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It is characterized by hyperproliferation and abnormal differentiation of keratinocytes. Keratinocyte death is also involved in many pathophysiological conditions and amplifies the inflammatory cascade. As a newly recognized form of cell death, ferroptosis is involved in several inflammatory diseases. In this study, we aimed to investigate a previously unrecognized role for ferroptosis in psoriasis. Ferroptosis is mediated by lipid peroxidation and iron overload. Compared with normal lesions, the mRNA expression of acyl-CoA synthetase long-chain family member 4 (<jats:italic>ACSL4<\/jats:italic>), prostaglandin-endoperoxide synthase 2 (<jats:italic>PTGS2<\/jats:italic>), and transferrin receptor (<jats:italic>TFRC<\/jats:italic>) were highly expressed in psoriatic lesions, with decreased levels of glutathione peroxidase 4 (<jats:italic>GPX4<\/jats:italic>), ferritin light chain (<jats:italic>FTL<\/jats:italic>), and ferritin heavy chain 1 (<jats:italic>FTH1<\/jats:italic>). The protein levels of ACSL4 and GPX4 were consistent with their mRNA levels. A similar tendency of ferroptosis was also observed in erastin-treated human primary keratinocytes and the Imiquimod (IMQ)-induced model of psoriasis. To investigate the correlation between inflammation and peroxidation, we analyzed single-cell RNA-sequencing data and identified 15 cell types. There was a high correlation between the activity of the lipid oxidation and the Th22\/Th17 response in keratinocytes at a single-cell level. Moreover, ferrostatin-1 (Fer-1), a potent inhibitor of lipid peroxidation, suppressed ferroptosis-related changes in erastin-treated keratinocytes and alleviated psoriasiform dermatitis of IMQ-induced models. Additionally, Fer-1 blocked inflammatory responses in vitro and in vivo, reducing the production of cytokines including <jats:italic>TNF-\u03b1<\/jats:italic>, <jats:italic>IL-6<\/jats:italic>, <jats:italic>IL-1\u03b1<\/jats:italic>, <jats:italic>IL-1\u03b2<\/jats:italic>, <jats:italic>IL-17<\/jats:italic>, <jats:italic>IL-22<\/jats:italic>, and <jats:italic>IL-23<\/jats:italic>. This study revealed an expression pattern of ferroptosis in which specific molecules enhance inflammatory reactions in psoriasis.<\/jats:p>","DOI":"10.1038\/s41419-021-04284-5","type":"journal-article","created":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T13:03:44Z","timestamp":1635339824000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":214,"title":["Inhibition of keratinocyte ferroptosis suppresses psoriatic inflammation"],"prefix":"10.1038","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9017-9192","authenticated-orcid":false,"given":"Yanhong","family":"Shou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3451-5865","authenticated-orcid":false,"given":"Yongsheng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2725-4903","authenticated-orcid":false,"given":"Jinhua","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,27]]},"reference":[{"key":"4284_CR1","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1001\/jama.2020.4006","volume":"323","author":"AW Armstrong","year":"2020","unstructured":"Armstrong AW, Read C. 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