{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:39:50Z","timestamp":1790393990039,"version":"4.1.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T00:00:00Z","timestamp":1516752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T00:00:00Z","timestamp":1516752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Dis"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>miR-375 is a tumor-suppressive microRNA (miRNA) in gastric cancer (GC). However, its molecular mechanism remains unclear. The aim of this study is to comprehensively investigate how miR-375 is involved in Hippo pathway by targeting multiple oncogenes. miR-375 expression in gastric cancer cell lines and primary GC was investigated by qRT-PCR. The regulation of YAP1, TEAD4, and CTGF expression by miR-375 was evaluated by qRT-PCR, western blot, and luciferase reporter assays, respectively. The functional roles of the related genes were examined by siRNA-mediated knockdown or ectopic expression assays. The clinical significance and expression correlation analysis of miR-375, YAP1, and CTGF were performed in primary GCs. TCGA cohort was also used to analyze the expression correlation of YAP1, TEAD4, CTGF, and miR-375 in primary GCs. miR-375 was down-regulated in GC due to promoter methylation and histone deacetylation. miR-375 downregulation was associated with unfavorable outcome and lymph node metastasis. Ectopic expression of miR-375 inhibited tumor growth in vitro and in vivo. Three components of Hippo pathway, YAP1, TEAD4 and CTGF, were revealed to be direct targets of miR-375. The expression of three genes showed a negative correlation with miR-375 expression and YAP1 re-expression partly abolished the tumor-suppressive effect of miR-375. Furthermore, CTGF was confirmed to be the key downstream of Hippo-YAP1 cascade and its knockdown phenocopied siYAP1 or miR-375 overexpression. YAP1 nuclear accumulation was\u00a0positively correlated with CTGF cytoplasmic expression in primary GC tissues. Verteporfin exerted an anti-oncogenic effect in GC cell lines by quenching CTGF expression through YAP1 degradation. In short, miR-375 was involved in the Hippo pathway by targeting YAP1-TEAD4-CTGF axis and enriched our knowledge on the miRNA dysregulation in gastric tumorigenesis.<\/jats:p>","DOI":"10.1038\/s41419-017-0134-0","type":"journal-article","created":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T15:14:02Z","timestamp":1516806842000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":125,"title":["miR-375 is involved in Hippo pathway by targeting YAP1\/TEAD4-CTGF axis in gastric carcinogenesis"],"prefix":"10.1038","volume":"9","author":[{"given":"Wei","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinglin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond W. M.","family":"Lung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4042-6957","authenticated-orcid":false,"given":"Joanna H. M.","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony W. H.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi Chun","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujuan","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wing Po","family":"Chak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvin H. K.","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse C. S.","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred S. L.","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ka Fai","family":"To","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,1,24]]},"reference":[{"key":"134_CR1","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1056\/NEJMoa001999","volume":"345","author":"N Uemura","year":"2001","unstructured":"Uemura, N. et al. Helicobacter pylori infection and the development of gastric cancer. N. Engl. J. Med. 345, 784\u2013789 (2001).","journal-title":"N. Engl. J. Med."