{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:39:40Z","timestamp":1787002780175,"version":"build-2736575974"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T00:00:00Z","timestamp":1710892800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T00:00:00Z","timestamp":1710892800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970969"],"award-info":[{"award-number":["81970969"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001088"],"award-info":[{"award-number":["82001088"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81830031"],"award-info":[{"award-number":["81830031"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["469177153"],"award-info":[{"award-number":["469177153"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Dis"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Craniofacial malformations, often associated with syndromes, are prevalent birth defects. Emerging evidence underscores the importance of m\n                    <jats:sup>6<\/jats:sup>\n                    A modifications in various bioprocesses such as stem cell differentiation, tissue development, and tumorigenesis. Here, in vivo, experiments with zebrafish models revealed that\n                    <jats:italic>mettl3<\/jats:italic>\n                    -knockdown embryos at 144\u2009h postfertilization exhibited aberrant craniofacial features, including altered mouth opening, jaw dimensions, ethmoid plate, tooth formation and hypoactive behavior. Similarly, low METTL3 expression inhibited the proliferation and migration of BMSCs, HEPM cells, and DPSCs. Loss of METTL3 led to reduced mRNA m\n                    <jats:sup>6<\/jats:sup>\n                    A methylation and PSEN1 expression, impacting craniofacial phenotypes. Co-injection of\n                    <jats:italic>mettl3<\/jats:italic>\n                    or\n                    <jats:italic>psen1<\/jats:italic>\n                    mRNA rescued the level of Sox10 fusion protein, promoted voluntary movement, and mitigated abnormal craniofacial phenotypes induced by\n                    <jats:italic>mettl3<\/jats:italic>\n                    knockdown in zebrafish. Mechanistically, YTHDF1 enhanced the mRNA stability of m\n                    <jats:sup>6<\/jats:sup>\n                    A-modified\n                    <jats:italic>PSEN1<\/jats:italic>\n                    , while decreased METTL3-mediated m\n                    <jats:sup>6<\/jats:sup>\n                    A methylation hindered \u03b2-catenin binding to PSEN1, suppressing Wnt\/\u03b2-catenin signaling. Pharmacological activation of the Wnt\/\u03b2-catenin pathway partially alleviated the phenotypes of\n                    <jats:italic>mettl3<\/jats:italic>\n                    morphant and reversed the decreases in cell proliferation and migration induced by METTL3 silencing. This study elucidates the pivotal role of METTL3 in craniofacial development via the METTL3\/YTHDF1\/PSEN1\/\u03b2-catenin signaling axis.\n                  <\/jats:p>","DOI":"10.1038\/s41419-024-06606-9","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T13:01:32Z","timestamp":1710939692000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["METTL3-dependent m6A modification of PSEN1 mRNA regulates craniofacial development through the Wnt\/\u03b2-catenin signaling pathway"],"prefix":"10.1038","volume":"15","author":[{"given":"Lan","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2413-4743","authenticated-orcid":false,"given":"Siyue","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6719-3447","authenticated-orcid":false,"given":"Barbara","family":"Vona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwen","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6899-5994","authenticated-orcid":false,"given":"Yongchu","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,20]]},"reference":[{"key":"6606_CR1","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/0039-6257(90)90067-6","volume":"35","author":"PD Fries","year":"1990","unstructured":"Fries PD, Katowitz JA. Congenital craniofacial anomalies of ophthalmic importance. Surv Ophthalmol. 