{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T17:42:21Z","timestamp":1793900541301,"version":"4.8.0"},"reference-count":113,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T00:00:00Z","timestamp":1634860800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T00:00:00Z","timestamp":1634860800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873948"],"award-info":[{"award-number":["81873948"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Dis"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Delayed wound healing causes problems for many patients both physically and psychologically, contributing to pain, economic burden, loss of function, and even amputation. Although many factors affect the wound healing process, abnormally prolonged or augmented inflammation in the wound site is a common cause of poor wound healing. Excessive neutrophil extracellular trap (NET) formation during this phase may amplify inflammation and hinder wound healing. However, the roles of NETs in wound healing are still unclear. Herein, we briefly introduce NET formation and discuss the possible NET-related mechanisms in wound healing. We conclude with a discussion of current studies, focusing on the roles of NETs in diabetic and normoglycemic wounds and the effectiveness of NET-targeting treatments in wound healing.<\/jats:p>","DOI":"10.1038\/s41419-021-04294-3","type":"journal-article","created":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T12:02:55Z","timestamp":1634904175000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":190,"title":["The emerging roles of neutrophil extracellular traps in wound healing"],"prefix":"10.1038","volume":"12","author":[{"given":"Shuainan","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huilin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5973-7080","authenticated-orcid":false,"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3406-8877","authenticated-orcid":false,"given":"Changhong","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6622-2587","authenticated-orcid":false,"given":"Kefang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,22]]},"reference":[{"key":"4294_CR1","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1177\/0022034509359125","volume":"89","author":"S Guo","year":"2010","unstructured":"Guo S, DiPietro LA. Factors affecting wound healing. J Dent Res 2010;89:219\u201329.","journal-title":"J Dent Res"},{"key":"4294_CR2","doi-asserted-by":"publisher","first-page":"1e-S","DOI":"10.1097\/01.prs.0000222562.60260.f9","volume":"117","author":"G Broughton","year":"2006","unstructured":"Broughton G, Janis JE, Attinger CE. Wound healing: an overview. Plast Reconstr Surg. 2006;117:1e-S\u201332e-S.","journal-title":"Plast Reconstr Surg"},{"key":"4294_CR3","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.3390\/ijms17122085","volume":"14","author":"R Zhao","year":"2016","unstructured":"Zhao R, Liang H, Clarke E, Jackson C, Xue M. Inflammation in chronic wounds. Int J Mol Sci. 2016;14:2085.","journal-title":"Int J Mol Sci"},{"key":"4294_CR4","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1038\/nature07039","volume":"453","author":"GC Gurtner","year":"2008","unstructured":"Gurtner GC, Werner S, Barrandon Y, Longaker MT. Wound repair and regeneration. Nature. 2008;453:314\u201321.","journal-title":"Nature"},{"key":"4294_CR5","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1007\/s00441-017-2785-7","volume":"371","author":"J Wang","year":"2018","unstructured":"Wang J. Neutrophils in tissue injury and repair. Cell Tissue Res. 2018;371:531\u20139.","journal-title":"Cell Tissue Res"},{"key":"4294_CR6","doi-asserted-by":"publisher","first-page":"494","DOI":"10.3390\/cells10030494","volume":"10","author":"M Sabbatini","year":"2021","unstructured":"Sabbatini M, Magnelli V, Ren\u00f2 F. NETosis in wound healing: when enough is enough. Cells. 2021;10:494.","journal-title":"Cells"},{"key":"4294_CR7","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1038\/nm.3887","volume":"21","author":"SL Wong","year":"2015","unstructured":"Wong SL, Demers M, Martinod K, Gallant M, Wang Y, Goldfine AB, et al. Diabetes primes neutrophils to undergo NETosis, which impairs wound healing. Nat Med 2015;21:815\u20139.","journal-title":"Nat Med"},{"key":"4294_CR8","doi-asserted-by":"publisher","first-page":"S43","DOI":"10.1016\/j.semarthrit.2019.09.011","volume":"49","author":"M Leppkes","year":"2019","unstructured":"Leppkes M, Schick M, Hohberger B, Mahajan A, Knopf J, Schett G, et al. Updates on NET formation in health and disease. Semin Arthritis Rheum 2019;49:S43\u2013S48.","journal-title":"Semin Arthritis Rheum"},{"key":"4294_CR9","doi-asserted-by":"publisher","first-page":"R65","DOI":"10.1530\/JME-20-0128","volume":"65","author":"R Njeim","year":"2020","unstructured":"Njeim R, Azar WS, Fares AH, Azar ST, Kfoury Kassouf H, Eid AA. NETosis contributes to the pathogenesis of diabetes and its complications. J Mol Endocrinol. 2020;65:R65\u2013R76.","journal-title":"J Mol Endocrinol"},{"key":"4294_CR10","first-page":"4","volume":"303","author":"V Brinkmann","year":"2004","unstructured":"Brinkmann V, Reichard U, Goosmann C, Fauler B, Uhlemann Y, Weiss DS, et al. Neutrophil extracellular traps kill bacteria. Nature. 2004;303:4.","journal-title":"Nature"},{"key":"4294_CR11","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/nm.4294","volume":"23","author":"SK Jorch","year":"2017","unstructured":"Jorch SK, Kubes P. An emerging role for neutrophil extracellular traps in noninfectious disease. Nat Med 2017;23:279\u201387.","journal-title":"Nat Med"},{"key":"4294_CR12","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.2337\/db15-0863","volume":"65","author":"GP Fadini","year":"2016","unstructured":"Fadini GP, Menegazzo L, Rigato M, Scattolini V, Poncina N, Bruttocao A, et al. NETosis delays diabetic wound healing in mice and humans. Diabetes. 