},{"key":"134_CR2","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1038\/nature13480","volume":"513","author":"The Cancer Genome Atlas Research N.","year":"2014","unstructured":"The Cancer Genome Atlas Research N. Comprehensive molecular characterization of gastric adenocarcinoma. Nature 513, 202\u2013209 (2014).","journal-title":"Nature"},{"key":"134_CR3","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.ccr.2008.02.011","volume":"13","author":"Q Zeng","year":"2008","unstructured":"Zeng, Q. & Hong, W. The emerging role of the hippo pathway in cell contact inhibition, organ size control, and cancer development in mammals. Cancer Cell 13, 188\u2013192 (2008).","journal-title":"Cancer Cell"},{"key":"134_CR4","doi-asserted-by":"publisher","first-page":"2747","DOI":"10.1101\/gad.1602907","volume":"21","author":"B Zhao","year":"2007","unstructured":"Zhao, B. et al. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev. 21, 2747\u20132761 (2007).","journal-title":"Genes Dev."},{"key":"134_CR5","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1016\/j.cell.2006.05.030","volume":"125","author":"L Zender","year":"2006","unstructured":"Zender, L. et al. Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell 125, 1253\u20131267 (2006).","journal-title":"Cell"},{"key":"134_CR6","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.cell.2014.06.003","volume":"158","author":"A Kapoor","year":"2014","unstructured":"Kapoor, A. et al. Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer. Cell 158, 185\u2013197 (2014).","journal-title":"Cell"},{"key":"134_CR7","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.cell.2014.06.004","volume":"158","author":"DD Shao","year":"2014","unstructured":"Shao, D. D. et al. KRAS and YAP1 converge to regulate EMT and tumor survival. Cell 158, 171\u2013184 (2014).","journal-title":"Cell"},{"key":"134_CR8","doi-asserted-by":"publisher","first-page":"2130","DOI":"10.1158\/1078-0432.CCR-10-2467","volume":"17","author":"W Kang","year":"2011","unstructured":"Kang, W. et al. Yes-associated protein 1 exhibits oncogenic property in gastric cancer and its nuclear accumulation associates with poor prognosis. Clin. Cancer Res. 17, 2130\u20132139 (2011).","journal-title":"Clin. Cancer Res."},{"key":"134_CR9","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-015-0323-3","volume":"14","author":"W Kang","year":"2015","unstructured":"Kang, W. et al. Targeting of YAP1 by microRNA-15a and microRNA-16-1 exerts tumor suppressor function in gastric adenocarcinoma. Mol. Cancer 14, 52 (2015).","journal-title":"Mol. Cancer"},{"key":"134_CR10","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.bbrc.2015.07.149","volume":"465","author":"G Zhu","year":"2015","unstructured":"Zhu, G. et al. Upregulation of miR-130b enhances stem cell-like phenotype in glioblastoma by inactivating the Hippo signaling pathway. Biochem. Biophys. Res. Commun. 465, 194\u2013199 (2015).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"134_CR11","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-014-0281-3","volume":"12","author":"W Kang","year":"2014","unstructured":"Kang, W. et al. let-7b\/g silencing activates AKT signaling to promote gastric carcinogenesis. J. Transl. Med. 12, 281 (2014).","journal-title":"J. Transl. Med."},{"key":"134_CR12","doi-asserted-by":"publisher","first-page":"e99516","DOI":"10.1371\/journal.pone.0099516","volume":"9","author":"Y Xu","year":"2014","unstructured":"Xu, Y. et al. Snail-regulated MiR-375 inhibits migration and invasion of gastric cancer cells by targeting JAK2. PLoS ONE 9, e99516 (2014).","journal-title":"PLoS ONE"},{"key":"134_CR13","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1038\/cr.2010.79","volume":"20","author":"L Ding","year":"2010","unstructured":"Ding, L. et al. MiR-375 frequently downregulated in gastric cancer inhibits cell proliferation by targeting JAK2. Cell Res. 20, 784\u2013793 (2010).","journal-title":"Cell Res."},{"key":"134_CR14","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.3892\/etm.2014.1627","volume":"7","author":"ZY Shen","year":"2014","unstructured":"Shen, Z. Y., Zhang, Z. Z., Liu, H., Zhao, E. H. & Cao, H. miR-375 inhibits the proliferation of gastric cancer cells by repressing ERBB2 expression. Exp. Ther. Med. 7, 1757\u20131761 (2014).","journal-title":"Exp. Ther. Med."