{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T15:53:00Z","timestamp":1793980380768,"version":"4.8.0"},"reference-count":75,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"The authors gratefully acknowledge support from the Mark Foundation for Cancer Research via an Aspire Award to the Letai and Bernards Laboratories","id":[{"id":"https:\/\/ror.org\/00v7th354","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Differ"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1038\/s41418-024-01431-1","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T06:50:50Z","timestamp":1736146250000},"page":"802-817","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Apoptotic priming in senescence predicts specific senolysis by quantitative analysis of mitochondrial dependencies"],"prefix":"10.1038","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9288-2722","authenticated-orcid":false,"given":"Julie A.","family":"MacDonald","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary A.","family":"Bradshaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fleur","family":"Jochems","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8677-3423","authenticated-orcid":false,"given":"Ren\u00e9","family":"Bernards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1993-9013","authenticated-orcid":false,"given":"Anthony","family":"Letai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,6]]},"reference":[{"key":"1431_CR1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2478\/v10039-012-0020-z","volume":"57","author":"M Ratajczak","year":"2012","unstructured":"Ratajczak M, Zuba-Surma E, Kucia M, Poniewierska A, Suszynska M, Ratajczak J. Pluripotent and multipotent stem cells in adult tissues. Adv Med Sci. 2012;57:1\u201317.","journal-title":"Adv Med Sci"},{"key":"1431_CR2","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1182\/blood.V81.11.2844.2844","volume":"81","author":"M Ogawa","year":"1993","unstructured":"Ogawa M. Differentiation and proliferation of hematopoietic stem cells. Blood. 1993;81:2844\u201353.","journal-title":"Blood"},{"key":"1431_CR3","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","volume":"126","author":"K Takahashi","year":"2006","unstructured":"Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126:663\u201376.","journal-title":"Cell"},{"key":"1431_CR4","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/bjc.1972.33","volume":"26","author":"JFR Kerr","year":"1972","unstructured":"Kerr JFR, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wideranging implications in tissue kinetics. Br J Cancer. 1972;26:239\u201357.","journal-title":"Br J Cancer"},{"key":"1431_CR5","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","volume":"25","author":"L Galluzzi","year":"2018","unstructured":"Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, et al. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ. 2018;25:486\u2013541.","journal-title":"Cell Death Differ"},{"key":"1431_CR6","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nrm3591","volume":"14","author":"TH Cheung","year":"2013","unstructured":"Cheung TH, Rando TA. Molecular regulation of stem cell quiescence. Nat Rev Mol Cell Biol. 2013;14:329\u201340.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1431_CR7","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/nature14131","volume":"520","author":"D Walter","year":"2015","unstructured":"Walter D, Lier A, Geiselhart A, Thalheimer FB, Huntscha S, Sobotta MC, et al. Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells. Nature. 2015;520:549\u201352.","journal-title":"Nature"},{"key":"1431_CR8","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.tcb.2018.02.001","volume":"28","author":"A Hernandez-Segura","year":"2018","unstructured":"Hernandez-Segura A, Nehme J, Demaria M. Hallmarks of cellular senescence. Trends Cell Biol. 2018;28:436\u201353.","journal-title":"Trends Cell Biol"},{"key":"1431_CR9","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.cell.2019.10.005","volume":"179","author":"V Gorgoulis","year":"2019","unstructured":"Gorgoulis V, Adams PD, Alimonti A, Bennett DC, Bischof O, Bishop C, et al. Cellular senescence: defining a path forward. Cell. 2019;179:813\u201327.","journal-title":"Cell"},{"key":"1431_CR10","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/nrm3823","volume":"15","author":"D Mu\u00f1oz-Esp\u00edn","year":"2014","unstructured":"Mu\u00f1oz-Esp\u00edn D, Serrano M. Cellular senescence: from physiology to pathology. Nat Rev Mol Cell Biol. 2014;15:482\u201396.