{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T03:10:08Z","timestamp":1779160208562,"version":"3.51.4"},"reference-count":88,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":35,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100000925","name":"Department of Health | National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1173662"],"award-info":[{"award-number":["1173662"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Discov."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Every day, billions of cells in the human body undergo apoptosis as part of normal tissue turnover. The swift clearance of these dying cells by phagocytes is an essential process to limit the release of intracellular contents that can disrupt tissue homeostasis and promote inflammation, autoimmunity, and chronic disease. Thus, as with the unseen yet continuous work of a well-run kitchen, effective apoptotic cell clearance sustains multicellular organisms. In cooking, ingredients must be deliberately gathered, trimmed, seasoned, cooked, and plated before becoming part of a satisfying meal. Analogously, apoptotic cells undergo an equally deliberate \u2018meal preparation\u2019 process in which they transform themselves to be optimally suited for consumption by professional and non-professional phagocytes. This preparation involves a coordinated suite of modifications, including the secretion of immunomodulatory factors, the internal partitioning of organelles, and the exposure of \u2018eat-me\u2019 signals. Additionally, maintaining membrane integrity during apoptosis can be viewed as a \u2018protective wrapping\u2019 that preserves \u2018edible\u2019 cargo while preventing the inflammatory spillover that would result from premature plasma membrane rupture (PMR). In this perspective, we highlight how these distinct, yet interconnected layers of apoptotic cell \u2018cooking\u2019 converge to shape and influence the eventual phagocytic encounter. A deeper understanding of how apoptotic cells prepare themselves for clearance not only reframes our view of cell death, but also offers opportunities to harness or correct these processes in pathological settings where clearance fails.<\/jats:p>","DOI":"10.1038\/s41420-026-03099-7","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T07:06:00Z","timestamp":1776150360000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bon app\u00e9tit, your phagocyte"],"prefix":"10.1038","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4614-5638","authenticated-orcid":false,"given":"Dilara C.","family":"Ozkocak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7950-6316","authenticated-orcid":false,"given":"Jascinta P.","family":"Santavanond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4657-9869","authenticated-orcid":false,"given":"Maria C.","family":"Tanzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9119-7173","authenticated-orcid":false,"given":"Ivan K. H.","family":"Poon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"key":"3099_CR1","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1016\/j.immuni.2024.03.002","volume":"57","author":"M Ma","year":"2024","unstructured":"Ma M, Jiang W, Zhou R. DAMPs and DAMP-sensing receptors in inflammation and diseases. Immunity. 2024;57:752\u201371. https:\/\/doi.org\/10.1016\/j.immuni.2024.03.002.","journal-title":"Immunity"},{"key":"3099_CR2","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1038\/s12276-023-01070-5","volume":"55","author":"B Moon","year":"2023","unstructured":"Moon B, Yang S, Moon H, Lee J, Park D. After cell death: the molecular machinery of efferocytosis. Exp Mol Med. 2023;55:1644\u201351. https:\/\/doi.org\/10.1038\/s12276-023-01070-5.","journal-title":"Exp Mol Med"},{"key":"3099_CR3","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1146\/annurev.pathmechdis.3.121806.151456","volume":"3","author":"KL Rock","year":"2008","unstructured":"Rock KL, Kono H. The inflammatory response to cell death. Annu Rev Pathol Mech Dis. 2008;3:99\u2013126. https:\/\/doi.org\/10.1146\/annurev.pathmechdis.3.121806.151456.","journal-title":"Annu Rev Pathol Mech Dis"},{"key":"3099_CR4","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1038\/s41586-021-03200-3","volume":"590","author":"E Hoijman","year":"2021","unstructured":"Hoijman E, H\u00e4kkinen HM, Tolosa-Ramon Q, Jim\u00e9nez-Delgado S, Wyatt C, Miret-Cuesta M, et al. Cooperative epithelial phagocytosis enables error correction in the early embryo. Nature. 2021;590:618\u201323. https:\/\/doi.org\/10.1038\/s41586-021-03200-3.","journal-title":"Nature"},{"key":"3099_CR5","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1016\/j.cell.2023.02.004","volume":"186","author":"AK Grootveld","year":"2023","unstructured":"Grootveld AK, Kyaw W, Panova V, Lau AWY, Ashwin E, Seuzaret G, et al. Apoptotic cell fragments locally activate tingible body macrophages in the germinal center. Cell. 2023;186:1144\u20131161. https:\/\/doi.org\/10.1016\/j.cell.2023.02.004.","journal-title":"Cell"},{"key":"3099_CR6","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/s42255-022-00728-0","volume":"5","author":"J Iker Etchegaray","year":"2023","unstructured":"Iker Etchegaray J, Kelley S, Penberthy K, Karvelyte L, Nagasaka Y, Gasperino S, et al. Phagocytosis in the retina promotes local insulin production in the eye. Nat Metab. 