},{"key":"134_CR15","doi-asserted-by":"publisher","first-page":"2339","DOI":"10.1158\/0008-5472.CAN-09-2777","volume":"70","author":"Y Tsukamoto","year":"2010","unstructured":"Tsukamoto, Y. et al. MicroRNA-375 is downregulated in gastric carcinomas and regulates cell survival by targeting PDK1 and 14-3-3zeta. Cancer Res. 70, 2339\u20132349 (2010).","journal-title":"Cancer Res."},{"key":"134_CR16","first-page":"1158","volume":"5","author":"N Li","year":"2014","unstructured":"Li, N. et al. miR-222\/VGLL4\/YAP-TEAD1 regulatory loop promotes proliferation and invasion of gastric cancer cells. Am. J. Cancer Res. 5, 1158\u20131168 (2014).","journal-title":"Am. J. Cancer Res."},{"key":"134_CR17","doi-asserted-by":"publisher","first-page":"pl1","DOI":"10.1126\/scisignal.2004088","volume":"6","author":"J Gao","year":"2013","unstructured":"Gao, J. et al. Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci. Signal. 6, pl1\u2013pl1 (2013).","journal-title":"Sci. Signal."},{"key":"134_CR18","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","volume":"2","author":"E Cerami","year":"2012","unstructured":"Cerami, E. et al. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2, 401\u2013404 (2012).","journal-title":"Cancer Discov."},{"key":"134_CR19","first-page":"e1780v1781","volume":"4","author":"J Anaya","year":"2016","unstructured":"Anaya, J. OncoLnc: linking TCGA survival data to mRNAs, miRNAs, and lncRNAs. PeerJ Prepr. 4, e1780v1781 (2016).","journal-title":"PeerJ Prepr."},{"key":"134_CR20","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.3748\/wjg.v22.i3.1279","volume":"22","author":"W Kang","year":"2016","unstructured":"Kang, W., Cheng, A. S., Yu, J. & To, K. F. Emerging role of Hippo pathway in gastric and other gastrointestinal cancers. World J. Gastroenterol. 22, 1279\u20131288 (2016).","journal-title":"World J. Gastroenterol."},{"key":"134_CR21","doi-asserted-by":"publisher","first-page":"3373","DOI":"10.4161\/cc.21397","volume":"11","author":"M Fujii","year":"2012","unstructured":"Fujii, M. et al. Convergent signaling in the regulation of connective tissue growth factor in malignant mesothelioma: TGFbeta signaling and defects in the Hippo signaling cascade. Cell Cycle 11, 3373\u20133379 (2012).","journal-title":"Cell Cycle"},{"key":"134_CR22","doi-asserted-by":"publisher","first-page":"2149","DOI":"10.1002\/hep.24587","volume":"54","author":"R Urtasun","year":"2011","unstructured":"Urtasun, R. et al. Connective tissue growth factor autocriny in human hepatocellular carcinoma: oncogenic role and regulation by epidermal growth factor receptor\/yes-associated protein-mediated activation. Hepatology 54, 2149\u20132158 (2011).","journal-title":"Hepatology"},{"key":"134_CR23","doi-asserted-by":"publisher","first-page":"e54211","DOI":"10.1371\/journal.pone.0054211","volume":"8","author":"HF Yuen","year":"2013","unstructured":"Yuen, H. F. et al. TAZ expression as a prognostic indicator in colorectal cancer. PLoS ONE 8, e54211 (2013).","journal-title":"PLoS ONE"},{"key":"134_CR24","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1111\/j.1349-7006.2010.01746.x","volume":"102","author":"Z Mao","year":"2011","unstructured":"Mao, Z. et al. Connective tissue growth factor enhances the migration of gastric cancer through downregulation of E-cadherin via the NF-kappaB pathway. Cancer Sci. 102, 104\u2013110 (2011).","journal-title":"Cancer Sci."},{"key":"134_CR25","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-10-122","volume":"10","author":"CG Jiang","year":"2011","unstructured":"Jiang, C. G. et al. Downregulation of connective tissue growth factor inhibits the growth and invasion of gastric cancer cells and attenuates peritoneal dissemination. Mol. Cancer 10, 122 (2011).","journal-title":"Mol. Cancer"},{"key":"134_CR26","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.cyto.2012.09.013","volume":"61","author":"CG Jiang","year":"2013","unstructured":"Jiang, C. G. et al. Connective tissue growth factor is a positive regulator of epithelial\u2013mesenchymal transition and promotes the adhesion with gastric cancer cells in human peritoneal mesothelial cells. Cytokine 61, 173\u2013180 (2013).","journal-title":"Cytokine"},{"key":"134_CR27","doi-asserted-by":"publisher","first-page":"2110","DOI":"10.3748\/wjg.14.2110","volume":"14","author":"LY Liu","year":"2008","unstructured":"Liu, L. Y., Han, Y. C., Wu, S. H. & Lv, Z. H. Expression of connective tissue growth factor in tumor tissues is an independent predictor of poor prognosis in patients with gastric cancer. World J. Gastroenterol. 