2016;65:1061\u201371.","journal-title":"Diabetes"},{"key":"4294_CR13","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/j.celrep.2014.06.044","volume":"8","author":"KD Metzler","year":"2014","unstructured":"Metzler KD, Goosmann C, Lubojemska A, Zychlinsky A, Papayannopoulos V. A myeloperoxidase-containing complex regulates neutrophil elastase release and actin dynamics during NETosis. Cell Rep. 2014;8:883\u201396.","journal-title":"Cell Rep"},{"key":"4294_CR14","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1083\/jcb.201006052","volume":"191","author":"V Papayannopoulos","year":"2010","unstructured":"Papayannopoulos V, Metzler KD, Hakkim A, Zychlinsky A. Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps. J Cell Biol. 2010;191:677\u201391.","journal-title":"J Cell Biol"},{"key":"4294_CR15","first-page":"1286","volume":"79","author":"NV Vorobjeva","year":"2014","unstructured":"Vorobjeva NV, Pinegin BV. Neutrophil extracellular traps: mechanisms of formation and role in health and disease. Biochemistry. 2014;79:1286\u201396.","journal-title":"Biochemistry"},{"key":"4294_CR16","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1083\/jcb.200806072","volume":"184","author":"Y Wang","year":"2009","unstructured":"Wang Y, Li M, Stadler S, Correll S, Li P, Wang D, et al. Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation. J Cell Biol. 2009;184:205\u201313.","journal-title":"J Cell Biol"},{"key":"4294_CR17","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1083\/jcb.200606027","volume":"176","author":"TA Fuchs","year":"2007","unstructured":"Fuchs TA, Abed U, Goosmann C, Hurwitz R, Schulze I, Wahn V, et al. Novel cell death program leads to neutrophil extracellular traps. J Cell Biol. 2007;176:231\u201341.","journal-title":"J Cell Biol"},{"key":"4294_CR18","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1038\/nri.2017.105","volume":"18","author":"V Papayannopoulos","year":"2018","unstructured":"Papayannopoulos V. Neutrophil extracellular traps in immunity and disease. Nat Rev Immunol 2018;18:134\u201347.","journal-title":"Nat Rev Immunol"},{"key":"4294_CR19","doi-asserted-by":"publisher","first-page":"2784","DOI":"10.1182\/blood-2013-04-457671","volume":"122","author":"BG Yipp","year":"2013","unstructured":"Yipp BG, Kubes P. NETosis: how vital is it? Blood. 2013;122:2784\u201394.","journal-title":"Blood"},{"key":"4294_CR20","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1038\/nm.2847","volume":"18","author":"BG Yipp","year":"2012","unstructured":"Yipp BG, Petri B, Salina D, Jenne CN, Scott BNV, Zbytnuik LD, et al. Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo. Nat Med 2012;18:1386\u201393.","journal-title":"Nat Med"},{"key":"4294_CR21","doi-asserted-by":"publisher","first-page":"7413","DOI":"10.4049\/jimmunol.1000675","volume":"185","author":"FH Pilsczek","year":"2010","unstructured":"Pilsczek FH, Salina D, Poon KKH, Fahey C, Yipp BG, Sibley CD, et al. A novel mechanism of rapid nuclear neutrophil extracellular trap formation in response to Staphylococcus aureus. J Immunol 2010;185:7413\u201325.","journal-title":"J Immunol"},{"key":"4294_CR22","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1038\/cdd.2009.96","volume":"16","author":"S Yousefi","year":"2009","unstructured":"Yousefi S, Mihalache C, Kozlowski E, Schmid I, Simon HU. Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps. Cell Death Differ. 2009;16:1438\u201344.","journal-title":"Cell Death Differ"},{"key":"4294_CR23","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1038\/s41581-019-0163-2","volume":"15","author":"C Daniel","year":"2019","unstructured":"Daniel C, Leppkes M, Mu\u00f1oz LE, Schley G, Schett G, Herrmann M. Extracellular DNA traps in inflammation, injury and healing. Nat Rev Nephrol 2019;15:559\u201375.","journal-title":"Nat Rev Nephrol"},{"key":"4294_CR24","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1002\/ajh.24185","volume":"90","author":"M Gavillet","year":"2015","unstructured":"Gavillet M, Martinod K, Renella R, Harris C, Shapiro NI, Wagner DD, et al. Flow cytometric assay for direct quantification of neutrophil extracellular traps in blood samples: flow method for NETs detection. Am J Hematol 2015;90:1155\u20138.","journal-title":"Am J Hematol"},{"key":"4294_CR25","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.cca.2016.05.029","volume":"459","author":"S Masuda","year":"2016","unstructured":"Masuda S, Nakazawa D, Shida H, Miyoshi A, Kusunoki Y, Tomaru U, et al. NETosis markers: Quest for specific, objective, and quantitative markers. Clin Chim Acta. 2016;459:89\u201393.","journal-title":"Clin Chim Acta"},{"key":"4294_CR26","first-page":"461","volume":"7","author":"MF Konig","year":"2016","unstructured":"Konig MF, Andrade F. A critical reappraisal of neutrophil extracellular traps and NETosis mimics based on differential requirements for protein citrullination. Front Immunol. 2016;7:461.","journal-title":"Front Immunol"},{"key":"4294_CR27","doi-asserted-by":"publisher","first-page":"e24437","DOI":"10.7554\/eLife.24437","volume":"6","author":"EF Kenny","year":"2017","unstructured":"Kenny EF, Herzig A, Kr\u00fcger R, Muth A, Mondal S, Thompson PR, et al. Diverse stimuli engage different neutrophil extracellular trap pathways. eLife. 