{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:34:32Z","timestamp":1792467272261,"version":"4.5.0"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T00:00:00Z","timestamp":1672617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T00:00:00Z","timestamp":1672617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Res"],"DOI":"10.1038\/s41422-022-00744-5","type":"journal-article","created":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T00:02:50Z","timestamp":1672617770000},"page":"55-70","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy"],"prefix":"10.1038","volume":"33","author":[{"given":"Zaizhou","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaige","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanlin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven P.","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peifeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiancheng","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinori","family":"Kawakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7371-4512","authenticated-orcid":false,"given":"Jing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Chase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Hodder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy P.","family":"Spicer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Scampavia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7865-8249","authenticated-orcid":false,"given":"Chunyang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9229-6288","authenticated-orcid":false,"given":"Lifeng","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3448-5494","authenticated-orcid":false,"given":"Pengfei","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7566-1212","authenticated-orcid":false,"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,1,2]]},"reference":[{"key":"744_CR1","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1126\/science.1253735","volume":"346","author":"JA Lo","year":"2014","unstructured":"Lo, J. A. & Fisher, D. E. The melanoma revolution: from UV carcinogenesis to a new era in therapeutics. Science 346, 945\u2013949 (2014).","journal-title":"Science"},{"key":"744_CR2","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/S0092-8674(02)00762-6","volume":"109","author":"GG McGill","year":"2002","unstructured":"McGill, G. G. et al. Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. Cell 109, 707\u2013718 (2002).","journal-title":"Cell"},{"key":"744_CR3","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1038\/nature05661","volume":"445","author":"V Gray-Schopfer","year":"2007","unstructured":"Gray-Schopfer, V., Wellbrock, C. & Marais, R. Melanoma biology and new targeted therapy. Nature 445, 851\u2013857 (2007).","journal-title":"Nature"},{"key":"744_CR4","doi-asserted-by":"publisher","first-page":"S109","DOI":"10.1038\/515S109a","volume":"515","author":"B Owens","year":"2014","unstructured":"Owens, B. Melanoma. Nature 515, S109 (2014).","journal-title":"Nature"},{"key":"744_CR5","doi-asserted-by":"publisher","first-page":"6659","DOI":"10.1038\/onc.2017.292","volume":"36","author":"J Leclerc","year":"2017","unstructured":"Leclerc, J., Ballotti, R. & Bertolotto, C. Pathways from senescence to melanoma: focus on MITF sumoylation. Oncogene 36, 6659\u20136667 (2017).","journal-title":"Oncogene"},{"key":"744_CR6","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.molmed.2006.07.008","volume":"12","author":"C Levy","year":"2006","unstructured":"Levy, C., Khaled, M. & Fisher, D. E. MITF: master regulator of melanocyte development and melanoma oncogene. Trends Mol. Med. 12, 406\u2013414 (2006).","journal-title":"Trends Mol. Med."},{"key":"744_CR7","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1038\/nrc1947","volume":"6","author":"LA Garraway","year":"2006","unstructured":"Garraway, L. A. & Sellers, W. R. Lineage dependency and lineage-survival oncogenes in human cancer. Nat. Rev. Cancer 6, 593\u2013602 (2006).","journal-title":"Nat. Rev. Cancer"},{"key":"744_CR8","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/j.1755-148X.2009.00653.x","volume":"23","author":"Y Cheli","year":"2010","unstructured":"Cheli, Y., Ohanna, M., Ballotti, R. & Bertolotto, C. Fifteen-year quest for microphthalmia-associated transcription factor target genes. Pigment Cell Melanoma Res. 23, 27\u201340 (2010).","journal-title":"Pigment Cell Melanoma Res."