2023;5:207\u201318. https:\/\/doi.org\/10.1038\/s42255-022-00728-0.","journal-title":"Nat Metab"},{"key":"3099_CR7","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09010-6","volume":"10","author":"CK Brock","year":"2019","unstructured":"Brock CK, Wallin ST, Ruiz OE, Samms KM, Mandal A, Sumner EA, et al. Stem cell proliferation is induced by apoptotic bodies from dying cells during epithelial tissue maintenance. Nat Commun. 2019;10:1044. https:\/\/doi.org\/10.1038\/s41467-019-09010-6.","journal-title":"Nat Commun"},{"key":"3099_CR8","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1038\/s41573-022-00470-y","volume":"21","author":"P Mehrotra","year":"2022","unstructured":"Mehrotra P, Ravichandran KS. Drugging the efferocytosis process: concepts and opportunities. Nat Rev Drug Discov. 2022;21:601\u201320. https:\/\/doi.org\/10.1038\/s41573-022-00470-y.","journal-title":"Nat Rev Drug Discov"},{"key":"3099_CR9","doi-asserted-by":"publisher","first-page":"1932","DOI":"10.1016\/S0140-6736(99)05246-0","volume":"354","author":"R Maini","year":"1999","unstructured":"Maini R, Clair EWS, Breedveld F, Furst D, Kalden J, Weisman M, et al. Infliximab (chimeric anti-tumour necrosis factor \u03b1 monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial. Lancet. 1999;354:1932\u20139. https:\/\/doi.org\/10.1016\/S0140-6736(99)05246-0.","journal-title":"Lancet"},{"key":"3099_CR10","doi-asserted-by":"publisher","first-page":"4622","DOI":"10.3748\/wjg.v24.i41.4622","volume":"24","author":"HF Nanini","year":"2018","unstructured":"Nanini HF, Bernardazzi C, Castro F, de Souza HSP. Damage-associated molecular patterns in inflammatory bowel disease: From biomarkers to therapeutic targets. World J Gastroenterol. 2018;24:4622\u201334. https:\/\/doi.org\/10.3748\/wjg.v24.i41.4622.","journal-title":"World J Gastroenterol"},{"key":"3099_CR11","doi-asserted-by":"publisher","first-page":"2132","DOI":"10.1073\/pnas.1720732115","volume":"115","author":"M Kawano","year":"2018","unstructured":"Kawano M, Nagata S. Lupus-like autoimmune disease caused by a lack of Xkr8, a caspase-dependent phospholipid scramblase. Proc Natl Acad Sci USA. 2018;115:2132\u20137. https:\/\/doi.org\/10.1073\/pnas.1720732115.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3099_CR12","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-71669-5","volume":"10","author":"T Tanaka","year":"2020","unstructured":"Tanaka T, Warner BM, Odani T, Ji Y, Mo YQ, Nakamura H, et al. LAMP3 induces apoptosis and autoantigen release in Sj\u00f6gren\u2019s syndrome patients. Sci Rep. 2020;10:15169. https:\/\/doi.org\/10.1038\/s41598-020-71669-5.","journal-title":"Sci Rep"},{"key":"3099_CR13","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1083\/jcb.201004096","volume":"189","author":"MR Elliott","year":"2010","unstructured":"Elliott MR, Ravichandran KS. Clearance of apoptotic cells: implications in health and disease. J Cell Biol. 2010;189:1059\u201370. https:\/\/doi.org\/10.1083\/jcb.201004096.","journal-title":"J Cell Biol"},{"key":"3099_CR14","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1038\/cdd.2016.7","volume":"23","author":"S Nagata","year":"2016","unstructured":"Nagata S, Suzuki J, Segawa K, Fujii T. Exposure of phosphatidylserine on the cell surface. Cell Death Differ. 2016;23:952\u201361. https:\/\/doi.org\/10.1038\/cdd.2016.7.","journal-title":"Cell Death Differ"},{"key":"3099_CR15","doi-asserted-by":"publisher","first-page":"SCI-31","DOI":"10.1182\/blood.V126.23.SCI-31.SCI-31","volume":"126","author":"S Nagata","year":"2015","unstructured":"Nagata S. Flippases and scramblases at plasma membranes that regulate phosphatidylserine exposure. Blood. 2015;126:SCI-31. https:\/\/doi.org\/10.1182\/blood.V126.23.SCI-31.SCI-31.","journal-title":"Blood"},{"key":"3099_CR16","doi-asserted-by":"publisher","first-page":"135","DOI":"10.4049\/jimmunol.1004073","volume":"188","author":"KE Blume","year":"2012","unstructured":"Blume KE, Soeroes S, Keppeler H, Stevanovic S, Kretschmer D, Rautenberg M, et al. Cleavage of annexin A1 by ADAM10 during secondary necrosis generates a monocytic \u2018find-me\u2019 signal. J Immunol Baltim Md 1950. 2012;188:135\u201345. https:\/\/doi.org\/10.4049\/jimmunol.1004073.","journal-title":"J Immunol Baltim Md 1950"},{"key":"3099_CR17","doi-asserted-by":"publisher","first-page":"1676","DOI":"10.1038\/s41556-025-01749-z","volume":"27","author":"E Boada-Romero","year":"2025","unstructured":"Boada-Romero E, Guy CS, Palacios G, Mari L, Poudel S, Li Z, et al. Membrane receptors cluster phosphatidylserine to activate LC3-associated phagocytosis. Nat Cell Biol. 2025;27:1676\u201387. https:\/\/doi.org\/10.1038\/s41556-025-01749-z.","journal-title":"Nat Cell Biol"},{"key":"3099_CR18","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1038\/nature09413","volume":"467","author":"FB Chekeni","year":"2010","unstructured":"Chekeni FB, Elliott MR, Sandilos JK, Walk SF, Kinchen JM, Lazarowski ER, et al. Pannexin 1 channels mediate \u2018find-me\u2019 signal release and membrane permeability during apoptosis. Nature. 