{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T06:19:44Z","timestamp":1776838784613,"version":"3.51.2"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T00:00:00Z","timestamp":1755907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T00:00:00Z","timestamp":1755907200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22H03099"],"award-info":[{"award-number":["JP22H03099"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22H04684"],"award-info":[{"award-number":["JP22H04684"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22K19538"],"award-info":[{"award-number":["JP22K19538"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP24K02516"],"award-info":[{"award-number":["JP24K02516"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JPJSCCA20200006"],"award-info":[{"award-number":["JPJSCCA20200006"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006680","name":"Takeda Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006680","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011746","name":"NOVARTIS Foundation (Japan) for the Promotion of Science (NOVARTIS Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011746","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007533","name":"Kobayashi Foundation for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007533","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP23ama221118"],"award-info":[{"award-number":["JP23ama221118"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP25ama221144"],"award-info":[{"award-number":["JP25ama221144"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP22zf0127008"],"award-info":[{"award-number":["JP22zf0127008"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"MEXT | Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJSP2109"],"award-info":[{"award-number":["JPMJSP2109"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009036","name":"MEXT | JST | Strategic International Collaborative Research Program","doi-asserted-by":"publisher","award":["JP22ama221411"],"award-info":[{"award-number":["JP22ama221411"]}],"id":[{"id":"10.13039\/501100009036","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009036","name":"MEXT | JST | Strategic International Collaborative Research Program","doi-asserted-by":"publisher","award":["JP23jm0210107"],"award-info":[{"award-number":["JP23jm0210107"]}],"id":[{"id":"10.13039\/501100009036","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chiba University IAAR Research Support Program"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Dis"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>SETD1A is a member of the KMT2 histone H3K4 methyltransferase family of mammalian proteins. Aberrant <jats:italic>SETD1A<\/jats:italic> expression is associated with a poor prognosis in patients with gastric cancer (GC). We found that the catalytic domain of SETD1A is nonessential for GC cell proliferation, whereas the non-catalytic FLOS domain is essential. The loss of SETD1A commonly reduces the expression of E2F target genes in GC cell lines from the three independent molecular subtypes. A pooled CRISPR screen and cDNA rescue experiment showed that TAF6 acts downstream of SETD1A\u2019s non-catalytic function, which is essential for GC cell proliferation. Both SETD1A and TAF6 are required for G1\/S cell cycle progression in GC cells. The mRNA expression of <jats:italic>E2F4<\/jats:italic> highly correlated with both the <jats:italic>SETD1A<\/jats:italic> and <jats:italic>TAF6<\/jats:italic> expression in patients with GC. Notably, E2F4 supported the expression of TAF6 but not that of SETD1A, suggesting that E2F4 serves as a coregulator of SETD1A, which is involved in regulating TAF6. These results demonstrate that the non-canonical roles of SETD1A and its downstream pathways are crucial for cell cycle progression in GC.