1990;35:87\u2013119.","journal-title":"Surv Ophthalmol"},{"key":"6606_CR2","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1097\/00019052-199804000-00004","volume":"11","author":"FV Elmslie","year":"1998","unstructured":"Elmslie FV, Reardon W. Craniofacial developmental abnormalities. Curr Opin Neurol. 1998;11:103\u20138.","journal-title":"Curr Opin Neurol"},{"key":"6606_CR3","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.clp.2015.02.005","volume":"42","author":"JA Hamm","year":"2015","unstructured":"Hamm JA, Robin NH. Newborn craniofacial malformations: orofacial clefting and craniosynostosis. Clin Perinatol. 2015;42:321\u201336.","journal-title":"Clin Perinatol"},{"key":"6606_CR4","first-page":"110","volume":"18","author":"N Kajdic","year":"2018","unstructured":"Kajdic N, Spazzapan P, Velnar T. Craniosynostosis - Recognition, clinical characteristics, and treatment. Bosn J Basic Med Sci. 2018;18:110\u20136.","journal-title":"Bosn J Basic Med Sci"},{"key":"6606_CR5","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1097\/PRS.0000000000008927","volume":"149","author":"KJ Zuo","year":"2022","unstructured":"Zuo KJ, Heinelt M, Ho ES, Forrest CR, Zuker RM, Borschel GH. Dynamic reconstruction of facial paralysis in craniofacial microsomia. Plast Reconstr Surg. 2022;149:919\u201329.","journal-title":"Plast Reconstr Surg"},{"key":"6606_CR6","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1016\/j.otc.2019.06.002","volume":"52","author":"B Hopkins","year":"2019","unstructured":"Hopkins B, Dean K, Appachi S, Drake AF. Craniofacial interventions in children. Otolaryngol Clin North Am. 2019;52:903\u201322.","journal-title":"Otolaryngol Clin North Am"},{"key":"6606_CR7","doi-asserted-by":"publisher","first-page":"953","DOI":"10.3390\/ijms23020953","volume":"23","author":"A Jaruga","year":"2022","unstructured":"Jaruga A, Ksiazkiewicz J, Kuzniarz K, Tylzanowski P. Orofacial cleft and mandibular prognathism-human genetics and animal models. Int J Mol Sci. 2022;23:953.","journal-title":"Int J Mol Sci"},{"key":"6606_CR8","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1038\/s41556-019-0315-4","volume":"21","author":"S Xiao","year":"2019","unstructured":"Xiao S, Cao S, Huang Q, Xia L, Deng M, Yang M, et al. The RNA N(6)-methyladenosine modification landscape of human fetal tissues. Nat Cell Biol. 2019;21:651\u201361.","journal-title":"Nat Cell Biol"},{"key":"6606_CR9","doi-asserted-by":"publisher","first-page":"6251","DOI":"10.1093\/nar\/gkaa347","volume":"48","author":"H Zhang","year":"2020","unstructured":"Zhang H, Shi X, Huang T, Zhao X, Chen W, Gu N, et al. Dynamic landscape and evolution of m6A methylation in human. Nucleic Acids Res. 2020;48:6251\u201364.","journal-title":"Nucleic Acids Res"},{"key":"6606_CR10","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1038\/s41580-019-0168-5","volume":"20","author":"S Zaccara","year":"2019","unstructured":"Zaccara S, Ries RJ, Jaffrey SR. Reading, writing and erasing mRNA methylation. Nat Rev Mol Cell Biol. 2019;20:608\u201324.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"6606_CR11","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.molcel.2019.04.025","volume":"74","author":"H Shi","year":"2019","unstructured":"Shi H, Wei J, He C. Where, when, and how: context-dependent functions of RNA methylation writers, readers, and erasers. Mol Cell. 2019;74:640\u201350.","journal-title":"Mol Cell"},{"key":"6606_CR12","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0843-z","volume":"9","author":"M Sorci","year":"2018","unstructured":"Sorci M, Ianniello Z, Cruciani S, Larivera S, Ginistrelli LC, Capuano E, et al. METTL3 regulates WTAP protein homeostasis. Cell Death Dis. 2018;9:796.","journal-title":"Cell Death Dis"},{"key":"6606_CR13","doi-asserted-by":"publisher","first-page":"e18434","DOI":"10.7554\/eLife.18434","volume":"5","author":"P Sledz","year":"2016","unstructured":"Sledz P, Jinek M. Structural insights into the molecular mechanism of the m(6)A writer complex. Elife. 2016;5:e18434.","journal-title":"Elife"},{"key":"6606_CR14","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1038\/nature18298","volume":"534","author":"X Wang","year":"2016","unstructured":"Wang X, Feng J, Xue Y, Guan Z, Zhang D, Liu Z, et al. Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex. Nature. 2016;534:575\u20138.","journal-title":"Nature"},{"key":"6606_CR15","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1126\/science.1261417","volume":"347","author":"S Geula","year":"2015","unstructured":"Geula S, Moshitch-Moshkovitz S, Dominissini D, Mansour AA, Kol N, Salmon-Divon M, et al. Stem cells. m6A mRNA methylation facilitates resolution of naive pluripotency toward differentiation. Science. 2015;347:1002\u20136.","journal-title":"Science"},{"key":"6606_CR16","doi-asserted-by":"publisher","first-page":"e2105192118","DOI":"10.1073\/pnas.2105192118","volume":"118","author":"KX Jin","year":"2021","unstructured":"Jin KX, Zuo R, Anastassiadis K, Klungland A, Marr C, Filipczyk A. N6-methyladenosine (m(6)A) depletion regulates pluripotency exit by activating signaling pathways in embryonic stem cells. Proc Natl Acad Sci USA. 2021;118:e2105192118.","journal-title":"Proc Natl Acad Sci USA"},{"key":"6606_CR17","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/s41556-018-0045-z","volume":"20","author":"H Huang","year":"2018","unstructured":"Huang H, Weng H, Sun W, Qin X, Shi H, Wu H, et al. Recognition of RNA N(6)-methyladenosine by IGF2BP proteins enhances mRNA stability and translation. Nat Cell Biol. 2018;20:285\u201395.","journal-title":"Nat Cell Biol"},{"key":"6606_CR18","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1126\/science.abe9582","volume":"376","author":"J Wei","year":"2022","unstructured":"Wei J, Yu X, Yang L, Liu X, Gao B, Huang B, et al. FTO mediates LINE1 m(6)A demethylation and chromatin regulation in mESCs and mouse development. Science. 2022;376:968\u201373.","journal-title":"Science"},{"key":"6606_CR19","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01204-7","volume":"19","author":"T Wang","year":"2020","unstructured":"Wang T, Kong S, Tao M, Ju S. The potential role of RNA N6-methyladenosine in cancer progression. Mol Cancer. 2020;19:88.","journal-title":"Mol Cancer"},{"key":"6606_CR20","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.stem.2021.09.014","volume":"29","author":"R Yin","year":"2022","unstructured":"Yin R, Chang J, Li Y, Gao Z, Qiu Q, Wang Q, et al. Differential m(6)A RNA landscapes across hematopoiesis reveal a role for IGF2BP2 in preserving hematopoietic stem cell function. Cell Stem Cell. 2022;29:149\u201359.e147.","journal-title":"Cell Stem Cell"},{"key":"6606_CR21","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/j.stem.2014.09.019","volume":"15","author":"PJ Batista","year":"2014","unstructured":"Batista PJ, Molinie B, Wang J, Qu K, Zhang J, Li L, et al. m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells. Cell Stem Cell. 2014;15:707\u201319.","journal-title":"Cell Stem Cell"},{"key":"6606_CR22","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1126\/science.aau1646","volume":"361","author":"M Frye","year":"2018","unstructured":"Frye M, Harada BT, Behm M, He C. RNA modifications modulate gene expression during development. Science. 2018;361:1346\u20139.","journal-title":"Science"},{"key":"6606_CR23","doi-asserted-by":"crossref","unstructured":"Guo S, Chen F, Li L, Dou S, Li Q, Huang Y, et al. Intracellular Fusobacterium nucleatum infection increases METTL3-mediated m6A methylation to promote the metastasis of esophageal squamous cell carcinoma. J Adv Res. 2023.","DOI":"10.1016\/j.jare.2023.08.014"},{"key":"6606_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.omtn.2020.01.033","volume":"20","author":"W Zhao","year":"2020","unstructured":"Zhao W, Cui Y, Liu L, Ma X, Qi X, Wang Y, et al. METTL3 facilitates oral squamous cell carcinoma tumorigenesis by enhancing c-Myc stability via YTHDF1-mediated m(6)A modification. Mol Ther Nucleic Acids. 2020;20:1\u201312.","journal-title":"Mol Ther Nucleic Acids"},{"key":"6606_CR25","doi-asserted-by":"publisher","first-page":"7239","DOI":"10.1093\/nar\/gkab378","volume":"49","author":"S Oerum","year":"2021","unstructured":"Oerum S, Meynier V, Catala M, Tisne C. A comprehensive review of m6A\/m6Am RNA methyltransferase structures. Nucleic Acids Res. 2021;49:7239\u201355.","journal-title":"Nucleic Acids Res"},{"key":"6606_CR26","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1038\/nature23883","volume":"549","author":"C Zhang","year":"2017","unstructured":"Zhang C, Chen Y, Sun B, Wang L, Yang Y, Ma D, et al. m(6)A modulates haematopoietic stem and progenitor cell specification. Nature. 