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With younger cancer patients and increasing survival rates, it is important to preserve their reproductive capacity. NME8 is highly expressed in testis and contains thioredoxin and NDPK domains, suggesting it may be a target against the CP-induced reproductive toxicity. We deleted exons 6\u20137 of the <jats:italic>Nme8<\/jats:italic> in mice based on human mutation sites and observed impaired transcript splicing. In mice, <jats:italic>Nme8<\/jats:italic> was not essential for spermatogenesis, possibly due to functional compensation by its paralog, <jats:italic>Nme5<\/jats:italic>. <jats:italic>Nme8<\/jats:italic> expression was elevated and translocated to the nucleus in response to two weeks of CP treatment. Under CP treatment, <jats:italic>Nme8<\/jats:italic> deficiency further impaired antioxidant capacity, induced lipid peroxidation and increased ROS level, and failed to activate autophagy, resulting in aggravated DNA damage in testes and sperm. Consequently, the proliferation and differentiation of spermatogonia and the meiosis of spermatocyte were almost completely halted, and sperm motility was impaired. Our research indicates that NME8 protects against CP-induced testis and sperm damage. This may provide new insights into the physiological functions of the <jats:italic>Nme<\/jats:italic> family and potential targets for preserving fertility in young male cancer patients.<\/jats:p>","DOI":"10.1038\/s41419-024-07118-2","type":"journal-article","created":{"date-parts":[[2024,10,6]],"date-time":"2024-10-06T01:01:36Z","timestamp":1728176496000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Nme8 is essential for protection against chemotherapy drug cisplatin-induced male reproductive toxicity in mice"],"prefix":"10.1038","volume":"15","author":[{"given":"Haixia","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengjiang","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aizhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runze","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3137-6804","authenticated-orcid":false,"given":"Bin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6619-7107","authenticated-orcid":false,"given":"Jiangang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,6]]},"reference":[{"key":"7118_CR1","first-page":"485","volume":"120","author":"E Kubikova","year":"2019","unstructured":"Kubikova E, Klein M, Svitok P, Stefanic J, Benus R, Polak S, et al. 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