2017;6:e24437.","journal-title":"eLife"},{"key":"4294_CR28","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1676","volume":"3","author":"C Tanikawa","year":"2012","unstructured":"Tanikawa C, Espinosa M, Suzuki A, Masuda K, Yamamoto K, Tsuchiya E, et al. Regulation of histone modification and chromatin structure by the p53\u2013PADI4 pathway. Nat Commun 2012;3:676.","journal-title":"Nat Commun"},{"key":"4294_CR29","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7673","volume":"6","author":"E Kolaczkowska","year":"2015","unstructured":"Kolaczkowska E, Jenne CN, Surewaard BGJ, Thanabalasuriar A, Lee W-Y, Sanz M-J, et al. Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculature. Nat Commun 2015;6:6673.","journal-title":"Nat Commun"},{"key":"4294_CR30","doi-asserted-by":"publisher","first-page":"869","DOI":"10.4049\/jimmunol.1700905","volume":"200","author":"S Gupta","year":"2018","unstructured":"Gupta S, Chan DW, Zaal KJ, Kaplan MJ. A high-throughput real-time imaging technique to quantify NETosis and distinguish mechanisms of cell death in human neutrophils. J Immunol 2018;200:869\u201379.","journal-title":"J Immunol"},{"key":"4294_CR31","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/nri3399","volume":"13","author":"E Kolaczkowska","year":"2013","unstructured":"Kolaczkowska E, Kubes P. Neutrophil recruitment and function in health and inflammation. Nat Rev Immunol 2013;13:159\u201375.","journal-title":"Nat Rev Immunol"},{"key":"4294_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0014-2999(02)02182-9","volume":"451","author":"K Kawabata","year":"2002","unstructured":"Kawabata K, Hagio T, Matsuoka S. The role of neutrophil elastase in acute lung injury. Eur J Pharmacol 2002;451:1\u201310.","journal-title":"Eur J Pharmacol"},{"key":"4294_CR33","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.jdermsci.2020.10.009","volume":"100","author":"T Phillips","year":"2020","unstructured":"Phillips T, Huitema L, Cepeda R, Cobos DL, Perez RIM, Garza MS, et al. Aberrant recruitment of leukocytes defines poor wound healing in patients with recessive dystrophic epidermolysis bullosa. J Dermatol Sci 2020;100:209\u201316.","journal-title":"J Dermatol Sci"},{"key":"4294_CR34","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1038\/80489","volume":"6","author":"GS Ashcroft","year":"2000","unstructured":"Ashcroft GS, Lei K, Jin W, Longenecker G, Kulkarni AB, Greenwell-Wild T, et al. Secretory leukocyte protease inhibitor mediates non-redundant functions necessary for normal wound healing. Nat Med 2000;6:1147\u201353.","journal-title":"Nat Med"},{"key":"4294_CR35","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1016\/S0092-8674(02)01141-8","volume":"111","author":"J Zhu","year":"2002","unstructured":"Zhu J, Nathan C, Jin W, Sim D, Ashcroft GS, Wahl SM, et al. Conversion of proepithelin to epithelins. Cell. 2002;111:867\u201378.","journal-title":"Cell"},{"key":"4294_CR36","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1038\/emm.2004.35","volume":"36","author":"SK Lee","year":"2004","unstructured":"Lee SK, Lee SS, Song IS, Kim YS, Park YW, Joo JY, et al. Paradoxical effects of elastase inhibitor guamerin on the tissue repair of two different wound models: sealed cutaneous and exposed tongue wounds. Exp Mol Med 2004;36:259\u201367.","journal-title":"Exp Mol Med"},{"key":"4294_CR37","doi-asserted-by":"publisher","first-page":"e2332","DOI":"10.1038\/cddis.2016.200","volume":"7","author":"K Csom\u00f3s","year":"2016","unstructured":"Csom\u00f3s K, Krist\u00f3f E, Jakob B, Csom\u00f3s I, Kov\u00e1cs G, Rotem O, et al. Protein cross-linking by chlorinated polyamines and transglutamylation stabilizes neutrophil extracellular traps. Cell Death Dis. 2016;7:e2332.","journal-title":"Cell Death Dis"},{"key":"4294_CR38","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.abb.2018.01.004","volume":"640","author":"Y Aratani","year":"2018","unstructured":"Aratani Y. Myeloperoxidase: Its role for host defense, inflammation, and neutrophil function. Arch Biochem Biophys 2018;640:47\u201352.","journal-title":"Arch Biochem Biophys"},{"key":"4294_CR39","doi-asserted-by":"publisher","first-page":"2021","DOI":"10.1007\/s10753-020-01294-x","volume":"43","author":"Z Cahilog","year":"2020","unstructured":"Cahilog Z, Zhao H, Wu L, Alam A, Eguchi S, Weng H, et al. The role of neutrophil NETosis in organ injury: novel inflammatory cell death mechanisms. Inflammation. 2020;43:2021\u201332.","journal-title":"Inflammation"},{"key":"4294_CR40","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1681\/ASN.2006040375","volume":"18","author":"D Odobasic","year":"2007","unstructured":"Odobasic D, Kitching AR, Semple TJ, Holdsworth SR. Endogenous myeloperoxidase promotes neutrophil-mediated renal injury, but attenuates T cell immunity inducing crescentic glomerulonephritis. J Am Soc Nephrol 2007;18:760\u201370.","journal-title":"J Am Soc Nephrol"},{"key":"4294_CR41","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1038\/nm.2053","volume":"15","author":"J Xu","year":"2009","unstructured":"Xu J, Zhang X, Pelayo R, Monestier M, Ammollo CT, Semeraro F, et al. Extracellular histones are major mediators of death in sepsis. Nat Med 2009;15:1318\u201321.","journal-title":"Nat Med"},{"key":"4294_CR42","doi-asserted-by":"publisher","first-page":"e2812","DOI":"10.1038\/cddis.2017.52","volume":"8","author":"E Silk","year":"2017","unstructured":"Silk E, Zhao H, Weng H, Ma D. The role of extracellular histone in organ injury. Cell Death Dis. 2017;8:e2812.","journal-title":"Cell Death Dis"},{"key":"4294_CR43","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1681\/ASN.2016080925","volume":"28","author":"D