{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T02:34:46Z","timestamp":1792722886862,"version":"4.5.0"},"reference-count":75,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Mol Immunol"],"DOI":"10.1038\/s41423-024-01130-4","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T08:03:55Z","timestamp":1706688235000},"page":"245-259","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Activation of leukotriene B4 receptor 1 is a prerequisite for complement receptor 3-mediated antifungal responses of neutrophils"],"prefix":"10.1038","volume":"21","author":[{"given":"Yan","family":"Xin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sihan","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linghong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0956-3654","authenticated-orcid":false,"given":"Xin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,31]]},"reference":[{"key":"1130_CR1","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1016\/j.chom.2020.04.011","volume":"27","author":"MS Lionakis","year":"2020","unstructured":"Lionakis MS, Hohl TM. Call to action: how to tackle emerging nosocomial fungal infections. Cell Host Microbe. 2020;27:859\u201362.","journal-title":"Cell Host Microbe"},{"key":"1130_CR2","doi-asserted-by":"publisher","first-page":"e0009421","DOI":"10.1128\/CMR.00094-21","volume":"35","author":"F Salazar","year":"2022","unstructured":"Salazar F, Bignell E, Brown GD, Cook PC, Warris A. Pathogenesis of respiratory viral and fungal coinfections. Clin Microbiol Rev. 2022;35:e0009421.","journal-title":"Clin Microbiol Rev"},{"key":"1130_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41577-022-00826-w","volume":"23","author":"MS Lionakis","year":"2023","unstructured":"Lionakis MS, Drummond RA, Hohl TM. Immune responses to human fungal pathogens and therapeutic prospects. Nat Rev Immunol. 2023;23:1\u201320.","journal-title":"Nat Rev Immunol"},{"key":"1130_CR4","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1038\/s41564-022-01172-2","volume":"7","author":"M Hoenigl","year":"2022","unstructured":"Hoenigl M, Seidel D, Sprute R, Cunha C, Oliverio M, Goldman GH, et al. COVID-19-associated fungal infections. Nat Microbiol. 2022;7:1127\u201340.","journal-title":"Nat Microbiol"},{"key":"1130_CR5","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/S2213-2600(21)00442-2","volume":"10","author":"JP Gangneux","year":"2022","unstructured":"Gangneux JP, Dannaoui E, Fekkar A, Luyt CE, Botterel F, De Prost N, et al. Fungal infections in mechanically ventilated patients with COVID-19 during the first wave: the French multicentre MYCOVID study. Lancet Respir Med. 2022;10:180\u201390.","journal-title":"Lancet Respir Med"},{"key":"1130_CR6","doi-asserted-by":"crossref","unstructured":"Qu J, Lv X. Cryptococcal meningitis in apparently immunocompetent patients. Crit Rev Microbiol. 2022:1\u201311.","DOI":"10.1080\/1040841X.2022.2159786"},{"key":"1130_CR7","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/S1474-4422(18)30030-9","volume":"17","author":"S Schwartz","year":"2018","unstructured":"Schwartz S, Kontoyiannis DP, Harrison T, Ruhnke M. Advances in the diagnosis and treatment of fungal infections of the CNS. Lancet Neurol. 2018;17:362\u201372.","journal-title":"Lancet Neurol"},{"key":"1130_CR8","first-page":"64","volume":"1","author":"SD Rao","year":"2013","unstructured":"Rao SD. Invasive fungal infections: a comprehensive review. Am J Infect Dis. 2013;1:64\u20139.","journal-title":"Am J Infect Dis"},{"key":"1130_CR9","doi-asserted-by":"publisher","first-page":"165rv113","DOI":"10.1126\/scitranslmed.3004404","volume":"4","author":"GD Brown","year":"2012","unstructured":"Brown GD, Denning DW, Gow NA, Levitz SM, Netea MG, White TC. Hidden killers: human fungal infections. Sci Transl Med. 2012;4:165rv113.","journal-title":"Sci Transl Med"},{"key":"1130_CR10","unstructured":"Alastruey-Izquierdo A, World Health Organization. WHO Fungal Priority Pathogens List to Guide Research, Development and Public Health Action. Geneva, Switzerland: World Health Organization; 2022."