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We investigated the role of Transcription Factor Activating Enhancer-Binding Protein 2\u03b5 (AP2\u03b5) in the progression of metastatic melanoma. Here, we observed that AP2\u03b5 is a potent activator of metastasis and newly revealed AP2\u03b5 to be an important player in melanoma plasticity. High levels of AP2\u03b5 lead to worsened prognosis of melanoma patients. Using a transgenic melanoma mouse model with a specific loss of AP2\u03b5 expression, we confirmed the impact of AP2\u03b5 to modulate the dynamic switch from a migratory to a proliferative phenotype. AP2\u03b5 deficient melanoma cells show a severely reduced migratory potential in vitro and reduced metastatic behavior in vivo. Consistently, we revealed increased activity of AP2\u03b5 in quiescent and migratory cells compared to heterogeneously proliferating cells in bioprinted 3D models. In conclusion, these findings disclose a yet-unknown role of AP2\u03b5 in maintaining plasticity and migration in malignant melanoma cells.<\/jats:p>","DOI":"10.1038\/s41419-024-06733-3","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T08:01:38Z","timestamp":1716278498000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Transcription factor activating enhancer-binding protein 2\u03b5 (AP2\u03b5) modulates phenotypic plasticity and progression of malignant melanoma"],"prefix":"10.1038","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3772-477X","authenticated-orcid":false,"given":"Sebastian","family":"Staebler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Rottensteiner-Brandl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zubeir","family":"El Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Kappelmann-Fenzl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Arkudas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Kengelbach-Weigand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8147-394X","authenticated-orcid":false,"given":"Anja-Katrin","family":"Bosserhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7150-3123","authenticated-orcid":false,"given":"Sonja K.","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,21]]},"reference":[{"key":"6733_CR1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.626129","volume":"10","author":"K Eddy","year":"2020","unstructured":"Eddy K, Shah R, Chen S. 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Snap-frozen tissue samples of human metastatic and primary melanomas were obtained from the tissue collection of the Institute of Pathology, University of Regensburg, Germany. Sampling and handling of patient material were carried out in accordance with the ethical principles of the Declaration of Helsinki. The use of human tissue material had been approved by the local ethics committee of the University of Regensburg (application number 09\/11 and 03\/151).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}],"article-number":"351"}}