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Here, we focus on elucidating the role of\n                    <jats:italic>Dhx37<\/jats:italic>\n                    in maintaining Sertoli-cell survival. RIP-seq and RNAi-RNA-seq reveal that\n                    <jats:italic>Dhx37<\/jats:italic>\n                    safeguards nucleolar integrity and PI3K\u2013AKT signaling, suppresses p53-driven apoptosis, and its loss triggers pro-apoptotic splicing. Cell-specific\n                    <jats:italic>Dhx37<\/jats:italic>\n                    knockout mice (\n                    <jats:italic>Dhx37<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    ) were subsequently generated to investigate the function of\n                    <jats:italic>Dhx37<\/jats:italic>\n                    in testicular development. In the\n                    <jats:italic>Dhx37<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice, we observed pronounced defects, including diminished testicular volume, lower testosterone levels, and marked vacuolization of the seminiferous tubules. Immunofluorescence staining revealed disruptions in both Sertoli and germ cell compartments, characterized by reduced cell proliferation and elevated apoptosis. The snRNA-seq disclosed marked changes in the expression of genes governing apoptosis and proliferation, findings that were further validated through qRT-PCR and Western blotting. In this study, we identified\n                    <jats:italic>Dhx37<\/jats:italic>\n                    as a pivotal determinant of nucleolar architecture in murine testicular Sertoli cells. Preservation of the nucleolus safeguards supporting normal testicular morphogenesis.\n                  <\/jats:p>","DOI":"10.1038\/s41420-025-02875-1","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T10:05:38Z","timestamp":1768385138000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Multi-omics analysis the effects of Dhx37 deficiency on testis development and nucleolar homeostasis"],"prefix":"10.1038","volume":"12","author":[{"given":"Yuqing","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanshuang","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyuan","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanjun","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liujun","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3807-7989","authenticated-orcid":false,"given":"Hongwei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2738-2080","authenticated-orcid":false,"given":"Huifang","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"key":"2875_CR1","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.semcdb.2021.06.016","volume":"121","author":"L O\u2019Donnell","year":"2022","unstructured":"O\u2019Donnell L, Smith LB, Rebourcet D. 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