},{"key":"1130_CR11","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1146\/annurev-immunol-101220-034306","volume":"40","author":"A Casadevall","year":"2022","unstructured":"Casadevall A. Immunity to invasive fungal diseases. Annu Rev Immunol. 2022;40:121\u201341.","journal-title":"Annu Rev Immunol"},{"key":"1130_CR12","doi-asserted-by":"crossref","unstructured":"Patin EC, Thompson A, Orr SJ. Pattern recognition receptors in fungal immunity. Semin Cell Dev Biol. 2019;89:24\u201333.","DOI":"10.1016\/j.semcdb.2018.03.003"},{"key":"1130_CR13","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.semcdb.2018.03.021","volume":"89","author":"K H\u00fcnniger","year":"2019","unstructured":"H\u00fcnniger K, Kurzai O. Phagocytes as central players in the defence against invasive fungal infection. Semin Cell Dev Biol. 2019;89:3\u201315.","journal-title":"Semin Cell Dev Biol"},{"key":"1130_CR14","doi-asserted-by":"crossref","unstructured":"Lionakis MS, Iliev ID, Hohl TM. Immunity against fungi. JCI insight. 2017;2:e93156.","DOI":"10.1172\/jci.insight.93156"},{"key":"1130_CR15","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/nrmicro.2015.21","volume":"14","author":"LP Erwig","year":"2016","unstructured":"Erwig LP, Gow NA. Interactions of fungal pathogens with phagocytes. Nat Rev Microbiol. 2016;14:163\u201376.","journal-title":"Nat Rev Microbiol"},{"key":"1130_CR16","doi-asserted-by":"publisher","first-page":"3127","DOI":"10.1128\/iai.64.8.3127-3133.1996","volume":"64","author":"A Vazquez-Torres","year":"1996","unstructured":"Vazquez-Torres A, Jones-Carson J, Balish E. Peroxynitrite contributes to the candidacidal activity of nitric oxide-producing macrophages. Infect Immun. 1996;64:3127\u201333.","journal-title":"Infect Immun"},{"key":"1130_CR17","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1128\/IAI.06146-11","volume":"80","author":"SC Cheng","year":"2012","unstructured":"Cheng SC, Joosten LA, Kullberg BJ, Netea MG. Interplay between Candida albicans and the mammalian innate host defense. Infect Immun. 2012;80:1304\u201313.","journal-title":"Infect Immun"},{"key":"1130_CR18","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1038\/ni.2987","volume":"15","author":"N Branzk","year":"2014","unstructured":"Branzk N, Lubojemska A, Hardison SE, Wang Q, Gutierrez MG, Brown GD, et al. Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens. Nat Immunol. 2014;15:1017\u201325.","journal-title":"Nat Immunol"},{"key":"1130_CR19","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1056\/NEJMra071371","volume":"357","author":"M Peters-Golden","year":"2007","unstructured":"Peters-Golden M, Henderson WR Jr. Leukotrienes. N Engl J Med. 2007;357:1841\u201354.","journal-title":"N Engl J Med"},{"key":"1130_CR20","doi-asserted-by":"publisher","first-page":"104857","DOI":"10.1016\/j.phrs.2020.104857","volume":"158","author":"R He","year":"2020","unstructured":"He R, Chen Y, Cai Q. The role of the LTB4-BLT1 axis in health and disease. Pharmacol Res. 2020;158:104857.","journal-title":"Pharmacol Res"},{"key":"1130_CR21","doi-asserted-by":"publisher","first-page":"4218","DOI":"10.1021\/bi00132a010","volume":"31","author":"L Orning","year":"1992","unstructured":"Orning L, Fitzpatrick F. Albumins activate peptide hydrolysis by the bifunctional enzyme LTA4 hydrolase\/aminopeptidase. Biochemistry. 