{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T00:09:10Z","timestamp":1793664550047,"version":"4.5.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T00:00:00Z","timestamp":1715644800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T00:00:00Z","timestamp":1715644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People\u2019s Republic of China","doi-asserted-by":"publisher","award":["2020YFC2002800"],"award-info":[{"award-number":["2020YFC2002800"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272181"],"award-info":[{"award-number":["82272181"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Mol Immunol"],"DOI":"10.1038\/s41423-024-01174-6","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T11:01:44Z","timestamp":1715684504000},"page":"689-706","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Neutrophil\u2013macrophage communication via extracellular vesicle transfer promotes itaconate accumulation and ameliorates cytokine storm syndrome"],"prefix":"10.1038","volume":"21","author":[{"given":"Haixia","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8758-1693","authenticated-orcid":false,"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,14]]},"reference":[{"key":"1174_CR1","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.1056\/NEJMra2026131","volume":"383","author":"DC Fajgenbaum","year":"2020","unstructured":"Fajgenbaum DC, June CH. Cytokine Storm. N Engl J Med. 2020;383:2255\u201373.","journal-title":"N Engl J Med."},{"key":"1174_CR2","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1146\/annurev-immunol-081619-104850","volume":"38","author":"DG Ryan","year":"2020","unstructured":"Ryan DG, O\u2019Neill LAJ. Krebs cycle reborn in macrophage immunometabolism. Annu Rev Immunol. 2020;38:289\u2013313.","journal-title":"Annu Rev Immunol"},{"key":"1174_CR3","doi-asserted-by":"publisher","first-page":"102591","DOI":"10.1016\/j.redox.2022.102591","volume":"59","author":"S Maassen","year":"2023","unstructured":"Maassen S, Coenen B, Ioannidis M, Harber K, Grijpstra P, Van den Bossche J, et al. Itaconate promotes a wound resolving phenotype in pro-inflammatory macrophages. Redox Biol. 2023;59:102591.","journal-title":"Redox Biol"},{"key":"1174_CR4","doi-asserted-by":"publisher","first-page":"864387","DOI":"10.3389\/fimmu.2022.864387","volume":"13","author":"E McKenna","year":"2022","unstructured":"McKenna E, Wubben R, Isaza-Correa JM, Melo AM, Mhaonaigh AU, Conlon N, et al. Neutrophils in COVID-19: Not Innocent Bystanders. Front Immunol. 2022;13:864387.","journal-title":"Front Immunol"},{"key":"1174_CR5","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1038\/s41577-020-0407-1","volume":"20","author":"M Laforge","year":"2020","unstructured":"Laforge M, Elbim C, Frere C, Hemadi M, Massaad C, Nuss P, et al. Tissue damage from neutrophil-induced oxidative stress in COVID-19. Nat Rev Immunol. 2020;20:515\u20136.","journal-title":"Nat Rev Immunol"},{"key":"1174_CR6","doi-asserted-by":"publisher","first-page":"2021","DOI":"10.1007\/s10753-020-01294-x","volume":"43","author":"Z Cahilog","year":"2020","unstructured":"Cahilog Z, Zhao H, Wu L, Alam A, Eguchi S, Weng H, et al. The Role of Neutrophil NETosis in Organ Injury: Novel Inflammatory Cell Death Mechanisms. Inflammation. 2020;43:2021\u201332.","journal-title":"Inflammation."},{"key":"1174_CR7","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1007\/s00441-017-2785-7","volume":"371","author":"J Wang","year":"2018","unstructured":"Wang J. Neutrophils in tissue injury and repair. Cell Tissue Res. 2018;371:531\u20139.","journal-title":"Cell Tissue Res"},{"key":"1174_CR8","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.cell.2020.11.025","volume":"184","author":"R Karki","year":"2021","unstructured":"Karki R, Sharma BR, Tuladhar S, Williams EP, Zalduondo L, Samir P, et al. Synergism of TNF-alpha and IFN-gamma Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes. Cell. 2021;184:149\u2013168.e17.","journal-title":"Cell."},{"key":"1174_CR9","doi-asserted-by":"publisher","first-page":"2200","DOI":"10.1073\/pnas.1820704116","volume":"116","author":"A Wang","year":"2019","unstructured":"Wang A, Pope SD, Weinstein JS, Yu S, Zhang C, Booth CJ, et al. Specific sequences of infectious challenge lead to secondary hemophagocytic lymphohistiocytosis-like disease in mice. Proc Natl Acad Sci USA. 2019;116:2200\u20139.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1174_CR10","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1038\/s41577-021-00536-9","volume":"21","author":"A Bonaventura","year":"2021","unstructured":"Bonaventura A, Vecchie A, Dagna L, Martinod K, Dixon DL, Van Tassell BW, et al. Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19. Nat Rev Immunol. 2021;21:319\u201329.","journal-title":"Nat Rev Immunol"},{"key":"1174_CR11","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1159\/000284367","volume":"2","author":"S Fox","year":"2010","unstructured":"Fox S, Leitch AE, Duffin R, Haslett C, Rossi AG. Neutrophil apoptosis: relevance to the innate immune response and inflammatory disease. J Innate Immun. 