Nakazawa","year":"2017","unstructured":"Nakazawa D, Kumar SV, Marschner J, Desai J, Holderied A, Rath L, et al. Histones and neutrophil extracellular traps enhance tubular necrosis and remote organ injury in ischemic AKI. J Am Soc Nephrol 2017;28:1753\u201368.","journal-title":"J Am Soc Nephrol"},{"key":"4294_CR44","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1111\/j.1749-6632.2001.tb03869.x","volume":"945","author":"S Holdenrieder","year":"2006","unstructured":"Holdenrieder S, Stieber P, Bodenm\u00fcller H, Busch M, Pawel J, Schalhorn A, et al. Circulating nucleosomes in serum. Ann N Y Acad Sci. 2006;945:93\u2013102.","journal-title":"Ann N Y Acad Sci"},{"key":"4294_CR45","doi-asserted-by":"publisher","first-page":"e2518","DOI":"10.1038\/cddis.2016.410","volume":"7","author":"G Marsman","year":"2016","unstructured":"Marsman G, Zeerleder S, Luken BM. Extracellular histones, cell-free DNA, or nucleosomes: differences in immunostimulation. Cell Death Dis. 2016;7:e2518.","journal-title":"Cell Death Dis"},{"key":"4294_CR46","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.clindermatol.2006.12.005","volume":"25","author":"NB Menke","year":"2007","unstructured":"Menke NB, Ward KR, Witten TM, Bonchev DG, Diegelmann RF. Impaired wound healing. Clin Dermatol. 2007;25:19\u201325.","journal-title":"Clin Dermatol"},{"key":"4294_CR47","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1046\/j.1524-475X.2002.10903.x","volume":"10","author":"GP Ladwig","year":"2002","unstructured":"Ladwig GP, Robson MC, Liu R, Kuhn MA, Muir DF, Schultz GS. Ratios of activated matrix metalloproteinase-9 to tissue inhibitor of matrix metalloproteinase-1 in wound fluids are inversely correlated with healing of pressure ulcers. Wound Rep Reg. 2002;10:26\u201337.","journal-title":"Wound Rep Reg"},{"key":"4294_CR48","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1006\/jsre.1998.5495","volume":"81","author":"BC Nwomeh","year":"1999","unstructured":"Nwomeh BC, Liang H-X, Cohen IK, Yager DR. MMP-8 Is the predominant collagenase in healing wounds and nonhealing ulcers. J Surg Res 1999;81:189\u201395.","journal-title":"J Surg Res"},{"key":"4294_CR49","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1046\/j.1524-475X.1998.60206.x","volume":"6","author":"BC Nwomeh","year":"1998","unstructured":"Nwomeh BC, Liang H-X, Diegelmann RF, Cohen IK, Yager DR. Dynamics of the matrix metalloproteinases MMP-1 and MMP-8 in acute open human dermal wounds. Wound Rep. Reg. 1998;6:127\u201334.","journal-title":"Wound Rep. Reg"},{"key":"4294_CR50","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1159\/000339613","volume":"49","author":"JM Reinke","year":"2012","unstructured":"Reinke JM, Sorg H. Wound repair and regeneration. Eur Surg Res 2012;49:35\u201343.","journal-title":"Eur Surg Res"},{"key":"4294_CR51","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1016\/j.jcyt.2019.09.002","volume":"21","author":"K Kaushik","year":"2019","unstructured":"Kaushik K, Das A. Endothelial progenitor cell therapy for chronic wound tissue regeneration. Cytotherapy. 2019;21:1137\u201350.","journal-title":"Cytotherapy"},{"key":"4294_CR52","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1136\/annrheumdis-2013-204837","volume":"74","author":"C Carmona-Rivera","year":"2015","unstructured":"Carmona-Rivera C, Zhao W, Yalavarthi S, Kaplan MJ. Neutrophil extracellular traps induce endothelial dysfunction in systemic lupus erythematosus through the activation of matrix metalloproteinase-2. Ann Rheum Dis 2015;74:1417\u201324.","journal-title":"Ann Rheum Dis"},{"key":"4294_CR53","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1161\/ATVBAHA.117.309002","volume":"37","author":"E Pieterse","year":"2017","unstructured":"Pieterse E, Rother N, Garsen M, Hofstra JM, Satchell SC, Hoffmann M, et al. Neutrophil extracellular traps drive endothelial-to-mesenchymal transition. Arterioscler Thromb Vasc Biol 2017;37:1371\u20139.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"4294_CR54","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1164\/rccm.201206-1037OC","volume":"187","author":"ST Abrams","year":"2013","unstructured":"Abrams ST, Zhang N, Manson J, Liu T, Dart C, Baluwa F, et al. Circulating histones are mediators of trauma-associated lung injury. Am J Respir Crit Care Med 2013;187:160\u20139.","journal-title":"Am J Respir Crit Care Med"},{"key":"4294_CR55","doi-asserted-by":"publisher","first-page":"e32366","DOI":"10.1371\/journal.pone.0032366","volume":"7","author":"M Saffarzadeh","year":"2012","unstructured":"Saffarzadeh M, Juenemann C, Queisser MA, Lochnit G, Barreto G, Galuska SP, et al. Neutrophil extracellular traps directly induce epithelial and endothelial cell death: a predominant role of histones. PLoS ONE. 2012;7:e32366.","journal-title":"PLoS ONE"},{"key":"4294_CR56","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1161\/ATVBAHA.118.311150","volume":"38","author":"EJ Folco","year":"2018","unstructured":"Folco EJ, Mawson TL, Vromman A, Bernardes-Souza B, Franck G, Persson O, et al. Neutrophil extracellular traps induce endothelial cell activation and tissue factor production through interleukin-1\u03b1 and cathepsin G. Arterioscler Thromb Vasc Biol 2018;38:1901\u201312.