1992;31:4218\u201323.","journal-title":"Biochemistry"},{"key":"1130_CR22","doi-asserted-by":"publisher","first-page":"11269","DOI":"10.1016\/S0021-9258(19)78120-4","volume":"269","author":"L Orning","year":"1994","unstructured":"Orning L, Gierse J, Fitzpatrick F. The bifunctional enzyme leukotriene-A4 hydrolase is an arginine aminopeptidase of high efficiency and specificity. J Biol Chem. 1994;269:11269\u201373.","journal-title":"J Biol Chem"},{"key":"1130_CR23","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/j.cell.2010.02.013","volume":"140","author":"DM Tobin","year":"2010","unstructured":"Tobin DM, Vary JC Jr, Ray JP, Walsh GS, Dunstan SJ, Bang ND, et al. The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans. Cell. 2010;140:717\u201330.","journal-title":"Cell"},{"key":"1130_CR24","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1111\/myc.13361","volume":"64","author":"LH Zhou","year":"2021","unstructured":"Zhou LH, Zhao HZ, Wang X, Wang RY, Jiang YK, Huang LP, et al. Immune reconstitution inflammatory syndrome in non\u2010HIV cryptococcal meningitis: cross\u2010talk between pathogen and host. Mycoses. 2021;64:1402\u201311.","journal-title":"Mycoses"},{"key":"1130_CR25","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1517\/14728222.2013.843671","volume":"18","author":"A Di Gennaro","year":"2014","unstructured":"Di Gennaro A, Haeggstr\u00f6m JZ. Targeting leukotriene B4 in inflammation. Expert Opin Ther Targets. 2014;18:79\u201393.","journal-title":"Expert Opin Ther Targets"},{"key":"1130_CR26","doi-asserted-by":"publisher","first-page":"3622","DOI":"10.4049\/jimmunol.1002956","volume":"186","author":"JC Simard","year":"2011","unstructured":"Simard JC, Simon MM, Tessier PA, Girard D. Damage-associated molecular pattern S100A9 increases bactericidal activity of human neutrophils by enhancing phagocytosis. J Immunol. 2011;186:3622\u201331.","journal-title":"J Immunol"},{"key":"1130_CR27","doi-asserted-by":"publisher","first-page":"4961","DOI":"10.4049\/jimmunol.158.10.4961","volume":"158","author":"SJ Suchard","year":"1997","unstructured":"Suchard SJ, Mansfield PJ, Boxer LA, Shayman JA. Mitogen-activated protein kinase activation during IgG-dependent phagocytosis in human neutrophils: inhibition by ceramide. J Immunol. 1997;158:4961\u20137.","journal-title":"J Immunol"},{"key":"1130_CR28","doi-asserted-by":"publisher","first-page":"622899","DOI":"10.3389\/fcimb.2021.622899","volume":"11","author":"SAM de Oliveira","year":"2021","unstructured":"de Oliveira SAM, Reis JN, Cat\u00e3o E, Amaral AC, Souza ACO, Ribeiro AM, et al. \u03b22 integrin-mediated susceptibility to paracoccidioides brasiliensis experimental infection in mice. Front Cell Infect Microbiol. 2021;11:622899.","journal-title":"Front Cell Infect Microbiol"},{"key":"1130_CR29","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1016\/j.chom.2022.02.017","volume":"30","author":"DD Li","year":"2022","unstructured":"Li DD, Jawale CV, Zhou C, Lin L, Trevejo-Nunez GJ, Rahman SA, et al. Fungal sensing enhances neutrophil metabolic fitness by regulating antifungal Glut1 activity. Cell Host Microbe. 