{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T15:42:00Z","timestamp":1777045320295,"version":"3.51.4"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T00:00:00Z","timestamp":1568937600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T00:00:00Z","timestamp":1568937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Mol Immunol"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1038\/s41423-019-0293-2","type":"journal-article","created":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T06:15:48Z","timestamp":1568960148000},"page":"138-149","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["DAPK1 (death associated protein kinase 1) mediates mTORC1 activation and antiviral activities in CD8+ T cells"],"prefix":"10.1038","volume":"18","author":[{"given":"Zhengping","family":"Wei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pingfei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huicheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoyu","family":"Bi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuyang","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minghui","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Pei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guihua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao-Hui","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huabin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuoya","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilin","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arian","family":"Laurence","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youming","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang-Ping","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,9,20]]},"reference":[{"key":"293_CR1","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nri3198","volume":"12","author":"H Chi","year":"2012","unstructured":"Chi, H. Regulation and function of mTOR signalling in T cell fate decisions. Nat. Rev. Immunol. 12, 325\u2013338 (2012).","journal-title":"Nat. Rev. Immunol."},{"key":"293_CR2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1146\/annurev-immunol-020711-075024","volume":"30","author":"JD Powell","year":"2012","unstructured":"Powell, J. D., Pollizzi, K. N., Heikamp, E. B. & Horton, M. R. Regulation of immune responses by mTOR. Annu. Rev. Immunol. 30, 39\u201368 (2012).","journal-title":"Annu. Rev. Immunol."},{"key":"293_CR3","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.cell.2017.03.035","volume":"169","author":"RA Saxton","year":"2017","unstructured":"Saxton, R. A. & Sabatini, D. M. mTOR Signaling in growth, metabolism, and disease. Cell 169, 361\u2013371 (2017).","journal-title":"Cell"},{"key":"293_CR4","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.immuni.2009.04.014","volume":"30","author":"GM Delgoffe","year":"2009","unstructured":"Delgoffe, G. M., Kole, T. P., Zheng, Y., Zarek, P. E., Matthews, K. L. & Xiao, B. et al. The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity 30, 832\u2013844 (2009).","journal-title":"Immunity"},{"key":"293_CR5","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/ni.2005","volume":"12","author":"GM Delgoffe","year":"2011","unstructured":"Delgoffe, G. M., Pollizzi, K. N., Waickman, A. T., Heikamp, E., Meyers, D. J. & Horton, M. R. et al. The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. Nat. Immunol. 12, 295\u2013303 (2011).","journal-title":"Nat. Immunol."