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1431_CR11","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/febs.15570","volume":"288","author":"E Gonz\u00e1lez\u2010Gualda","year":"2021","unstructured":"Gonz\u00e1lez\u2010Gualda E, Baker AG, Fruk L, Mu\u00f1oz\u2010Esp\u00edn D. A guide to assessing cellular senescence in vitro and in vivo. FEBS J. 2021;288:56\u201380.","journal-title":"FEBS J"},{"key":"1431_CR12","doi-asserted-by":"crossref","unstructured":"Jochems F, Thijssen B, De Conti G, Jansen R, Pogacar Z, Groot K, et al. The cancer SENESCopedia: a delineation of cancer cell senescence. Cell Rep. 2021;36:109441.","DOI":"10.1016\/j.celrep.2021.109441"},{"key":"1431_CR13","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.cell.2019.01.018","volume":"176","author":"GE Neurohr","year":"2019","unstructured":"Neurohr GE, Terry RL, Lengefeld J, Bonney M, Brittingham GP, Moretto F, et al. Excessive cell growth causes cytoplasm dilution and contributes to senescence. Cell. 2019;176:1083\u20131097.e18.","journal-title":"Cell"},{"key":"1431_CR14","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ceb.2016.03.020","volume":"40","author":"T Chandra","year":"2016","unstructured":"Chandra T, Kirschner K. Chromosome organisation during ageing and senescence. Curr Opin Cell Biol. 2016;40:161\u20137.","journal-title":"Curr Opin Cell Biol"},{"key":"1431_CR15","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1242\/jcs.059246","volume":"123","author":"S Mai","year":"2010","unstructured":"Mai S, Klinkenberg M, Auburger G, Bereiter-Hahn J, Jendrach M. Decreased expression of Drp1 and Fis1 mediates mitochondrial elongation in senescent cells and enhances resistance to oxidative stress through PINK1. J Cell Sci. 2010;123:917\u201326.","journal-title":"J Cell Sci"},{"key":"1431_CR16","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1474-9726.2006.00199.x","volume":"5","author":"BY Lee","year":"2006","unstructured":"Lee BY, Han JA, Im JS, Morrone A, Johung K, Goodwin EC, et al. Senescence\u2010associated \u03b2\u2010galactosidase is lysosomal \u03b2\u2010galactosidase. Aging Cell. 2006;5:187\u201395.","journal-title":"Aging Cell"},{"key":"1431_CR17","doi-asserted-by":"crossref","unstructured":"Sharpless NE, Sherr CJ. Forging a signature of in vivo senescence. Nat Rev Cancer. 2015;15:397\u2013408.","DOI":"10.1038\/nrc3960"},{"key":"1431_CR18","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev-pathol-121808-102144","volume":"5","author":"JP Copp\u00e9","year":"2010","unstructured":"Copp\u00e9 JP, Desprez PY, Krtolica A, Campisi J. The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol. 2010;5:99\u2013118.","journal-title":"Annu Rev Pathol"},{"key":"1431_CR19","doi-asserted-by":"crossref","first-page":"e301","DOI":"10.1371\/journal.pbio.0060301","volume":"6","author":"JP Copp\u00e9","year":"2008","unstructured":"Copp\u00e9 JP, Patil CK, Rodier F, Sun Y, Mu\u00f1oz DP, Goldstein J, et al. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol. 2008;6:e301.","journal-title":"PLoS Biol"},{"key":"1431_CR20","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1038\/s41591-022-01923-y","volume":"28","author":"S Chaib","year":"2022","unstructured":"Chaib S, Tchkonia T, Kirkland JL. Cellular senescence and senolytics: the path to the clinic. Nat Med. 2022;28:1556\u201368.","journal-title":"Nat Med"},{"key":"1431_CR21","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1111\/febs.16735","volume":"290","author":"DJ Baker","year":"2023","unstructured":"Baker DJ, Narita M, Mu\u00f1oz\u2010C\u00e1noves P. Cellular senescence: beneficial, harmful, and highly complex. FEBS J. 2023;290:1156\u201360.","journal-title":"FEBS J"},{"key":"1431_CR22","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1111\/febs.16573","volume":"290","author":"V Moiseeva","year":"2023","unstructured":"Moiseeva V, Cisneros A, Cobos AC, Tarrega AB, O\u00f1ate CS, Perdiguero E, et al. Context\u2010dependent roles of cellular senescence in normal, aged, and disease states. FEBS J. 2023;290:1161\u201385.","journal-title":"FEBS J"},{"key":"1431_CR23","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1038\/s42255-019-0122-z","volume":"1","author":"A Guerrero","year":"2019","unstructured":"Guerrero A, Herranz N, Sun B, Wagner V, Gallage S, Guiho R, et al. Cardiac glycosides are broad-spectrum senolytics. Nat Metab. 