2022;30:530\u2013544.e6.","journal-title":"Cell Host Microbe"},{"key":"1130_CR30","doi-asserted-by":"publisher","first-page":"e85083","DOI":"10.1371\/journal.pone.0085083","volume":"9","author":"A Secatto","year":"2014","unstructured":"Secatto A, Soares EM, Locachevic GA, Assis PA, Paula-Silva FW, Serezani CH, et al. The leukotriene B4\/BLT1 axis is a key determinant in susceptibility and resistance to histoplasmosis. PLoS ONE. 2014;9:e85083.","journal-title":"PLoS ONE"},{"key":"1130_CR31","doi-asserted-by":"publisher","first-page":"e2390","DOI":"10.1371\/journal.pntd.0002390","volume":"7","author":"PC Santos","year":"2013","unstructured":"Santos PC, Santos DA, Ribeiro LS, Fagundes CT, de Paula TP, Avila TV, et al. The pivotal role of 5-lipoxygenase-derived LTB4 in controlling pulmonary paracoccidioidomycosis. PLoS Negl Trop Dis. 2013;7:e2390.","journal-title":"PLoS Negl Trop Dis"},{"key":"1130_CR32","doi-asserted-by":"publisher","first-page":"119","DOI":"10.3390\/jof7020119","volume":"7","author":"E Bojang","year":"2021","unstructured":"Bojang E, Ghuman H, Kumwenda P, Hall RA. Immune sensing of Candida albicans. J Fungi. 2021;7:119.","journal-title":"J Fungi"},{"key":"1130_CR33","doi-asserted-by":"publisher","first-page":"6528","DOI":"10.1128\/IAI.00909-06","volume":"74","author":"CR Bonnett","year":"2006","unstructured":"Bonnett CR, Cornish EJ, Harmsen AG, Burritt JB. Early neutrophil recruitment and aggregation in the murine lung inhibit germination of Aspergillus fumigatus conidia. Infect Immun. 2006;74:6528\u201339.","journal-title":"Infect Immun"},{"key":"1130_CR34","doi-asserted-by":"publisher","first-page":"6514","DOI":"10.1128\/IAI.01551-06","volume":"74","author":"M Feldmesser","year":"2006","unstructured":"Feldmesser M. Role of neutrophils in invasive aspergillosis. Infect Immun. 2006;74:6514\u20136.","journal-title":"Infect Immun"},{"key":"1130_CR35","doi-asserted-by":"publisher","first-page":"e1003079","DOI":"10.1371\/journal.ppat.1003079","volume":"9","author":"MS Lionakis","year":"2013","unstructured":"Lionakis MS, Netea MG. Candida and host determinants of susceptibility to invasive candidiasis. PLoS Pathog. 2013;9:e1003079.","journal-title":"PLoS Pathog"},{"key":"1130_CR36","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1159\/000321157","volume":"3","author":"MS Lionakis","year":"2010","unstructured":"Lionakis MS, Lim JK, Lee CCR, Murphy PM. Organ-specific innate immune responses in a mouse model of invasive candidiasis. J Innate Immun. 2010;3:180\u201399.","journal-title":"J Innate Immun"},{"key":"1130_CR37","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1016\/j.devcel.2012.02.003","volume":"22","author":"PV Afonso","year":"2012","unstructured":"Afonso PV, Janka-Junttila M, Lee YJ, McCann CP, Oliver CM, Aamer KA, et al. LTB4 is a signal-relay molecule during neutrophil chemotaxis. Dev Cell. 2012;22:1079\u201391.","journal-title":"Dev Cell"},{"key":"1130_CR38","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1084\/jem.192.3.439","volume":"192","author":"AM Tager","year":"2000","unstructured":"Tager AM, Dufour JH, Goodarzi K, Bercury SD, von Andrian UH, Luster AD. BLTR mediates leukotriene B4\u2013induced chemotaxis and adhesion and plays a dominant role in eosinophil accumulation in a murine model of peritonitis. J Exp Med. 2000;192:439\u201346.","journal-title":"J Exp Med"},{"key":"1130_CR39","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1038\/ni970","volume":"4","author":"AM Tager","year":"2003","unstructured":"Tager AM, Bromley SK, Medoff BD, Islam SA, Bercury SD, Friedrich EB, et al. Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment. Nat Immunol. 2003;4:982\u201390.","journal-title":"Nat Immunol"},{"key":"1130_CR40","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1038\/ni972","volume":"4","author":"K Goodarzi","year":"2003","unstructured":"Goodarzi K, Goodarzi M, Tager AM, Luster AD, von Andrian UH. Leukotriene B4 and BLT1 control cytotoxic effector T cell recruitment to inflamed tissues. Nat Immunol. 