2017;549:273\u20136.","journal-title":"Nature"},{"key":"6606_CR27","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/bs.ctdb.2023.01.005","volume":"153","author":"R Chidiac","year":"2023","unstructured":"Chidiac R, Angers S. Wnt signaling in stem cells during development and cell lineage specification. Curr Top Dev Biol. 2023;153:121\u201343.","journal-title":"Curr Top Dev Biol"},{"key":"6606_CR28","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/j.cell.2017.05.016","volume":"169","author":"R Nusse","year":"2017","unstructured":"Nusse R, Clevers H. Wnt\/beta-catenin signaling, disease, and emerging therapeutic modalities. Cell. 2017;169:985\u201399.","journal-title":"Cell"},{"key":"6606_CR29","doi-asserted-by":"publisher","first-page":"3977","DOI":"10.1242\/dev.01943","volume":"132","author":"N Wada","year":"2005","unstructured":"Wada N, Javidan Y, Nelson S, Carney TJ, Kelsh RN, Schilling TF. Hedgehog signaling is required for cranial neural crest morphogenesis and chondrogenesis at the midline in the zebrafish skull. Development. 2005;132:3977\u201388.","journal-title":"Development"},{"key":"6606_CR30","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1016\/j.omtn.2021.10.023","volume":"26","author":"Z Chen","year":"2021","unstructured":"Chen Z, Zhong X, Xia M, Zhong J. The roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseases. Mol Ther Nucleic Acids. 2021;26:1270\u20139.","journal-title":"Mol Ther Nucleic Acids"},{"key":"6606_CR31","doi-asserted-by":"publisher","first-page":"10970","DOI":"10.3390\/ijms231810970","volume":"23","author":"J Bagaria","year":"2022","unstructured":"Bagaria J, Bagyinszky E, An SSA. Genetics, functions, and clinical impact of presenilin-1 (PSEN1) gene. Int J Mol Sci. 2022;23:10970.","journal-title":"Int J Mol Sci"},{"key":"6606_CR32","doi-asserted-by":"publisher","first-page":"8907","DOI":"10.1021\/acs.jmedchem.5b01200","volume":"58","author":"T Neumann","year":"2015","unstructured":"Neumann T, Benajiba L, Goring S, Stegmaier K, Schmidt B. Evaluation of improved glycogen synthase kinase-3alpha inhibitors in models of acute myeloid leukemia. J Med Chem. 2015;58:8907\u201319.","journal-title":"J Med Chem"},{"key":"6606_CR33","doi-asserted-by":"publisher","first-page":"5664","DOI":"10.1158\/0008-5472.CAN-17-0799","volume":"77","author":"F Cichocki","year":"2017","unstructured":"Cichocki F, Valamehr B, Bjordahl R, Zhang B, Rezner B, Rogers P, et al. GSK3 inhibition drives maturation of NK cells and enhances their antitumor activity. Cancer Res. 2017;77:5664\u201375.","journal-title":"Cancer Res"},{"key":"6606_CR34","doi-asserted-by":"publisher","first-page":"2593","DOI":"10.1242\/dev.127.12.2593","volume":"127","author":"M Handler","year":"2000","unstructured":"Handler M, Yang X, Shen J. Presenilin-1 regulates neuronal differentiation during neurogenesis. Development. 2000;127:2593\u2013606.","journal-title":"Development"},{"key":"6606_CR35","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/s41392-020-00450-x","volume":"6","author":"X Jiang","year":"2021","unstructured":"Jiang X, Liu B, Nie Z, Duan L, Xiong Q, Jin Z, et al. The role of m6A modification in the biological functions and diseases. Signal Transduct Target Ther. 2021;6:74.","journal-title":"Signal Transduct Target Ther"},{"key":"6606_CR36","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.stem.2015.09.005","volume":"17","author":"F Aguilo","year":"2015","unstructured":"Aguilo F, Zhang F, Sancho A, Fidalgo M, Di Cecilia S, Vashisht A, et al. Coordination of m(6)A mRNA methylation and gene transcription by ZFP217 regulates pluripotency and reprogramming. Cell Stem Cell. 2015;17:689\u2013704.","journal-title":"Cell Stem Cell"},{"key":"6606_CR37","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1038\/s41590-023-01548-4","volume":"24","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Zhang W, Zhao J, Ito T, Jin J, Aparicio AO, et al. m(6)A RNA modification regulates innate lymphoid cell responses in a lineage-specific manner. Nat Immunol. 