2010;467:863\u20137. https:\/\/doi.org\/10.1038\/nature09413.","journal-title":"Nature"},{"key":"3099_CR19","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1038\/nature08296","volume":"461","author":"MR Elliott","year":"2009","unstructured":"Elliott MR, Chekeni FB, Trampont PC, Lazarowski ER, Kadl A, Walk SF, et al. Nucleotides released by apoptotic cells act as a find-me signal for phagocytic clearance. Nature. 2009;461:282\u20136. https:\/\/doi.org\/10.1038\/nature08296.","journal-title":"Nature"},{"key":"3099_CR20","doi-asserted-by":"publisher","first-page":"e3001259","DOI":"10.1371\/journal.pbio.3001259","volume":"19","author":"SM Pontejo","year":"2021","unstructured":"Pontejo SM, Murphy PM. Chemokines act as phosphatidylserine-bound \u201cfind-me\u201d signals in apoptotic cell clearance. PLoS Biol. 2021;19:e3001259. https:\/\/doi.org\/10.1371\/journal.pbio.3001259.","journal-title":"PLoS Biol"},{"key":"3099_CR21","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1038\/s41418-019-0342-5","volume":"27","author":"R Tixeira","year":"2020","unstructured":"Tixeira R, Phan TK, Caruso S, Shi B, Atkin-Smith GK, Nedeva C, et al. ROCK1 but not LIMK1 or PAK2 is a key regulator of apoptotic membrane blebbing and cell disassembly. Cell Death Differ. 2020;27:102\u201316. https:\/\/doi.org\/10.1038\/s41418-019-0342-5.","journal-title":"Cell Death Differ"},{"key":"3099_CR22","doi-asserted-by":"publisher","unstructured":"Julian L, Naylor G, Wickman GR, Rath N, Castino G, Stevenson D, et al. Defective apoptotic cell contractility provokes sterile inflammation, leading to liver damage and tumour suppression. eLife. 10:e61983. https:\/\/doi.org\/10.7554\/eLife.61983","DOI":"10.7554\/eLife.61983"},{"key":"3099_CR23","doi-asserted-by":"publisher","DOI":"10.1126\/science.abo7027","volume":"384","author":"I Liebold","year":"2024","unstructured":"Liebold I, Al Jawazneh A, Casar C, Lanzloth C, Leyk S, Hamley M, et al. Apoptotic cell identity induces distinct functional responses to IL-4 in efferocytic macrophages. Science. 2024;384:eabo7027. https:\/\/doi.org\/10.1126\/science.abo7027.","journal-title":"Science"},{"key":"3099_CR24","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/S0005-2760(97)00082-9","volume":"1349","author":"G Atsumi","year":"1997","unstructured":"Atsumi G, Murakami M, Tajima M, Shimbara S, Hara N, Kudo I. The perturbed membrane of cells undergoing apoptosis is susceptible to type II secretory phospholipase A2 to liberate arachidonic acid. Biochim Biophys Acta BBA - Lipids Lipid Metab. 1997;1349:43\u201354. https:\/\/doi.org\/10.1016\/S0005-2760(97)00082-9.","journal-title":"Biochim Biophys Acta BBA - Lipids Lipid Metab"},{"key":"3099_CR25","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1172\/JCI36226","volume":"119","author":"I Bournazou","year":"2009","unstructured":"Bournazou I, Pound JD, Duffin R, Bournazos S, Melville LA, Brown SB, et al. Apoptotic human cells inhibit migration of granulocytes via release of lactoferrin. J Clin Invest. 2009;119:20\u201332. https:\/\/doi.org\/10.1172\/JCI36226. PubMed PMID: 19033648.","journal-title":"J Clin Invest"},{"key":"3099_CR26","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1038\/s41586-020-2121-3","volume":"580","author":"CB Medina","year":"2020","unstructured":"Medina CB, Mehrotra P, Arandjelovic S, Perry JSA, Guo Y, Morioka S, et al. Metabolites released from apoptotic cells act as tissue messengers. Nature. 2020;580:130\u20135. https:\/\/doi.org\/10.1038\/s41586-020-2121-3.","journal-title":"Nature"},{"key":"3099_CR27","doi-asserted-by":"publisher","unstructured":"Shi B, Phan TK, Poon IKH Extracellular vesicles from the dead: the final message. Trends Cell Biol. 2024;0. https:\/\/doi.org\/10.1016\/j.tcb.2024.09.005","DOI":"10.1016\/j.tcb.2024.09.005"},{"key":"3099_CR28","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14128","volume":"8","author":"C Rogers","year":"2017","unstructured":"Rogers C, Fernandes-Alnemri T, Mayes L, Alnemri D, Cingolani G, Alnemri ES. Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic\/pyroptotic cell death. Nat Commun. 2017;8:14128. https:\/\/doi.org\/10.1038\/ncomms14128.","journal-title":"Nat Commun"},{"key":"3099_CR29","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8439","volume":"6","author":"GK Atkin-Smith","year":"2015","unstructured":"Atkin-Smith GK, Tixeira R, Paone S, Mathivanan S, Collins C, Liem M, et al. A novel mechanism of generating extracellular vesicles during apoptosis via a beads-on-a-string membrane structure. Nat Commun. 