14, 2110\u20132114 (2008).","journal-title":"World J. Gastroenterol."},{"key":"134_CR28","doi-asserted-by":"publisher","first-page":"8642","DOI":"10.1158\/0008-5472.CAN-10-1345","volume":"70","author":"CJ Huntoon","year":"2010","unstructured":"Huntoon, C. J. et al. Heat shock protein 90 inhibition depletes LATS1 and LATS2, two regulators of the mammalian hippo tumor suppressor pathway. Cancer Res. 70, 8642\u20138650 (2010).","journal-title":"Cancer Res."},{"key":"134_CR29","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1073\/pnas.1216462110","volume":"110","author":"R Fan","year":"2013","unstructured":"Fan, R., Kim, N. G. & Gumbiner, B. M. Regulation of Hippo pathway by mitogenic growth factors via phosphoinositide 3-kinase and phosphoinositide-dependent kinase-1. Proc. Natl. Acad. Sci. USA 110, 2569\u20132574 (2013).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"134_CR30","doi-asserted-by":"publisher","first-page":"326","DOI":"10.4161\/epi.6.3.14404","volume":"6","author":"VK Hill","year":"2011","unstructured":"Hill, V. K. et al. Frequent epigenetic inactivation of KIBRA, an upstream member of the Salvador\/Warts\/Hippo (SWH) tumor suppressor network, is associated with specific genetic event in B-cell acute lymphocytic leukemia. Epigenetics 6, 326\u2013332 (2011).","journal-title":"Epigenetics"},{"key":"134_CR31","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1038\/ncb3464","volume":"19","author":"C Li","year":"2017","unstructured":"Li, C. et al. A ROR1-HER3-lncRNA signalling axis modulates the Hippo-YAP pathway to regulate bone metastasis. Nat. Cell. Biol. 19, 106\u2013119 (2017).","journal-title":"Nat. Cell. Biol."},{"key":"134_CR32","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1159\/000336919","volume":"30","author":"A Link","year":"2012","unstructured":"Link, A., Kupcinskas, J., Wex, T. & Malfertheiner, P. Macro-role of microRNA in gastric cancer. Dig. Dis. 30, 255\u2013267 (2012).","journal-title":"Dig. Dis."},{"key":"134_CR33","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/j.bbrc.2010.03.036","volume":"394","author":"AM Liu","year":"2010","unstructured":"Liu, A. M., Poon, R. T. & Luk, J. M. MicroRNA-375 targets Hippo-signaling effector YAP in liver cancer and inhibits tumor properties. Biochem. Biophys. Res. Commun. 394, 623\u2013627 (2010).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"134_CR34","doi-asserted-by":"publisher","first-page":"6165","DOI":"10.1158\/0008-5472.CAN-11-1020","volume":"71","author":"E Nishikawa","year":"2011","unstructured":"Nishikawa, E. et al. miR-375 is activated by ASH1 and inhibits YAP1 in a lineage-dependent manner in lung cancer. Cancer Res. 71, 6165\u20136173 (2011).","journal-title":"Cancer Res."},{"key":"134_CR35","doi-asserted-by":"publisher","first-page":"e96767","DOI":"10.1371\/journal.pone.0096767","volume":"9","author":"LL Christensen","year":"2014","unstructured":"Christensen, L. L. et al. Functional screening identifies miRNAs influencing apoptosis and proliferation in colorectal cancer. PLoS ONE9, e96767 (2014).","journal-title":"PLoS ONE"},{"key":"134_CR36","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.neo.2014.03.010","volume":"16","author":"S Hong","year":"2014","unstructured":"Hong, S. et al. SHOX2 is a direct miR-375 target and a novel epithelial-to-mesenchymal transition inducer in breast cancer cells. Neoplasia 16, 279\u2013290 (2014). e275.","journal-title":"Neoplasia"},{"key":"134_CR37","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1136\/gutjnl-2011-300178","volume":"61","author":"KL Kong","year":"2012","unstructured":"Kong, K. L. et al. MicroRNA-375 inhibits tumour growth and metastasis in oesophageal squamous cell carcinoma through repressing insulin-like growth factor 1 receptor. Gut 61, 33\u201342 (2012).","journal-title":"Gut"},{"key":"134_CR38","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.bbrc.2014.01.028","volume":"444","author":"Y Wang","year":"2014","unstructured":"Wang, Y., Tang, Q., Li, M., Jiang, S. & Wang, X. MicroRNA-375 inhibits colorectal cancer growth by targeting PIK3CA. Biochem. Biophys. Res. Commun. 