{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T05:41:39Z","timestamp":1793338899818,"version":"4.5.0"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T00:00:00Z","timestamp":1538956800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Res"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1038\/s41422-018-0097-4","type":"journal-article","created":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T16:28:58Z","timestamp":1539016138000},"page":"1062-1076","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":201,"title":["A dynamic N6-methyladenosine methylome regulates intrinsic and acquired resistance to tyrosine kinase inhibitors"],"prefix":"10.1038","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4750-1200","authenticated-orcid":false,"given":"Fei","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aref","family":"Al-Kali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiuxia","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4319-7424","authenticated-orcid":false,"given":"Chuan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Litzow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,10,8]]},"reference":[{"key":"97_CR1","first-page":"920","volume":"89","author":"A Beghini","year":"2004","unstructured":"Beghini, A. et al. KIT activating mutations: incidence in adult and pediatric acute myeloid leukemia, and identification of an internal tandem duplication. Haematologica 89, 920\u2013925 (2004).","journal-title":"Haematologica"},{"key":"97_CR2","doi-asserted-by":"publisher","first-page":"2527","DOI":"10.1182\/blood-2007-05-091215","volume":"111","author":"U Bacher","year":"2008","unstructured":"Bacher, U., Haferlach, C., Kern, W., Haferlach, T. & Schnittger, S. Prognostic relevance of FLT3-TKD mutations in AML: the combination matters--an analysis of 3082 patients. Blood 111, 2527\u20132537 (2008).","journal-title":"Blood"},{"key":"97_CR3","doi-asserted-by":"crossref","unstructured":"Vainchenker, W., & Constantinescu, S. N. A unique activating mutation in JAK2 (V617F) is at the origin of polycythemia vera and allows a new classification of myeloproliferative diseases. Education Program, 195\u2013200 (2005).","DOI":"10.1182\/asheducation-2005.1.195"},{"key":"97_CR4","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1038\/315550a0","volume":"315","author":"E Shtivelman","year":"1985","unstructured":"Shtivelman, E., Lifshitz, B., Gale, R. P. & Canaani, E. Fused transcript of abl and bcr genes in chronic myelogenous leukaemia. Nature 315, 550\u2013554 (1985).","journal-title":"Nature"},{"key":"97_CR5","doi-asserted-by":"publisher","first-page":"11011","DOI":"10.1073\/pnas.0504952102","volume":"102","author":"TA Carter","year":"2005","unstructured":"Carter, T. A. et al. Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases. Proc. Natl Acad. Sci. USA 102, 11011\u201311016 (2005).","journal-title":"Proc. Natl Acad. Sci. U. S. A"},{"key":"97_CR6","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.ccr.2009.09.028","volume":"16","author":"T O\u2019Hare","year":"2009","unstructured":"O\u2019Hare, T. et al. AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell. 16, 401\u2013412 (2009).","journal-title":"Cancer Cell."},{"key":"97_CR7","doi-asserted-by":"crossref","first-page":"3498","DOI":"10.1182\/blood.V95.11.3498","volume":"95","author":"E Weisberg","year":"2000","unstructured":"Weisberg, E. & Griffin, J. D. Mechanism of resistance to the ABL tyrosine kinase inhibitor STI571 in BCR\/ABL-transformed hematopoietic cell lines. Blood 95, 3498\u20133505 (2000).","journal-title":"Blood"},{"key":"97_CR8","doi-asserted-by":"publisher","first-page":"874","DOI":"10.18632\/oncotarget.360","volume":"2","author":"M Dufies","year":"2011","unstructured":"Dufies, M. et al. Mechanisms of AXL overexpression and function in Imatinib-resistant chronic myeloid leukemia cells. Oncotarget 2, 874\u2013885 (2011).","journal-title":"Oncotarget"},{"key":"97_CR9","doi-asserted-by":"publisher","first-page":"34227","DOI":"10.1074\/jbc.M402290200","volume":"279","author":"Y Dai","year":"2004","unstructured":"Dai, Y., Rahmani, M., Corey, S. J., Dent, P. & Grant, S. A Bcr\/Abl-independent, Lyn-dependent form of imatinib mesylate (STI-571) resistance is associated with altered expression of Bcl-2. J. Biol. Chem. 279, 34227\u201334239 (2004).","journal-title":"J. Biol. Chem."