2003;4:965\u201373.","journal-title":"Nat Immunol"},{"key":"1130_CR41","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/j.biochi.2009.12.002","volume":"92","author":"A Toda","year":"2010","unstructured":"Toda A, Terawaki K, Yamazaki S, Saeki K, Shimizu T, Yokomizo T. Attenuated Th1 induction by dendritic cells from mice deficient in the leukotriene B4 receptor 1. Biochimie. 2010;92:682\u201391.","journal-title":"Biochimie"},{"key":"1130_CR42","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1084\/jem.192.3.433","volume":"192","author":"B Haribabu","year":"2000","unstructured":"Haribabu B, Verghese MW, Steeber DA, Sellars DD, Bock CB, Snyderman R. Targeted disruption of the leukotriene B4 receptor in mice reveals its role in inflammation and platelet-activating factor\u2013induced anaphylaxis. J Exp Med. 2000;192:433\u20138.","journal-title":"J Exp Med"},{"key":"1130_CR43","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1128\/CDLI.11.5.936-941.2004","volume":"11","author":"MJ Scott","year":"2004","unstructured":"Scott MJ, Cheadle WG, Hoth JJ, Peyton JC, Subbarao K, Shao WH, et al. Leukotriene B4 receptor (BLT-1) modulates neutrophil influx into the peritoneum but not the lung and liver during surgically induced bacterial peritonitis in mice. Clin Vaccin Immunol. 2004;11:936\u201341.","journal-title":"Clin Vaccin Immunol"},{"key":"1130_CR44","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/j.immuni.2012.06.018","volume":"37","author":"MK Oyoshi","year":"2012","unstructured":"Oyoshi MK, He R, Li Y, Mondal S, Yoon J, Afshar R, et al. Leukotriene B4-driven neutrophil recruitment to the skin is essential for allergic skin inflammation. Immunity. 2012;37:747\u201358.","journal-title":"Immunity"},{"key":"1130_CR45","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.chom.2017.11.009","volume":"23","author":"E Lee","year":"2018","unstructured":"Lee E, Gillrie MR, Li L, Arnason JW, Kim JH, Babes L, et al. Leukotriene B4-mediated neutrophil recruitment causes pulmonary capillaritis during lethal fungal sepsis. Cell Host Microbe. 2018;23:121\u2013133.e4.","journal-title":"Cell Host Microbe"},{"key":"1130_CR46","doi-asserted-by":"publisher","first-page":"1984","DOI":"10.3389\/fimmu.2017.01984","volume":"8","author":"AK Caffrey-Carr","year":"2018","unstructured":"Caffrey-Carr AK, Hilmer KM, Kowalski CH, Shepardson KM, Temple RM, Cramer RA, et al. Host-derived leukotriene B4 is critical for resistance against invasive pulmonary aspergillosis. Front Immunol. 2018;8:1984.","journal-title":"Front Immunol"},{"key":"1130_CR47","doi-asserted-by":"publisher","first-page":"105226","DOI":"10.1016\/j.isci.2022.105226","volume":"25","author":"A Hopke","year":"2022","unstructured":"Hopke A, Lin T, Scherer AK, Shay AE, Timmer KD, Wilson-Mifsud B, et al. Transcellular biosynthesis of leukotriene B4 orchestrates neutrophil swarming to fungi. Iscience. 2022;25:105226.","journal-title":"Iscience"},{"key":"1130_CR48","doi-asserted-by":"publisher","first-page":"3316","DOI":"10.1182\/blood-2009-01-199919","volume":"114","author":"CH Serezani","year":"2009","unstructured":"Serezani CH, Aronoff DM, Sitrin RG, Peters-Golden M. Fc\u03b3RI ligation leads to a complex with BLT1 in lipid rafts that enhances rat lung macrophage antimicrobial functions. Blood. 2009;114:3316\u201324.","journal-title":"Blood"},{"key":"1130_CR49","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1182\/blood-2004-08-3323","volume":"106","author":"CH Serezani","year":"2005","unstructured":"Serezani CH, Aronoff DM, Jancar S, Mancuso P, Peters-Golden M. Leukotrienes enhance the bactericidal activity of alveolar macrophages against Klebsiella pneumoniae through the activation of NADPH oxidase. Blood. 