484_CR32","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.phytochem.2014.12.026","volume":"115","author":"S Birtic","year":"2015","unstructured":"Birtic S, Dussort P, Pierre FX, Bily AC, Roller M. Carnosic acid. Phytochemistry. 2015;115:9\u201319.","journal-title":"Phytochemistry"},{"key":"484_CR33","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/bonekey.2014.65","volume":"3","author":"S Marino","year":"2014","unstructured":"Marino S, Logan JG, Mellis D, Capulli M. Generation and culture of osteoclasts. BoneKEy Rep. 2014;3:570.","journal-title":"BoneKEy Rep"},{"key":"484_CR34","doi-asserted-by":"crossref","first-page":"47366","DOI":"10.1074\/jbc.M208284200","volume":"277","author":"H Hotokezaka","year":"2002","unstructured":"Hotokezaka H, Sakai E, Kanaoka K, Saito K, Matsuo K-i, Kitaura H, et al. U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264. 7 cells into osteoclast-like cells. J Biol Chem. 2002;277:47366\u201372.","journal-title":"J Biol Chem"},{"key":"484_CR35","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jff.2017.01.040","volume":"31","author":"Z Xie","year":"2017","unstructured":"Xie Z, Wan X, Zhong L, Yang H, Li P, Xu X. Carnosic acid alleviates hyperlipidemia and insulin resistance by promoting the degradation of SREBPs via the 26S proteasome. J Funct Foods. 2017;31:217\u201328.","journal-title":"J Funct Foods"},{"key":"484_CR36","doi-asserted-by":"crossref","first-page":"8912","DOI":"10.1073\/pnas.0401420101","volume":"101","author":"PJ Willy","year":"2004","unstructured":"Willy PJ, Murray IR, Qian J, Busch BB, Stevens WC, Martin R, et al. Regulation of PPAR\u03b3 coactivator 1\u03b1 (PGC-1\u03b1) signaling by an estrogen-related receptor \u03b1 (ERR\u03b1) ligand. Proc Natl Acad Sci USA. 2004;101:8912\u20137.","journal-title":"Proc Natl Acad Sci USA"},{"key":"484_CR37","doi-asserted-by":"crossref","first-page":"325","DOI":"10.2174\/1568010054022015","volume":"4","author":"Y Tanaka","year":"2005","unstructured":"Tanaka Y, Nakayamada S, Okada Y. Osteoblasts and osteoclasts in bone remodeling and inflammation. Curr Drug Targets-Inflamm Allergy. 2005;4:325\u20138.","journal-title":"Curr Drug Targets-Inflamm Allergy"},{"key":"484_CR38","unstructured":"Sims NA, Martin TJ. Coupling the activities of bone formation and resorption: a multitude of signals within the basic multicellular unit. BoneKEy Rep. 2014;3:481."},{"key":"484_CR39","first-page":"597","volume":"14","author":"A Ghadiri-Anari","year":"2016","unstructured":"Ghadiri-Anari A, Mortezaii-Shoroki Z, Modarresi M, Dehghan A. Association of lipid profile with bone mineral density in postmenopausal women in Yazd province. International. J Reprod Biomed. 2016;14:597.","journal-title":"J Reprod Biomed"},{"key":"484_CR40","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1146\/annurev-pathol-011110-130203","volume":"6","author":"X Feng","year":"2011","unstructured":"Feng X, McDonald JM. Disorders of bone remodeling. Annu Rev Pathol. 2011;6:121\u201345.","journal-title":"Annu Rev Pathol"},{"key":"484_CR41","doi-asserted-by":"crossref","first-page":"2668","DOI":"10.1001\/jama.287.20.2668","volume":"287","author":"R Lindsay","year":"2002","unstructured":"Lindsay R, Gallagher JC, Kleerekoper M, Pickar JH. Effect of lower doses of conjugated equine estrogens with and without medroxyprogesterone acetate on bone in early postmenopausal women. J Am Med Assoc. 2002;287:2668\u201376.","journal-title":"J Am Med Assoc"},{"key":"484_CR42","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1056\/NEJM200101253440407","volume":"344","author":"M Clemons","year":"2001","unstructured":"Clemons M, Goss P. Estrogen and the risk of breast cancer. N Engl J Med. 2001;344:276\u201385.","journal-title":"N Engl J Med"},{"key":"484_CR43","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.tem.2010.03.005","volume":"21","author":"S-H Chung","year":"2010","unstructured":"Chung S-H, Franceschi S, Lambert PF. Estrogen and ER\u03b1: culprits in cervical cancer? Trends Endocrinol Metab. 2010;21:504\u201311.","journal-title":"Trends Endocrinol Metab"},{"key":"484_CR44","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1002\/ijc.2910440515","volume":"44","author":"HO Adami","year":"1989","unstructured":"Adami HO, Persson I, Hoover R, Schairer C, Bergkvist L. Risk of cancer in women receiving hormone replacement therapy. Int J Cancer. 1989;44:833\u20139.","journal-title":"Int J Cancer"},{"key":"484_CR45","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.tem.2014.10.001","volume":"25","author":"ER Nelson","year":"2014","unstructured":"Nelson ER, Chang C-y, McDonnell DP. Cholesterol and breast cancer pathophysiology. Trends Endocrinol Metab. 2014;25:649\u201355.","journal-title":"Trends Endocrinol Metab"},{"key":"484_CR46","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.ajpath.2010.11.005","volume":"178","author":"G Llaverias","year":"2011","unstructured":"Llaverias G, Danilo C, Mercier I, Daumer K, Capozza F, Williams TM, et al. Role of cholesterol in the development and progression of breast cancer. Am J Pathol. 