},{"key":"97_CR10","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/nature09883","volume":"473","author":"C Duy","year":"2011","unstructured":"Duy, C. et al. BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition. Nature 473, 384\u2013388 (2011).","journal-title":"Nature"},{"key":"97_CR11","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.cell.2010.02.027","volume":"141","author":"SV Sharma","year":"2010","unstructured":"Sharma, S. V. et al. A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations. Cell 141, 69\u201380 (2010).","journal-title":"Cell"},{"key":"97_CR12","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1038\/ng.2913","volume":"46","author":"B Knoechel","year":"2014","unstructured":"Knoechel, B. et al. An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia. Nat. Genet. 46, 364\u2013370 (2014).","journal-title":"Nat. Genet."},{"key":"97_CR13","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1038\/nm.4040","volume":"22","author":"AN Hata","year":"2016","unstructured":"Hata, A. N. et al. Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition. Nat. Med. 22, 262\u2013269 (2016).","journal-title":"Nat. Med."},{"key":"97_CR14","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/nrg3724","volume":"15","author":"Y Fu","year":"2014","unstructured":"Fu, Y., Dominissini, D., Rechavi, G. & He, C. Gene expression regulation mediated through reversible m(6)A RNA methylation. Nat. Rev. Genet. 15, 293\u2013306 (2014).","journal-title":"Nat. Rev. Genet."},{"key":"97_CR15","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.stem.2015.01.016","volume":"16","author":"T Chen","year":"2015","unstructured":"Chen, T. et al. m(6)A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency. Cell. Stem. Cell. 16, 289\u2013301 (2015).","journal-title":"Cell. Stem. Cell."},{"key":"97_CR16","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/nrm3785","volume":"15","author":"KD Meyer","year":"2014","unstructured":"Meyer, K. D. & Jaffrey, S. R. The dynamic epitranscriptome: N6-methyladenosine and gene expression control. Nat. Rev. Mol. Cell Biol. 15, 313\u2013326 (2014).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"97_CR17","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.celrep.2014.05.048","volume":"8","author":"S Schwartz","year":"2014","unstructured":"Schwartz, S. et al. Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5\u2019 sites. Cell Rep. 8, 284\u2013296 (2014).","journal-title":"Cell Rep."},{"key":"97_CR18","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/nchembio.1432","volume":"10","author":"J Liu","year":"2014","unstructured":"Liu, J. et al. A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation. Nat. Chem. Biol. 10, 93\u201395 (2014).","journal-title":"Nat. Chem. Biol."},{"key":"97_CR19","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1038\/nchembio.687","volume":"7","author":"G Jia","year":"2011","unstructured":"Jia, G. et al. N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat. Chem. Biol. 7, 885\u2013887 (2011).","journal-title":"Nat. Chem. Biol."},{"key":"97_CR20","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.molcel.2012.10.015","volume":"49","author":"G Zheng","year":"2013","unstructured":"Zheng, G. et al. ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Mol. Cell 49, 18\u201329 (2013).","journal-title":"Mol. Cell"},{"key":"97_CR21","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1101\/gad.269415.115","volume":"29","author":"S Ke","year":"2015","unstructured":"Ke, S. et al. A majority of m6A residues are in the last exons, allowing the potential for 3\u2019 UTR regulation. Genes Dev. 29, 2037\u20132053 (2015).","journal-title":"Genes Dev."},{"key":"97_CR22","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/nature12730","volume":"505","author":"X Wang","year":"2014","unstructured":"Wang, X. et al. N6-methyladenosine-dependent regulation of messenger RNA stability. Nature 505, 117\u2013120 (2014).","journal-title":"Nature"},{"key":"97_CR23","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1016\/j.cell.2017.05.045","volume":"169","author":"IA Roundtree","year":"2017","unstructured":"Roundtree, I. A., Evans, M. E., Pan, T. & He, C. Dynamic RNA modifications in gene expression regulation. Cell 169, 1187\u20131200 (2017).","journal-title":"Cell"},{"key":"97_CR24","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1038\/nature21355","volume":"542","author":"BS Zhao","year":"2017","unstructured":"Zhao, B. S. et al. m(6)A-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transition. Nature 542, 475\u2013478 (2017).","journal-title":"Nature"},{"key":"97_CR25","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1016\/j.cell.2015.05.014","volume":"161","author":"X Wang","year":"2015","unstructured":"Wang, X. et al. N(6)-methyladenosine modulates messenger RNA translation efficiency. Cell 161, 1388\u20131399 (2015).","journal-title":"Cell"},{"key":"97_CR26","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1038\/cr.2014.151","volume":"24","author":"X Zhao","year":"2014","unstructured":"Zhao, X. et al. FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis. Cell Res. 24, 1403\u20131419 (2014).","journal-title":"Cell Res."