2005;106:1067\u201375.","journal-title":"Blood"},{"key":"1130_CR50","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1165\/ajrcmb.23.6.4246","volume":"23","author":"P Mancuso","year":"2000","unstructured":"Mancuso P, Peters-Golden M. Modulation of alveolar macrophage phagocytosis by leukotrienes is Fc receptor\u2013mediated and protein kinase C-dependent. Am J Respir Cell Mol Biol. 2000;23:727\u201333.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"1130_CR51","doi-asserted-by":"publisher","first-page":"41113","DOI":"10.1074\/jbc.M110.175497","volume":"285","author":"F Okamoto","year":"2010","unstructured":"Okamoto F, Saeki K, Sumimoto H, Yamasaki S, Yokomizo T. Leukotriene B4 augments and restores Fc\u03b3Rs-dependent phagocytosis in macrophages. J Biol Chem. 2010;285:41113\u201321.","journal-title":"J Biol Chem"},{"key":"1130_CR52","doi-asserted-by":"publisher","first-page":"28902","DOI":"10.1074\/jbc.M111.235309","volume":"286","author":"M Morato-Marques","year":"2011","unstructured":"Morato-Marques M, Campos MR, Kane S, Rangel AP, Lewis C, Ballinger MN, et al. Leukotrienes target F-actin\/cofilin-1 to enhance alveolar macrophage anti-fungal activity. J Biol Chem. 2011;286:28902\u201313.","journal-title":"J Biol Chem"},{"key":"1130_CR53","doi-asserted-by":"publisher","first-page":"e0287821","DOI":"10.1128\/mBio.02878-21","volume":"12","author":"LD McDonough","year":"2021","unstructured":"McDonough LD, Mishra AA, Tosini N, Kakade P, Penumutchu S, Liang SH, et al. Candida albicans isolates 529L and CHN1 exhibit stable colonization of the murine gastrointestinal tract. Mbio. 2021;12:e0287821.","journal-title":"Mbio"},{"key":"1130_CR54","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1111\/j.1365-2958.2007.05759.x","volume":"64","author":"W Wu","year":"2007","unstructured":"Wu W, Lockhart SR, Pujol C, Srikantha T, Soll DR. Heterozygosity of genes on the sex chromosome regulates Candida albicans virulence. Mol Microbiol. 2007;64:1587\u2013604.","journal-title":"Mol Microbiol"},{"key":"1130_CR55","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1101\/gr.174623.114","volume":"25","author":"MP Hirakawa","year":"2015","unstructured":"Hirakawa MP, Martinez DA, Sakthikumar S, Anderson MZ, Berlin A, Gujja S, et al. Genetic and phenotypic intra-species variation in Candida albicans. Genome Res. 2015;25:413\u201325.","journal-title":"Genome Res"},{"key":"1130_CR56","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1038\/mi.2017.2","volume":"10","author":"FA Sch\u00f6nherr","year":"2017","unstructured":"Sch\u00f6nherr FA, Sparber F, Kirchner FR, Guiducci E, Trautwein-Weidner K, Gladiator A, et al. The intraspecies diversity of C. albicans triggers qualitatively and temporally distinct host responses that determine the balance between commensalism and pathogenicity. Mucosal Immunol. 2017;10:1335\u201350.","journal-title":"Mucosal Immunol"},{"key":"1130_CR57","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.molimm.2009.09.018","volume":"47","author":"R van Bruggen","year":"2009","unstructured":"van Bruggen R, Drewniak A, Jansen M, van Houdt M, Roos D, Chapel H, et al. Complement receptor 3, not Dectin-1, is the major receptor on human neutrophils for \u03b2-glucan-bearing particles. Mol Immunol. 2009;47:575\u201381.","journal-title":"Mol Immunol"},{"key":"1130_CR58","doi-asserted-by":"publisher","first-page":"7317","DOI":"10.1128\/IAI.73.11.7317-7323.2005","volume":"73","author":"PS Mobberley-Schuman","year":"2005","unstructured":"Mobberley-Schuman PS, Weiss AA. Influence of CR3 (CD11b\/CD18) expression on phagocytosis of bordetella pertussis by human neutrophils. Infect Immun. 