2019;1:1074\u201388.","journal-title":"Nat Metab"},{"key":"1431_CR24","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-12888-x","volume":"10","author":"F Triana-Mart\u00ednez","year":"2019","unstructured":"Triana-Mart\u00ednez F, Picallos-Rabina P, Da Silva-\u00c1lvarez S, Pietrocola F, Llanos S, Rodilla V, et al. Identification and characterization of Cardiac Glycosides as senolytic compounds. Nat Commun. 2019;10:4731.","journal-title":"Nat Commun"},{"key":"1431_CR25","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/s41586-020-2403-9","volume":"583","author":"C Amor","year":"2020","unstructured":"Amor C, Feucht J, Leibold J, Ho YJ, Zhu C, Alonso-Curbelo D, et al. Senolytic CAR T cells reverse senescence-associated pathologies. Nature. 2020;583:127\u201332.","journal-title":"Nature"},{"key":"1431_CR26","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/s43587-023-00560-5","volume":"4","author":"C Amor","year":"2024","unstructured":"Amor C, Fern\u00e1ndez-Maestre I, Chowdhury S, Ho YJ, Nadella S, Graham C, et al. Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction. Nat Aging. 2024;4:336\u201349.","journal-title":"Nat Aging"},{"key":"1431_CR27","doi-asserted-by":"crossref","first-page":"955","DOI":"10.18632\/aging.101202","volume":"9","author":"Y Zhu","year":"2017","unstructured":"Zhu Y, Doornebal EJ, Pirtskhalava T, Giorgadze N, Wentworth M, Fuhrmann-Stroissnigg H, et al. New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463. Aging. 2017;9:955\u201363.","journal-title":"Aging"},{"key":"1431_CR28","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ebiom.2018.09.015","volume":"36","author":"MJ Yousefzadeh","year":"2018","unstructured":"Yousefzadeh MJ, Zhu Y, McGowan SJ, Angelini L, Fuhrmann-Stroissnigg H, Xu M, et al. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. 2018;36:18\u201328.","journal-title":"EBioMedicine"},{"key":"1431_CR29","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1111\/acel.12344","volume":"14","author":"Y Zhu","year":"2015","unstructured":"Zhu Y, Tchkonia T, Pirtskhalava T, Gower AC, Ding H, Giorgadze N, et al. The achilles\u2019 heel of senescent cells: From transcriptome to senolytic drugs. Aging Cell. 2015;14:644\u201358.","journal-title":"Aging Cell"},{"key":"1431_CR30","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/acel.12445","volume":"15","author":"Y Zhu","year":"2016","unstructured":"Zhu Y, Tchkonia T, Fuhrmann\u2010Stroissnigg H, Dai HM, Ling YY, Stout MB, et al. Identification of a novel senolytic agent, navitoclax, targeting the Bcl\u20102 family of anti\u2010apoptotic factors. Aging Cell. 2016;15:428\u201335.","journal-title":"Aging Cell"},{"key":"1431_CR31","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/nm.4010","volume":"22","author":"J Chang","year":"2016","unstructured":"Chang J, Wang Y, Shao L, Laberge RM, Demaria M, Campisi J, et al. Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice. Nat Med. 2016;22:78\u201383.","journal-title":"Nat Med"},{"key":"1431_CR32","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1038\/s41418-020-0564-6","volume":"27","author":"A Shahbandi","year":"2020","unstructured":"Shahbandi A, Rao SG, Anderson AY, Frey WD, Olayiwola JO, Ungerleider NA, et al. BH3 mimetics selectively eliminate chemotherapy-induced senescent cells and improve response in TP53 wild-type breast cancer. Cell Death Differ. 2020;27:3097\u2013116.","journal-title":"Cell Death Differ"},{"key":"1431_CR33","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1002\/1878-0261.12761","volume":"14","author":"T Saleh","year":"2020","unstructured":"Saleh T, Carpenter VJ, Tyutyunyk-Massey L, Murray G, Leverson JD, Souers AJ, et al. Clearance of therapy-induced senescent tumor cells by the senolytic ABT-263 via interference with BCL-XL\u2013BAX interaction. Mol Oncol. 