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However, the exact function of OMD during mineralization and its association with BMP2 remain poorly understood. Herein, the expression pattern of OMD during osteogenesis was investigated in human dental pulp stem cells. Silencing\n                    <jats:italic>OMD<\/jats:italic>\n                    gene significantly suppressed the alkaline phosphatase activity, mineralized nodule formation and osteogenesis-associated gene transcription. Besides, OMD could enhance BMP2-induced expression of\n                    <jats:italic>SP7<\/jats:italic>\n                    and\n                    <jats:italic>RUNX2<\/jats:italic>\n                    with concentration dependence in vitro. Rat mandibular bone defect model revealed that scaffolds injected with the combination of OMD and suboptimal BMP2 exhibited more mature and abundant mineralized bone than that treated with OMD or suboptimal BMP2 alone. Mechanistically, OMD could bind to BMP2 via its terminal leucine-rich repeats and formed complexes with BMP2 and its membrane receptors, thus promoting BMP\/SMAD signal transduction. In addition, OMD was a putative target gene of SMAD4, which plays a pivotal role in this pathway. Collectively, these data elucidate that OMD may act as a positive coordinator in osteogenesis through BMP2\/SMADs signaling.\n                  <\/jats:p>","DOI":"10.1038\/s41419-021-03404-5","type":"journal-article","created":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T05:05:38Z","timestamp":1612415138000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Osteomodulin positively regulates osteogenesis through interaction with BMP2"],"prefix":"10.1038","volume":"12","author":[{"given":"Wenzhen","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengying","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4374-1055","authenticated-orcid":false,"given":"Daming","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9861-514X","authenticated-orcid":false,"given":"Zhengwei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,1]]},"reference":[{"key":"3404_CR1","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1016\/j.tibtech.2016.04.001","volume":"7","author":"DO Visscher","year":"2016","unstructured":"Visscher, D. 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The original Figure E, the magnified ALP staining image labeled as siRNA2 was inadvertently imported from siRNA1 due to insufficient image annotation. Consequently, these two panels exhibit overlapping regions, as both derive from siRNA1-treated cells. While the overview ALP staining results for both siRNA1 and siRNA2 were correctly presented, the magnified images contained this error.","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 January 2026","order":9,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":10,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":11,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s41419-025-08120-y","URL":"https:\/\/doi.org\/10.1038\/s41419-025-08120-y","order":12,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the Ethics Committee of Shanghai Ninth People\u2019s Hospital affiliated with Shanghai Jiao Tong University, School of Medicine, China (Document No. 201769). Animal protocols were approved by the Animal Experimental Ethics Committee of the Ninth People\u2019s Hospital affiliated with the Shanghai Jiao Tong University School of Medicine (Shanghai, China) (Document No. SH9H-2019-A729-1).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}}],"article-number":"147"}}