},{"key":"744_CR9","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/nature03664","volume":"436","author":"LA Garraway","year":"2005","unstructured":"Garraway, L. A. et al. Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature 436, 117\u2013122 (2005).","journal-title":"Nature"},{"key":"744_CR10","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1038\/nature10539","volume":"480","author":"C Bertolotto","year":"2011","unstructured":"Bertolotto, C. et al. A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma. Nature 480, 94\u201398 (2011).","journal-title":"Nature"},{"key":"744_CR11","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nature10630","volume":"480","author":"S Yokoyama","year":"2011","unstructured":"Yokoyama, S. et al. A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma. Nature 480, 99\u2013103 (2011).","journal-title":"Nature"},{"key":"744_CR12","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1038\/nature12688","volume":"504","author":"CM Johannessen","year":"2013","unstructured":"Johannessen, C. M. et al. A melanocyte lineage program confers resistance to MAP kinase pathway inhibition. Nature 504, 138\u2013142 (2013).","journal-title":"Nature"},{"key":"744_CR13","doi-asserted-by":"publisher","first-page":"E536","DOI":"10.1073\/pnas.1418163112","volume":"112","author":"D Perna","year":"2015","unstructured":"Perna, D. et al. BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma model. Proc. Natl. Acad. Sci. USA 112, E536\u2013E545 (2015).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"744_CR14","doi-asserted-by":"publisher","first-page":"4321","DOI":"10.1073\/pnas.1205575110","volume":"110","author":"R Haq","year":"2013","unstructured":"Haq, R. et al. BCL2A1 is a lineage-specific antiapoptotic melanoma oncogene that confers resistance to BRAF inhibition. Proc. Natl. Acad. Sci. USA 110, 4321\u20134326 (2013).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"744_CR15","doi-asserted-by":"publisher","first-page":"2307","DOI":"10.1038\/onc.2010.598","volume":"30","author":"Y Cheli","year":"2011","unstructured":"Cheli, Y. et al. Mitf is the key molecular switch between mouse or human melanoma initiating cells and their differentiated progeny. Oncogene 30, 2307\u20132318 (2011).","journal-title":"Oncogene"},{"key":"744_CR16","doi-asserted-by":"publisher","first-page":"3036","DOI":"10.1038\/onc.2011.33","volume":"30","author":"AE Thurber","year":"2011","unstructured":"Thurber, A. E. et al. Inverse expression states of the BRN2 and MITF transcription factors in melanoma spheres and tumour xenografts regulate the NOTCH pathway. Oncogene 30, 3036\u20133048 (2011).","journal-title":"Oncogene"},{"key":"744_CR17","doi-asserted-by":"publisher","first-page":"2304","DOI":"10.1038\/onc.2010.641","volume":"30","author":"CR Goding","year":"2011","unstructured":"Goding, C. R. Commentary. A picture of Mitf in melanoma immortality. Oncogene 30, 2304\u20132306 (2011).","journal-title":"Oncogene"},{"key":"744_CR18","doi-asserted-by":"publisher","first-page":"10365","DOI":"10.1074\/jbc.M513094200","volume":"281","author":"GG McGill","year":"2006","unstructured":"McGill, G. G., Haq, R., Nishimura, E. K. & Fisher, D. E. c-Met expression is regulated by Mitf in the melanocyte lineage. J. Biol. Chem. 281, 10365\u201310373 (2006).","journal-title":"J. Biol. Chem."},{"key":"744_CR19","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.ccr.2004.10.014","volume":"6","author":"J Du","year":"2004","unstructured":"Du, J. et al. Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF. Cancer Cell 6, 565\u2013576 (2004).","journal-title":"Cancer Cell"},{"key":"744_CR20","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1083\/jcb.200410115","volume":"168","author":"AE Loercher","year":"2005","unstructured":"Loercher, A. E., Tank, E. M., Delston, R. B. & Harbour, J. W. MITF links differentiation with cell cycle arrest in melanocytes by transcriptional activation of INK4A. J. Cell Biol. 168, 35\u201340 (2005).","journal-title":"J. Cell Biol."