{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T04:48:52Z","timestamp":1785041332557,"version":"3.55.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T00:00:00Z","timestamp":1738022400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T00:00:00Z","timestamp":1738022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Dis"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Lymphangiogenesis is vital for tissue fluid homeostasis, immune function, and lipid absorption. Abnormal lymphangiogenesis has been implicated in several diseases such as cancers, inflammatory, and autoimmune diseases. In this study, we elucidate the role of tsRNA-0032 in lymphangiogenesis and its molecular mechanism. tsRNA-0032 expression is significantly decreased in corneal suture model and human lymphatic endothelial cell (HLEC) model under inflammatory condition. Overexpression of tsRNA-0032 exerts anti-lymphangiogenic effects by inhibiting HLEC proliferation, migration, and tube formation. Moreover, overexpression of tsRNA-0032 inhibits suture-induced corneal lymphangiogenesis. tsRNA-0032 is mainly located in the cytoplasm and interacts with Ago2 protein. Overexpression of tsRNA-0032 reduces ATP production and decreases pyruvate and lactate levels by targeting PKM2, a key enzyme in glycolysis. This regulation of glycolysis alters cellular energy and metabolic balance in HLECs, contributing to anti-lymphangiogenic effects. Clinical data reveals that tsRNA-0032 levels are significantly reduced in corneal tissues of transplant recipients compared to donors, while PKM2 expression is elevated, highlighting the clinical relevance of tsRNA-0032\/PKM2 axis in corneal lymphangiogenesis. This study offers new insights into the regulation of lymphangiogenesis and presents potential therapeutic targets for lymphangiogenesis-related diseases.<\/jats:p>","DOI":"10.1038\/s41419-025-07366-w","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T22:10:14Z","timestamp":1738015814000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Targeting glycolytic reprogramming by tsRNA-0032 for treating pathological lymphangiogenesis"],"prefix":"10.1038","volume":"16","author":[{"given":"Fan","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziran","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianjun","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuting","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiumiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7338-6413","authenticated-orcid":false,"given":"Biao","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,28]]},"reference":[{"key":"7366_CR1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41392-023-01723-x","volume":"9","author":"Z Hu","year":"2024","unstructured":"Hu Z, Zhao X, Wu Z, Qu B, Yuan M, Xing Y, et al. Lymphatic vessel: origin, heterogeneity, biological functions, and therapeutic targets. Signal Transduct Target Ther. 2024;9:9.","journal-title":"Signal Transduct Target Ther"},{"key":"7366_CR2","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.cell.2010.01.045","volume":"140","author":"T Tammela","year":"2010","unstructured":"Tammela T, Alitalo K. Lymphangiogenesis: molecular mechanisms and future promise. Cell. 2010;140:460\u201376.","journal-title":"Cell"},{"key":"7366_CR3","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/nrc3677","volume":"14","author":"SA Stacker","year":"2014","unstructured":"Stacker SA, Williams SP, Karnezis T, Shayan R, Fox SB, Achen MG. Lymphangiogenesis and lymphatic vessel remodelling in cancer. Nat Rev Cancer. 