2020;14:2504\u201319.","journal-title":"Mol Oncol"},{"key":"1431_CR34","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1158\/0008-5472.CAN-07-5836","volume":"68","author":"C Tse","year":"2008","unstructured":"Tse C, Shoemaker AR, Adickes J, Anderson MG, Chen J, Jin S, et al. ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor. Cancer Res. 2008;68:3421\u20138.","journal-title":"Cancer Res"},{"key":"1431_CR35","doi-asserted-by":"crossref","first-page":"7294","DOI":"10.1093\/nar\/gkz555","volume":"47","author":"G Casella","year":"2019","unstructured":"Casella G, Munk R, Kim KM, Piao Y, De S, Abdelmohsen K, et al. Transcriptome signature of cellular senescence. Nucleic Acids Res. 2019;47:7294\u2013305.","journal-title":"Nucleic Acids Res"},{"key":"1431_CR36","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0531-5565(00)00083-8","volume":"35","author":"F Bringold","year":"2000","unstructured":"Bringold F, Serrano M. Tumor suppressors and oncogenes in cellular senescence. Exp Gerontol. 2000;35:317\u201329.","journal-title":"Exp Gerontol"},{"key":"1431_CR37","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/16476","volume":"397","author":"JJL Jacobs","year":"1999","unstructured":"Jacobs JJL, Kieboom K, Marino S, DePinho RA, van Lohuizen M. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature. 1999;397:164\u20138.","journal-title":"Nature"},{"key":"1431_CR38","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1016\/j.exger.2004.06.025","volume":"39","author":"NE Sharpless","year":"2004","unstructured":"Sharpless NE. Ink4a\/Arf links senescence and aging. Exp Gerontol. 2004;39:1751\u20139.","journal-title":"Exp Gerontol"},{"key":"1431_CR39","doi-asserted-by":"crossref","first-page":"7936","DOI":"10.1074\/jbc.274.12.7936","volume":"274","author":"AC Lee","year":"1999","unstructured":"Lee AC, Fenster BE, Ito H, Takeda K, Bae NS, Hirai T, et al. Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species. J Biol Chem. 1999;274:7936\u201340.","journal-title":"J Biol Chem"},{"key":"1431_CR40","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/s41586-023-06621-4","volume":"622","author":"S Victorelli","year":"2023","unstructured":"Victorelli S, Salmonowicz H, Chapman J, Martini H, Vizioli MG, Riley JS, et al. Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature. 2023;622:627\u201336.","journal-title":"Nature"},{"key":"1431_CR41","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.ccell.2020.10.010","volume":"38","author":"S Bhatt","year":"2020","unstructured":"Bhatt S, Pioso MS, Olesinski EA, Yilma B, Ryan JA, Mashaka T, et al. Reduced mitochondrial apoptotic priming drives resistance to BH3 mimetics in acute myeloid leukemia. Cancer Cell. 2020;38:872\u2013890.e6.","journal-title":"Cancer Cell"},{"key":"1431_CR42","volume":"15","author":"K Wang","year":"2024","unstructured":"Wang K, Zerdes I, Johansson HJ, Sarhan D, Sun Y, Kanellis DC, et al. Longitudinal molecular profiling elucidates immunometabolism dynamics in breast cancer. Nat Commun. 2024;15:3837.","journal-title":"Nat Commun"},{"key":"1431_CR43","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.redox.2016.12.001","volume":"11","author":"A H\u00f6hn","year":"2017","unstructured":"H\u00f6hn A, Weber D, Jung T, Ott C, Hugo M, Kochlik B, et al. Happily (n)ever after: aging in the context of oxidative stress, proteostasis loss and cellular senescence. Redox Biol. 2017;11:482\u2013501.","journal-title":"Redox Biol"},{"key":"1431_CR44","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.chembiol.2008.02.010","volume":"15","author":"WS Yang","year":"2008","unstructured":"Yang WS, Stockwell BR. Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-Harboring cancer cells. Chem Biol. 2008;15:234\u201345.","journal-title":"Chem Biol"},{"key":"1431_CR45","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","volume":"156","author":"WS Yang","year":"2014","unstructured":"Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, et al. Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014;156:317\u201331.","journal-title":"Cell"},{"key":"1431_CR46","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/nature19830","volume":"538","author":"A Kotschy","year":"2016","unstructured":"Kotschy A, Szlavik Z, Murray J, Davidson J, Maragno AL, Le Toumelin-Braizat G, et al. The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models. Nature. 2016;538:477\u201382.","journal-title":"Nature"},{"key":"1431_CR47","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.canlet.2011.12.021","volume":"332","author":"VDG Moore","year":"2013","unstructured":"Moore VDG, Letai A. BH3 profiling-measuring integrated function of the mitochondrial apoptotic pathway to predict cell fate decisions. Cancer Lett. 2013;332:202\u20135.","journal-title":"Cancer Lett"},{"key":"1431_CR48","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ymeth.2013.04.006","volume":"61","author":"J Ryan","year":"2013","unstructured":"Ryan J, Letai A. BH3 profiling in whole cells by fluorimeter or FACS. Methods. 2013;61:156\u201364.","journal-title":"Methods"},{"key":"1431_CR49","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/978-1-4939-8861-7_4","volume":"1877","author":"C Fraser","year":"2019","unstructured":"Fraser C, Ryan J, Sarosiek K. BH3 profiling: a functional assay to measure apoptotic priming and dependencies. Methods Mol Biol. 2019;1877:61\u201376.","journal-title":"Methods Mol Biol"},{"key":"1431_CR50","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.cell.2013.10.041","volume":"155","author":"M Storer","year":"2013","unstructured":"Storer M, Mas A, Robert-Moreno A, Pecoraro M, Ortells MC, Di Giacomo V, et al. Senescence is a developmental mechanism that contributes to embryonic growth and patterning. Cell. 2013;155:1119\u201330.","journal-title":"Cell"},{"key":"1431_CR51","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/j.cell.2013.10.019","volume":"155","author":"D Mu\u00f1oz-Esp\u00edn","year":"2013","unstructured":"Mu\u00f1oz-Esp\u00edn D, Ca\u00f1amero M, Maraver A, G\u00f3mez-L\u00f3pez G, Contreras J, Murillo-Cuesta S, et al. Programmed cell senescence during mammalian embryonic development. Cell. 2013;155:1104\u201318.","journal-title":"Cell"},{"key":"1431_CR52","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.cmet.2020.05.002","volume":"32","author":"L Grosse","year":"2020","unstructured":"Grosse L, Wagner N, Emelyanov A, Molina C, Lacas-Gervais S, Wagner KD, et al. Defined p16High Senescent cell types are indispensable for mouse healthspan. Cell Metab. 2020;32:87\u201399.e6.","journal-title":"Cell Metab"},{"key":"1431_CR53","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.devcel.2014.11.012","volume":"31","author":"M Demaria","year":"2014","unstructured":"Demaria M, Ohtani N, Youssef SA, Rodier F, Toussaint W, Mitchell JR, et al. An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA. Dev Cell. 2014;31:722\u201333.","journal-title":"Dev Cell"},{"key":"1431_CR54","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1111\/ajt.17102","volume":"22","author":"CM Liao","year":"2022","unstructured":"Liao CM, Wulfmeyer VC, Chen R, Erlangga Z, Sinning J, von M\u00e4ssenhausen A, et al. Induction of ferroptosis selectively eliminates senescent tubular cells. Am J Transplant. 2022;22:2158\u201368.","journal-title":"Am J Transplant"},{"key":"1431_CR55","doi-asserted-by":"crossref","unstructured":"Li S, Livingston MJ, Ma Z, Hu X, Wen L, Ding HF, et al. Tubular cell senescence promotes maladaptive kidney repair and chronic kidney disease after cisplatin nephrotoxicity. JCI Insight. 2023;8:e166643.","DOI":"10.1172\/jci.insight.166643"},{"key":"1431_CR56","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nature24297","volume":"551","author":"MJ Hangauer","year":"2017","unstructured":"Hangauer MJ, Viswanathan VS, Ryan MJ, Bole D, Eaton JK, Matov A, et al. Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition. Nature. 2017;551:247\u201350.","journal-title":"Nature"},{"key":"1431_CR57","doi-asserted-by":"crossref","first-page":"6381","DOI":"10.18632\/aging.204207","volume":"14","author":"D Rysanek","year":"2022","unstructured":"Rysanek D, Vasicova P, Kolla JN, Sedlak D, Andera L, Bartek J, et al. Synergism of BCL-2 family inhibitors facilitates selective elimination of senescent cells. Aging. 