444, 199\u2013204 (2014).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"134_CR39","doi-asserted-by":"publisher","first-page":"3357","DOI":"10.1038\/onc.2011.500","volume":"31","author":"XX He","year":"2012","unstructured":"He, X. X. et al. MicroRNA-375 targets AEG-1 in hepatocellular carcinoma and suppresses liver cancer cell growth in vitro and in vivo. Oncogene 31, 3357\u20133369 (2012).","journal-title":"Oncogene"},{"key":"134_CR40","doi-asserted-by":"publisher","first-page":"950","DOI":"10.3892\/ijmm.2014.1638","volume":"33","author":"J Zhou","year":"2014","unstructured":"Zhou, J. et al. MicroRNA-375 targets PDK1 in pancreatic carcinoma and suppresses cell growth through the Akt signaling pathway. Int. J. Mol. Med. 33, 950\u2013956 (2014).","journal-title":"Int. J. Mol. Med."},{"key":"134_CR41","doi-asserted-by":"publisher","first-page":"2849","DOI":"10.1007\/s10620-011-1711-1","volume":"56","author":"X Li","year":"2011","unstructured":"Li, X., Lin, R. & Li, J. Epigenetic silencing of microRNA-375 regulates PDK1 expression in esophageal cancer. Dig. Dis. Sci. 56, 2849\u20132856 (2011).","journal-title":"Dig. Dis. Sci."},{"key":"134_CR42","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1002\/ijc.28563","volume":"135","author":"JW Yan","year":"2014","unstructured":"Yan, J. W., Lin, J. S. & He, X. X. The emerging role of miR\u2010375 in cancer. Int. J. Cancer 135, 1011\u20131018 (2014).","journal-title":"Int. J. Cancer"},{"key":"134_CR43","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-016-0198-1","volume":"8","author":"F Zehentmayr","year":"2016","unstructured":"Zehentmayr, F. et al. Hsa-miR-375 is a predictor of local control in early stage breast cancer. Clin. Epigenetics 8, 28 (2016).","journal-title":"Clin. Epigenetics"},{"key":"134_CR44","doi-asserted-by":"publisher","first-page":"4170","DOI":"10.1158\/0008-5472.CAN-13-3569","volume":"74","author":"S Song","year":"2014","unstructured":"Song, S. et al. Hippo coactivator YAP1 upregulates SOX9 and endows esophageal cancer cells with stem-like properties. Cancer Res. 74, 4170\u20134182 (2014).","journal-title":"Cancer Res."},{"key":"134_CR45","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1101\/gad.192856.112","volume":"26","author":"Y Liu-Chittenden","year":"2012","unstructured":"Liu-Chittenden, Y. et al. Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP. Genes Dev. 26, 1300\u20131305 (2012).","journal-title":"Genes Dev."},{"key":"134_CR46","doi-asserted-by":"publisher","first-page":"1962","DOI":"10.1101\/gad.1664408","volume":"22","author":"B Zhao","year":"2008","unstructured":"Zhao, B. et al. TEAD mediates YAP-dependent gene induction and growth control. Genes Dev. 22, 1962\u20131971 (2008).","journal-title":"Genes Dev."},{"key":"134_CR47","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1053\/j.gastro.2008.04.003","volume":"135","author":"QW Wong","year":"2008","unstructured":"Wong, Q. W. et al. MicroRNA-223 is commonly repressed in hepatocellular carcinoma and potentiates expression of Stathmin1. Gastroenterology 135, 257\u2013269 (2008).","journal-title":"Gastroenterology"}],"container-title":["Cell Death &amp; Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41419-017-0134-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41419-017-0134-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41419-017-0134-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T11:34:51Z","timestamp":1671536091000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41419-017-0134-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,24]]},"references-count":47,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,2]]}},"alternative-id":["134"],"URL":"https:\/\/doi.org\/10.1038\/s41419-017-0134-0","relation":{},"ISSN":["2041-4889"],"issn-type":[{"value":"2041-4889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,24]]},"assertion":[{"value":"20 June 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 January 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"92"}}