2015;6:7439. https:\/\/doi.org\/10.1038\/ncomms8439.","journal-title":"Nat Commun"},{"key":"3099_CR30","doi-asserted-by":"publisher","first-page":"5026","DOI":"10.1182\/blood-2008-06-162404","volume":"112","author":"LA Truman","year":"2008","unstructured":"Truman LA, Ford CA, Pasikowska M, Pound JD, Wilkinson SJ, Dumitriu IE, et al. CX3CL1\/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis. Blood. 2008;112:5026\u201336. https:\/\/doi.org\/10.1182\/blood-2008-06-162404.","journal-title":"Blood"},{"key":"3099_CR31","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/j.cmet.2020.01.001","volume":"31","author":"A Yurdagul","year":"2020","unstructured":"Yurdagul A, Subramanian M, Wang X, Crown SB, Ilkayeva OR, Darville L, et al. Macrophage metabolism of apoptotic cell-derived arginine promotes continual efferocytosis and resolution of injury. Cell Metab. 2020;31:518\u2013533.e10. https:\/\/doi.org\/10.1016\/j.cmet.2020.01.001.","journal-title":"Cell Metab"},{"key":"3099_CR32","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1038\/s42255-024-01115-7","volume":"6","author":"SR Sukka","year":"2024","unstructured":"Sukka SR, Ampomah PB, Darville LNF, Ngai D, Wang X, Kuriakose G, et al. Efferocytosis drives a tryptophan metabolism pathway in macrophages to promote tissue resolution. Nat Metab. 2024;6:1736\u201355. https:\/\/doi.org\/10.1038\/s42255-024-01115-7.","journal-title":"Nat Metab"},{"key":"3099_CR33","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1038\/s43018-024-00731-2","volume":"5","author":"Y Astuti","year":"2024","unstructured":"Astuti Y, Raymant M, Quaranta V, Clarke K, Abudula M, Smith O, et al. Efferocytosis reprograms the tumor microenvironment to promote pancreatic cancer liver metastasis. Nat Cancer. 2024;5:774\u201390. https:\/\/doi.org\/10.1038\/s43018-024-00731-2.","journal-title":"Nat Cancer"},{"key":"3099_CR34","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/34112","volume":"391","author":"M Enari","year":"1998","unstructured":"Enari M, Sakahira H, Yokoyama H, Okawa K, Iwamatsu A, Nagata S. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature. 1998;391:43\u201350. https:\/\/doi.org\/10.1038\/34112.","journal-title":"Nature"},{"key":"3099_CR35","doi-asserted-by":"publisher","first-page":"4059","DOI":"10.1242\/jcs.02529","volume":"118","author":"JD Lane","year":"2005","unstructured":"Lane JD, Allan VJ, Woodman PG. Active relocation of chromatin and endoplasmic reticulum into blebs in late apoptotic cells. J Cell Sci. 2005;118:4059\u201371. https:\/\/doi.org\/10.1242\/jcs.02529.","journal-title":"J Cell Sci"},{"key":"3099_CR36","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-53049-w","volume":"9","author":"ME Maes","year":"2019","unstructured":"Maes ME, Grosser JA, Fehrman RL, Schlamp CL, Nickells RW. Completion of BAX recruitment correlates with mitochondrial fission during apoptosis. Sci Rep. 2019;9:16565. https:\/\/doi.org\/10.1038\/s41598-019-53049-w.","journal-title":"Sci Rep"},{"key":"3099_CR37","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.14670\/HH-25.1457","volume":"25","author":"JPX Cheng","year":"2010","unstructured":"Cheng JPX, Lane JD. Organelle dynamics and membrane trafficking in apoptosis and autophagy. Histol Histopathol. 2010;25:1457\u201372. https:\/\/doi.org\/10.14670\/HH-25.1457.","journal-title":"Histol Histopathol"},{"key":"3099_CR38","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/bjc.1972.33","volume":"26","author":"JF Kerr","year":"1972","unstructured":"Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer. 1972;26:239\u201357. https:\/\/doi.org\/10.1038\/bjc.1972.33.","journal-title":"Br J Cancer"},{"key":"3099_CR39","doi-asserted-by":"publisher","first-page":"e82","DOI":"10.1038\/cddis.2010.59","volume":"1","author":"JPX Cheng","year":"2010","unstructured":"Cheng JPX, Betin VMS, Weir H, Shelmani GMA, Moss DK, Lane JD. Caspase cleavage of the Golgi stacking factor GRASP65 is required for Fas\/CD95-mediated apoptosis. Cell Death Dis. 2010;1:e82\u2013e82. https:\/\/doi.org\/10.1038\/cddis.2010.59.","journal-title":"Cell Death Dis"},{"key":"3099_CR40","doi-asserted-by":"publisher","first-page":"830","DOI":"10.3389\/fcell.2020.00830","volume":"8","author":"Q He","year":"2020","unstructured":"He Q, Liu H, Deng S, Chen X, Li D, Jiang X, et al. The Golgi Apparatus May Be a Potential Therapeutic Target for Apoptosis-Related Neurological Diseases. Front Cell Dev Biol. 2020;8:830. https:\/\/doi.org\/10.3389\/fcell.2020.00830.","journal-title":"Front Cell Dev Biol"},{"key":"3099_CR41","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1111\/j.1600-0854.2007.00542.x","volume":"8","author":"S Mukherjee","year":"2007","unstructured":"Mukherjee S, Chiu R, Leung SM, Shields D. Fragmentation of the golgi apparatus: an early apoptotic event independent of the cytoskeleton. Traffic. 2007;8:369\u201378. https:\/\/doi.org\/10.1111\/j.1600-0854.2007.00542.x.","journal-title":"Traffic"},{"key":"3099_CR42","doi-asserted-by":"publisher","first-page":"20684","DOI":"10.1073\/pnas.1116848108","volume":"108","author":"Y Berda-Haddad","year":"2011","unstructured":"Berda-Haddad Y, Robert S, Salers P, Zekraoui L, Farnarier C, Dinarello CA, et al. Sterile inflammation of endothelial cell-derived apoptotic bodies is mediated by interleukin-1\u03b1. Proc Natl Acad Sci USA. 2011;108:20684\u20139. https:\/\/doi.org\/10.1073\/pnas.1116848108.