2005;73:7317\u201323.","journal-title":"Infect Immun"},{"key":"1130_CR59","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-37997-y","volume":"13","author":"H Witt","year":"2023","unstructured":"Witt H, Yan Z, Henann D, Franck C, Reichner J. Mechanosensitive traction force generation is regulated by the neutrophil activation state. Sci Rep. 2023;13:11098.","journal-title":"Sci Rep."},{"key":"1130_CR60","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1007\/BF02592978","volume":"26","author":"G Berton","year":"1996","unstructured":"Berton G, Yan SR, Fumagalli L, Lowell CA. Neutrophil activation by adhesion: mechanisms and pathophysiological implications. Int J Clin Lab Res. 1996;26:160\u201377.","journal-title":"Int J Clin Lab Res"},{"key":"1130_CR61","first-page":"341","volume":"277","author":"DL Allen","year":"1996","unstructured":"Allen DL, Hoffman WP, Marder P, Matchett MR, Leiter PA, Abbott DL, et al. The effects of LY293111Na, a leukotriene B4 receptor antagonist, on the pulmonary neutrophilia and CD11b expression caused by inhalation of a leukotriene B4 aerosol in rhesus monkeys. J Pharmacol Exp Ther. 1996;277:341\u20139.","journal-title":"J Pharmacol Exp Ther"},{"key":"1130_CR62","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1111\/j.1365-2125.1996.tb00008.x","volume":"42","author":"P Marder","year":"1996","unstructured":"Marder P, Spaethe SM, Froelich LL, Cerimele BJ, Petersen BH, Tanner T, et al. Inhibition of ex vivo neutrophil activation by oral LY293111, a novel leukotriene B4 receptor antagonist. Br J Clin Pharmacol. 1996;42:457\u201364.","journal-title":"Br J Clin Pharmacol"},{"key":"1130_CR63","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1136\/ard.2002.004499","volume":"63","author":"R Alten","year":"2004","unstructured":"Alten R, Gromnica-Ihle E, Pohl C, Emmerich J, Steffgen J, Roscher R, et al. Inhibition of leukotriene B4-induced CD11B\/CD18 (Mac-1) expression by BIIL 284, a new long acting LTB4 receptor antagonist, in patients with rheumatoid arthritis. Ann Rheum Dis. 2004;63:170\u20136.","journal-title":"Ann Rheum Dis"},{"key":"1130_CR64","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1016\/S0006-2952(96)00884-2","volume":"53","author":"JP van Pelt","year":"1997","unstructured":"van Pelt JP, de Jong EM, van Erp PE, Mitchell MI, Marder P, Spaethe SM, et al. The regulation of CD11b integrin levels on human blood leukocytes and leukotriene B4-stimulated skin by a specific leukotriene B4 receptor antagonist (LY293111). Biochem Pharm. 1997;53:1005\u201312.","journal-title":"Biochem Pharm"},{"key":"1130_CR65","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1182\/blood-2005-03-0944","volume":"106","author":"AM Condliffe","year":"2005","unstructured":"Condliffe AM, Davidson K, Anderson KE, Ellson CD, Crabbe T, Okkenhaug K, et al. Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood. 2005;106:1432\u201340.","journal-title":"Blood"},{"key":"1130_CR66","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.smim.2016.02.004","volume":"28","author":"DJ van Rees","year":"2016","unstructured":"van Rees DJ, Szilagyi K, Kuijpers TW, Matlung HL, van den Berg TK. Immunoreceptors on neutrophils. Semin Immunol. 2016;28:94\u2013108.","journal-title":"Semin Immunol"},{"key":"1130_CR67","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1016\/j.it.2019.05.003","volume":"40","author":"MA Cassatella","year":"2019","unstructured":"Cassatella MA, \u00d6stberg NK, Tamassia N, Soehnlein O. Biological roles of neutrophil-derived granule proteins and cytokines. Trends Immunol. 