{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T11:35:05Z","timestamp":1793705705934,"version":"4.5.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T00:00:00Z","timestamp":1635811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T00:00:00Z","timestamp":1635811200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772706"],"award-info":[{"award-number":["81772706"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Dis"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Long non-coding RNAs (lncRNAs) act as important regulators of tumorigenesis and development in bladder cancer. However, the underlying molecular mechanisms remain elusive. We previously identified a novel lncRNA signature related to immunity and progression in bladder cancer. Here we further explored the function of RP11-89, a lncRNA discovered in the previous signature. Loss- and gain-of function experiments were performed using CCK-8 assay, flow cytometry, Transwell assays, scratch tests and subcutaneous nude mouse models. High-throughput RNA sequencing was conducted to identify dysregulated genes in bladder cancer cells with RP11-89 knockdown or overexpression. Regulation of RP11-89 on miR-129-5p and PROM2 was explored through luciferase reporter assay, RIP assay and RNA pull-down assay. RP11-89 promoted cell proliferation, migration and tumorigenesis and inhibited cell cycle arrest via the miR-129-5p\/PROM2 axis. We found that RP11-89 \u201csponges\u201d miR-129-5p and upregulates PROM2. Elevated PROM2 in cells was associated with attenuated ferroptosis through iron export, formation of multivesicular bodies and less mitochondrial abnormalities. We demonstrated that RP11-89 is a novel tumorigenic regulator that inhibits ferroptosis via PROM2-activated iron export. RP11-89 may serve as a potential biomarker for targeted therapy in bladder cancer.<\/jats:p>","DOI":"10.1038\/s41419-021-04296-1","type":"journal-article","created":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T04:02:48Z","timestamp":1635825768000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":157,"title":["LncRNA RP11-89 facilitates tumorigenesis and ferroptosis resistance through PROM2-activated iron export by sponging miR-129-5p in bladder cancer"],"prefix":"10.1038","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5412-5373","authenticated-orcid":false,"given":"Wenjie","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunguang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangning","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqiang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6855-9861","authenticated-orcid":false,"given":"Mengfei","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1179-2800","authenticated-orcid":false,"given":"Yuanyuan","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6761-5195","authenticated-orcid":false,"given":"Dingwei","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8015-420X","authenticated-orcid":false,"given":"Yiping","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,2]]},"reference":[{"key":"4296_CR1","doi-asserted-by":"publisher","first-page":"145","DOI":"10.3322\/caac.21601","volume":"70","author":"RL Siegel","year":"2020","unstructured":"Siegel RL, Miller KD, Jemal A. Colorectal cancer statistics, 2020. Cancer J Clin. 2020;70:145\u201364.","journal-title":"Cancer J Clin."},{"key":"4296_CR2","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/s41580-020-00315-9","volume":"22","author":"L Statello","year":"2021","unstructured":"Statello L, Guo CJ, Chen LL, Huarte M. Gene regulation by long non-coding RNAs and its biological functions. Nat Rev Mol Cell Biol. 2021;22:96\u2013118.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"4296_CR3","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1016\/j.eururo.2013.12.003","volume":"65","author":"ES Martens-Uzunova","year":"2014","unstructured":"Martens-Uzunova ES, Bottcher R, Croce CM, Jenster G, Visakorpi T, Calin GA. Long noncoding RNA in prostate, bladder, and kidney cancer. Eur Urol. 2014;65:1140\u201351.","journal-title":"Eur Urol"},{"key":"4296_CR4","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/nrm.2017.104","volume":"19","author":"JD Ransohoff","year":"2018","unstructured":"Ransohoff JD, Wei Y, Khavari PA. The functions and unique features of long intergenic non-coding RNA. Nat Rev Mol Cell Biol. 2018;19:143\u201357.