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"4294_CR57","doi-asserted-by":"publisher","first-page":"6690","DOI":"10.1111\/jcmm.15321","volume":"24","author":"Y Lu","year":"2020","unstructured":"Lu Y, Dong Y, Zhang Y, Shen D, Wang X, Ge R, et al. Antiphospholipid antibody\u2010activated NETs exacerbate trophoblast and endothelial cell injury in obstetric antiphospholipid syndrome. J Cell Mol Med 2020;24:6690\u2013703.","journal-title":"J Cell Mol Med"},{"key":"4294_CR58","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.jdermsci.2018.08.010","volume":"92","author":"R Safi","year":"2018","unstructured":"Safi R, Kallas R, Bardawil T, Mehanna CJ, Abbas O, Hamam R, et al. Neutrophils contribute to vasculitis by increased release of neutrophil extracellular traps in Beh\u00e7et\u2019s disease. J Dermatol Sci 2018;92:143\u201350.","journal-title":"J Dermatol Sci"},{"key":"4294_CR59","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1016\/S0140-6736(05)67700-8","volume":"366","author":"V Falanga","year":"2005","unstructured":"Falanga V. Wound healing and its impairment in the diabetic foot. Lancet. 2005;366:1736\u201343.","journal-title":"Lancet"},{"key":"4294_CR60","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.jdermsci.2017.05.010","volume":"88","author":"S Tonello","year":"2017","unstructured":"Tonello S, Rizzi M, Migliario M, Rocchetti V, Ren\u00f2 F. Low concentrations of neutrophil extracellular traps induce proliferation in human keratinocytes via NF-kB activation. J Dermatol Sci 2017;88:110\u20136.","journal-title":"J Dermatol Sci"},{"key":"4294_CR61","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1016\/j.jid.2019.10.017","volume":"140","author":"K Bitschar","year":"2020","unstructured":"Bitschar K, Staudenmaier L, Klink L, Focken J, Sauer B, Fehrenbacher B, et al. Staphylococcus aureus skin colonization is enhanced by the Interaction of neutrophil extracellular traps with keratinocytes. J Invest Dermatol 2020;140:1054. e4","journal-title":"J Invest Dermatol"},{"key":"4294_CR62","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1002\/path.4359","volume":"233","author":"A Chrysanthopoulou","year":"2014","unstructured":"Chrysanthopoulou A, Mitroulis I, Apostolidou E, Arelaki S, Mikroulis D, Konstantinidis T, et al. Neutrophil extracellular traps promote differentiation and function of fibroblasts: NETs induce fibrosis via differentiation of fibroblasts. J Pathol 2014;233:294\u2013307.","journal-title":"J Pathol"},{"key":"4294_CR63","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s00395-019-0740-3","volume":"114","author":"TM Hofbauer","year":"2019","unstructured":"Hofbauer TM, Mangold A, Scherz T, Seidl V, Panzenb\u00f6ck A, Ondracek AS, et al. Neutrophil extracellular traps and fibrocytes in ST-segment elevation myocardial infarction. Basic Res Cardiol 2019;114:33.","journal-title":"Basic Res Cardiol"},{"key":"4294_CR64","doi-asserted-by":"publisher","first-page":"2064","DOI":"10.3389\/fimmu.2018.02064","volume":"9","author":"A Arampatzioglou","year":"2018","unstructured":"Arampatzioglou A, Papazoglou D, Konstantinidis T, Chrysanthopoulou A, Mitsios A, Angelidou I, et al. Clarithromycin enhances the antibacterial activity and wound healing capacity in type 2 Diabetes Mellitus by increasing LL-37 load on neutrophil extracellular traps. Front Immunol 2018;9:2064.","journal-title":"Front Immunol"},{"key":"4294_CR65","doi-asserted-by":"publisher","first-page":"3964","DOI":"10.4049\/jimmunol.0903356","volume":"184","author":"T Lucas","year":"2010","unstructured":"Lucas T, Waisman A, Ranjan R, Roes J, Krieg T, M\u00fcller W, et al. Differential roles of macrophages in diverse phases of skin repair. J Immunol 2010;184:3964\u201377.","journal-title":"J Immunol"},{"key":"4294_CR66","doi-asserted-by":"publisher","first-page":"2647","DOI":"10.4049\/jimmunol.1300436","volume":"191","author":"C Farrera","year":"2013","unstructured":"Farrera C, Fadeel B. Macrophage clearance of neutrophil extracellular traps is a silent process. J Immunol 2013;191:2647\u201356.","journal-title":"J Immunol"},{"key":"4294_CR67","doi-asserted-by":"publisher","first-page":"2276","DOI":"10.4049\/jimmunol.1800159","volume":"203","author":"B Lazzaretto","year":"2019","unstructured":"Lazzaretto B, Fadeel B. Intra- and extracellular degradation of neutrophil extracellular traps by macrophages and dendritic cells. J Immunol 2019;203:2276\u201390.","journal-title":"J Immunol"},{"key":"4294_CR68","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0538-5","volume":"9","author":"L Chen","year":"2018","unstructured":"Chen L, Zhao Y, Lai D, Zhang P, Yang Y, Li Y, et al. Neutrophil extracellular traps promote macrophage pyroptosis in sepsis. Cell Death Dis. 2018;9:597.","journal-title":"Cell Death Dis"},{"key":"4294_CR69","doi-asserted-by":"publisher","first-page":"e134796","DOI":"10.1172\/jci.insight.134796","volume":"5","author":"T Josefs","year":"2020","unstructured":"Josefs T, Barrett TJ, Brown EJ, Quezada A, Wu X, Voisin M, et al. Neutrophil extracellular traps promote macrophage inflammation and impair atherosclerosis resolution in diabetic mice. JCI Insight. 2020;5:e134796.","journal-title":"JCI Insight"},{"key":"4294_CR70","first-page":"944","volume":"77","author":"A Barrera-Vargas","year":"2018","unstructured":"Barrera-Vargas A, G\u00f3mez-Mart\u00edn D, Carmona-Rivera C, Merayo-Chalico J, Torres-Ruiz J, Manna Z, et al. Differential ubiquitination in NETs regulates macrophage responses in systemic lupus erythematosus. Ann Rheum Dis 2018;77:944\u201350.","journal-title":"Ann Rheum Dis"},{"key":"4294_CR71","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/s00011-020-01328-y","volume":"69","author":"GV Ganesh","year":"2020","unstructured":"Ganesh GV, Ramkumar KM. Macrophage mediation in normal and diabetic wound healing responses. Inflamm Res 2020;69:347\u201363.","journal-title":"Inflamm Res"},{"key":"4294_CR72","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1189\/jlb.4MR0316-102R","volume":"100","author":"LA DiPietro","year":"2016","unstructured":"DiPietro LA. Angiogenesis and wound repair: when enough is enough. J Leukoc Biol 2016;100:979\u201384.","journal-title":"J Leukoc Biol"},{"key":"4294_CR73","doi-asserted-by":"publisher","first-page":"3708","DOI":"10.1182\/blood-2011-01-332676","volume":"118","author":"TA Fuchs","year":"2011","unstructured":"Fuchs TA, Bhandari AA, Wagner DD. Histones induce rapid and profound thrombocytopenia in mice. Blood. 