},{"key":"744_CR21","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1038\/nature03269","volume":"433","author":"S Carreira","year":"2005","unstructured":"Carreira, S. et al. Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression. Nature 433, 764\u2013769 (2005).","journal-title":"Nature"},{"key":"744_CR22","doi-asserted-by":"publisher","first-page":"17025","DOI":"10.1073\/pnas.0909292106","volume":"106","author":"S Zhu","year":"2009","unstructured":"Zhu, S. et al. A genomic screen identifies TYRO3 as a MITF regulator in melanoma. Proc. Natl. Acad. Sci. USA 106, 17025\u201317030 (2009).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"744_CR23","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1421","volume":"2","author":"X Zhao","year":"2011","unstructured":"Zhao, X., Fiske, B., Kawakami, A., Li, J. & Fisher, D. E. Regulation of MITF stability by the USP13 deubiquitinase. Nat. Commun. 2, 414 (2011).","journal-title":"Nat. Commun."},{"key":"744_CR24","doi-asserted-by":"publisher","first-page":"2770","DOI":"10.1101\/gad.8.22.2770","volume":"8","author":"TJ Hemesath","year":"1994","unstructured":"Hemesath, T. J. et al. Microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family. Genes Dev. 8, 2770\u20132780 (1994).","journal-title":"Genes Dev."},{"key":"744_CR25","doi-asserted-by":"publisher","first-page":"2647","DOI":"10.1101\/gad.198192.112","volume":"26","author":"V Pogenberg","year":"2012","unstructured":"Pogenberg, V. et al. Restricted leucine zipper dimerization and specificity of DNA recognition of the melanocyte master regulator MITF. Genes Dev. 26, 2647\u20132658 (2012).","journal-title":"Genes Dev."},{"key":"744_CR26","doi-asserted-by":"publisher","first-page":"2038","DOI":"10.1182\/blood.V97.7.2038","volume":"97","author":"E Morii","year":"2001","unstructured":"Morii, E. et al. Importance of leucine zipper domain of mi transcription factor (MITF) for differentiation of mast cells demonstrated using mi(ce)\/mi(ce) mutant mice of which MITF lacks the zipper domain. Blood 97, 2038\u20132044 (2001).","journal-title":"Blood"},{"key":"744_CR27","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1093\/nar\/gkz1104","volume":"48","author":"V Pogenberg","year":"2020","unstructured":"Pogenberg, V. et al. Mechanism of conditional partner selectivity in MITF\/TFE family transcription factors with a conserved coiled coil stammer motif. Nucleic Acids Res. 48, 934\u2013948 (2020).","journal-title":"Nucleic Acids Res."},{"key":"744_CR28","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/ng1194-251","volume":"8","author":"M Tassabehji","year":"1994","unstructured":"Tassabehji, M., Newton, V. E. & Read, A. P. Waardenburg syndrome type 2 caused by mutations in the human microphthalmia (MITF) gene. Nat. Genet. 8, 251\u2013255 (1994).","journal-title":"Nat. Genet."},{"key":"744_CR29","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1002\/humu.21211","volume":"31","author":"V Pingault","year":"2010","unstructured":"Pingault, V. et al. Review and update of mutations causing Waardenburg syndrome. Human Mut. 31, 391\u2013406 (2010).","journal-title":"Human Mut."},{"key":"744_CR30","doi-asserted-by":"crossref","unstructured":"Wildhardt, G. et al. Spectrum of novel mutations found in Waardenburg syndrome types 1 and 2: implications for molecular genetic diagnostics. BMJ Open 3, e001917 (2013).","DOI":"10.1136\/bmjopen-2012-001917"},{"key":"744_CR31","doi-asserted-by":"publisher","first-page":"4357","DOI":"10.1093\/hmg\/ddt285","volume":"22","author":"C Grill","year":"2013","unstructured":"Grill, C. et al. MITF mutations associated with pigment deficiency syndromes and melanoma have different effects on protein function. Human Mol. Genet. 22, 4357\u20134367 (2013).","journal-title":"Human Mol. Genet."},{"key":"744_CR32","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1146\/annurev.cellbio.16.1.653","volume":"16","author":"C Grandori","year":"2000","unstructured":"Grandori, C., Cowley, S. M., James, L. P. & Eisenman, R. N. The Myc\/Max\/Mad network and the transcriptional control of cell behavior. Ann. Rev. Cell Dev. Biol. 16, 653\u2013699 (2000).","journal-title":"Ann. Rev. Cell Dev. Biol."