},{"key":"293_CR6","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.immuni.2017.08.011","volume":"47","author":"L Xu","year":"2017","unstructured":"Xu, L., Huang, Q., Wang, H., Hao, Y., Bai, Q. & Hu, J. et al. The kinase mTORC1 promotes the generation and suppressive function of follicular regulatory T cells. Immunity 47, 538\u2013551 (2017).","journal-title":"Immunity"},{"key":"293_CR7","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/nature12297","volume":"499","author":"H Zeng","year":"2013","unstructured":"Zeng, H., Yang, K., Cloer, C., Neale, G., Vogel, P. & Chi, H. mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function. Nature 499, 485\u2013490 (2013).","journal-title":"Nature"},{"key":"293_CR8","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.immuni.2016.08.017","volume":"45","author":"H Zeng","year":"2016","unstructured":"Zeng, H., Cohen, S., Guy, C., Shrestha, S., Neale, G. & Brown, S. A. et al. mTORC1 and mTORC2 kinase signaling and glucose metabolism drive follicular helper T cell differentiation. Immunity 45, 540\u2013554 (2016).","journal-title":"Immunity"},{"key":"293_CR9","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.immuni.2015.08.017","volume":"43","author":"JP Ray","year":"2015","unstructured":"Ray, J. P., Staron, M. M., Shyer, J. A., Ho, P. C., Marshall, H. D. & Gray, S. M. et al. The interleukin-2-mTORc1 kinase axis defines the signaling, differentiation, and metabolism of T helper 1 and follicular B helper T cells. Immunity 43, 690\u2013702 (2015).","journal-title":"Immunity"},{"key":"293_CR10","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.immuni.2009.10.010","volume":"32","author":"RR Rao","year":"2010","unstructured":"Rao, R. R., Li, Q., Odunsi, K. & Shrikant, P. A. The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and eomesodermin. Immunity 32, 67\u201378 (2010).","journal-title":"Immunity"},{"key":"293_CR11","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/ni.3438","volume":"17","author":"KN Pollizzi","year":"2016","unstructured":"Pollizzi, K. N., Sun, I. H., Patel, C. H., Lo, Y. C., Oh, M. H. & Waickman, A. T. et al. Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8(+) T cell differentiation. Nat. Immunol. 17, 704\u2013711 (2016).","journal-title":"Nat. Immunol."},{"key":"293_CR12","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nature08155","volume":"460","author":"K Araki","year":"2009","unstructured":"Araki, K., Turner, A. P., Shaffer, V. O., Gangappa, S., Keller, S. A. & Bachmann, M. F. et al. mTOR regulates memory CD8 T-cell differentiation. Nature 460, 108\u2013112 (2009).","journal-title":"Nature"},{"key":"293_CR13","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.immuni.2011.04.006","volume":"34","author":"Q Li","year":"2011","unstructured":"Li, Q., Rao, R. R., Araki, K., Pollizzi, K., Odunsi, K. & Powell, J. D. et al. A central role for mTOR kinase in homeostatic proliferation induced CD8+ T cell memory and tumor immunity. Immunity 34, 541\u2013553 (2011).","journal-title":"Immunity"},{"key":"293_CR14","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.4049\/jimmunol.1400074","volume":"193","author":"RT Sowell","year":"2014","unstructured":"Sowell, R. T., Rogozinska, M., Nelson, C. E., Vezys, V. & Marzo, A. L. Cutting edge: generation of effector cells that localize to mucosal tissues and form resident memory CD8 T cells is controlled by mTOR. J. Immunol. 193, 2067\u20132071 (2014).","journal-title":"J. Immunol."},{"key":"293_CR15","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1172\/JCI77746","volume":"125","author":"KN Pollizzi","year":"2015","unstructured":"Pollizzi, K. N., Patel, C. H., Sun, I. H., Oh, M. H., Waickman, A. T. & Wen, J. et al. mTORC1 and mTORC2 selectively regulate CD8(+) T cell differentiation. J. Clin. Investig. 125, 2090\u20132108 (2015).","journal-title":"J. Clin. Investig."},{"key":"293_CR16","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1038\/ncb2822","volume":"15","author":"J Zhang","year":"2013","unstructured":"Zhang, J., Kim, J., Alexander, A., Cai, S., Tripathi, D. N. & Dere, R. et al. A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS. Nat. Cell Biol. 15, 1186\u20131196 (2013).","journal-title":"Nat. Cell Biol."