},{"key":"97_CR27","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/nature11112","volume":"485","author":"D Dominissini","year":"2012","unstructured":"Dominissini, D. et al. Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature 485, 201\u2013206 (2012).","journal-title":"Nature"},{"key":"97_CR28","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.ccell.2016.11.017","volume":"31","author":"Z Li","year":"2017","unstructured":"Li, Z. et al. FTO Plays an oncogenic role in acute myeloid leukemia as a N6-methyladenosine RNA demethylase. Cancer Cell. 31, 127\u2013141 (2017).","journal-title":"Cancer Cell."},{"key":"97_CR29","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/j.ccr.2011.11.004","volume":"20","author":"LM Packer","year":"2011","unstructured":"Packer, L. M. et al. Nilotinib and MEK inhibitors induce synthetic lethality through paradoxical activation of RAF in drug-resistant chronic myeloid leukemia. Cancer Cell. 20, 715\u2013727 (2011).","journal-title":"Cancer Cell."},{"key":"97_CR30","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1182\/blood.V96.3.1070","volume":"96","author":"FX Mahon","year":"2000","unstructured":"Mahon, F. X. et al. Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571: diverse mechanisms of resistance. Blood 96, 1070\u20131079 (2000).","journal-title":"Blood"},{"key":"97_CR31","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1158\/0008-5472.CAN-03-1484","volume":"64","author":"NJ Donato","year":"2004","unstructured":"Donato, N. J. et al. Imatinib mesylate resistance through BCR-ABL independence in chronic myelogenous leukemia. Cancer Res. 64, 672\u2013677 (2004).","journal-title":"Cancer Res."},{"key":"97_CR32","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.ccr.2005.01.007","volume":"7","author":"E Weisberg","year":"2005","unstructured":"Weisberg, E. et al. Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl. Cancer Cell. 7, 129\u2013141 (2005).","journal-title":"Cancer Cell."},{"key":"97_CR33","doi-asserted-by":"publisher","first-page":"e83510","DOI":"10.1371\/journal.pone.0083510","volume":"8","author":"J Ding","year":"2013","unstructured":"Ding, J. et al. Inhibition of PI3K\/mTOR overcomes nilotinib resistance in BCR-ABL1 positive leukemia cells through translational down-regulation of MDM2. PLoS. ONE. 8, e83510 (2013).","journal-title":"PLoS. One."},{"key":"97_CR34","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/nature11303","volume":"489","author":"P Koppikar","year":"2012","unstructured":"Koppikar, P. et al. Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy. Nature 489, 155\u2013159 (2012).","journal-title":"Nature"},{"key":"97_CR35","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1016\/j.cell.2012.05.003","volume":"149","author":"KD Meyer","year":"2012","unstructured":"Meyer, K. D. et al. Comprehensive analysis of mRNA methylation reveals enrichment in 3\u2019 UTRs and near stop codons. Cell 149, 1635\u20131646 (2012).","journal-title":"Cell"},{"key":"97_CR36","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1038\/nature15377","volume":"526","author":"J Zhou","year":"2015","unstructured":"Zhou, J. et al. Dynamic m(6)A mRNA methylation directs translational control of heat shock response. Nature 526, 591\u2013594 (2015).","journal-title":"Nature"},{"key":"97_CR37","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.ccr.2014.05.019","volume":"26","author":"HJ Lee","year":"2014","unstructured":"Lee, H. J. et al. Drug resistance via feedback activation of Stat3 in oncogene-addicted cancer cells. Cancer Cell. 26, 207\u2013221 (2014).","journal-title":"Cancer Cell."},{"key":"97_CR38","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.cell.2017.11.031","volume":"172","author":"R Su","year":"2018","unstructured":"Su, R. et al. R-2HG exhibits anti-tumor activity by targeting FTO\/m(6)A\/MYC\/CEBPA signaling. Cell 172, 90\u2013105 (2018).","journal-title":"Cell"},{"key":"97_CR39","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1038\/nchembio.1654","volume":"10","author":"C Xu","year":"2014","unstructured":"Xu, C. et al. Structural basis for selective binding of m(6)A RNA by the YTHDC1 YTH domain. Nat. Chem. Bio 10, 927\u2013929 (2014).","journal-title":"Nat. Chem. Bio"},{"key":"97_CR40","doi-asserted-by":"publisher","first-page":"17963","DOI":"10.1021\/ja3064149","volume":"134","author":"B Chen","year":"2012","unstructured":"Chen, B. et al. Development of cell-active N6-methyladenosine RNA demethylase FTO inhibitor. J. Am. Chem. Soc. 134, 17963\u201317971 (2012).","journal-title":"J. Am. Chem. Soc."