2011;178:402\u201312.","journal-title":"Am J Pathol"},{"key":"484_CR47","doi-asserted-by":"crossref","first-page":"4670","DOI":"10.1158\/0008-5472.CAN-04-0250","volume":"64","author":"T Suzuki","year":"2004","unstructured":"Suzuki T, Miki Y, Moriya T, Shimada N, Ishida T, Hirakawa H, et al. Estrogen-related receptor \u03b1 in human breast carcinoma as a potent prognostic factor. Cancer Res. 2004;64:4670\u20136.","journal-title":"Cancer Res"},{"key":"484_CR48","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jsbmb.2008.12.005","volume":"113","author":"K Jarzabek","year":"2009","unstructured":"Jarzabek K, Koda M, Kozlowski L, Sulkowski S, Kottler M-L, Wolczynski S. The significance of the expression of ERR\u03b1 as a potential biomarker in breast cancer. J Steroid Biochem Mol Biol. 2009;113:127\u201333.","journal-title":"J Steroid Biochem Mol Biol"},{"key":"484_CR49","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jsbmb.2009.02.010","volume":"114","author":"RA Stein","year":"2009","unstructured":"Stein RA, Gaillard S, McDonnell DP. Estrogen-related receptor alpha induces the expression of vascular endothelial growth factor in breast cancer cells. J Steroid Biochem Mol Biol. 2009;114:106\u201312.","journal-title":"J Steroid Biochem Mol Biol"},{"key":"484_CR50","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/s41388-018-0579-3","volume":"38","author":"G Vargas","year":"2019","unstructured":"Vargas G, Bouchet M, Bouazza L, Reboul P, Boyault C, Gervais M, et al. ERR\u03b1 promotes breast cancer cell dissemination to bone by increasing RANK expression in primary breast tumors. Oncogene. 2019;38:950.","journal-title":"Oncogene"},{"key":"484_CR51","doi-asserted-by":"crossref","first-page":"16967","DOI":"10.1039\/C9RA03423D","volume":"9","author":"H Pei","year":"2019","unstructured":"Pei H, Peng Y, Zhao Q, Chen Y. Small molecule PROTACs: an emerging technology for targeted therapy in drug discovery. RSC Adv. 2019;9:16967\u201376.","journal-title":"RSC Adv"},{"key":"484_CR52","doi-asserted-by":"crossref","unstructured":"An S, Fu L. Small-molecule PROTACs: an emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018;36:553\u201362.","DOI":"10.1016\/j.ebiom.2018.09.005"},{"key":"484_CR53","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1021\/acsmedchemlett.9b00025","volume":"10","author":"L Peng","year":"2019","unstructured":"Peng L, Zhang Z, Lei C, Li S, Ren X, Chang Y, et al. Identification of New Small-Molecule Inducers of Estrogen-related Receptor \u03b1 (ERR\u03b1) degradation. ACS Medicinal Chem Lett. 2019;10:767\u201372.","journal-title":"ACS Medicinal Chem Lett"},{"key":"484_CR54","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nchembio.1858","volume":"11","author":"DP Bondeson","year":"2015","unstructured":"Bondeson DP, Mares A, Smith IE, Ko E, Campos S, Miah AH, et al. Catalytic in vivo protein knockdown by small-molecule PROTACs. Nat Chem Biol. 2015;11:611.","journal-title":"Nat Chem Biol"},{"key":"484_CR55","doi-asserted-by":"crossref","first-page":"4465","DOI":"10.1021\/ja209924v","volume":"134","author":"DL Buckley","year":"2012","unstructured":"Buckley DL, Van Molle I, Gareiss PC, Tae HS, Michel J, Noblin DJ, et al. Targeting the von Hippel\u2013Lindau E3 ubiquitin ligase using small molecules to disrupt the VHL\/HIF-1\u03b1 interaction. J Am Chem Soc. 2012;134:4465\u20138.","journal-title":"J Am Chem Soc"},{"key":"484_CR56","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1002\/art.38521","volume":"66","author":"S Li","year":"2014","unstructured":"Li S, Shu B, Zhang Y, Li J, Guo J, Wang Y, et al. CHIP regulates osteoclast formation through promoting TRAF6 protein degradation. Arthritis Rheumatol. 2014;66:1854.","journal-title":"Arthritis Rheumatol"}],"container-title":["Cell Death &amp; Differentiation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41418-019-0484-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41418-019-0484-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41418-019-0484-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T17:14:45Z","timestamp":1684602885000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41418-019-0484-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,6]]},"references-count":56,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["484"],"URL":"https:\/\/doi.org\/10.1038\/s41418-019-0484-5","relation":{},"ISSN":["1350-9047","1476-5403"],"issn-type":[{"value":"1350-9047","type":"print"},{"value":"1476-5403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,6]]},"assertion":[{"value":"3 July 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 December 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 January 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}