2014;14:159\u201372.","journal-title":"Nat Rev Cancer"},{"key":"7366_CR4","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.cell.2020.06.039","volume":"182","author":"G Oliver","year":"2020","unstructured":"Oliver G, Kipnis J, Randolph GJ, Harvey NL. The lymphatic vasculature in the 21(st) century: novel functional roles in homeostasis and disease. Cell. 2020;182:270\u201396.","journal-title":"Cell"},{"key":"7366_CR5","doi-asserted-by":"publisher","first-page":"11628","DOI":"10.3390\/ijms222111628","volume":"22","author":"HK Lee","year":"2021","unstructured":"Lee HK, Lee SM, Lee DI. Corneal lymphangiogenesis: current pathophysiological understandings and its functional role in ocular surface disease. Int J Mol Sci. 2021;22:11628.","journal-title":"Int J Mol Sci"},{"key":"7366_CR6","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.jtos.2021.07.003","volume":"22","author":"SJ Lee","year":"2021","unstructured":"Lee SJ, Im ST, Wu J, Cho CS, Jo DH, Chen Y, et al. Corneal lymphangiogenesis in dry eye disease is regulated by substance P\/neurokinin-1 receptor system through controlling expression of vascular endothelial growth factor receptor 3. Ocul Surf. 2021;22:72\u20139.","journal-title":"Ocul Surf"},{"key":"7366_CR7","doi-asserted-by":"publisher","first-page":"535","DOI":"10.4049\/jimmunol.0903180","volume":"184","author":"T Dietrich","year":"2010","unstructured":"Dietrich T, Bock F, Yuen D, Hos D, Bachmann BO, Zahn G, et al. Cutting edge: lymphatic vessels, not blood vessels, primarily mediate immune rejections after transplantation. J Immunol. 2010;184:535\u20139.","journal-title":"J Immunol"},{"key":"7366_CR8","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abq0375","volume":"8","author":"Z Li","year":"2023","unstructured":"Li Z, Antila S, Nurmi H, Chilov D, Korhonen EA, Fang S, et al. Blockade of VEGFR3 signaling leads to functional impairment of dural lymphatic vessels without affecting autoimmune neuroinflammation. Sci Immunol. 2023;8:eabq0375.","journal-title":"Sci Immunol"},{"key":"7366_CR9","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1161\/CIRCRESAHA.121.318142","volume":"129","author":"T Makinen","year":"2021","unstructured":"Makinen T, Boon LM, Vikkula M, Alitalo K. Lymphatic malformations: genetics, mechanisms and therapeutic strategies. Circ Res. 2021;129:136\u201354.","journal-title":"Circ Res"},{"key":"7366_CR10","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/S0140-6736(89)90417-0","volume":"2","author":"RY Calne","year":"1989","unstructured":"Calne RY, Collier DS, Lim S, Pollard SG, Samaan A, White DJ, et al. Rapamycin for immunosuppression in organ allografting. Lancet. 1989;2:227.","journal-title":"Lancet"},{"key":"7366_CR11","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1038\/s43018-021-00272-y","volume":"2","author":"S Garcia-Silva","year":"2021","unstructured":"Garcia-Silva S, Benito-Martin A, Nogues L, Hernandez-Barranco A, Mazariegos MS, Santos V, et al. Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism. Nat Cancer. 2021;2:1387\u2013405.","journal-title":"Nat Cancer"},{"key":"7366_CR12","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.coi.2018.04.003","volume":"53","author":"M Sainz-Jaspeado","year":"2018","unstructured":"Sainz-Jaspeado M, Claesson-Welsh L. Cytokines regulating lymphangiogenesis. Curr Opin Immunol. 2018;53:58\u201363.","journal-title":"Curr Opin Immunol"},{"key":"7366_CR13","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.3390\/cells11111750","volume":"11","author":"B Singla","year":"2022","unstructured":"Singla B, Aithabathula RV, Kiran S, Kapil S, Kumar S, Singh UP. Reactive oxygen species in regulating lymphangiogenesis and lymphatic function. Cells. 2022;11:1750.","journal-title":"Cells"},{"key":"7366_CR14","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.1111\/bjh.19332","volume":"204","author":"K Soureas","year":"2024","unstructured":"Soureas K, Papadimitriou MA, Malandrakis P, Papanota AM, Adamopoulos PG, Ntanasis-Stathopoulos I, et al. Small RNA-seq and clinical evaluation of tRNA-derived fragments in multiple myeloma: loss of mitochondrial i-tRFHisGTG results in patients\u2019 poor treatment outcome. Br J Haematol. 2024;204:1790\u2013800.","journal-title":"Br J Haematol"},{"key":"7366_CR15","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1016\/j.tibs.2021.05.001","volume":"46","author":"Q Chen","year":"2021","unstructured":"Chen Q, Zhang X, Shi J, Yan M, Zhou T. Origins and evolving functionalities of tRNA-derived small RNAs. Trends Biochem Sci. 2021;46:790\u2013804.","journal-title":"Trends Biochem Sci"},{"key":"7366_CR16","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-022-01499-8","volume":"21","author":"K Li","year":"2022","unstructured":"Li K, Lin Y, Luo Y, Xiong X, Wang L, Durante K, et al. A signature of saliva-derived exosomal small RNAs as predicting biomarker for esophageal carcinoma: a multicenter prospective study. Mol Cancer. 