2022;14:6381\u2013414.","journal-title":"Aging"},{"key":"1431_CR58","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-35657-9","volume":"13","author":"J Kohli","year":"2022","unstructured":"Kohli J, Ge C, Fitsiou E, Doepner M, Brandenburg SM, Faller WJ, et al. Targeting anti-apoptotic pathways eliminates senescent melanocytes and leads to nevi regression. Nat Commun. 2022;13:7923.","journal-title":"Nat Commun"},{"key":"1431_CR59","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.15252\/embr.201439245","volume":"15","author":"BG Childs","year":"2014","unstructured":"Childs BG, Baker DJ, Kirkland JL, Campisi J, Deursen JM. Senescence and apoptosis: dueling or complementary cell fates? EMBO Rep. 2014;15:1139\u201353.","journal-title":"EMBO Rep"},{"key":"1431_CR60","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1126\/science.1206727","volume":"334","author":"T Ni Chonghaile","year":"2011","unstructured":"Ni Chonghaile T, Sarosiek KA, Vo TT, Ryan JA, Tammareddi A, Moore Vdel G, et al. Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy. Science. 2011;334:1129\u201333.","journal-title":"Science"},{"key":"1431_CR61","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1021\/cb500259e","volume":"9","author":"A Primikyri","year":"2014","unstructured":"Primikyri A, Chatziathanasiadou MV, Karali E, Kostaras E, Mantzaris MD, Hatzimichael E, et al. Direct binding of Bcl-2 family proteins by quercetin triggers its pro-apoptotic activity. ACS Chem Biol. 2014;9:2737\u201341.","journal-title":"ACS Chem Biol"},{"key":"1431_CR62","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/s41556-018-0054-y","volume":"20","author":"P Gutierrez-Martinez","year":"2018","unstructured":"Gutierrez-Martinez P, Hogdal L, Nagai M, Kruta M, Singh R, Sarosiek K, et al. Diminished apoptotic priming and ATM signalling confer a survival advantage onto aged haematopoietic stem cells in response to DNA damage. Nat Cell Biol. 2018;20:413\u201321.","journal-title":"Nat Cell Biol"},{"key":"1431_CR63","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ccell.2016.11.011","volume":"31","author":"KA Sarosiek","year":"2017","unstructured":"Sarosiek KA, Fraser C, Muthalagu N, Bhola PD, Chang W, McBrayer SK, et al. Developmental regulation of mitochondrial apoptosis by c-Myc Governs Age- and tissue-specific sensitivity to cancer therapeutics. Cancer Cell. 2017;31:142\u201356.","journal-title":"Cancer Cell"},{"key":"1431_CR64","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.cell.2015.01.042","volume":"160","author":"J Montero","year":"2015","unstructured":"Montero J, Sarosiek KA, DeAngelo JD, Maertens O, Ryan J, Ercan D, et al. Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy. Cell. 2015;160:977\u201389.","journal-title":"Cell"},{"key":"1431_CR65","doi-asserted-by":"crossref","unstructured":"Bhola PD, Ahmed E, Guerriero JL, Sicinska E, Su E, Lavrova E, et al. High-throughput dynamic BH3 profiling may quickly and accurately predict effective therapies in solid tumors. Sci Signal. 2020;13:eaay1451.","DOI":"10.1126\/scisignal.aay1451"},{"key":"1431_CR66","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.ccr.2008.02.010","volume":"13","author":"R Wiedemeyer","year":"2008","unstructured":"Wiedemeyer R, Brennan C, Heffernan TP, Xiao Y, Mahoney J, Protopopov A, et al. Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development. Cancer Cell. 2008;13:355\u201364.","journal-title":"Cancer Cell"},{"key":"1431_CR67","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.gpb.2022.01.004","volume":"20","author":"S Zheng","year":"2022","unstructured":"Zheng S, Wang W, Aldahdooh J, Malyutina A, Shadbahr T, Tanoli Z, et al. SynergyFinder Plus: toward better interpretation and annotation of drug combination screening datasets. Genom Proteom Bioinform. 2022;20:587\u201396.","journal-title":"Genom Proteom Bioinform"},{"key":"1431_CR68","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.ymeth.2007.11.010","volume":"44","author":"G Brumatti","year":"2008","unstructured":"Brumatti G, Sheridan C, Martin SJ. Expression and purification of recombinant annexin V for the detection of membrane alterations on apoptotic cells. Methods. 