2019;40:648\u201364.","journal-title":"Trends Immunol"},{"key":"1130_CR68","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1111\/imr.13154","volume":"314","author":"WM Nauseef","year":"2023","unstructured":"Nauseef WM. Human neutrophils \u2260 murine neutrophils: does it matter? Immunol Rev. 2023;314:442\u201356.","journal-title":"Immunol Rev"},{"key":"1130_CR69","doi-asserted-by":"publisher","unstructured":"Wang J, An H, Ding M, Liu Y, Wang S, Jin Q, et al. Potent bacterial vaccines require Fc\u03b3RIIB-mediated pathogen capture by liver sinusoidal endothelium. bioRxiv. 2022. https:\/\/doi.org\/10.1101\/2022.07.19.500551.","DOI":"10.1101\/2022.07.19.500551"},{"key":"1130_CR70","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/ni1408","volume":"8","author":"PR Taylor","year":"2007","unstructured":"Taylor PR, Tsoni SV, Willment JA, Dennehy KM, Rosas M, Findon H, et al. Dectin-1 is required for beta-glucan recognition and control of fungal infection. Nat Immunol. 2007;8:31\u201338.","journal-title":"Nat Immunol"},{"key":"1130_CR71","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.chom.2020.05.002","volume":"28","author":"Y Guo","year":"2020","unstructured":"Guo Y, Kasahara S, Jhingran A, Tosini NL, Zhai B, Aufiero MA, et al. During Aspergillus infection, monocyte-derived DCs, neutrophils, and plasmacytoid DCs enhance innate immune defense through CXCR3-dependent crosstalk. Cell Host Microbe. 2020;28:104\u2013116.e4.","journal-title":"Cell Host Microbe"},{"key":"1130_CR72","doi-asserted-by":"publisher","first-page":"2427","DOI":"10.4049\/jimmunol.1800620","volume":"201","author":"Y Guo","year":"2018","unstructured":"Guo Y, Chang Q, Cheng L, Xiong S, Jia X, Lin X, et al. C-type lectin receptor CD23 is required for host defense against Candida albicans and Aspergillus fumigatus infection. J Immunol. 2018;201:2427\u201340.","journal-title":"J Immunol"},{"key":"1130_CR73","doi-asserted-by":"publisher","first-page":"3.20.1","DOI":"10.1002\/0471142735.im0320s22","volume":"22","author":"Y Luo","year":"1997","unstructured":"Luo Y, Dorf ME. Isolation of mouse neutrophils. Curr Protoc Immunol. 1997;22:3.20.1\u20133.20.6.","journal-title":"Curr Protoc Immunol"},{"key":"1130_CR74","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/978-94-017-0623-0_13","volume":"24","author":"JM Voyich","year":"2003","unstructured":"Voyich JM, DeLeo FR. Host-pathogen interactions: leukocyte phagocytosis and associated sequelae. Adv Flow Cytometry Appl Biol Res. 2003;24:79\u201390.","journal-title":"Adv Flow Cytometry Appl Biol Res"},{"key":"1130_CR75","doi-asserted-by":"publisher","first-page":"e21820","DOI":"10.1096\/fj.202100516RR","volume":"35","author":"J Fischer","year":"2021","unstructured":"Fischer J, Gresnigt MS, Werz O, Hube B, Garscha U. Candida albicans\u2010induced leukotriene biosynthesis in neutrophils is restricted to the hyphal morphology. FASEB J. 2021;35:e21820.","journal-title":"FASEB J"}],"container-title":["Cellular & Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41423-024-01130-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41423-024-01130-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41423-024-01130-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,2]],"date-time":"2024-03-02T15:05:10Z","timestamp":1709391910000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41423-024-01130-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,31]]},"references-count":75,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["1130"],"URL":"https:\/\/doi.org\/10.1038\/s41423-024-01130-4","relation":{},"ISSN":["2042-0226"],"issn-type":[{"value":"2042-0226","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,31]]},"assertion":[{"value":"8 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 December 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 January 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}