},{"key":"293_CR17","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.immuni.2013.09.015","volume":"39","author":"K Yang","year":"2013","unstructured":"Yang, K., Shrestha, S., Zeng, H., Karmaus, P. W., Neale, G. & Vogel, P. et al. T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming. Immunity 39, 1043\u20131056 (2013).","journal-title":"Immunity"},{"key":"293_CR18","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/nri3307","volume":"12","author":"SM Kaech","year":"2012","unstructured":"Kaech, S. M. & Cui, W. Transcriptional control of effector and memory CD8+ T cell differentiation. Nat. Rev. Immunol. 12, 749\u2013761 (2012).","journal-title":"Nat. Rev. Immunol."},{"key":"293_CR19","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/nri3156","volume":"12","author":"O Boyman","year":"2012","unstructured":"Boyman, O. & Sprent, J. The role of interleukin-2 during homeostasis and activation of the immune system. Nat. Rev. Immunol. 12, 180\u2013190 (2012).","journal-title":"Nat. Rev. Immunol."},{"key":"293_CR20","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.immuni.2013.01.004","volume":"38","author":"W Liao","year":"2013","unstructured":"Liao, W., Lin, J. X. & Leonard, W. J. Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy. Immunity 38, 13\u201325 (2013).","journal-title":"Immunity"},{"key":"293_CR21","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.immuni.2017.04.028","volume":"46","author":"RG Jones","year":"2017","unstructured":"Jones, R. G. & Pearce, E. J. MenTORing immunity: mTOR signaling in the development and function of tissue-resident immune cells. Immunity 46, 730\u2013742 (2017).","journal-title":"Immunity"},{"key":"293_CR22","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.it.2014.11.005","volume":"36","author":"KN Pollizzi","year":"2015","unstructured":"Pollizzi, K. N. & Powell, J. D. Regulation of T cells by mTOR: the known knowns and the known unknowns. Trends Immunol. 36, 13\u201320 (2015).","journal-title":"Trends Immunol."},{"key":"293_CR23","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.immuni.2011.01.012","volume":"34","author":"AN Macintyre","year":"2011","unstructured":"Macintyre, A. N., Finlay, D., Preston, G., Sinclair, L. V., Waugh, C. M. & Tamas, P. et al. Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism. Immunity 34, 224\u2013236 (2011).","journal-title":"Immunity"},{"key":"293_CR24","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1084\/jem.20112607","volume":"209","author":"DK Finlay","year":"2012","unstructured":"Finlay, D. K., Rosenzweig, E., Sinclair, L. V., Feijoo-Carnero, C., Hukelmann, J. L. & Rolf, J. et al. PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells. J. Exp. Med. 209, 2441\u20132453 (2012).","journal-title":"J. Exp. Med."},{"key":"293_CR25","doi-asserted-by":"crossref","first-page":"ra55","DOI":"10.1126\/scisignal.2005169","volume":"7","author":"KS Hamilton","year":"2014","unstructured":"Hamilton, K. S., Phong, B., Corey, C., Cheng, J., Gorentla, B. & Zhong, X. et al. T cell receptor-dependent activation of mTOR signaling in T cells is mediated by Carma1 and MALT1, but not Bcl10. Sci. Signal 7, ra55 (2014).","journal-title":"Sci. Signal"},{"key":"293_CR26","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1101\/gad.9.1.15","volume":"9","author":"LP Deiss","year":"1995","unstructured":"Deiss, L. P., Feinstein, E., Berissi, H., Cohen, O. & Kimchi, A. Identification of a novel serine\/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death. Genes Dev. 9, 15\u201330 (1995).","journal-title":"Genes Dev."},{"key":"293_CR27","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3389\/fnmol.2016.00046","volume":"9","author":"P Singh","year":"2016","unstructured":"Singh, P., Ravanan, P. & Talwar, P. Death associated protein kinase 1 (DAPK1): a regulator of apoptosis and autophagy. Front. Mol. Neurosci. 9, 46 (2016).","journal-title":"Front. Mol. Neurosci."