},{"key":"97_CR41","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1093\/nar\/gku1276","volume":"43","author":"Y Huang","year":"2015","unstructured":"Huang, Y. et al. Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5. Nucleic Acids Res. 43, 373\u2013384 (2015).","journal-title":"Nucleic Acids Res."},{"key":"97_CR42","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1126\/science.1261417","volume":"347","author":"S Geula","year":"2015","unstructured":"Geula, S. et al. m6A mRNA methylation facilitates resolution of naive pluripotency toward differentiation. Science 347, 1002\u20131006 (2015).","journal-title":"Science"},{"key":"97_CR43","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/nature21022","volume":"541","author":"J Mauer","year":"2017","unstructured":"Mauer, J. et al. Reversible methylation of m(6)Am in the 5\u2019 cap controls mRNA stability. Nature 541, 371\u2013375 (2017).","journal-title":"Nature"},{"key":"97_CR44","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.molcel.2017.10.002","volume":"68","author":"RA Coots","year":"2017","unstructured":"Coots, R. A. et al. m(6)A facilitates eIF4F-independent mRNA translation. Mol. Cell 68, 504\u2013514 (2017).","journal-title":"Mol. Cell"},{"key":"97_CR45","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/nmeth.1314","volume":"6","author":"EK Schmidt","year":"2009","unstructured":"Schmidt, E. K., Clavarino, G., Ceppi, M. & Pierre, P. SUnSET, a nonradioactive method to monitor protein synthesis. Nat. Methods 6, 275\u2013277 (2009).","journal-title":"Nat. Methods"},{"key":"97_CR46","doi-asserted-by":"publisher","first-page":"2234","DOI":"10.1182\/blood-2011-08-375535","volume":"119","author":"WT Parker","year":"2012","unstructured":"Parker, W. T., Ho, M., Scott, H. S., Hughes, T. P. & Branford, S. Poor response to second-line kinase inhibitors in chronic myeloid leukemia patients with multiple low-level mutations, irrespective of their resistance profile. Blood 119, 2234\u20132238 (2012).","journal-title":"Blood"},{"key":"97_CR47","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.ccell.2016.02.003","volume":"29","author":"MP Smith","year":"2016","unstructured":"Smith, M. P. et al. Inhibiting drivers of non-mutational drug tolerance is a salvage strategy for targeted melanoma therapy. Cancer Cell. 29, 270\u2013284 (2016).","journal-title":"Cancer Cell."},{"key":"97_CR48","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1038\/nn.3449","volume":"16","author":"ME Hess","year":"2013","unstructured":"Hess, M. E. et al. The fat mass and obesity associated gene (FTO) regulates activity of the dopaminergic midbrain circuitry. Nat. Neurosci. 16, 1042\u20131048 (2013).","journal-title":"Nat. Neurosci."},{"key":"97_CR49","doi-asserted-by":"publisher","first-page":"2557","DOI":"10.1073\/pnas.1222796110","volume":"110","author":"P Gulati","year":"2013","unstructured":"Gulati, P. et al. Role for the obesity-related FTO gene in the cellular sensing of amino acids. Proc. Natl Acad. Sci. USA 110, 2557\u20132562 (2013).","journal-title":"Proc. Natl Acad. Sci. U. S. A"},{"key":"97_CR50","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1016\/j.cell.2013.10.047","volume":"155","author":"S Schwartz","year":"2013","unstructured":"Schwartz, S. et al. High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis. Cell 155, 1409\u20131421 (2013).","journal-title":"Cell"},{"key":"97_CR51","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/j.stem.2014.09.019","volume":"15","author":"PJ Batista","year":"2014","unstructured":"Batista, P. J. et al. m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells. Cell. Stem. Cell. 15, 707\u2013719 (2014).","journal-title":"Cell. Stem. Cell."},{"key":"97_CR52","doi-asserted-by":"publisher","first-page":"11356","DOI":"10.1093\/nar\/gkx778","volume":"45","author":"M Bartosovic","year":"2017","unstructured":"Bartosovic, M. et al. N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3\u2019-end processing. Nucleic Acids Res. 45, 11356\u201311370 (2017).","journal-title":"Nucleic Acids Res."