2022;21:21.","journal-title":"Mol Cancer"},{"key":"7366_CR17","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.735105","volume":"12","author":"P Yang","year":"2021","unstructured":"Yang P, Zhang X, Chen S, Tao Y, Ning M, Zhu Y, et al. A novel serum tsRNA for diagnosis and prediction of nephritis in SLE. Front Immunol. 2021;12:735105.","journal-title":"Front Immunol"},{"key":"7366_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.122475","volume":"341","author":"Q Zhang","year":"2024","unstructured":"Zhang Q, Zhao X, Sun M, Dong D. Novel insights into transfer RNA-derived small RNA (tsRNA) in cardio-metabolic diseases. Life Sci. 2024;341:122475.","journal-title":"Life Sci"},{"key":"7366_CR19","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.7150\/thno.92943","volume":"14","author":"Y Liang","year":"2024","unstructured":"Liang Y, Kong L, Zhang Y, Zhang Y, Shi M, Huang J, et al. Transfer RNA derived fragment, tRF-Glu-CTC, aggravates the development of neovascular age-related macular degeneration. Theranostics. 2024;14:1500\u201316.","journal-title":"Theranostics"},{"key":"7366_CR20","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-024-05338-w","volume":"22","author":"Y Ma","year":"2024","unstructured":"Ma Y, Zhang Y, Zhang HY, Zhao Y, Li XM, Jiang YF, et al. Dual anti-angiogenic and anti-inflammatory action of tRNA-Cys-5-0007 in ocular vascular disease. J Transl Med. 2024;22:562.","journal-title":"J Transl Med"},{"key":"7366_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2022.101157","volume":"96","author":"T Clahsen","year":"2023","unstructured":"Clahsen T, Hadrian K, Notara M, Schlereth SL, Howaldt A, Prokosch V, et al. The novel role of lymphatic vessels in the pathogenesis of ocular diseases. Prog Retin Eye Res. 2023;96:101157.","journal-title":"Prog Retin Eye Res"},{"key":"7366_CR22","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12977","volume":"54","author":"T Zong","year":"2021","unstructured":"Zong T, Yang Y, Zhao H, Li L, Liu M, Fu X, et al. tsRNAs: novel small molecules from cell function and regulatory mechanism to therapeutic targets. Cell Prolif. 2021;54:e12977.","journal-title":"Cell Prolif"},{"key":"7366_CR23","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1038\/s41392-020-00217-4","volume":"5","author":"Y Xie","year":"2020","unstructured":"Xie Y, Yao L, Yu X, Ruan Y, Li Z, Guo J. Action mechanisms and research methods of tRNA-derived small RNAs. Signal Transduct Target Ther. 2020;5:109.","journal-title":"Signal Transduct Target Ther"},{"key":"7366_CR24","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1093\/nar\/gkac022","volume":"50","author":"A Di Fazio","year":"2022","unstructured":"Di Fazio A, Schlackow M, Pong SK, Alagia A, Gullerova M. Dicer dependent tRNA derived small RNAs promote nascent RNA silencing. Nucleic Acids Res. 2022;50:1734\u201352.","journal-title":"Nucleic Acids Res"},{"key":"7366_CR25","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s13578-019-0317-8","volume":"9","author":"Z Zhang","year":"2019","unstructured":"Zhang Z, Deng X, Liu Y, Liu Y, Sun L, Chen F. PKM2, function and expression and regulation. Cell Biosci. 2019;9:52.","journal-title":"Cell Biosci"},{"key":"7366_CR26","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.ajpath.2020.10.003","volume":"191","author":"H Jiang","year":"2021","unstructured":"Jiang H, Zou Y, Zhao J, Li X, Yang S, Zhou X, et al. Pyruvate kinase M2 mediates glycolysis in the lymphatic endothelial cells and promotes the progression of lymphatic malformations. Am J Pathol. 2021;191:204\u201315.","journal-title":"Am J Pathol"},{"key":"7366_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104463","volume":"149","author":"C Guo","year":"2019","unstructured":"Guo C, He J, Song X, Tan L, Wang M, Jiang P, et al. Pharmacological properties and derivatives of shikonin-a review in recent years. Pharmacol Res. 2019;149:104463.","journal-title":"Pharmacol Res"},{"key":"7366_CR28","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.survophthal.2014.06.001","volume":"60","author":"PJ Park","year":"2015","unstructured":"Park PJ, Chang M, Garg N, Zhu J, Chang JH, Shukla D. Corneal lymphangiogenesis in herpetic stromal keratitis. Surv Ophthalmol. 