},{"key":"293_CR28","doi-asserted-by":"crossref","first-page":"47460","DOI":"10.1074\/jbc.M105133200","volume":"276","author":"G Shohat","year":"2001","unstructured":"Shohat, G., Spivak-Kroizman, T., Cohen, O., Bialik, S., Shani, G. & Berrisi, H. et al. The pro-apoptotic function of death-associated protein kinase is controlled by a unique inhibitory autophosphorylation-based mechanism. J. Biol. Chem. 276, 47460\u201347467 (2001).","journal-title":"J. Biol. Chem."},{"key":"293_CR29","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S1570-9639(02)00443-0","volume":"1600","author":"G Shohat","year":"2002","unstructured":"Shohat, G., Shani, G., Eisenstein, M. & Kimchi, A. The DAP-kinase family of proteins: study of a novel group of calcium-regulated death-promoting kinases. Biochim. Biophys. Acta 1600, 45\u201350 (2002).","journal-title":"Biochim. Biophys. Acta"},{"key":"293_CR30","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1074\/jbc.M805165200","volume":"284","author":"C Stevens","year":"2009","unstructured":"Stevens, C., Lin, Y., Harrison, B., Burch, L., Ridgway, R. A. & Sansom, O. et al. Peptide combinatorial libraries identify TSC2 as a death-associated protein kinase (DAPK) death domain-binding protein and reveal a stimulatory role for DAPK in mTORC1 signaling. J. Biol. Chem. 284, 334\u2013344 (2009).","journal-title":"J. Biol. Chem."},{"key":"293_CR31","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/s10495-013-0924-5","volume":"19","author":"R Shiloh","year":"2014","unstructured":"Shiloh, R., Bialik, S. & Kimchi, A. The DAPK family: a structure-function analysis. Apoptosis 19, 286\u2013297 (2014).","journal-title":"Apoptosis"},{"key":"293_CR32","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1172\/JCI70805","volume":"125","author":"J Zhao","year":"2015","unstructured":"Zhao, J., Zhao, D., Poage, G. M., Mazumdar, A., Zhang, Y. & Hill, J. L. et al. Death-associated protein kinase 1 promotes growth of p53-mutant cancers. J. Clin. Investig. 125, 2707\u20132720 (2015).","journal-title":"J. Clin. Investig."},{"key":"293_CR33","doi-asserted-by":"crossref","first-page":"3238","DOI":"10.4049\/jimmunol.180.5.3238","volume":"180","author":"YT Chuang","year":"2008","unstructured":"Chuang, Y. T., Fang, L. W., Lin-Feng, M. H., Chen, R. H. & Lai, M. Z. The tumor suppressor death-associated protein kinase targets to TCR-stimulated NF-kappa B activation. J. Immunol. 180, 3238\u20133249 (2008).","journal-title":"J. Immunol."},{"key":"293_CR34","volume":"7","author":"TF Chou","year":"2016","unstructured":"Chou, T. F., Chuang, Y. T., Hsieh, W. C., Chang, P. Y., Liu, H. Y. & Mo, S. T. et al. Tumour suppressor death-associated protein kinase targets cytoplasmic HIF-1alpha for Th17 suppression. Nat. Commun. 7, 11904 (2016).","journal-title":"Nat. Commun."},{"key":"293_CR35","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.immuni.2004.10.008","volume":"21","author":"MA McGargill","year":"2004","unstructured":"McGargill, M. A., Wen, B. G., Walsh, C. M. & Hedrick, S. M. A deficiency in Drak2 results in a T cell hypersensitivity and an unexpected resistance to autoimmunity. Immunity 21, 781\u2013791 (2004).","journal-title":"Immunity"},{"key":"293_CR36","doi-asserted-by":"crossref","first-page":"4559","DOI":"10.1093\/cercor\/bhv096","volume":"25","author":"L Pei","year":"2015","unstructured":"Pei, L., Wang, S., Jin, H., Bi, L., Wei, N. & Yan, H. et al. A novel mechanism of spine damages in stroke via DAPK1 and Tau. Cereb. Cortex 25, 4559\u20134571 (2015).","journal-title":"Cereb. Cortex"},{"key":"293_CR37","doi-asserted-by":"crossref","first-page":"10843","DOI":"10.1523\/JNEUROSCI.2258-16.2016","volume":"36","author":"S Shu","year":"2016","unstructured":"Shu, S., Zhu, H., Tang, N., Chen, W., Li, X. & Li, H. et al. Selective degeneration of entorhinal-CA1 synapses in Alzheimer\u2019s disease via activation of DAPK1. J. Neurosci. 36, 10843\u201310852 (2016).","journal-title":"J. Neurosci."