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3099_CR43","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1038\/sj.cdd.4402239","volume":"15","author":"M Schiller","year":"2008","unstructured":"Schiller M, Bekeredjian-Ding I, Heyder P, Blank N, Ho AD, Lorenz HM. Autoantigens are translocated into small apoptotic bodies during early stages of apoptosis. Cell Death Differ. 2008;15:183\u201391. https:\/\/doi.org\/10.1038\/sj.cdd.4402239.","journal-title":"Cell Death Differ"},{"key":"3099_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s42003-020-0955-8","volume":"3","author":"GK Atkin-Smith","year":"2020","unstructured":"Atkin-Smith GK, Duan M, Zanker DJ, Loh L, Nguyen THO, Koutsakos M, et al. Monocyte apoptotic bodies are vehicles for influenza A virus propagation. Commun Biol. 2020;3:1\u201314. https:\/\/doi.org\/10.1038\/s42003-020-0955-8.","journal-title":"Commun Biol"},{"key":"3099_CR45","doi-asserted-by":"publisher","unstructured":"Phan TK, Sheerin D, Shi B, Dayton M, Mackewicz L, Ozkocak DC, et al. Voltage-gated T-type calcium channel blockers reduce apoptotic body mediated SARS-CoV-2 cell-to-cell spread and subsequent cytokine storm [Internet]. bioRxiv; 2023. p. 2023.11.03.565419. Available from: https:\/\/doi.org\/10.1101\/2023.11.03.565419.","DOI":"10.1101\/2023.11.03.565419"},{"key":"3099_CR46","doi-asserted-by":"publisher","unstructured":"Shi B, Tang C, Rutter SF, Audi O, Ozkocak DC, Trenerry AM, et al. NINJ1 oligomerises on large apoptotic cell-derived extracellular vesicles to regulate vesicle stability and cellular content release. Front Immunol. 2025 Aug;16. https:\/\/doi.org\/10.3389\/fimmu.2025.1599809.","DOI":"10.3389\/fimmu.2025.1599809"},{"key":"3099_CR47","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.cell.2023.11.040","volume":"187","author":"GK Voeltz","year":"2024","unstructured":"Voeltz GK, Sawyer EM, Hajn\u00f3czky G, Prinz WA. Making the connection: how membrane contact sites have changed our view of organelle biology. Cell. 2024;187:257\u201370. https:\/\/doi.org\/10.1016\/j.cell.2023.11.040.","journal-title":"Cell"},{"key":"3099_CR48","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/sj.cdd.4400404","volume":"5","author":"VA Fadok","year":"1998","unstructured":"Fadok VA, Bratton DL, Frasch SC, Warner ML, Henson PM. The role of phosphatidylserine in recognition of apoptotic cells by phagocytes. Cell Death Differ. 1998;5:551\u201362. https:\/\/doi.org\/10.1038\/sj.cdd.4400404.","journal-title":"Cell Death Differ"},{"key":"3099_CR49","doi-asserted-by":"publisher","unstructured":"Nagata S, Sakuragi T, Segawa K. Flippase and scramblase for phosphatidylserine exposure. Curr Opin Immunol. 2020 Feb; Innate immunity 62:31\u20138. https:\/\/doi.org\/10.1016\/j.coi.2019.11.009.","DOI":"10.1016\/j.coi.2019.11.009"},{"key":"3099_CR50","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1038\/s41418-022-00931-2","volume":"29","author":"Kim OH","year":"2022","unstructured":"Kim OH, Kang GH, Hur J, Lee J, Jung Y, Hong IS, et al. Externalized phosphatidylinositides on apoptotic cells are eat-me signals recognized by CD14. Cell Death Differ. 2022;29:1423\u201332. https:\/\/doi.org\/10.1038\/s41418-022-00931-2.","journal-title":"Cell Death Differ"},{"key":"3099_CR51","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.cell.2005.08.032","volume":"123","author":"SJ Gardai","year":"2005","unstructured":"Gardai SJ, McPhillips KA, Frasch SC, Janssen WJ, Starefeldt A, Murphy-Ullrich JE, et al. Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte. Cell. 2005;123:321\u201334. https:\/\/doi.org\/10.1016\/j.cell.2005.08.032.","journal-title":"Cell"},{"key":"3099_CR52","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1038\/emboj.2009.1","volume":"28","author":"T Panaretakis","year":"2009","unstructured":"Panaretakis T, Kepp O, Brockmeier U, Tesniere A, Bjorklund A, Chapman DC, et al. Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death. EMBO J. 2009;28:578\u201390. https:\/\/doi.org\/10.1038\/emboj.2009.1.","journal-title":"EMBO J"},{"key":"3099_CR53","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1038\/nri3607","volume":"14","author":"IKH Poon","year":"2014","unstructured":"Poon IKH, Lucas CD, Rossi AG, Ravichandran KS. Apoptotic cell clearance: basic biology and therapeutic potential. Nat Rev Immunol. 2014;14:166\u201380. https:\/\/doi.org\/10.1038\/nri3607.","journal-title":"Nat Rev Immunol"},{"key":"3099_CR54","doi-asserted-by":"publisher","first-page":"661","DOI":"10.4049\/jimmunol.1401719","volume":"195","author":"Z Lv","year":"2015","unstructured":"Lv Z, Bian Z, Shi L, Niu S, Ha B, Tremblay A, et al. Loss of cell surface CD47 \u2018clustering\u2019 formation and binding avidity to SIRP\u03b1 facilitate apoptotic cell clearance by macrophage. J Immunol Baltim Md 1950. 