2008;44:235\u201340.","journal-title":"Methods"},{"key":"1431_CR69","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1515\/hsz-2016-0107","volume":"397","author":"J Ryan","year":"2016","unstructured":"Ryan J, Montero J, Rocco J, Letai A. iBH3: simple, fixable BH3 profiling to determine apoptotic priming in primary tissue by flow cytometry. Biol Chem. 2016;397:671\u20138.","journal-title":"Biol Chem"},{"key":"1431_CR70","doi-asserted-by":"crossref","first-page":"7150","DOI":"10.1021\/ac502040v","volume":"86","author":"GC McAlister","year":"2014","unstructured":"McAlister GC, Nusinow DP, Jedrychowski MP, W\u00fchr M, Huttlin EL, Erickson BK, et al. MultiNotch MS3 enables accurate, sensitive, and multiplexed detection of differential expression across cancer cell line proteomes. Anal Chem. 2014;86:7150\u20138.","journal-title":"Anal Chem"},{"key":"1431_CR71","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jprot.2016.07.005","volume":"148","author":"JA Paulo","year":"2016","unstructured":"Paulo JA, O\u2019Connell JD, Everley RA, O\u2019Brien J, Gygi MA, Gygi SP. Quantitative mass spectrometry-based multiplexing compares the abundance of 5000 S. cerevisiae proteins across 10 carbon sources. J Proteom. 2016;148:85\u201393.","journal-title":"J Proteom"},{"key":"1431_CR72","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2105-10-48","volume":"10","author":"E Eden","year":"2009","unstructured":"Eden E, Navon R, Steinfeld I, Lipson D, Yakhini Z. GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists. BMC Bioinform. 2009;10:48.","journal-title":"BMC Bioinform"},{"key":"1431_CR73","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa M, Goto S. KEGG: Kyoto Encyclopedia of Genes and Genomes. Nucleic Acids Res. 2000;28:27\u201330.","journal-title":"Nucleic Acids Res"},{"key":"1431_CR74","doi-asserted-by":"crossref","first-page":"D587","DOI":"10.1093\/nar\/gkac963","volume":"51","author":"M Kanehisa","year":"2023","unstructured":"Kanehisa M, Furumichi M, Sato Y, Kawashima M, Ishiguro-Watanabe M. KEGG for taxonomy-based analysis of pathways and genomes. Nucleic Acids Res. 2023;51:D587\u201392.","journal-title":"Nucleic Acids Res"},{"key":"1431_CR75","doi-asserted-by":"crossref","first-page":"D543","DOI":"10.1093\/nar\/gkab1038","volume":"50","author":"Y Perez-Riverol","year":"2022","unstructured":"Perez-Riverol Y, Bai J, Bandla C, Garc\u00eda-Seisdedos D, Hewapathirana S, Kamatchinathan S, et al. The PRIDE database resources in 2022: a hub for mass spectrometry-based proteomics evidences. Nucleic Acids Res. 2022;50:D543\u201352.","journal-title":"Nucleic Acids Res"}],"container-title":["Cell Death &amp; Differentiation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41418-024-01431-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41418-024-01431-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41418-024-01431-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T08:06:15Z","timestamp":1747641975000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41418-024-01431-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,6]]},"references-count":75,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["1431"],"URL":"https:\/\/doi.org\/10.1038\/s41418-024-01431-1","relation":{},"ISSN":["1350-9047","1476-5403"],"issn-type":[{"value":"1350-9047","type":"print"},{"value":"1476-5403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,6]]},"assertion":[{"value":"14 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 November 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 December 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 January 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"JAM, GAB, and FJ declare no competing interests. RB discloses he is the co-founder of Oncosence BV, Chief Scientific Officer at Agendia Inc., and board member of Lixte Biotechnology Holdings, Inc. AL discloses that he is on the Scientific Advisory Boards of Zentalis Pharmaceuticals and Flash Therapeutics.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}