<\/jats:p>","DOI":"10.1038\/s41419-025-07976-4","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T23:24:36Z","timestamp":1755905076000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Non-catalytic role of SETD1A promotes gastric cancer cell proliferation through the E2F4\u2013TAF6 axis in the cell cycle"],"prefix":"10.1038","volume":"16","author":[{"given":"Meng","family":"Ning","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5418-1981","authenticated-orcid":false,"given":"Takayuki","family":"Hoshii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genki","family":"Usui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shintaro","family":"Izumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanako","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5365-8975","authenticated-orcid":false,"given":"Makoto","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahityar","family":"Rahmutulla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Fukuyo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Abe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuo","family":"Ushiku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Kaneda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,8,23]]},"reference":[{"key":"7976_CR1","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.1002\/ijc.31937","volume":"144","author":"J Ferlay","year":"2019","unstructured":"Ferlay J, Colombet M, Soerjomataram I, Mathers C, Parkin DM, Pi\u00f1eros M, et al. Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int J Cancer. 2019;144:1941\u201353.","journal-title":"Int J Cancer"},{"key":"7976_CR2","first-page":"5438","volume":"59","author":"M Toyota","year":"1999","unstructured":"Toyota M, Ahuja N, Suzuki H, Itoh F, Ohe-Toyota M, Imai K, et al. Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype. Cancer Res. 1999;59:5438\u201342.","journal-title":"Cancer Res"},{"key":"7976_CR3","first-page":"2847","volume":"61","author":"GH Kang","year":"2001","unstructured":"Kang GH, Shim YH, Jung HY, Kim WH, Ro JY, Rhyu MG. CpG island methylation in premalignant stages of gastric carcinoma. Cancer Res. 2001;61:2847\u201351.","journal-title":"Cancer Res"},{"key":"7976_CR4","first-page":"6645","volume":"62","author":"A Kaneda","year":"2002","unstructured":"Kaneda A, Kaminishi M, Yanagihara K, Sugimura T, Ushijima T. Identification of silencing of nine genes in human gastric cancers. Cancer Res. 2002;62:6645\u201350.","journal-title":"Cancer Res"},{"key":"7976_CR5","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/S0002-9440(10)63156-2","volume":"164","author":"T Etoh","year":"2004","unstructured":"Etoh T, Kanai Y, Ushijima S, Nakagawa T, Nakanishi Y, Sasako M, et al. Increased DNA methyltransferase 1 (DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG islands in gastric cancers. Am J Pathol. 2004;164:689\u201399.","journal-title":"Am J Pathol"},{"key":"7976_CR6","doi-asserted-by":"publisher","first-page":"4358","DOI":"10.1038\/s41388-018-0285-1","volume":"37","author":"H Cui","year":"2018","unstructured":"Cui H, Hu Y, Guo D, Zhang A, Gu Y, Zhang S, et al. DNA methyltransferase 3A isoform b contributes to repressing E-cadherin through cooperation of DNA methylation and H3K27\/H3K9 methylation in EMT-related metastasis of gastric cancer. Oncogene. 2018;37:4358\u201371.","journal-title":"Oncogene"},{"key":"7976_CR7","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1111\/j.1349-7006.2006.00203.x","volume":"97","author":"Y Matsukawa","year":"2006","unstructured":"Matsukawa Y, Semba S, Kato H, Ito A, Yanagihara K, Yokozaki H. Expression of the enhancer of zeste homolog 2 is correlated with poor prognosis in human gastric cancer. Cancer Sci. 2006;97:484\u201391.","journal-title":"Cancer Sci"},{"key":"7976_CR8","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1002\/1878-0261.12689","volume":"14","author":"J Wu","year":"2020","unstructured":"Wu J, Chai H, Xu X, Yu J, Gu Y. Histone methyltransferase SETD1A interacts with HIF1\u03b1 to enhance glycolysis and promote cancer progression in gastric cancer. Mol Oncol. 