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"4296_CR5","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1038\/nrg3074","volume":"12","author":"M Esteller","year":"2011","unstructured":"Esteller M. Non-coding RNAs in human disease. Nat Rev Genet. 2011;12:861\u201374.","journal-title":"Nat Rev Genet"},{"key":"4296_CR6","doi-asserted-by":"publisher","first-page":"115.","DOI":"10.1186\/s12943-020-01232-3","volume":"19","author":"X He","year":"2020","unstructured":"He X, Chai P, Li F, Zhang L, Zhou C, Yuan X, et al. A novel LncRNA transcript, RBAT1, accelerates tumorigenesis through interacting with HNRNPL and cis-activating E2F3. Mol Cancer. 2020;19:115.","journal-title":"Mol Cancer"},{"key":"4296_CR7","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","volume":"149","author":"S Dixon","year":"2012","unstructured":"Dixon S, Lemberg K, Lamprecht M, Skouta R, Zaitsev E, Gleason C, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149:1060\u201372.","journal-title":"Cell"},{"key":"4296_CR8","doi-asserted-by":"publisher","unstructured":"Jiang X, Stockwell B, Conrad, M. Ferroptosis: mechanisms, biology and role in disease. Nat Rev Mol Cell Biol. 2021. https:\/\/doi.org\/10.1038\/s41580-020-00324-8.","DOI":"10.1038\/s41580-020-00324-8"},{"key":"4296_CR9","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","volume":"149","author":"SJ Dixon","year":"2012","unstructured":"Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev, Eleina M, Gleason CE, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 2012;149:1060\u201372.","journal-title":"Cell"},{"key":"4296_CR10","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.molcel.2018.10.042","volume":"73","author":"M Gao","year":"2019","unstructured":"Gao M, Yi J, Zhu J, Minikes AM, Monian P, Thompson CB, et al. Role of mitochondria in ferroptosis. Mol Cell. 2019;73:354\u201363.","journal-title":"Mol Cell"},{"key":"4296_CR11","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1016\/j.ccell.2019.04.002","volume":"35","author":"B Hassannia","year":"2019","unstructured":"Hassannia B, Vandenabeele P, Berghe TV. Targeting ferroptosis to iron out cancer. Cancer Cell. 2019;35:830\u201349.","journal-title":"Cancer Cell"},{"key":"4296_CR12","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1038\/s41589-019-0408-1","volume":"15","author":"M Conrad","year":"2019","unstructured":"Conrad M, Pratt DA. The chemical basis of ferroptosis. Nat Chem Biol. 2019;15:1137\u201347.","journal-title":"Nat Chem Biol"},{"key":"4296_CR13","doi-asserted-by":"publisher","unstructured":"Chen X, Kang R, Kroemer G, Tang D. Broadening horizons: the role of ferroptosis in cancer. Nat Rev Clin Oncol. 2021. https:\/\/doi.org\/10.1038\/s41571-020-00462-0.","DOI":"10.1038\/s41571-020-00462-0"},{"key":"4296_CR14","doi-asserted-by":"publisher","unstructured":"Wang H, Cheng Y, Mao C, Liu S, Xiao D, Huang, J, et al. Emerging mechanisms and targeted therapy of ferroptosis in cancer. Mol Ther. 2021. https:\/\/doi.org\/10.1016\/j.ymthe.2021.03.022.","DOI":"10.1016\/j.ymthe.2021.03.022"},{"key":"4296_CR15","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1038\/nature24297","volume":"551","author":"M Hangauer","year":"2017","unstructured":"Hangauer M, Viswanathan V, Ryan M, Bole D, Eaton J, Matov A, et al. Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition. Nature. 2017;551:247\u201350.","journal-title":"Nature"},{"key":"4296_CR16","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/nature23007","volume":"547","author":"V Viswanathan","year":"2017","unstructured":"Viswanathan V, Ryan M, Dhruv H, Gill S, Eichhoff O, Seashore-Ludlow B, et al. Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway. Nature. 2017;547:453\u20137.","journal-title":"Nature"},{"key":"4296_CR17","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1016\/j.cell.2018.04.012","volume":"173","author":"L Wang","year":"2018","unstructured":"Wang L, Leite de Oliveira R, Huijberts S, Bosdriesz E, Pencheva N, Brunen D, et al. An acquired vulnerability of drug-resistant melanoma with therapeutic potential. Cell. 2018;173:1413\u201314.","journal-title":"Cell"},{"key":"4296_CR18","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1158\/2159-8290.CD-19-0338","volume":"9","author":"X Lang","year":"2019","unstructured":"Lang X, Green M, Wang W, Yu J, Choi J, Jiang L, et al. Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11. Cancer Discov. 2019;9:1673\u201385.","journal-title":"Cancer Discov"},{"key":"4296_CR19","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1158\/0008-5472.CAN-18-3037","volume":"79","author":"T Liu","year":"2019","unstructured":"Liu T, Jiang L, Tavana O, Gu W. The deubiquitylase OTUB1 mediates ferroptosis via stabilization of SLC7A11. Cancer Res. 2019;79:1913\u201324.","journal-title":"Cancer Res."},{"key":"4296_CR20","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/s41586-019-1170-y","volume":"569","author":"W Wang","year":"2019","unstructured":"Wang W, Green M, Choi J, Gij\u00f3n M, Kennedy P, Johnson J, et al. CD8 T cells regulate tumour ferroptosis during cancer immunotherapy. Nature. 2019;569:270\u20134.","journal-title":"Nature"},{"key":"4296_CR21","doi-asserted-by":"publisher","first-page":"406.","DOI":"10.1038\/s41419-020-2618-6","volume":"11","author":"D Kim","year":"2020","unstructured":"Kim D, Kim W, Kim S, Moon D, Lee SJ. Disease TGF-\u03b21-mediated repression of SLC7A11 drives vulnerability to GPX4 inhibition in hepatocellular carcinoma cells.Cell Death Dis. 2020;11:406.","journal-title":"Cell Death Dis"},{"key":"4296_CR22","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1016\/j.cell.2019.04.024","volume":"177","author":"DR Green","year":"2019","unstructured":"Green DR. The coming decade of cell death research: five riddles. Cell. 2019;177:1094\u2013107.","journal-title":"Cell"},{"key":"4296_CR23","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1016\/j.cmet.2021.02.015","volume":"33","author":"X Ma","year":"2021","unstructured":"Ma X, Xiao L, Liu L, Ye L, Su P, Bi E, et al. CD36-mediated ferroptosis dampens intratumoral CD8 T cell effector function and impairs their antitumor ability. Cell Metab. 2021;33:1001\u201312.","journal-title":"Cell Metab"},{"key":"4296_CR24","doi-asserted-by":"publisher","first-page":"3503.","DOI":"10.1038\/s41467-018-05992-x","volume":"9","author":"L Wang","year":"2018","unstructured":"Wang L, Saci A, Szabo P, Chasalow S, Castillo-Martin M, Domingo-Domenech J, et al. EMT-related and stroma-related gene expression and resistance to PD-1 blockade in urothelial cancer. Nat Commun. 2018;9:3503.","journal-title":"Nat Commun."},{"key":"4296_CR25","doi-asserted-by":"publisher","first-page":"4326","DOI":"10.1111\/jcmm.16494","volume":"25","author":"W-J Luo","year":"2021","unstructured":"Luo W-J, Tian X, Xu W-H, Qu Y-Y, Zhu W-K, Wu J, et al. Construction of an immune-related LncRNA signature with prognostic significance for bladder cancer. J Cell Mol Med. 2021;25:4326\u201339.","journal-title":"J Cell Mol Med"},{"key":"4296_CR26","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.biopha.2018.05.105","volume":"105","author":"Q Liu","year":"2018","unstructured":"Liu Q, Jiang J, Fu Y, Liu T, Yu Y, Zhang X. MiR-129-5p functions as a tumor suppressor in gastric cancer progression through targeting ADAM9. Biomed Pharmacother. 2018;105:420\u20137.","journal-title":"Biomed Pharmacother"},{"key":"4296_CR27","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-021-01820-3","volume":"21","author":"B Gao","year":"2021","unstructured":"Gao B, Wang L, Zhang N, Han M, Zhang Y, Liu H, et al. miR-129-5p inhibits clear cell renal cell carcinoma cell proliferation, migration and invasion by targeting SPN. Cancer Cell Int. 2021;21:263.","journal-title":"Cancer Cell Int"},{"key":"4296_CR28","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/nature12477","volume":"500","author":"L Alexandrov","year":"2013","unstructured":"Alexandrov L, Nik-Zainal S, Wedge D, Aparicio S, Behjati S, Biankin A, et al. Signatures of mutational processes in human cancer. Nature. 2013;500:415\u201321.","journal-title":"Nature"},{"key":"4296_CR29","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1038\/nature12213","volume":"499","author":"M Lawrence","year":"2013","unstructured":"Lawrence M, Stojanov P, Polak P, Kryukov G, Cibulskis K, Sivachenko A, et al. Mutational heterogeneity in cancer and the search for new cancer-associated genes. Nature. 2013;499:214\u20138.","journal-title":"Nature"},{"key":"4296_CR30","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/s41568-020-00313-1","volume":"21","author":"L Tran","year":"2021","unstructured":"Tran L, Xiao J, Agarwal N, Duex J. Theodorescu, D. Advances in bladder cancer biology and therapy. Nat Rev Cancer. 