},{"key":"744_CR33","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/S0092-8674(02)01284-9","volume":"112","author":"SK Nair","year":"2003","unstructured":"Nair, S. K. & Burley, S. K. X-ray structures of Myc-Max and Mad-Max recognizing DNA. Molecular bases of regulation by proto-oncogenic transcription factors. Cell 112, 193\u2013205 (2003).","journal-title":"Cell"},{"key":"744_CR34","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1126\/science.3289117","volume":"240","author":"WH Landschulz","year":"1988","unstructured":"Landschulz, W. H., Johnson, P. F. & McKnight, S. L. The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins. Science 240, 1759\u20131764 (1988).","journal-title":"Science"},{"key":"744_CR35","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/S0014-5793(01)03166-0","volume":"509","author":"MC Tchan","year":"2001","unstructured":"Tchan, M. C. & Weiss, A. S. Asn(78) and His(81) form a destabilizing locus within the Max HLH-LZ homodimer. FEBS Lett. 509, 177\u2013180 (2001).","journal-title":"FEBS Lett."},{"key":"744_CR36","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1177\/1087057116675274","volume":"22","author":"J Wang","year":"2017","unstructured":"Wang, J. et al. Development of an HTS-compatible assay for discovery of melanoma-related microphthalmia transcription factor disruptors using alphaScreen technology.\u00a0SLAS Discov. 22, 58\u201366 (2017).","journal-title":"SLAS Discov."},{"key":"744_CR37","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1111\/j.1755-148X.2008.00505.x","volume":"21","author":"KS Hoek","year":"2008","unstructured":"Hoek, K. S. et al. Novel MITF targets identified using a two-step DNA microarray strategy. Pigment Cell Melanoma Res. 21, 665\u2013676 (2008).","journal-title":"Pigment Cell Melanoma Res."},{"key":"744_CR38","doi-asserted-by":"publisher","first-page":"e48333","DOI":"10.15252\/embr.201948333","volume":"21","author":"DA Raja","year":"2020","unstructured":"Raja, D. A. et al. pH-controlled histone acetylation amplifies melanocyte differentiation downstream of MITF. EMBO Rep. 21, e48333 (2020).","journal-title":"EMBO Rep."},{"key":"744_CR39","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1038\/onc.2016.178","volume":"36","author":"A Bianchi-Smiraglia","year":"2017","unstructured":"Bianchi-Smiraglia, A. et al. Microphthalmia-associated transcription factor suppresses invasion by reducing intracellular GTP pools. Oncogene 36, 84\u201396 (2017).","journal-title":"Oncogene"},{"key":"744_CR40","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/j.modgep.2003.07.002","volume":"3","author":"LL Baxter","year":"2003","unstructured":"Baxter, L. L. & Pavan, W. J. Pmel17 expression is Mitf-dependent and reveals cranial melanoblast migration during murine development. Gene Exp. Patterns 3, 703\u2013707 (2003).","journal-title":"Gene Exp. Patterns"},{"key":"744_CR41","doi-asserted-by":"publisher","first-page":"7097","DOI":"10.1158\/1078-0432.CCR-17-0010","volume":"23","author":"M Ennen","year":"2017","unstructured":"Ennen, M. et al. MITF-high and MITF-low cells and a novel subpopulation expressing genes of both cell states contribute to intra- and intertumoral heterogeneity of primary melanoma. Clin. Cancer Res. 23, 7097\u20137107 (2017).","journal-title":"Clin. Cancer Res."},{"key":"744_CR42","doi-asserted-by":"publisher","first-page":"14417","DOI":"10.1074\/jbc.RA118.003729","volume":"293","author":"Q Wu","year":"2018","unstructured":"Wu, Q. et al. Microphthalmia-associated transcription factor up-regulates acetylcholinesterase expression during melanogenesis of murine melanoma cells. J. Biol. Chem. 293, 14417\u201314428 (2018).","journal-title":"J. Biol. Chem."},{"key":"744_CR43","doi-asserted-by":"publisher","first-page":"E420","DOI":"10.1073\/pnas.1424576112","volume":"112","author":"D Ploper","year":"2015","unstructured":"Ploper, D. et al. MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells. Proc. Natl. Acad. Sci. USA 112, E420\u2013E429 (2015).