2020;14:1397\u2013409.","journal-title":"Mol Oncol"},{"key":"7976_CR9","doi-asserted-by":"crossref","unstructured":"J. Wu, H. Chai, H. Shan, C. Pan, X. Xu, W. Dong, et al. Histone methyltransferase SETD1A induces epithelial-mesenchymal transition to promote invasion and metastasis through epigenetic reprogramming of snail in gastric cancer. Front Cell Dev Biol. 2021;9:657888.","DOI":"10.3389\/fcell.2021.657888"},{"key":"7976_CR10","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1016\/j.cell.2018.06.038","volume":"174","author":"PL Hsu","year":"2018","unstructured":"Hsu PL, Li H, Lau H-T, Leonen C, Dhall A, Ong S-E, et al. Crystal structure of the COMPASS H3K4 methyltransferase catalytic module. Cell. 2018;174:1106\u20131116.e9.","journal-title":"Cell"},{"key":"7976_CR11","doi-asserted-by":"publisher","first-page":"4894","DOI":"10.1038\/s41388-021-01840-3","volume":"40","author":"J Wang","year":"2021","unstructured":"Wang J, Xiu J, Baca Y, Battaglin F, Arai H, Kawanishi N, et al. Large-scale analysis of KMT2 mutations defines a distinctive molecular subset with treatment implication in gastric cancer. Oncogene. 2021;40:4894\u2013905.","journal-title":"Oncogene"},{"key":"7976_CR12","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1002\/path.4761","volume":"240","author":"H Rokutan","year":"2016","unstructured":"Rokutan H, Hosoda F, Hama N, Nakamura H, Totoki Y, Furukawa E, et al. Comprehensive mutation profiling of mucinous gastric carcinoma. J Pathol. 2016;240:137\u201348.","journal-title":"J Pathol"},{"key":"7976_CR13","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.bbrc.2019.03.001","volume":"512","author":"X Zeng","year":"2019","unstructured":"Zeng X, Pan D, Wu H, Chen H, Yuan W, Zhou J, et al. Transcriptional activation of ANO1 promotes gastric cancer progression. Biochem Biophys Res Commun. 2019;512:131\u20136.","journal-title":"Biochem Biophys Res Commun"},{"key":"7976_CR14","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.bbrc.2018.08.143","volume":"504","author":"W Xiong","year":"2018","unstructured":"Xiong W, Deng Z, Tang Y, Deng Z, Li M. Downregulation of KMT2D suppresses proliferation and induces apoptosis of gastric cancer. Biochem Biophys Res Commun. 2018;504:129\u201336.","journal-title":"Biochem Biophys Res Commun"},{"key":"7976_CR15","doi-asserted-by":"publisher","first-page":"1732","DOI":"10.1101\/gad.303768.117","volume":"31","author":"CC Sze","year":"2017","unstructured":"Sze CC, Cao K, Collings CK, Marshall SA, Rendleman EJ, Ozark PA, et al. Histone H3K4 methylation-dependent and -independent functions of Set1A\/COMPASS in embryonic stem cell self-renewal and differentiation. Genes Dev. 2017;31:1732\u20137.","journal-title":"Genes Dev"},{"key":"7976_CR16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2118385119","volume":"119","author":"BK Cenik","year":"2022","unstructured":"Cenik BK, Sze CC, Ryan CA, Das S, Cao K, Douillet D, et al. A synthetic lethality screen reveals ING5 as a genetic dependency of catalytically dead Set1A\/COMPASS in mouse embryonic stem cells. Proc Natl Acad Sci USA. 2022;119:e2118385119.","journal-title":"Proc Natl Acad Sci USA"},{"key":"7976_CR17","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36236-2","volume":"14","author":"AL Hughes","year":"2023","unstructured":"Hughes AL, Szczurek AT, Kelley JR, Lastuvkova A, Turberfield AH, Dimitrova E, et al. A CpG island-encoded mechanism protects genes from premature transcription termination. Nat Commun. 2023;14:726.","journal-title":"Nat Commun"},{"key":"7976_CR18","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1016\/j.cell.2018.01.032","volume":"172","author":"T Hoshii","year":"2018","unstructured":"Hoshii T, Cifani P, Feng Z, Huang C-H, Koche R, Chen C-W, et al. A non-catalytic function of SETD1A regulates cyclin K and the DNA damage response. Cell. 2018;172:1007\u20131021.e17.","journal-title":"Cell"},{"key":"7976_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111727","volume":"41","author":"T Hoshii","year":"2022","unstructured":"Hoshii T, Perlee S, Kikuchi S, Rahmutulla B, Fukuyo M, Masuda T, et al. SETD1A regulates transcriptional pause release of heme biosynthesis genes in leukemia. Cell Rep. 2022;41:111727.","journal-title":"Cell Rep"},{"key":"7976_CR20","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1038\/sj.gt.3301206","volume":"7","author":"S