2011;118:3708\u201314.","journal-title":"Blood"},{"key":"4294_CR74","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1111\/wrr.12560","volume":"25","author":"HI Korkmaz","year":"2017","unstructured":"Korkmaz HI, Ulrich MMW, Vogels S, de Wit T, van Zuijlen PPM, Krijnen PAJ, et al. Neutrophil extracellular traps coincide with a pro-coagulant status of microcirculatory endothelium in burn wounds: NETs and thrombi formation in burns. Wound Rep Reg. 2017;25:609\u201317.","journal-title":"Wound Rep Reg"},{"key":"4294_CR75","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1126\/science.aam8897","volume":"358","author":"M Jim\u00e9nez-Alc\u00e1zar","year":"2017","unstructured":"Jim\u00e9nez-Alc\u00e1zar M, Rangaswamy C, Panda R, Bitterling J, Simsek YJ, Long AT, et al. Host DNases prevent vascular occlusion by neutrophil extracellular traps. Science. 2017;358:1202\u20136.","journal-title":"Science"},{"key":"4294_CR76","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1182\/blood.2020008913","volume":"138","author":"R Wang","year":"2021","unstructured":"Wang R, Zhu Y, Liu Z, Chang L, Bai X, Kang L, et al. Neutrophil extracellular traps promote tPA-induced brain hemorrhage via cGAS in mice with stroke. Blood. 2021;138:91\u2013103.","journal-title":"Blood"},{"key":"4294_CR77","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1097\/SLA.0000000000003586","volume":"272","author":"JH Eustache","year":"2020","unstructured":"Eustache JH, Tohme S, Milette S, Rayes RF, Tsung A, Spicer JD. Casting a wide Net on surgery: the central role of neutrophil extracellular traps. Ann Surg. 2020;272:277\u201383.","journal-title":"Ann Surg"},{"key":"4294_CR78","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16191-y","volume":"11","author":"L Kang","year":"2020","unstructured":"Kang L, Yu H, Yang X, Zhu Y, Bai X, Wang R, et al. Neutrophil extracellular traps released by neutrophils impair revascularization and vascular remodeling after stroke. Nat Commun 2020;11:2488.","journal-title":"Nat Commun"},{"key":"4294_CR79","doi-asserted-by":"publisher","first-page":"eaay5356","DOI":"10.1126\/science.aay5356","volume":"369","author":"F Binet","year":"2020","unstructured":"Binet F, Cagnone G, Crespo-Garcia S, Hata M, Neault M, Dejda A, et al. Neutrophil extracellular traps target senescent vasculature for tissue remodeling in retinopathy. Science. 2020;369:eaay5356.","journal-title":"Science"},{"key":"4294_CR80","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1161\/ATVBAHA.116.307634","volume":"36","author":"L Aldabbous","year":"2016","unstructured":"Aldabbous L, Abdul-Salam V, McKinnon T, Duluc L, Pepke-Zaba J, Southwood M, et al. Neutrophil extracellular traps promote angiogenesis: evidence from vascular pathology in pulmonary hypertension. Arterioscler Thromb Vasc Biol 2016;36:2078\u201387.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"4294_CR81","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1161\/CIRCRESAHA.119.314581","volume":"125","author":"N Sorvillo","year":"2019","unstructured":"Sorvillo N, Cherpokova D, Martinod K, Wagner DD. Extracellular DNA NET-works with dire consequences for health. Circ Res 2019;125:470\u201388.","journal-title":"Circ Res"},{"key":"4294_CR82","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1111\/imm.12437","volume":"145","author":"O Rodr\u00edguez-Espinosa","year":"2015","unstructured":"Rodr\u00edguez-Espinosa O, Rojas-Espinosa O, Moreno-Altamirano MMB, L\u00f3pez-Villegas EO, S\u00e1nchez-Garc\u00eda FJ. Metabolic requirements for neutrophil extracellular traps formation. Immunology. 2015;145:213\u201324.","journal-title":"Immunology"},{"key":"4294_CR83","doi-asserted-by":"publisher","first-page":"e0245594","DOI":"10.1371\/journal.pone.0245594","volume":"16","author":"VF Martins","year":"2021","unstructured":"Martins VF, Dobson CR, Begur M, Parekh J, Ball ST, Gonzalez F, et al. Surgical site peptidylarginine deaminase 4 (PAD4), a biomarker of NETosis, correlates with insulin resistance in total joint arthroplasty patients: a preliminary report. PLoS ONE. 2021;16:e0245594.","journal-title":"PLoS ONE"},{"key":"4294_CR84","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1042\/CS20180600","volume":"133","author":"D Liu","year":"2019","unstructured":"Liu D, Yang P, Gao M, Yu T, Shi Y, Zhang M, et al. NLRP3 activation induced by neutrophil extracellular traps sustains inflammatory response in the diabetic wound. Clin Sci. 2019;133:565\u201382.","journal-title":"Clin Sci"},{"key":"4294_CR85","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1161\/CIRCULATIONAHA.117.032636","volume":"138","author":"M Westerterp","year":"2018","unstructured":"Westerterp M, Fotakis P, Ouimet M, Bochem AE, Zhang H, Molusky MM, et al. Cholesterol efflux pathways suppress inflammasome activation, NETosis, and atherogenesis. Circulation. 2018;138:898\u2013912.","journal-title":"Circulation"},{"key":"4294_CR86","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1038\/s41420-020-00318-7","volume":"6","author":"W Huang","year":"2020","unstructured":"Huang W, Jiao J, Liu J, Huang M, Hu Y, Ran W, et al. MFG-E8 accelerates wound healing in diabetes by regulating \u201cNLRP3 inflammasome-neutrophil extracellular traps\u201d axis. Cell Death Discov. 