2015;195:661\u201371. https:\/\/doi.org\/10.4049\/jimmunol.1401719.","journal-title":"J Immunol Baltim Md 1950"},{"key":"3099_CR55","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1016\/j.devcel.2024.01.020","volume":"59","author":"T Le","year":"2024","unstructured":"Le T, Ferling I, Qiu L, Nabaile C, Assun\u00e7\u00e3o L, Roskelley CD, et al. Redistribution of the glycocalyx exposes phagocytic determinants on apoptotic cells. Dev Cell. 2024;59:853\u2013868.e7. https:\/\/doi.org\/10.1016\/j.devcel.2024.01.020.","journal-title":"Dev Cell"},{"key":"3099_CR56","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-44619-8","volume":"15","author":"LZ Drexhage","year":"2024","unstructured":"Drexhage LZ, Zhang S, Dupont M, Ragaller F, Sjule E, Cabezas-Caballero J, et al. Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosis. Nat Commun. 2024;15:541. https:\/\/doi.org\/10.1038\/s41467-023-44619-8.","journal-title":"Nat Commun"},{"key":"3099_CR57","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1016\/j.celrep.2019.12.079","volume":"30","author":"MC Tanzer","year":"2020","unstructured":"Tanzer MC, Frauenstein A, Stafford CA, Phulphagar K, Mann M, Meissner F. Quantitative and dynamic catalogs of proteins released during apoptotic and necroptotic cell death. Cell Rep. 2020;30:1260\u20131270.e5. https:\/\/doi.org\/10.1016\/j.celrep.2019.12.079.","journal-title":"Cell Rep"},{"key":"3099_CR58","doi-asserted-by":"publisher","unstructured":"Barth ND, Marwick JA, Vendrell M, Rossi AG, Dransfield I The \u201cPhagocytic Synapse\u201d and clearance of apoptotic cells. Front Immunol. 2017;8:01708. https:\/\/doi.org\/10.3389\/fimmu.2017.01708.","DOI":"10.3389\/fimmu.2017.01708"},{"key":"3099_CR59","doi-asserted-by":"publisher","unstructured":"Brokatzky D, Gomes MC, Robertin S, Albino C, Miles SL, Mostowy S Septins promote macrophage pyroptosis by regulating gasdermin D cleavage and ninjurin-1-mediated plasma membrane rupture. Cell Chem Biol. 2024 Aug; Special Issue Bridging Chem Biol. 2024;31:1518\u20131528.e6. https:\/\/doi.org\/10.1016\/j.chembiol.2024.07.003.","DOI":"10.1016\/j.chembiol.2024.07.003"},{"key":"3099_CR60","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1038\/s41586-021-03218-7","volume":"591","author":"N Kayagaki","year":"2021","unstructured":"Kayagaki N, Kornfeld OS, Lee BL, Stowe IB, O\u2019Rourke K, Li Q, et al. NINJ1 mediates plasma membrane rupture during lytic cell death. Nature. 2021;591:131\u20136. https:\/\/doi.org\/10.1038\/s41586-021-03218-7.","journal-title":"Nature"},{"key":"3099_CR61","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1038\/s44318-024-00055-y","volume":"43","author":"S Ramos","year":"2024","unstructured":"Ramos S, Hartenian E, Santos JC, Walch P, Broz P. NINJ1 induces plasma membrane rupture and release of damage-associated molecular pattern molecules during ferroptosis. EMBO J. 2024;43:1164\u201386. https:\/\/doi.org\/10.1038\/s44318-024-00055-y.","journal-title":"EMBO J"},{"key":"3099_CR62","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1038\/s41580-022-00564-w","volume":"24","author":"P Vandenabeele","year":"2023","unstructured":"Vandenabeele P, Bultynck G, Savvides SN. Pore-forming proteins as drivers of membrane permeabilization in cell death pathways. Nat Rev Mol Cell Biol. 2023;24:312\u201333. https:\/\/doi.org\/10.1038\/s41580-022-00564-w.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"3099_CR63","doi-asserted-by":"publisher","first-page":"R392","DOI":"10.1016\/j.cub.2017.12.034","volume":"28","author":"NW Andrews","year":"2018","unstructured":"Andrews NW, Corrotte M. Plasma membrane repair. Curr Biol. 2018;28:R392\u20137. https:\/\/doi.org\/10.1016\/j.cub.2017.12.034.","journal-title":"Curr Biol"},{"key":"3099_CR64","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/S0092-8674(01)00421-4","volume":"106","author":"A Reddy","year":"2001","unstructured":"Reddy A, Caler EV, Andrews NW. Plasma membrane repair is mediated by Ca2+-regulated exocytosis of lysosomes. Cell. 2001;106:157\u201369. https:\/\/doi.org\/10.1016\/S0092-8674(01)00421-4.","journal-title":"Cell"},{"key":"3099_CR65","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1038\/s41556-021-00706-w","volume":"23","author":"A Claude-Taupin","year":"2021","unstructured":"Claude-Taupin A, Jia J, Bhujabal Z, Garfa-Traor\u00e9 M, Kumar S, da Silva GPD, et al. ATG9A protects the plasma membrane from programmed and incidental permeabilization. Nat Cell Biol. 2021;23:846\u201358. https:\/\/doi.org\/10.1038\/s41556-021-00706-w.","journal-title":"Nat Cell Biol"},{"key":"3099_CR66","doi-asserted-by":"publisher","first-page":"E2281","DOI":"10.1073\/pnas.1407133111","volume":"111","author":"EJ Dickson","year":"2014","unstructured":"Dickson EJ, Jensen JB, Hille B. Golgi and plasma membrane pools of PI(4)P contribute to plasma membrane PI(4,5)P2 and maintenance of KCNQ2\/3 ion channel current. Proc Natl Acad Sci USA. 2014;111:E2281\u201390. https:\/\/doi.org\/10.1073\/pnas.1407133111.