Morita","year":"2000","unstructured":"Morita S, Kojima T, Kitamura T. Plat-E: an efficient and stable system for transient packaging of retroviruses. Gene Ther. 2000;7:1063\u20136.","journal-title":"Gene Ther"},{"key":"7976_CR21","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202357108","volume":"24","author":"S Perlee","year":"2023","unstructured":"Perlee S, Kikuchi S, Nakadai T, Masuda T, Ohtsuki S, Matsumoto M, et al. SETD1A function in leukemia is mediated through interaction with mitotic regulators BuGZ\/BUB3. EMBO Rep. 2023;24:e57108.","journal-title":"EMBO Rep"},{"key":"7976_CR22","doi-asserted-by":"crossref","unstructured":"Hoshii T, Kikuchi S, Kujirai T, Masuda T, Ito T, Yasuda S, et al. BOD1L mediates chromatin binding and non-canonical function of H3K4 methyltransferase SETD1A. Nucleic Acids Res. 2024;52:9463\u20139480.","DOI":"10.1093\/nar\/gkae605"},{"key":"7976_CR23","doi-asserted-by":"publisher","DOI":"10.1093\/narcan\/zcae020","volume":"6","author":"T Zhu","year":"2024","unstructured":"Zhu T, Okabe A, Usui G, Fujiki R, Komiyama D, Huang KK, et al. Integrated enhancer regulatory network by enhancer\u2013promoter looping in gastric cancer. NAR Cancer. 2024;6:zcae020.","journal-title":"NAR Cancer"},{"key":"7976_CR24","doi-asserted-by":"publisher","DOI":"10.1186\/s42047-022-00112-y","volume":"5","author":"A Rodrigues","year":"2022","unstructured":"Rodrigues A, Nogueira C, Marinho LC, Velozo G, Sousa J, Silva PG, et al. Computer-assisted tumor grading, validation of PD-L1 scoring, and quantification of CD8-positive immune cell density in urothelial carcinoma, a visual guide for pathologists using QuPath. Surgical Exp Pathol. 2022;5:12.","journal-title":"Surgical Exp Pathol"},{"key":"7976_CR25","volume":"5","author":"B Gy\u0151rffy","year":"2024","unstructured":"Gy\u0151rffy B. Integrated analysis of public datasets for the discovery and validation of survival-associated genes in solid tumors. Innovation. 2024;5:100625.","journal-title":"Innovation"},{"key":"7976_CR26","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/s41586-020-2374-x","volume":"585","author":"M S\u0142abicki","year":"2020","unstructured":"S\u0142abicki M, Kozicka Z, Petzold G, Li Y-D, Manojkumar M, Bunker RD, et al. The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K. Nature. 2020;585:293\u20137.","journal-title":"Nature"},{"key":"7976_CR27","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-09660-w","volume":"7","author":"X Bian","year":"2017","unstructured":"Bian X, Yang Z, Feng H, Sun H, Liu Y. A combination of species identification and STR profiling identifies cross-contaminated cells from 482 human tumor cell lines. Sci Rep. 2017;7:9774.","journal-title":"Sci Rep"},{"key":"7976_CR28","doi-asserted-by":"crossref","unstructured":"Sze CC, Ozark PA, Cao K, Ugarenko M, Das S, Wang L, et al. Coordinated regulation of cellular identity\u2013associated H3K4me3 breadth by the COMPASS family. Sci Adv. 2020;6:eaaz4764.","DOI":"10.1126\/sciadv.aaz4764"},{"key":"7976_CR29","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.ccell.2017.05.002","volume":"31","author":"Y Chen","year":"2017","unstructured":"Chen Y, Anastassiadis K, Kranz A, Stewart AF, Arndt K, Waskow C, et al. MLL2, not MLL1, plays a major role in sustaining MLL\u2014rearranged acute myeloid leukemia. Cancer Cell. 2017;31:755\u2013770.e6.","journal-title":"Cancer Cell"},{"key":"7976_CR30","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10786-w","volume":"10","author":"K Tajima","year":"2019","unstructured":"Tajima K, Matsuda S, Yae T, Drapkin BJ, Morris R, Boukhali M, et al. SETD1A protects from senescence through regulation of the mitotic gene expression program. Nature Commun. 2019;10:2854.","journal-title":"Nature Commun"},{"key":"7976_CR31","doi-asserted-by":"crossref","unstructured":"Chen X, Qi Y, Wu Z, Wang X, Li J, Zhao D, et al. Structural insights into preinitiation complex assembly on core promoters. Science. 