2015;60:60\u201371.","journal-title":"Surv Ophthalmol"},{"key":"7366_CR29","doi-asserted-by":"publisher","first-page":"14451","DOI":"10.1128\/JVI.01841-14","volume":"88","author":"KM Bryant-Hudson","year":"2014","unstructured":"Bryant-Hudson KM, Gurung HR, Zheng M, Carr DJ. Tumor necrosis factor alpha and interleukin-6 facilitate corneal lymphangiogenesis in response to herpes simplex virus 1 infection. J Virol. 2014;88:14451\u20137.","journal-title":"J Virol"},{"key":"7366_CR30","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1002\/med.21496","volume":"38","author":"M Yamakawa","year":"2018","unstructured":"Yamakawa M, Doh SJ, Santosa SM, Montana M, Qin EC, Kong H, et al. Potential lymphangiogenesis therapies: learning from current antiangiogenesis therapies-a review. Med Res Rev. 2018;38:1769\u201398.","journal-title":"Med Res Rev"},{"key":"7366_CR31","doi-asserted-by":"publisher","first-page":"308","DOI":"10.3389\/fimmu.2019.00308","volume":"10","author":"S Schwager","year":"2019","unstructured":"Schwager S, Detmar M. Inflammation and lymphatic function. Front Immunol. 2019;10:308.","journal-title":"Front Immunol"},{"key":"7366_CR32","doi-asserted-by":"publisher","first-page":"1992","DOI":"10.1111\/ajt.15806","volume":"20","author":"BW Wong","year":"2020","unstructured":"Wong BW. Lymphatic vessels in solid organ transplantation and immunobiology. Am J Transplant. 2020;20:1992\u20132000.","journal-title":"Am J Transplant"},{"key":"7366_CR33","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1038\/modpathol.3800410","volume":"18","author":"SS Dadras","year":"2005","unstructured":"Dadras SS, Lange-Asschenfeldt B, Velasco P, Nguyen L, Vora A, Muzikansky A, et al. Tumor lymphangiogenesis predicts melanoma metastasis to sentinel lymph nodes. Mod Pathol. 2005;18:1232\u201342.","journal-title":"Mod Pathol"},{"key":"7366_CR34","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.1152\/physrev.00039.2021","volume":"102","author":"LC Dieterich","year":"2022","unstructured":"Dieterich LC, Tacconi C, Ducoli L, Detmar M. Lymphatic vessels in cancer. Physiol Rev. 2022;102:1837\u201379.","journal-title":"Physiol Rev"},{"key":"7366_CR35","doi-asserted-by":"publisher","first-page":"1764","DOI":"10.1182\/blood.2019001736","volume":"134","author":"L Lim","year":"2019","unstructured":"Lim L, Bui H, Farrelly O, Yang J, Li L, Enis D, et al. Hemostasis stimulates lymphangiogenesis through release and activation of VEGFC. Blood. 2019;134:1764\u201375.","journal-title":"Blood"},{"key":"7366_CR36","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.374","volume":"11","author":"QY Lin","year":"2021","unstructured":"Lin QY, Zhang YL, Bai J, Liu JQ, Li HH. VEGF-C\/VEGFR-3 axis protects against pressure-overload induced cardiac dysfunction through regulation of lymphangiogenesis. Clin Transl Med. 2021;11:e374.","journal-title":"Clin Transl Med"},{"key":"7366_CR37","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-06250-9","volume":"14","author":"L Zhang","year":"2023","unstructured":"Zhang L, Liu J, Hou Y. Classification, function, and advances in tsRNA in non-neoplastic diseases. Cell Death Dis. 2023;14:748.","journal-title":"Cell Death Dis"},{"key":"7366_CR38","first-page":"1656","volume":"13","author":"Y Zhao","year":"2023","unstructured":"Zhao Y, Li X, Ye C, Huang C, Lv X, Li J. The biogenesis, mechanism and function of the tRNA-derived small RNA (tsRNA): a review compared with microRNA. Am J Cancer Res. 2023;13:1656\u201366.","journal-title":"Am J Cancer Res"},{"key":"7366_CR39","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1186\/s13018-023-03878-3","volume":"18","author":"J Pan","year":"2023","unstructured":"Pan J, Liu Z, Shen B, Xu J, Dai G, Xu W, et al. tsRNA-04002 alleviates intervertebral disk degeneration by targeting PRKCA to inhibit apoptosis of nucleus pulposus cells. J Orthop Surg Res. 2023;18:413.","journal-title":"J Orthop Surg Res"},{"key":"7366_CR40","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1038\/s41418-024-01311-8","volume":"31","author":"J Cai","year":"2024","unstructured":"Cai J, Li C, Liu S, Tan M, Sun Y, Sun X, et al. Angiogenin-mediated tsRNAs control inflammation and metabolic disorder by regulating NLRP3 inflammasome. Cell Death Differ. 