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3099_CR67","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1038\/s41590-024-02024-3","volume":"26","author":"CL Holley","year":"2025","unstructured":"Holley CL, Monteleone M, Fisch D, Libert AES, Ju RJ, Choi JH, et al. Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells. Nat Immunol. 2025;26:42\u201352. https:\/\/doi.org\/10.1038\/s41590-024-02024-3.","journal-title":"Nat Immunol"},{"key":"3099_CR68","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/cdd.2009.195","volume":"17","author":"IKH Poon","year":"2010","unstructured":"Poon IKH, Hulett MD, Parish CR. Molecular mechanisms of late apoptotic\/necrotic cell clearance. Cell Death Differ. 2010;17:381\u201397. https:\/\/doi.org\/10.1038\/cdd.2009.195.","journal-title":"Cell Death Differ"},{"key":"3099_CR69","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aam7828","volume":"9","author":"A Galleu","year":"2017","unstructured":"Galleu A, Riffo-Vasquez Y, Trento C, Lomas C, Dolcetti L, Cheung TS, et al. Apoptosis in mesenchymal stromal cells induces in vivo recipient-mediated immunomodulation. Sci Transl Med. 2017;9:eaam7828. https:\/\/doi.org\/10.1126\/scitranslmed.aam7828.","journal-title":"Sci Transl Med"},{"key":"3099_CR70","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26834-3","volume":"12","author":"SHM Pang","year":"2021","unstructured":"Pang SHM, D\u2019Rozario J, Mendonca S, Bhuvan T, Payne NL, Zheng D, et al. Mesenchymal stromal cell apoptosis is required for their therapeutic function. Nat Commun. 2021;12:6495. https:\/\/doi.org\/10.1038\/s41467-021-26834-3.","journal-title":"Nat Commun"},{"key":"3099_CR71","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1016\/j.immuni.2019.04.018","volume":"50","author":"S Morioka","year":"2019","unstructured":"Morioka S, Mauer\u00f6der C, Ravichandran KS. Living on the edge: efferocytosis at the interface of homeostasis and pathology. Immunity. 2019;50:1149\u201362. https:\/\/doi.org\/10.1016\/j.immuni.2019.04.018.","journal-title":"Immunity"},{"key":"3099_CR72","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1161\/CIRCULATIONAHA.116.025684","volume":"135","author":"Y Kojima","year":"2017","unstructured":"Kojima Y, Weissman IL, Leeper NJ. The role of efferocytosis in atherosclerosis. Circulation. 2017;135:476\u201389. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.116.025684.","journal-title":"Circulation"},{"key":"3099_CR73","doi-asserted-by":"publisher","first-page":"19386","DOI":"10.1073\/pnas.1215006109","volume":"109","author":"J Ahn","year":"2012","unstructured":"Ahn J, Gutman D, Saijo S, Barber GN. STING manifests self DNA-dependent inflammatory disease. Proc Natl Acad Sci USA. 2012;109:19386\u201391. https:\/\/doi.org\/10.1073\/pnas.1215006109.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3099_CR74","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41419-024-06947-5","volume":"15","author":"S Schuermans","year":"2024","unstructured":"Schuermans S, Kestens C, Marques PE. Systemic mechanisms of necrotic cell debris clearance. Cell Death Dis. 2024;15:1\u201316. https:\/\/doi.org\/10.1038\/s41419-024-06947-5.","journal-title":"Cell Death Dis"},{"key":"3099_CR75","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.adl3852","volume":"10","author":"J Better","year":"2025","unstructured":"Better J, Estiri M, Wetstein M, Pervizaj-Oruqaj L, Malainou C, Ogungbemi-Alt V, et al. Cell type\u2013specific efferocytosis determines functional plasticity of alveolar macrophages. Sci Immunol. 2025;10:eadl3852. https:\/\/doi.org\/10.1126\/sciimmunol.adl3852.","journal-title":"Sci Immunol"},{"key":"3099_CR76","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1016\/j.immuni.2017.10.006","volume":"47","author":"AW Roberts","year":"2017","unstructured":"Roberts AW, Lee BL, Deguine J, John S, Shlomchik MJ, Barton GM. Tissue-resident macrophages are locally programmed for silent clearance of apoptotic cells. Immunity. 2017;47:913\u2013927.e6. https:\/\/doi.org\/10.1016\/j.immuni.2017.10.006.","journal-title":"Immunity"},{"key":"3099_CR77","doi-asserted-by":"publisher","first-page":"2629","DOI":"10.1096\/fj.08-107169","volume":"22","author":"DR Gude","year":"2008","unstructured":"Gude DR, Alvarez SE, Paugh SW, Mitra P, Yu J, Griffiths R, et al. Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a \u201ccome-and-get-me\u201d signal. FASEB J. 2008;22:2629\u201338. https:\/\/doi.org\/10.1096\/fj.08-107169.","journal-title":"FASEB J"},{"key":"3099_CR78","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/S0092-8674(03)00422-7","volume":"113","author":"K Lauber","year":"2003","unstructured":"Lauber K, Bohn E, Kr\u00f6ber SM, Xiao YJ, Blumenthal SG, Lindemann RK, et al. Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal. Cell. 2003;113:717\u201330. https:\/\/doi.org\/10.1016\/S0092-8674(03)00422-7.","journal-title":"Cell"},{"key":"3099_CR79","doi-asserted-by":"publisher","first-page":"1974","DOI":"10.4049\/jimmunol.2200342","volume":"210","author":"J Hur","year":"2023","unstructured":"Hur J, Kim YJ, Choi DA, Kang DW, Kim J, Yoo HS, et al. Role of gasdermin E in the biogenesis of apoptotic cell\u2013derived exosomes. J Immunol. 