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"744_CR44","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1038\/nrg2538","volume":"10","author":"JM Vaquerizas","year":"2009","unstructured":"Vaquerizas, J. M., Kummerfeld, S. K., Teichmann, S. A. & Luscombe, N. M. A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10, 252\u2013263 (2009).","journal-title":"Nat. Rev. Genet."},{"key":"744_CR45","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.trecan.2015.07.001","volume":"1","author":"AS Bhagwat","year":"2015","unstructured":"Bhagwat, A. S. & Vakoc, C. R. Targeting Transcription Factors in Cancer. Trends Cancer 1, 53\u201365 (2015).","journal-title":"Trends Cancer"},{"key":"744_CR46","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1038\/nrd2199","volume":"5","author":"JP Overington","year":"2006","unstructured":"Overington, J. P., Al-Lazikani, B. & Hopkins, A. L. How many drug targets are there? Nat. Rev. Drug Discov. 5, 993\u2013996 (2006).","journal-title":"Nat. Rev. Drug Discov."},{"key":"744_CR47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bcp.2015.12.006","volume":"107","author":"J Hagenbuchner","year":"2016","unstructured":"Hagenbuchner, J. & Ausserlechner, M. J. Targeting transcription factors by small compounds-Current strategies and future implications. Biochem. Pharmacol. 107, 1\u201313 (2016).","journal-title":"Biochem. Pharmacol."},{"key":"744_CR48","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1016\/j.cbpa.2008.08.019","volume":"12","author":"LK Henchey","year":"2008","unstructured":"Henchey, L. K., Jochim, A. L. & Arora, P. S. Contemporary strategies for the stabilization of peptides in the alpha-helical conformation. Curr. Opin. Chem. Biol. 12, 692\u2013697 (2008).","journal-title":"Curr. Opin. Chem. Biol."},{"key":"744_CR49","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1006\/jmbi.2001.4537","volume":"307","author":"W Fieber","year":"2001","unstructured":"Fieber, W. et al. Structure, function, and dynamics of the dimerization and DNA-binding domain of oncogenic transcription factor v-Myc. J. Mol. Biol. 307, 1395\u20131410 (2001).","journal-title":"J. Mol. Biol."},{"key":"744_CR50","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1111\/j.1600-0749.2006.00322.x","volume":"19","author":"KS Hoek","year":"2006","unstructured":"Hoek, K. S. et al. Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature. Pigment Cell Res. 19, 290\u2013302 (2006).","journal-title":"Pigment Cell Res."},{"key":"744_CR51","doi-asserted-by":"publisher","first-page":"2148","DOI":"10.1111\/febs.14040","volume":"284","author":"I Arozarena","year":"2017","unstructured":"Arozarena, I. & Wellbrock, C. Targeting invasive properties of melanoma cells. FEBS J. 284, 2148\u20132162 (2017).","journal-title":"FEBS J."},{"key":"744_CR52","doi-asserted-by":"publisher","first-page":"5554","DOI":"10.1158\/0008-5472.CAN-04-4570","volume":"65","author":"J Choi","year":"2005","unstructured":"Choi, J. et al. Bcl-2 promotes invasion and lung metastasis by inducing matrix metalloproteinase-2. Cancer Res. 65, 5554\u20135560 (2005).","journal-title":"Cancer Res."},{"key":"744_CR53","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1083\/jcb.201209135","volume":"200","author":"JA Martina","year":"2013","unstructured":"Martina, J. A. & Puertollano, R. Rag GTPases mediate amino acid-dependent recruitment of TFEB and MITF to lysosomes. J. Cell Biol. 200, 475\u2013491 (2013).","journal-title":"J. Cell Biol."},{"key":"744_CR54","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1080\/15548627.2018.1531197","volume":"15","author":"DG Ozturk","year":"2019","unstructured":"Ozturk, D. G. et al. MITF-MIR211 axis is a novel autophagy amplifier system during cellular stress. Autophagy 15, 375\u2013390 (2019).","journal-title":"Autophagy"},{"key":"744_CR55","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/S1074-7613(04)00020-2","volume":"20","author":"YN Lee","year":"2004","unstructured":"Lee, Y. N., Nechushtan, H., Figov, N. & Razin, E. The function of lysyl-tRNA synthetase and Ap4A as signaling regulators of MITF activity in FcepsilonRI-activated mast cells. Immunity 20, 145\u2013151 (2004).","journal-title":"Immunity"},{"key":"744_CR56","doi-asserted-by":"publisher","first-page":"2483","DOI":"10.1007\/s00018-014-1565-8","volume":"71","author":"JA Martina","year":"2014","unstructured":"Martina, J. A., Diab, H. I., Li, H. & Puertollano, R. Novel roles for the MiTF\/TFE family of transcription factors in organelle biogenesis, nutrient sensing, and energy homeostasis. Cell. Mol. Life Sci. 71, 2483\u20132497 (2014).","journal-title":"Cell. Mol. Life Sci."