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However, the underlying mechanism is still unclear. Here, we report that WDR60 is essential for embryonic development and plays a critical role in the multipolar-bipolar transition and migration of newborn neurons during brain development. Mechanically, we found that WDR60 was located at the microtubule-organizing center to control microtubule organization and possibly, the trafficking of cellular components. Importantly, the migration defect caused by <jats:italic>Wdr60<\/jats:italic> knockdown could be rescued by the stable form of \u03b1-Tubulin, \u03b1-Tubulin<jats:sup>K40Q<\/jats:sup> (an acetylation-mimicking mutant). These findings identified a non-cilia function of WDR60 and provided insight into its biological function, as well as the pathogenesis of WDR60 deficiency associated with SRPS.<\/jats:p>","DOI":"10.1038\/s41419-020-03363-3","type":"journal-article","created":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T20:14:49Z","timestamp":1610482489000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["SRPS associated protein WDR60 regulates the multipolar-to-bipolar transition of migrating neurons during cortical development"],"prefix":"10.1038","volume":"12","author":[{"given":"Cui","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0488-2624","authenticated-orcid":false,"given":"Yufang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4809-2851","authenticated-orcid":false,"given":"Zhiheng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,12]]},"reference":[{"key":"3363_CR1","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1038\/nrg799","volume":"3","author":"A Gupta","year":"2002","unstructured":"Gupta, A., Tsai, L. 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All animal experiments were approved by the Institutional Animal Care and Use Committee at Institute of Genetics and Developmental Biology, Chinese Academy of Sciences.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}}],"article-number":"75"}}