2023;210:1974\u201389. https:\/\/doi.org\/10.4049\/jimmunol.2200342.","journal-title":"J Immunol"},{"key":"3099_CR80","doi-asserted-by":"publisher","first-page":"E11721","DOI":"10.1073\/pnas.1811432115","volume":"115","author":"SJ Park","year":"2018","unstructured":"Park SJ, Kim JM, Kim J, Hur J, Park S, Kim K, et al. Molecular mechanisms of biogenesis of apoptotic exosome-like vesicles and their roles as damage-associated molecular patterns. Proc Natl Acad Sci. 2018;115:E11721\u201330. https:\/\/doi.org\/10.1073\/pnas.1811432115.","journal-title":"Proc Natl Acad Sci"},{"key":"3099_CR81","doi-asserted-by":"publisher","unstructured":"Beillevaire D, Migneault F, Turgeon J, Gingras D, Rimbaud AK, Marcoux G, et al. Autolysosomes and caspase-3 control the biogenesis and release of immunogenic apoptotic exosomes. Cell Death Dis. 2022;13. Located at: Scopus. https:\/\/doi.org\/10.1038\/s41419-022-04591-5.","DOI":"10.1038\/s41419-022-04591-5"},{"key":"3099_CR82","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-44021-9","volume":"9","author":"AA Baxter","year":"2019","unstructured":"Baxter AA, Phan TK, Hanssen E, Liem M, Hulett MD, Mathivanan S, et al. Analysis of extracellular vesicles generated from monocytes under conditions of lytic cell death. Sci Rep. 2019;9:7538. https:\/\/doi.org\/10.1038\/s41598-019-44021-9.","journal-title":"Sci Rep"},{"key":"3099_CR83","doi-asserted-by":"publisher","first-page":"1848","DOI":"10.1038\/sj.cdd.4402201","volume":"14","author":"M Obeid","year":"2007","unstructured":"Obeid M, Panaretakis T, Joza N, Tufi R, Tesniere A, van Endert P, et al. Calreticulin exposure is required for the immunogenicity of \u03b3-irradiation and UVC light-induced apoptosis. Cell Death Differ. 2007;14:1848\u201350. https:\/\/doi.org\/10.1038\/sj.cdd.4402201.","journal-title":"Cell Death Differ"},{"key":"3099_CR84","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1038\/417182a","volume":"417","author":"R Hanayama","year":"2002","unstructured":"Hanayama R, Tanaka M, Miwa K, Shinohara A, Iwamatsu A, Nagata S. Identification of a factor that links apoptotic cells to phagocytes. Nature. 2002;417:182\u20137. https:\/\/doi.org\/10.1038\/417182a.","journal-title":"Nature"},{"key":"3099_CR85","doi-asserted-by":"publisher","first-page":"2093","DOI":"10.1182\/blood-2010-09-303842","volume":"117","author":"IKH Poon","year":"2011","unstructured":"Poon IKH, Patel KK, Davis DS, Parish CR, Hulett MD. Histidine-rich glycoprotein: the Swiss Army knife of mammalian plasma. Blood. 2011;117:2093\u2013101. https:\/\/doi.org\/10.1182\/blood-2010-09-303842.","journal-title":"Blood"},{"key":"3099_CR86","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1002\/art.33448","volume":"64","author":"NR Jog","year":"2012","unstructured":"Jog NR, Frisoni L, Shi Q, Monestier M, Hernandez S, Craft J, et al. Caspase-activated DNase is required for maintenance of tolerance to lupus nuclear autoantigens. Arthritis Rheum. 2012;64:1247\u201356. https:\/\/doi.org\/10.1002\/art.33448.","journal-title":"Arthritis Rheum"},{"key":"3099_CR87","doi-asserted-by":"publisher","first-page":"3298","DOI":"10.1016\/j.yexcr.2006.06.033","volume":"312","author":"KA Orlando","year":"2006","unstructured":"Orlando KA, Pittman RN. Rho kinase regulates phagocytosis, surface expression of GlcNAc, and Golgi fragmentation of apoptotic PC12 cells. Exp Cell Res. 2006;312:3298\u2013311. https:\/\/doi.org\/10.1016\/j.yexcr.2006.06.033.","journal-title":"Exp Cell Res"},{"key":"3099_CR88","doi-asserted-by":"publisher","unstructured":"Borges JP, Wang Y, David L, Volchuk A, Martins B, Cai R, et al. NINJ1 is activated by calcium-driven plasma membrane lipid scrambling during lytic cell death [Internet]. bioRxiv; 2024. p. 2024.10.23.619800. Available from: https:\/\/www.biorxiv.org\/content\/10.1101\/2024.10.23.619800v1. https:\/\/doi.org\/10.1101\/2024.10.23.619800.","DOI":"10.1101\/2024.10.23.619800"}],"container-title":["Cell Death Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41420-026-03099-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41420-026-03099-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41420-026-03099-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T02:55:51Z","timestamp":1779159351000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41420-026-03099-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,14]]},"references-count":88,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["3099"],"URL":"https:\/\/doi.org\/10.1038\/s41420-026-03099-7","relation":{},"ISSN":["2058-7716"],"issn-type":[{"value":"2058-7716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,14]]},"assertion":[{"value":"19 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 March 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 April 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"231"}}