2020;6:84.","journal-title":"Cell Death Discov"},{"key":"4294_CR87","doi-asserted-by":"publisher","first-page":"2467","DOI":"10.2337\/db20-0585","volume":"69","author":"C Liu","year":"2020","unstructured":"Liu C, Teo MHY, Pek SLT, Wu X, Leong ML, Tay HM, et al. A multifunctional role of Leucine-Rich \u03b1-2-Glycoprotein 1 in cutaneous wound healing under normal and diabetic conditions. Diabetes. 2020;69:2467\u201380.","journal-title":"Diabetes"},{"key":"4294_CR88","doi-asserted-by":"publisher","first-page":"BSR20171459","DOI":"10.1042\/BSR20171459","volume":"38","author":"SK Das","year":"2018","unstructured":"Das SK, Yuan YF, Li MQ. Specific PKC \u03b2II inhibitor: one stone two birds in the treatment of diabetic foot ulcers. Biosci Rep. 2018;38:BSR20171459.","journal-title":"Biosci Rep"},{"key":"4294_CR89","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1038\/s41423-019-0252-y","volume":"17","author":"YS Lee","year":"2020","unstructured":"Lee YS, Kang SU, Lee M-H, Kim H-J, Han C-H, Won H-R, et al. GnRH impairs diabetic wound healing through enhanced NETosis. Cell Mol Immunol 2020;17:856\u201364.","journal-title":"Cell Mol Immunol"},{"key":"4294_CR90","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1089\/wound.2019.0943","volume":"9","author":"S Yang","year":"2020","unstructured":"Yang S, Gu Z, Lu C, Zhang T, Guo X, Xue G, et al. Neutrophil extracellular traps are markers of wound healing impairment in patients with diabetic foot ulcers treated in a multidisciplinary setting. Adv Wound Care. 2020;9:16\u201327.","journal-title":"Adv Wound Care"},{"key":"4294_CR91","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1007\/s00592-018-1129-8","volume":"55","author":"L Menegazzo","year":"2018","unstructured":"Menegazzo L, Scattolini V, Cappellari R, Bonora BM, Albiero M, Bortolozzi M, et al. The antidiabetic drug metformin blunts NETosis in vitro and reduces circulating NETosis biomarkers in vivo. Acta Diabetol 2018;55:593\u2013601.","journal-title":"Acta Diabetol"},{"key":"4294_CR92","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1016\/j.jid.2018.10.015","volume":"139","author":"T Miura","year":"2019","unstructured":"Miura T, Kawakami K, Kanno E, Tanno H, Tada H, Sato N, et al. Dectin-2\u2013mediated signaling leads to delayed skin wound healing through enhanced neutrophilic inflammatory response and neutrophil extracellular trap formation. J Invest Dermatol 2019;139:702\u201311.","journal-title":"J Invest Dermatol"},{"key":"4294_CR93","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.jid.2020.04.030","volume":"141","author":"K Yamaguchi","year":"2021","unstructured":"Yamaguchi K, Kanno E, Tanno H, Sasaki A, Kitai Y, Miura T, et al. Distinct roles for dectin-1 and dectin-2 in skin wound healing and neutrophilic inflammatory responses. J Invest Dermatol 2021;141:164.","journal-title":"J Invest Dermatol"},{"key":"4294_CR94","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1172\/JCI92880","volume":"128","author":"EX Stavrou","year":"2018","unstructured":"Stavrou EX, Fang C, Bane KL, Long AT, Naudin C, Kucukal E, et al. Factor XII and uPAR upregulate neutrophil functions to influence wound healing. J Clin Invest. 2018;128:944\u201359.","journal-title":"J Clin Invest"},{"key":"4294_CR95","doi-asserted-by":"publisher","first-page":"538","DOI":"10.4049\/jimmunol.1100450","volume":"187","author":"E Villanueva","year":"2011","unstructured":"Villanueva E, Yalavarthi S, Berthier CC, Hodgin JB, Khandpur R, Lin AM, et al. Netting neutrophils induce endothelial damage, infiltrate tissues, and expose immunostimulatory molecules in systemic lupus erythematosus. J Immunol 2011;187:538\u201352.","journal-title":"J Immunol"},{"key":"4294_CR96","doi-asserted-by":"publisher","first-page":"614347","DOI":"10.3389\/fimmu.2021.614347","volume":"12","author":"A Heuer","year":"2021","unstructured":"Heuer A, Stiel C, Elrod J, K\u00f6nigs I, Vincent D, Schlegel P, et al. Therapeutic targeting of neutrophil extracellular traps improves primary and secondary intention wound healing in mice. Front Immunol 2021;12:614347.","journal-title":"Front Immunol"},{"key":"4294_CR97","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1182\/blood.2019002329","volume":"135","author":"K Gollomp","year":"2020","unstructured":"Gollomp K, Sarkar A, Harikumar S, Seeholzer SH, Arepally GM, Hudock K, et al. Fc-modified HIT-like monoclonal antibody as a novel treatment for sepsis. Blood. 2020;135:743\u201354.","journal-title":"Blood"},{"key":"4294_CR98","doi-asserted-by":"publisher","first-page":"3212","DOI":"10.1039\/D0BM00355G","volume":"8","author":"T Kaur","year":"2020","unstructured":"Kaur T, Dumoga S, Koul V, Singh N. Modulating neutrophil extracellular traps for wound healing. Biomater Sci 2020;8:3212\u201323.","journal-title":"Biomater Sci"},{"key":"4294_CR99","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-33385-z","volume":"8","author":"Y Zhou","year":"2018","unstructured":"Zhou Y, An L-L, Chaerkady R, Mittereder N, Clarke L, Cohen TS, et al. Evidence for a direct link between PAD4-mediated citrullination and the oxidative burst in human neutrophils. Sci Rep. 2018;8:15228.","journal-title":"Sci Rep."