},{"key":"97_CR53","doi-asserted-by":"publisher","first-page":"1730","DOI":"10.1038\/leu.2015.56","volume":"29","author":"XN Gao","year":"2015","unstructured":"Gao, X. N. et al. AML1\/ETO cooperates with HIF1alpha to promote leukemogenesis through DNMT3a transactivation. Leukemia 29, 1730\u20131740 (2015).","journal-title":"Leukemia"},{"key":"97_CR54","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1038\/leu.2016.349","volume":"31","author":"F Yan","year":"2017","unstructured":"Yan, F. et al. Fatty acid-binding protein FABP4 mechanistically links obesity with aggressive AML by enhancing aberrant DNA methylation in AML cells. Leukemia 31, 1434\u20131442 (2017).","journal-title":"Leukemia"},{"key":"97_CR55","doi-asserted-by":"publisher","first-page":"6919","DOI":"10.1038\/onc.2017.305","volume":"36","author":"F Yan","year":"2017","unstructured":"Yan, F. et al. A regulatory circuit composed of DNA methyltransferases and receptor tyrosine kinases controls lung cancer cell aggressiveness. Oncogene 36, 6919\u20136928 (2017).","journal-title":"Oncogene"},{"key":"97_CR56","doi-asserted-by":"publisher","first-page":"6254","DOI":"10.1158\/1078-0432.CCR-17-0235","volume":"23","author":"N Shen","year":"2017","unstructured":"Shen, N. et al. Inactivation of receptor tyrosine kinases reverts aberrant DNA methylation in acute myeloid leukemia. Clin. Cancer Res. 23, 6254\u20136266 (2017).","journal-title":"Clin. Cancer Res."},{"key":"97_CR57","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1038\/nprot.2012.148","volume":"8","author":"D Dominissini","year":"2013","unstructured":"Dominissini, D., Moshitch-Moshkovitz, S., Salmon-Divon, M., Amariglio, N. & Rechavi, G. Transcriptome-wide mapping of N(6)-methyladenosine by m(6)A-seq based on immunocapturing and massively parallel sequencing. Nat. Protoc. 8, 176\u2013189 (2013).","journal-title":"Nat. Protoc."},{"key":"97_CR58","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2013-14-4-r36","volume":"14","author":"D Kim","year":"2013","unstructured":"Kim, D. et al. TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Genome Biol. 14, R36 (2013).","journal-title":"Genome Biol."},{"key":"97_CR59","doi-asserted-by":"publisher","first-page":"i378","DOI":"10.1093\/bioinformatics\/btw281","volume":"32","author":"X Cui","year":"2016","unstructured":"Cui, X., Meng, J., Zhang, S., Chen, Y. & Huang, Y. A novel algorithm for calling mRNA m6A peaks by modeling biological variances in MeRIP-seq data. Bioinformatics 32, i378\u2013i385 (2016).","journal-title":"Bioinformatics"},{"key":"97_CR60","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1186\/s12859-015-0623-z","volume":"16","author":"C Jia","year":"2015","unstructured":"Jia, C. et al. MetaDiff: differential isoform expression analysis using random-effects meta-regression. BMC Bioinform. 16, 208 (2015).","journal-title":"BMC Bioinform."},{"key":"97_CR61","first-page":"8367534","volume":"2016","author":"X Cui","year":"2016","unstructured":"Cui, X. et al. Guitar: an R\/Bioconductor package for gene annotation guided transcriptomic analysis of RNA-related genomic features. Biomed. Res. Int. 2016, 8367534 (2016).","journal-title":"Biomed. Res. Int."},{"key":"97_CR62","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.molcel.2010.05.004","volume":"38","author":"S Heinz","year":"2010","unstructured":"Heinz, S. et al. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol. Cell 38, 576\u2013589 (2010).","journal-title":"Mol. Cell"},{"key":"97_CR63","doi-asserted-by":"crossref","first-page":"34453","DOI":"10.18632\/oncotarget.16431","volume":"8","author":"J Pang","year":"2017","unstructured":"Pang, J. et al. Thymoquinone exerts potent growth-suppressive activity on leukemia through DNA hypermethylation reversal in leukemia cells. Oncotarget 8, 34453\u201334467 (2017).","journal-title":"Oncotarget"}],"container-title":["Cell Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41422-018-0097-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41422-018-0097-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41422-018-0097-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:17:08Z","timestamp":1684617428000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41422-018-0097-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,8]]},"references-count":63,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["97"],"URL":"https:\/\/doi.org\/10.1038\/s41422-018-0097-4","relation":{},"ISSN":["1001-0602","1748-7838"],"issn-type":[{"value":"1001-0602","type":"print"},{"value":"1748-7838","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,8]]},"assertion":[{"value":"6 June 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 September 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 September 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 October 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"C.H. is a scientific founder of the Accent Therapeutics, Inc.. The other authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}