2021;21:104\u201321.","journal-title":"Nat Rev Cancer"},{"key":"4296_CR31","doi-asserted-by":"publisher","first-page":"25.","DOI":"10.1186\/s12943-020-1143-7","volume":"19","author":"Y Zhan","year":"2020","unstructured":"Zhan Y, Chen Z, He S, Gong Y, He A, Li Y, et al. Long non-coding RNA SOX2OT promotes the stemness phenotype of bladder cancer cells by modulating SOX2. Mol Cancer. 2020;19:25.","journal-title":"Mol Cancer"},{"key":"4296_CR32","doi-asserted-by":"publisher","unstructured":"Xu Y, Qiu M, Shen M, Dong S, Ye G, Shi X, et al. The emerging regulatory roles of long non-coding RNAs implicated in cancer metabolism. Mol Ther. 2021. https:\/\/doi.org\/10.1016\/j.ymthe.2021.03.017.","DOI":"10.1016\/j.ymthe.2021.03.017"},{"key":"4296_CR33","doi-asserted-by":"publisher","first-page":"5403","DOI":"10.1038\/s41388-021-01948-6","volume":"40","author":"D Li","year":"2021","unstructured":"Li D, She J, Hu X, Zhang M, Sun R, Qin S. The ELF3-regulated lncRNA UBE2CP3 is over-stabilized by RNA\u2013RNA interactions and drives gastric cancer metastasis via miR-138-5p\/ITGA2 axis. Oncogene2021;40:5403\u201315.","journal-title":"Oncogene"},{"key":"4296_CR34","doi-asserted-by":"publisher","first-page":"2098","DOI":"10.1111\/jcmm.14050","volume":"24","author":"C Wu","year":"2020","unstructured":"Wu C, Miao C, Tang Q, Zhou X, Xi P, Chang P, et al. MiR-129-5p promotes docetaxel resistance in prostate cancer by down-regulating CAMK2N1 expression. J Cell Mol Med. 2020;24:2098\u2013108.","journal-title":"J Cell Mol Med"},{"key":"4296_CR35","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.devcel.2019.10.007","volume":"51","author":"CW Brown","year":"2019","unstructured":"Brown CW, Amante JJ, Chhoy P, Baer CE, Dixon SJ, Mercurio AM. Prominin2 drives ferroptosis resistance by stimulating iron export. Dev Cell. 2019;51:575\u201386.","journal-title":"Dev Cell"},{"key":"4296_CR36","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1038\/s41417-019-0109-7","volume":"27","author":"SK Saha","year":"2020","unstructured":"Saha SK, Islam SMR, Kwak KS, Rahman MS, Cho SG. PROM1 and PROM2 expression differentially modulates clinical prognosis of cancer: a multiomics analysis. Cancer Gene Ther. 2020;27:147\u201367.","journal-title":"Cancer Gene Ther"},{"key":"4296_CR37","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/nrc3183","volume":"12","author":"B Keith","year":"2011","unstructured":"Keith B, Johnson R, Simon MC. HIF1\u0251 and HIF2\u0251: sibling rivalry in hypoxic tumour growth and progression. Nat Rev Cancer. 2011;12:9\u201322.","journal-title":"Nat Rev Cancer"},{"key":"4296_CR38","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1200\/JCO.2017.74.2627","volume":"36","author":"K Courtney","year":"2018","unstructured":"Courtney K, Infante J, Lam E, Figlin R, Rini B, Brugarolas J, et al. Phase I dose-escalation trial of PT2385, a first-in-class hypoxia-inducible factor-2\u0251 antagonist in patients with previously treated advanced clear cell renal cell carcinoma. J Clin Oncol. 2018;36:867\u201374.","journal-title":"J Clin Oncol"},{"key":"4296_CR39","first-page":"54367","volume":"12","author":"P Guo","year":"2020","unstructured":"Guo P, Wang L, Shang W, Chen J, Chen Z, Xiong F, et al. In situ intravesical immunostimulatory gel for triple therapy of bladder. Cancer 2020;12:54367\u201377.","journal-title":"Cancer"},{"key":"4296_CR40","doi-asserted-by":"publisher","first-page":"686044","DOI":"10.3389\/fonc.2021.686044","volume":"11","author":"L Yang","year":"2021","unstructured":"Yang L, Li C, Qin Y, Zhang G, Zhao B, Wang Z, et al. A novel prognostic model based on ferroptosis-related gene signature for bladder cancer. Front Oncol. 2021;11:686044.","journal-title":"Front Oncol"},{"key":"4296_CR41","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-021-02096-3","volume":"21","author":"JC Luan","year":"2021","unstructured":"Luan JC, Zeng TY, Zhang QJ, Xia DR, Cong R, Yao LY, et al. A novel signature constructed by ferroptosis-associated genes (FAGs) for the prediction of prognosis in bladder urothelial carcinoma (BLCA) and associated with immune infiltration. Cancer Cell Int. 2021;21:414.","journal-title":"Cancer Cell Int"},{"key":"4296_CR42","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/s41568-020-00313-1","volume":"21","author":"L Tran","year":"2021","unstructured":"Tran L, Xiao JF, Agarwal N, Duex JE, Theodorescu D. Advances in bladder cancer biology and therapy. Nat Rev Cancer. 