2023;24:1256\u201364.","journal-title":"Nat Immunol"},{"key":"6606_CR38","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1177\/00220345211051594","volume":"101","author":"W Cai","year":"2022","unstructured":"Cai W, Ji Y, Han L, Zhang J, Ni Y, Cheng Y, et al. METTL3-dependent glycolysis regulates dental pulp stem cell differentiation. J Dent Res. 2022;101:580\u20139.","journal-title":"J Dent Res"},{"key":"6606_CR39","doi-asserted-by":"publisher","first-page":"1983","DOI":"10.1016\/j.devcel.2023.07.003","volume":"58","author":"X Ibarra-Soria","year":"2023","unstructured":"Ibarra-Soria X, Thierion E, Mok GF, Munsterberg AE, Odom DT, Marioni JC. A transcriptional and regulatory map of mouse somite maturation. Dev Cell. 2023;58:1983\u201395.e7.","journal-title":"Dev Cell"},{"key":"6606_CR40","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.arr.2008.11.003","volume":"8","author":"RA Boonen","year":"2009","unstructured":"Boonen RA, van Tijn P, Zivkovic D. Wnt signaling in Alzheimer\u2019s disease: up or down, that is the question. Ageing Res Rev. 2009;8:71\u201382.","journal-title":"Ageing Res Rev"},{"key":"6606_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.113310","volume":"42","author":"T Vanova","year":"2023","unstructured":"Vanova T, Sedmik J, Raska J, Amruz Cerna K, Taus P, Pospisilova V, et al. Cerebral organoids derived from patients with Alzheimer\u2019s disease with PSEN1\/2 mutations have defective tissue patterning and altered development. Cell Rep. 2023;42:113310.","journal-title":"Cell Rep."},{"key":"6606_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108615","volume":"34","author":"C Arber","year":"2021","unstructured":"Arber C, Lovejoy C, Harris L, Willumsen N, Alatza A, Casey JM, et al. Familial Alzheimer\u2019s disease mutations in PSEN1 lead to premature human stem cell neurogenesis. Cell Rep. 2021;34:108615.","journal-title":"Cell Rep."},{"key":"6606_CR43","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/j.tig.2017.07.015","volume":"33","author":"ML Martik","year":"2017","unstructured":"Martik ML, Bronner ME. Regulatory logic underlying diversification of the neural crest. Trends Genet. 2017;33:715\u201327.","journal-title":"Trends Genet"},{"key":"6606_CR44","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.devcel.2016.06.020","volume":"38","author":"AP Singh","year":"2016","unstructured":"Singh AP, Dinwiddie A, Mahalwar P, Schach U, Linker C, Irion U, et al. Pigment cell progenitors in Zebrafish remain multipotent through metamorphosis. Dev Cell. 2016;38:316\u201330.","journal-title":"Dev Cell"},{"key":"6606_CR45","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-04099-4","volume":"12","author":"X Lai","year":"2021","unstructured":"Lai X, Liu J, Zou Z, Wang Y, Wang Y, Liu X, et al. SOX10 ablation severely impairs the generation of postmigratory neural crest from human pluripotent stem cells. Cell Death Dis. 2021;12:814.","journal-title":"Cell Death Dis"},{"key":"6606_CR46","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1038\/s42003-021-02211-0","volume":"4","author":"RL Cunningham","year":"2021","unstructured":"Cunningham RL, Kramer ET, DeGeorgia SK, Godoy PM, Zarov AP, Seneviratne S, et al. Functional in vivo characterization of sox10 enhancers in neural crest and melanoma development. Commun Biol. 2021;4:695.","journal-title":"Commun Biol"},{"key":"6606_CR47","doi-asserted-by":"publisher","first-page":"e42736","DOI":"10.7554\/eLife.42736","volume":"8","author":"D Giovannone","year":"2019","unstructured":"Giovannone D, Paul S, Schindler S, Arata C, Farmer DT, Patel P, et al. Programmed conversion of hypertrophic chondrocytes into osteoblasts and marrow adipocytes within zebrafish bones. Elife. 