},{"key":"4294_CR100","first-page":"616","volume":"12","author":"J Jones","year":"2009","unstructured":"Jones J, Causey C, Knuckley B, Slack-Noyes JL. Protein arginine deiminase 4 (PAD4): current understanding and future therapeutic potential. Curr Opin Drug Discovery Dev. 2009;12:616\u201327.","journal-title":"Curr Opin Drug Discovery Dev"},{"key":"4294_CR101","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1189\/jlb.3AB0815-379RR","volume":"100","author":"A Hosseinzadeh","year":"2016","unstructured":"Hosseinzadeh A, Thompson PR, Segal BH, Urban CF. Nicotine induces neutrophil extracellular traps. J Leukoc Biol. 2016;100:1105\u201312.","journal-title":"J Leukoc Biol"},{"key":"4294_CR102","doi-asserted-by":"publisher","first-page":"e92926","DOI":"10.1172\/jci.insight.92926","volume":"2","author":"RA Gordon","year":"2017","unstructured":"Gordon RA, Herter JM, Rosetti F, Campbell AM, Nishi H, Kashgarian M, et al. Lupus and proliferative nephritis are PAD4 independent in murine models. JCI Insight. 2017;2:e92926.","journal-title":"JCI Insight"},{"key":"4294_CR103","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1042\/CS20200240","volume":"134","author":"MKS Lee","year":"2020","unstructured":"Lee MKS, Sreejit G, Nagareddy PR, Murphy AJ. Attack of the NETs! NETosis primes IL-1\u03b2-mediated inflammation in diabetic foot ulcers. Clin Sci. 2020;134:1399\u2013401.","journal-title":"Clin Sci"},{"key":"4294_CR104","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.2337\/db13-0483","volume":"63","author":"F Liu","year":"2014","unstructured":"Liu F, Chen D-D, Sun X, Xie H-H, Yuan H, Jia W, et al. Hydrogen sulfide improves wound healing via restoration of endothelial progenitor cell functions and activation of angiopoietin-1 in type 2 diabetes. Diabetes. 2014;63:1763\u201378.","journal-title":"Diabetes"},{"key":"4294_CR105","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.mce.2018.10.013","volume":"480","author":"C Yang","year":"2019","unstructured":"Yang C, Chen L, Chen W, Li N, Chen M, Li X, et al. Hydrogen sulfide primes diabetic wound to close through inhibition of NETosis. Mol Cell Endocrinol 2019;480:74\u201382.","journal-title":"Mol Cell Endocrinol"},{"key":"4294_CR106","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.it.2007.06.002","volume":"28","author":"N Borregaard","year":"2007","unstructured":"Borregaard N, S\u00f8rensen OE, Theilgaard-M\u00f6nch K. Neutrophil granules: a library of innate immunity proteins. Trends Immunol 2007;28:340\u20135.","journal-title":"Trends Immunol"},{"key":"4294_CR107","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1038\/nrgastro.2017.183","volume":"15","author":"M Honda","year":"2018","unstructured":"Honda M, Kubes P. Neutrophils and neutrophil extracellular traps in the liver and gastrointestinal system. Nat Rev Gastroenterol Hepatol 2018;15:206\u201321.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"4294_CR108","doi-asserted-by":"publisher","first-page":"2178","DOI":"10.1182\/blood-2018-11-844530","volume":"133","author":"FVS Castanheira","year":"2019","unstructured":"Castanheira FVS, Kubes P. Neutrophils and NETs in modulating acute and chronic inflammation. Blood. 2019;133:2178\u201385.","journal-title":"Blood"},{"key":"4294_CR109","doi-asserted-by":"publisher","first-page":"328","DOI":"10.3389\/fimmu.2016.00328","volume":"7","author":"S Yousefi","year":"2016","unstructured":"Yousefi S, Simon H-U. NETosis \u2013 does it really represent nature\u2019s \u201csuicide bomber\u201d? Front Immunol. 2016;7:328.","journal-title":"Front Immunol"},{"key":"4294_CR110","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1038\/nm.4027","volume":"22","author":"C Lood","year":"2016","unstructured":"Lood C, Blanco LP, Purmalek MM, Carmona-Rivera C, De Ravin SS, Smith CK, et al. Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease. Nat Med 2016;22:146\u201353.","journal-title":"Nat Med"},{"key":"4294_CR111","first-page":"S6","volume":"34","author":"J Hahn","year":"2016","unstructured":"Hahn J, Knopf J, Maueroeder C, Kienhoefer D, Leppkes M, Herrmann M. Neutrophils and neutrophil extracellular traps orchestrate initiation and resolution of inflammation. Clin Exp Rheumatol 2016;34:S6\u2013S8.","journal-title":"Clin Exp Rheumatol"},{"key":"4294_CR112","doi-asserted-by":"publisher","first-page":"2176","DOI":"10.3389\/fimmu.2019.02176","volume":"10","author":"J Knopf","year":"2019","unstructured":"Knopf J, Leppkes M, Schett G, Herrmann M, Mu\u00f1oz LE. Aggregated NETs sequester and detoxify extracellular histones. Front Immunol 2019;10:2176.","journal-title":"Front Immunol"},{"key":"4294_CR113","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1002\/JLB.3AB0918-370R","volume":"106","author":"MJ Podolska","year":"2019","unstructured":"Podolska MJ, Mahajan A, Hahn J, Knopf J, Mauer\u00f6der C, Petru L, et al. Treatment with DNases rescues hidden neutrophil elastase from aggregated NETs. J Leukoc Biol 2019;106:1359\u201366.","journal-title":"J Leukoc Biol"}],"container-title":["Cell Death &amp; Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41419-021-04294-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41419-021-04294-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41419-021-04294-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T09:21:21Z","timestamp":1669972881000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41419-021-04294-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,22]]},"references-count":113,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,11]]}},"alternative-id":["4294"],"URL":"https:\/\/doi.org\/10.1038\/s41419-021-04294-3","relation":{},"ISSN":["2041-4889"],"issn-type":[{"value":"2041-4889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,22]]},"assertion":[{"value":"3 June 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 September 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 October 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"984"}}