},{"key":"744_CR57","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1038\/nature14587","volume":"524","author":"RM Perera","year":"2015","unstructured":"Perera, R. M. et al. Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism. Nature 524, 361\u2013365 (2015).","journal-title":"Nature"},{"key":"744_CR58","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.ccr.2006.04.021","volume":"9","author":"IJ Davis","year":"2006","unstructured":"Davis, I. J. et al. Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers. Cancer Cell 9, 473\u2013484 (2006).","journal-title":"Cancer Cell"},{"key":"744_CR59","doi-asserted-by":"crossref","unstructured":"Zhang, W. Z. et al. The protein complex crystallography beamline (BL19U1) at the Shanghai Synchrotron Radiation Facility. Nucl. Sci. Tech. 30, 170 (2019).","DOI":"10.1007\/s41365-019-0683-2"},{"key":"744_CR60","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1107\/S0907444994003112","volume":"50","author":"Collaborative Computational Project, N.","year":"1994","unstructured":"Collaborative Computational Project, N. The CCP4 suite: programs for protein crystallography. Acta Crystallogr. D Biol. Crystallogr. 50, 760\u2013763 (1994).","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"744_CR61","doi-asserted-by":"publisher","first-page":"2126","DOI":"10.1107\/S0907444904019158","volume":"60","author":"P Emsley","year":"2004","unstructured":"Emsley, P. & Cowtan, K. Coot: model-building tools for molecular graphics. Acta Crystallogr. D Biol. Crystallogr. 60, 2126\u20132132 (2004).","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"744_CR62","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1107\/S0907444909011548","volume":"65","author":"PD Adams","year":"2009","unstructured":"Adams, P. D., Mustyakimov, M., Afonine, P. V. & Langan, P. Generalized X-ray and neutron crystallographic analysis: more accurate and complete structures for biological macromolecules. Acta Crystallogr. D Biol. Crystallogr. 65, 567\u2013573 (2009).","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"744_CR63","doi-asserted-by":"publisher","first-page":"16056","DOI":"10.1021\/bi048233g","volume":"43","author":"MH Roehrl","year":"2004","unstructured":"Roehrl, M. H., Wang, J. Y. & Wagner, G. A general framework for development and data analysis of competitive high-throughput screens for small-molecule inhibitors of protein-protein interactions by fluorescence polarization. Biochemistry 43, 16056\u201316066 (2004).","journal-title":"Biochemistry"}],"container-title":["Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41422-022-00744-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41422-022-00744-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41422-022-00744-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T16:04:31Z","timestamp":1672761871000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41422-022-00744-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,2]]},"references-count":63,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["744"],"URL":"https:\/\/doi.org\/10.1038\/s41422-022-00744-5","relation":{},"ISSN":["1748-7838"],"issn-type":[{"value":"1748-7838","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,2]]},"assertion":[{"value":"16 August 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Dr. D.E.F. has a financial interest in Soltego Inc., a company developing SIK inhibitors for topical skin darkening treatments that might be used for a broad set of human applications. Dr. D.E.F. interests were reviewed and are managed by Massachusetts General Hospital and Partners HealthCare in accordance with their competing interests policies.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}