2019;8:e42736.","journal-title":"Elife"},{"key":"6606_CR48","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-017-1336-6","volume":"18","author":"PJ Hsu","year":"2017","unstructured":"Hsu PJ, Shi H, He C. Epitranscriptomic influences on development and disease. Genome Biol. 2017;18:197.","journal-title":"Genome Biol"},{"key":"6606_CR49","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1038\/s41418-023-01130-3","volume":"30","author":"Y Feng","year":"2023","unstructured":"Feng Y, Guo S, Zhao Y, Dong H, Qian J, Hu Y, et al. DNA 5mC and RNA m(6)A modification successively facilitates the initiation and perpetuation stages of HSC activation in liver fibrosis progression. Cell Death Differ. 2023;30:1211\u201320.","journal-title":"Cell Death Differ"},{"key":"6606_CR50","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-023-00452-1","volume":"11","author":"W Ren","year":"2023","unstructured":"Ren W, Yuan Y, Li Y, Mutti L, Peng J, Jiang X. The function and clinical implication of YTHDF1 in the human system development and cancer. Biomark Res. 2023;11:5.","journal-title":"Biomark Res"},{"key":"6606_CR51","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1164\/rccm.202009-3419OC","volume":"203","author":"L Hu","year":"2021","unstructured":"Hu L, Wang J, Huang H, Yu Y, Ding J, Yu Y, et al. YTHDF1 regulates pulmonary hypertension through translational control of MAGED1. Am J Respir Crit Care Med. 2021;203:1158\u201372.","journal-title":"Am J Respir Crit Care Med"},{"key":"6606_CR52","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1038\/s41418-019-0427-1","volume":"27","author":"X Chen","year":"2020","unstructured":"Chen X, Wang H, Yu M, Kim JK, Qi H, Ha P, et al. Cumulative inactivation of Nell-1 in Wnt1 expressing cell lineages results in craniofacial skeletal hypoplasia and postnatal hydrocephalus. Cell Death Differ. 2020;27:1415\u201330.","journal-title":"Cell Death Differ"},{"key":"6606_CR53","doi-asserted-by":"publisher","first-page":"7111","DOI":"10.7150\/thno.45286","volume":"10","author":"X Sun","year":"2020","unstructured":"Sun X, Zhang R, Chen H, Du X, Chen S, Huang J, et al. Fgfr3 mutation disrupts chondrogenesis and bone ossification in zebrafish model mimicking CATSHL syndrome partially via enhanced Wnt\/beta-catenin signaling. Theranostics. 2020;10:7111\u201330.","journal-title":"Theranostics"},{"key":"6606_CR54","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1172\/JCI129308","volume":"130","author":"J Marquez","year":"2020","unstructured":"Marquez J, Criscione J, Charney RM, Prasad MS, Hwang WY, Mis EK, et al. Disrupted ER membrane protein complex-mediated topogenesis drives congenital neural crest defects. J Clin Invest. 2020;130:813\u201326.","journal-title":"J Clin Invest"},{"key":"6606_CR55","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.782445","volume":"9","author":"G Sutton","year":"2021","unstructured":"Sutton G, Kelsh RN, Scholpp S. Review: the role of Wnt\/beta-catenin signalling in neural crest development in zebrafish. Front Cell Dev Biol. 2021;9:782445.","journal-title":"Front Cell Dev Biol"},{"key":"6606_CR56","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-021-01006-6","volume":"14","author":"R Restuadi","year":"2022","unstructured":"Restuadi R, Steyn FJ, Kabashi E, Ngo ST, Cheng FF, Nabais MF, et al. Functional characterisation of the amyotrophic lateral sclerosis risk locus GPX3\/TNIP1. Genome Med. 2022;14:7.","journal-title":"Genome Med"},{"key":"6606_CR57","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1016\/j.cell.2022.04.003","volume":"185","author":"A Chen","year":"2022","unstructured":"Chen A, Liao S, Cheng M, Ma K, Wu L, Lai Y, et al. Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays. Cell 2022;185:1777\u201392.e1721.","journal-title":"Cell"},{"key":"6606_CR58","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1016\/j.devcel.2022.04.009","volume":"57","author":"C Liu","year":"2022","unstructured":"Liu C, Li R, Li Y, Lin X, Zhao K, Liu Q, et al. Spatiotemporal mapping of gene expression landscapes and developmental trajectories during zebrafish embryogenesis. Dev Cell. 2022;57:1284\u201398.e1285.","journal-title":"Dev Cell"},{"key":"6606_CR59","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1177\/0022034519872951","volume":"98","author":"Q Jiang","year":"2019","unstructured":"Jiang Q, Mei L, Zou Y, Ding Q, Cannon RD, Chen H, et al. Genetic polymorphisms in FGFR2 underlie skeletal malocclusion. J Dent Res. 2019;98:1340\u20137.","journal-title":"J Dent Res"},{"key":"6606_CR60","doi-asserted-by":"publisher","DOI":"10.1038\/srep11250","volume":"5","author":"F Chen","year":"2015","unstructured":"Chen F, Li Q, Gu M, Li X, Yu J, Zhang YB. Identification of a Mutation in FGF23 involved in mandibular prognathism. Sci Rep. 2015;5:11250.","journal-title":"Sci Rep."