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We observed that TUG1 was upregulated in PA tissues and was associated with invasion, knosp grade and tumor size. TUG1 particularly bound to miR-187-3p. TUG1 knockdown inhibited cell proliferation, invasion, migration, and epithelial\u2013mesenchymal transition, promoted apoptosis, and regulated the expression of NF-\u03baB p65 and inhibitor of \u03baB (I\u03baB)-\u03b1 in PA cells lines in vitro, and also inhibited tumor growth in vivo, and these effects were reversed by miR-187-3p reduction. Similarly, miR-187-3p elevation inhibited PA cell malignant behaviors and modulated the expression of NF-\u03baB p65 and I\u03baB-\u03b1 in PA cells, and reduced in vivo tumor growth as well. TUG1 inhibition downregulated TESC, which was targeted by miR-187-3p. In conclusion, this study suggests that TUG1 sponges miR-187-3p to affect PA development by elevating TESC and regulating the NF-\u03baB signaling pathway.<\/jats:p>","DOI":"10.1038\/s41419-021-03812-7","type":"journal-article","created":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T18:02:30Z","timestamp":1621620150000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Long non-coding RNA TUG1\/microRNA-187-3p\/TESC axis modulates progression of pituitary adenoma via regulating the NF-\u03baB signaling pathway"],"prefix":"10.1038","volume":"12","author":[{"given":"Rui","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haitao","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haocong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinghao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianxin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,5,21]]},"reference":[{"key":"3812_CR1","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1097\/COC.0b013e31819d878d","volume":"33","author":"CS Platta","year":"2010","unstructured":"Platta, C. 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