2024;31:1057\u201369.","journal-title":"Cell Death Differ"},{"key":"7366_CR41","doi-asserted-by":"publisher","first-page":"2451","DOI":"10.1161\/CIRCULATIONAHA.117.028034","volume":"136","author":"P Caruso","year":"2017","unstructured":"Caruso P, Dunmore BJ, Schlosser K, Schoors S, Dos Santos C, Perez-Iratxeta C, et al. Identification of microRNA-124 as a major regulator of enhanced endothelial cell glycolysis in pulmonary arterial hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and pyruvate kinase M2. Circulation. 2017;136:2451\u201367.","journal-title":"Circulation"},{"key":"7366_CR42","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/j.kint.2023.01.007","volume":"103","author":"Z Chen","year":"2023","unstructured":"Chen Z, Zhu Z, Liang W, Luo Z, Hu J, Feng J, et al. Reduction of anaerobic glycolysis contributes to angiotensin II-induced podocyte injury with foot process effacement. Kidney Int. 2023;103:735\u201348.","journal-title":"Kidney Int"},{"key":"7366_CR43","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.cmet.2018.06.021","volume":"28","author":"J Cong","year":"2018","unstructured":"Cong J, Wang X, Zheng X, Wang D, Fu B, Sun R, et al. Dysfunction of natural killer cells by FBP1-Induced inhibition of glycolysis during lung cancer progression. Cell Metab. 2018;28:243\u2013255.e245.","journal-title":"Cell Metab"},{"key":"7366_CR44","doi-asserted-by":"publisher","first-page":"2550","DOI":"10.1158\/0008-5472.CAN-10-2828","volume":"71","author":"F Vegran","year":"2011","unstructured":"Vegran F, Boidot R, Michiels C, Sonveaux P, Feron O. Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-\u03baB\/IL-8 pathway that drives tumor angiogenesis. Cancer Res. 2011;71:2550\u201360.","journal-title":"Cancer Res"},{"key":"7366_CR45","doi-asserted-by":"publisher","first-page":"10643","DOI":"10.1021\/acs.analchem.0c01741","volume":"92","author":"A Galaz","year":"2020","unstructured":"Galaz A, Cortes-Molina F, Arce-Molina R, Romero-Gomez I, Mardones GA, Felipe Barros L, et al. Imaging of the lactate\/pyruvate ratio using a genetically encoded dorster eesonance energy transfer indicator. Anal Chem. 2020;92:10643\u201350.","journal-title":"Anal Chem"},{"key":"7366_CR46","doi-asserted-by":"publisher","first-page":"2332","DOI":"10.1016\/j.celrep.2020.01.060","volume":"30","author":"A Rossi","year":"2020","unstructured":"Rossi A, Rigotto G, Valente G, Giorgio V, Basso E, Filadi R, et al. Defective mitochondrial pyruvate flux affects cell bioenergetics in Alzheimer\u2019s disease-related models. Cell Rep. 2020;30:2332\u201348.e2310.","journal-title":"Cell Rep"},{"key":"7366_CR47","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1158\/2326-6066.CIR-21-0778","volume":"10","author":"A Riedel","year":"2022","unstructured":"Riedel A, Helal M, Pedro L, Swietlik JJ, Shorthouse D, Schmitz W, et al. Tumor-derived lactic acid modulates activation and metabolic status of draining lymph node stroma. Cancer Immunol Res. 2022;10:482\u201397.","journal-title":"Cancer Immunol Res"}],"container-title":["Cell Death &amp; Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41419-025-07366-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41419-025-07366-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41419-025-07366-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T22:55:04Z","timestamp":1738018504000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41419-025-07366-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,28]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["7366"],"URL":"https:\/\/doi.org\/10.1038\/s41419-025-07366-w","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4896824\/v1","asserted-by":"object"}]},"ISSN":["2041-4889"],"issn-type":[{"value":"2041-4889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,28]]},"assertion":[{"value":"11 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 December 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"51"}}