2021;21:104\u201321.","journal-title":"Nat Rev Cancer"},{"key":"4296_CR43","doi-asserted-by":"publisher","DOI":"10.1038\/s41585-021-00481-1.","author":"N Lobo","year":"2021","unstructured":"Lobo N, Brooks NA, Zlotta AR, Cirillo JD, Boorjian S, Black PC, et al. 100 years of Bacillus Calmette\u2013Gu\u00e9rin immunotherapy: from cattle to COVID-19. Nat Rev Urol. 2021. https:\/\/doi.org\/10.1038\/s41585-021-00481-1.","journal-title":"Nat Rev Urol"},{"key":"4296_CR44","doi-asserted-by":"publisher","first-page":"2062","DOI":"10.1093\/bioinformatics\/bts344","volume":"28","author":"A Jeggari","year":"2012","unstructured":"Jeggari A, Marks DS, Larsson E. miRcode: a map of putative microRNA target sites in the long non-coding transcriptome. Bioinformatics 2012;28:2062\u20133.","journal-title":"Bioinformatics"},{"key":"4296_CR45","doi-asserted-by":"publisher","first-page":"D92","DOI":"10.1093\/nar\/gkt1248","volume":"42","author":"J Li","year":"2014","unstructured":"Li J, Liu S, Zhou H, Qu L, Yang JH. starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data. Nucleic Acids Res. 2014;42:D92\u201397.","journal-title":"Nucleic Acids Res"},{"key":"4296_CR46","doi-asserted-by":"publisher","first-page":"R90.","DOI":"10.1186\/gb-2010-11-8-r90","volume":"11","author":"D Betel","year":"2010","unstructured":"Betel D, Koppal A, Agius P, Sander C, Leslie C. Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites. Genome Biol. 2010;11:R90.","journal-title":"Genome Biol."},{"key":"4296_CR47","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/978-1-4939-1062-5_25","volume":"1182","author":"H Dweep","year":"2014","unstructured":"Dweep H, Gretz N, Sticht C. miRWalk database for miRNA-target interactions. RNA Mapp. 2014;1182:289\u2013305.","journal-title":"RNA Mapp"},{"key":"4296_CR48","doi-asserted-by":"publisher","first-page":"baaa021.","DOI":"10.1093\/database\/baaa021","volume":"2020","author":"N Zhou","year":"2020","unstructured":"Zhou N, Bao J. FerrDb: a manually curated resource for regulators and markers of ferroptosis and ferroptosis-disease associations. Database. 2020;2020:baaa021.","journal-title":"Database"},{"key":"4296_CR49","doi-asserted-by":"publisher","first-page":"185.","DOI":"10.1186\/s13059-019-1758-4","volume":"20","author":"D Otasek","year":"2019","unstructured":"Otasek D, Morris J, Bou\u00e7as J, Pico A, Demchak B. Cytoscape automation: empowering workflow-based network analysis. Genome Biol. 2019;20:185.","journal-title":"Genome Biol."},{"key":"4296_CR50","doi-asserted-by":"publisher","first-page":"1523.","DOI":"10.1038\/s41467-019-09234-6","volume":"10","author":"Y Zhou","year":"2019","unstructured":"Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi A, Tanaseichuk O, et al. Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat Commun. 2019;10:1523.","journal-title":"Nat Commun."}],"container-title":["Cell Death &amp; Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41419-021-04296-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41419-021-04296-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41419-021-04296-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T22:49:46Z","timestamp":1699742986000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41419-021-04296-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,2]]},"references-count":50,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,11]]}},"alternative-id":["4296"],"URL":"https:\/\/doi.org\/10.1038\/s41419-021-04296-1","relation":{},"ISSN":["2041-4889"],"issn-type":[{"value":"2041-4889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,2]]},"assertion":[{"value":"9 June 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 October 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 October 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 November 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All experiments performed with human samples were approved by the Fudan University Shanghai Cancer Center (FUSCC) Ethics Committee. Written informed consent was obtained from all patients. All animal procedures were approved by the Animal Care and Use Committee of the Medical Institution of Fudan University Shanghai Cancer Center.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1043"}}