},{"key":"6606_CR61","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202100926","volume":"10","author":"R Hesselbarth","year":"2021","unstructured":"Hesselbarth R, Esser TU, Roshanbinfar K, Schrufer S, Schubert DW, Engel FB. CHIR99021 promotes hiPSC-derived cardiomyocyte proliferation in engineered 3D microtissues. Adv Health Mater. 2021;10:e2100926.","journal-title":"Adv Health Mater"},{"key":"6606_CR62","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-7-273","volume":"7","author":"O Naujok","year":"2014","unstructured":"Naujok O, Lentes J, Diekmann U, Davenport C, Lenzen S. Cytotoxicity and activation of the Wnt\/beta-catenin pathway in mouse embryonic stem cells treated with four GSK3 inhibitors. BMC Res Notes. 2014;7:273.","journal-title":"BMC Res Notes"},{"key":"6606_CR63","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/0166-3542(83)90011-6","volume":"3","author":"E de Clercq","year":"1983","unstructured":"de Clercq E, Montgomery JA. Broad-spectrum antiviral activity of the carbocyclic analog of 3-deazaadenosine. Antivir Res. 1983;3:17\u201324.","journal-title":"Antivir Res"},{"key":"6606_CR64","doi-asserted-by":"publisher","first-page":"e91","DOI":"10.1093\/nar\/gkw104","volume":"44","author":"Y Zhou","year":"2016","unstructured":"Zhou Y, Zeng P, Li YH, Zhang Z, Cui Q. SRAMP: prediction of mammalian N6-methyladenosine (m6A) sites based on sequence-derived features. Nucleic Acids Res. 2016;44:e91.","journal-title":"Nucleic Acids Res"},{"key":"6606_CR65","doi-asserted-by":"publisher","first-page":"15995","DOI":"10.1002\/anie.201807942","volume":"57","author":"Y Xiao","year":"2018","unstructured":"Xiao Y, Wang Y, Tang Q, Wei L, Zhang X, Jia G. An elongation- and ligation-based qPCR amplification method for the radiolabeling-free detection of locus-specific N(6)-methyladenosine modification. Angew Chem Int Ed Engl. 2018;57:15995\u201316000.","journal-title":"Angew Chem Int Ed Engl"},{"key":"6606_CR66","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42665-w","volume":"14","author":"H Chen","year":"2023","unstructured":"Chen H, Zhao X, Yang W, Zhang Q, Hao R, Jiang S, et al. RNA N6-methyladenosine modification-based biomarkers for absorbed ionizing radiation dose estimation. Nat Commun. 2023;14:6912.","journal-title":"Nat Commun"},{"key":"6606_CR67","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/S0076-6879(08)02617-7","volume":"448","author":"CY Chen","year":"2008","unstructured":"Chen CY, Ezzeddine N, Shyu AB. Messenger RNA half-life measurements in mammalian cells. Methods Enzymol. 2008;448:335\u201357.","journal-title":"Methods Enzymol"}],"container-title":["Cell Death &amp; Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41419-024-06606-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41419-024-06606-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41419-024-06606-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T13:01:39Z","timestamp":1710939699000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41419-024-06606-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,20]]},"references-count":67,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["6606"],"URL":"https:\/\/doi.org\/10.1038\/s41419-024-06606-9","relation":{},"ISSN":["2041-4889"],"issn-type":[{"value":"2041-4889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,20]]},"assertion":[{"value":"23 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 March 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 March 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study was approved by the Nanjing Medical University Institution Review Board. All animal experiments were approved by the Animal Ethics Committee of the Affiliated Stomatology Hospital of Nanjing Medical University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}],"article-number":"229"}}