2021;372:eaba8490.","DOI":"10.1126\/science.aba8490"},{"key":"7976_CR32","doi-asserted-by":"publisher","first-page":"2658","DOI":"10.1101\/gad.11.20.2658","volume":"11","author":"EH Wang","year":"1997","unstructured":"Wang EH, Zou S, Tjian R. TAFII250-dependent transcription of cyclin A is directed by ATF activator proteins. Genes Dev. 1997;11:2658\u201369.","journal-title":"Genes Dev"},{"key":"7976_CR33","doi-asserted-by":"publisher","first-page":"4823","DOI":"10.1093\/emboj\/18.17.4823","volume":"18","author":"D Metzger","year":"1999","unstructured":"Metzger D, Scheer E, Soldatov A, Tora L. Mammalian TAFII30 is required for cell cycle progression and specific cellular differentiation programmes. EMBO J. 1999;18:4823\u20134834-4834.","journal-title":"EMBO J"},{"key":"7976_CR34","doi-asserted-by":"publisher","first-page":"4307","DOI":"10.1128\/MCB.23.12.4307-4318.2003","volume":"23","author":"WS Mohan Jr.","year":"2003","unstructured":"Mohan WS Jr., Scheer E, Wendling O, Metzger D, Tora L. TAF10 (TAF(II)30) is necessary for TFIID stability and early embryogenesis in mice. Mol Cell Biol. 2003;23:4307\u201318.","journal-title":"Mol Cell Biol"},{"key":"7976_CR35","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.ydbio.2005.05.043","volume":"285","author":"AK Indra","year":"2005","unstructured":"Indra AK, Mohan WS, Frontini M, Scheer E, Messaddeq N, Metzger D, et al. TAF10 is required for the establishment of skin barrier function in foetal, but not in adult mouse epidermis. Dev Biol. 2005;285:28\u201337.","journal-title":"Dev Biol"},{"key":"7976_CR36","doi-asserted-by":"publisher","first-page":"4978","DOI":"10.7150\/ijbs.99590","volume":"20","author":"S Baral","year":"2024","unstructured":"Baral S, Yu Y, Sun Q, Jiang M, Li R, Cheng Y, et al. Transcription factor E2F4 promote proliferation, migration, and invasion of gastric cancer cells by transcriptionally activating DSCC1. Int J Biol Sci. 2024;20:4978\u201398.","journal-title":"Int J Biol Sci"},{"key":"7976_CR37","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10901-x","volume":"10","author":"J Hsu","year":"2019","unstructured":"Hsu J, Arand J, Chaikovsky A, Mooney NA, Demeter J, Brison CM, et al. E2F4 regulates transcriptional activation in mouse embryonic stem cells independently of the RB family. Nat Commun. 2019;10:2939.","journal-title":"Nat Commun"},{"key":"7976_CR38","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1128\/MCB.16.4.1436","volume":"16","author":"K Moberg","year":"1996","unstructured":"Moberg K, Starz MA, Lees JA. E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry. Mol Cell Biol. 1996;16:1436\u201349.","journal-title":"Mol Cell Biol"},{"key":"7976_CR39","doi-asserted-by":"publisher","first-page":"2665","DOI":"10.1101\/gad.8.22.2665","volume":"8","author":"D Ginsberg","year":"1994","unstructured":"Ginsberg D, Vairo G, Chittenden T, Xiao ZX, Xu G, Wydner KL, et al. E2F-4, a new member of the E2F transcription factor family, interacts with p107. Genes Dev. 1994;8:2665\u201379.","journal-title":"Genes Dev"}],"container-title":["Cell Death &amp; Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41419-025-07976-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41419-025-07976-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41419-025-07976-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T11:23:45Z","timestamp":1757417025000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41419-025-07976-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,23]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["7976"],"URL":"https:\/\/doi.org\/10.1038\/s41419-025-07976-4","relation":{},"ISSN":["2041-4889"],"issn-type":[{"value":"2041-4889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,23]]},"assertion":[{"value":"2 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 August 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All the clinical specimens were approved by the Ethical Review Committee of the University of Tokyo Hospital (approval number: G3521-(21)). Informed consent was obtained from all the patients. All methods were performed in accordance with the relevant guidelines and regulations of Chiba University and Japan.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}],"article-number":"639"}}