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The discovery of dysregulated microRNAs and their roles in placental development has provided a new avenue for elucidating the mechanism involved in this pregnancy-specific disorder. Here, the roles of human miR-181a-5p, a microRNA that is increased in both the plasma and placenta of severe pre-eclamptic patients, in invasion and migration of trophoblasts were investigated. Ectopic-expression of miR-181a-5p impaired the invasion and migration of HTR-8\/SVneo cells, whereas miR-181a-5p inhibition had the opposite effects. <jats:italic>IGF2BP2<\/jats:italic>, which harbors a highly conserved miR-181a-5p-binding site within its 3\u02b9-UTR, was identified to be directly inhibited by miR-181a-5p. Moreover, siRNAs targeting <jats:italic>IGF2BP2<\/jats:italic> imitated the effects of overexpressed miR-181a-5p on HTR-8\/SVneo cell invasion and migration, whereas restoring <jats:italic>IGF2BP2<\/jats:italic> expression by overexpressing a plasmid encoding <jats:italic>IGF2BP2<\/jats:italic> partially reversed the studied inhibitory functions of miR-181a-5p. Thus, we demonstrated here that miR-181a-5p suppresses the invasion and migration of cytotrophoblasts, and its inhibitory effects were at least partially mediated by the suppression of <jats:italic>IGF2BP2<\/jats:italic> expression, thus shedding new light on the roles of miR-181a-5p in the pathogenesis of severe pre-eclampsia.<\/jats:p>","DOI":"10.1038\/s41419-017-0045-0","type":"journal-article","created":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T15:14:00Z","timestamp":1516115640000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["miR-181a-5p suppresses invasion and migration of HTR-8\/SVneo cells by directly targeting IGF2BP2"],"prefix":"10.1038","volume":"9","author":[{"given":"Liang","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-yan","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin-li","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-man","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-na","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-ying","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-pu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,1,16]]},"reference":[{"key":"45_CR1","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1016\/j.mam.2012.12.008","volume":"34","author":"L Ji","year":"2013","unstructured":"Ji, L. et al. 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