},{"key":"293_CR38","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/ni.3314","volume":"17","author":"JL Hukelmann","year":"2016","unstructured":"Hukelmann, J. L., Anderson, K. E., Sinclair, L. V., Grzes, K. M., Murillo, A. B. & Hawkins, P. T. et al. The cytotoxic T cell proteome and its shaping by the kinase mTOR. Nat. Immunol. 17, 104\u2013112 (2016).","journal-title":"Nat. Immunol."},{"key":"293_CR39","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.immuni.2016.07.022","volume":"45","author":"SH Ross","year":"2016","unstructured":"Ross, S. H., Rollings, C., Anderson, K. E., Hawkins, P. T., Stephens, L. R. & Cantrell, D. A. Phosphoproteomic analyses of interleukin 2 signaling reveal integrated JAK kinase-dependent and -independent networks in CD8(+) T cells. Immunity 45, 685\u2013700 (2016).","journal-title":"Immunity"},{"key":"293_CR40","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/ncb840","volume":"4","author":"CJ Potter","year":"2002","unstructured":"Potter, C. J., Pedraza, L. G. & Xu, T. Akt regulates growth by directly phosphorylating Tsc2. Nat. Cell Biol. 4, 658\u2013665 (2002).","journal-title":"Nat. Cell Biol."},{"key":"293_CR41","doi-asserted-by":"crossref","first-page":"7388","DOI":"10.4049\/jimmunol.0902294","volume":"183","author":"RJ Salmond","year":"2009","unstructured":"Salmond, R. J., Emery, J., Okkenhaug, K. & Zamoyska, R. MAPK, phosphatidylinositol 3-kinase, and mammalian target of rapamycin pathways converge at the level of ribosomal protein S6 phosphorylation to control metabolic signaling in CD8 T cells. J. Immunol. 183, 7388\u20137397 (2009).","journal-title":"J. Immunol."},{"key":"293_CR42","doi-asserted-by":"crossref","first-page":"4615","DOI":"10.4049\/jimmunol.1501473","volume":"195","author":"RJ Salmond","year":"2015","unstructured":"Salmond, R. J., Brownlie, R. J., Meyuhas, O. & Zamoyska, R. Mechanistic target of rapamycin complex 1\/S6 kinase 1 signals influence T cell activation independently of ribosomal protein S6 phosphorylation. J. Immunol. 195, 4615\u20134622 (2015).","journal-title":"J. Immunol."},{"key":"293_CR43","doi-asserted-by":"crossref","first-page":"14799","DOI":"10.1073\/pnas.1618517114","volume":"113","author":"WL Liu","year":"2016","unstructured":"Liu, W. L., Yang, H. C., Hsu, C. S., Wang, C. C., Wang, T. S. & Kao, J. H. et al. Pegylated IFN-alpha suppresses hepatitis C virus by promoting the DAPK-mTOR pathway. Proc. Natl Acad. Sci. USA 113, 14799\u201314804 (2016).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"293_CR44","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.coi.2017.04.005","volume":"46","author":"H Zeng","year":"2017","unstructured":"Zeng, H. & Chi, H. mTOR signaling in the differentiation and function of regulatory and effector T cells. Curr. Opin. Immunol. 46, 103\u2013111 (2017).","journal-title":"Curr. Opin. Immunol."}],"container-title":["Cellular & Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41423-019-0293-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41423-019-0293-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41423-019-0293-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T17:22:26Z","timestamp":1684603346000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41423-019-0293-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,20]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["293"],"URL":"https:\/\/doi.org\/10.1038\/s41423-019-0293-2","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.736648072.793568347","asserted-by":"object"}]},"ISSN":["1672-7681","2042-0226"],"issn-type":[{"value":"1672-7681","type":"print"},{"value":"2042-0226","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,20]]},"assertion":[{"value":"25 August 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 August 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 September 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}