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Their strategic positioning around these vessels enables them to perform key functions in immune surveillance and response to inflammation and injury. These cells are crucial for modulating the immune response within the brain, contributing to normal central nervous system (CNS) processes. In pathological conditions, the role of PVMs becomes more complex. Depending on the specific disease or injury, they may contribute to inflammation, blood-brain barrier (BBB) dysfunction, and the clearance of abnormal materials. PVMs are implicated in degenerative diseases, cerebrovascular impairment, and microhemorrhages associated with amyloid-\u03b2 immunotherapy. Despite their important roles in the CNS, research on PVMs remains limited, and the mechanisms underlying their involvement in both physiological and pathological processes within the brain are not yet fully elucidated. 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