2010;2:216\u201327.","journal-title":"J Innate Immun"},{"key":"1174_CR12","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1038\/nri2779","volume":"10","author":"O Soehnlein","year":"2010","unstructured":"Soehnlein O, Lindbom L. Phagocyte partnership during the onset and resolution of inflammation. Nat Rev Immunol. 2010;10:427\u201339.","journal-title":"Nat Rev Immunol"},{"key":"1174_CR13","doi-asserted-by":"publisher","first-page":"14274","DOI":"10.1074\/jbc.M115.685792","volume":"291","author":"T Cordes","year":"2016","unstructured":"Cordes T, Wallace M, Michelucci A, Divakaruni AS, Sapcariu SC, Sousa C, et al. Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels. J Biol Chem. 2016;291:14274\u201384.","journal-title":"J Biol Chem"},{"key":"1174_CR14","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13078-5","volume":"10","author":"ST Liao","year":"2019","unstructured":"Liao ST, Han C, Xu DQ, Fu XW, Wang JS, Kong LY. 4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects. Nat Commun. 2019;10:5091.","journal-title":"Nat Commun"},{"key":"1174_CR15","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1038\/nature25986","volume":"556","author":"EL Mills","year":"2018","unstructured":"Mills EL, Ryan DG, Prag HA, Dikovskaya D, Menon D, Zaslona Z, et al. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature. 2018;556:113\u20137.","journal-title":"Nature."},{"key":"1174_CR16","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1038\/s41586-018-0052-z","volume":"556","author":"M Bambouskova","year":"2018","unstructured":"Bambouskova M, Gorvel L, Lampropoulou V, Sergushichev A, Loginicheva E, Johnson K, et al. Electrophilic properties of itaconate and derivatives regulate the IkappaBzeta-ATF3 inflammatory axis. Nature. 2018;556:501\u20134.","journal-title":"Nature."},{"key":"1174_CR17","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/s41556-022-00853-8","volume":"24","author":"LL Chen","year":"2022","unstructured":"Chen LL, Morcelle C, Cheng ZL, Chen X, Xu Y, Gao Y, et al. Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses. Nat Cell Biol. 2022;24:353\u201363.","journal-title":"Nat Cell Biol"},{"key":"1174_CR18","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1038\/s42255-020-0210-0","volume":"2","author":"A Swain","year":"2020","unstructured":"Swain A, Bambouskova M, Kim H, Andhey PS, Duncan D, Auclair K, et al. Comparative evaluation of itaconate and its derivatives reveals divergent inflammasome and type I interferon regulation in macrophages. Nat Metab. 2020;2:594\u2013602.","journal-title":"Nat Metab"},{"key":"1174_CR19","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1038\/nature02738","volume":"430","author":"M Yamamoto","year":"2004","unstructured":"Yamamoto M, Yamazaki S, Uematsu S, Sato S, Hemmi H, Hoshino K, et al. Regulation of Toll\/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta. Nature. 2004;430:218\u201322.","journal-title":"Nature."},{"key":"1174_CR20","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1038\/s41589-019-0323-5","volume":"15","author":"W Qin","year":"2019","unstructured":"Qin W, Qin K, Zhang Y, Jia W, Chen Y, Cheng B, et al. S-glycosylation-based cysteine profiling reveals regulation of glycolysis by itaconate. Nat Chem Biol. 2019;15:983\u201391.","journal-title":"Nat Chem Biol"},{"key":"1174_CR21","doi-asserted-by":"publisher","first-page":"112064","DOI":"10.1016\/j.celrep.2023.112064","volume":"42","author":"KL Tomlinson","year":"2023","unstructured":"Tomlinson KL, Riquelme SA, Baskota SU, Drikic M, Monk IR, Stinear TP, et al. Staphylococcus aureus stimulates neutrophil itaconate production that suppresses the oxidative burst. Cell Rep. 2023;42:112064.","journal-title":"Cell Rep"},{"key":"1174_CR22","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.1038\/s42255-022-00676-9","volume":"4","author":"H Zhao","year":"2022","unstructured":"Zhao H, Teng D, Yang L, Xu X, Chen J, Jiang T, et al. Myeloid-derived itaconate suppresses cytotoxic CD8(+) T cells and promotes tumour growth. Nat Metab. 2022;4:1660\u201373.","journal-title":"Nat Metab"},{"key":"1174_CR23","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34306-5","volume":"13","author":"P Sun","year":"2022","unstructured":"Sun P, Zhang Z, Wang B, Liu C, Chen C, Liu P, et al. A genetically encoded fluorescent biosensor for detecting itaconate with subcellular resolution in living macrophages. Nat Commun. 2022;13:6562.","journal-title":"Nat Commun"},{"key":"1174_CR24","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-92489-1","volume":"11","author":"X Gu","year":"2021","unstructured":"Gu X, Jin B, Qi Z, Yin X. Identification of potential microRNAs and KEGG pathways in denervation muscle atrophy based on meta-analysis. Sci Rep. 2021;11:13560.","journal-title":"Sci Rep"},{"key":"1174_CR25","doi-asserted-by":"publisher","first-page":"870267","DOI":"10.1155\/2014\/870267","volume":"2014","author":"AB Gilicze","year":"2014","unstructured":"Gilicze AB, Wiener Z, Toth S, Buzas E, Pallinger E, Falcone FH, et al. Myeloid-derived microRNAs, miR-223, miR27a, and miR-652, are dominant players in myeloid regulation. Biomed Res Int. 2014;2014:870267.","journal-title":"Biomed Res Int"},{"key":"1174_CR26","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1111\/j.1365-2141.2009.07632.x","volume":"145","author":"J Feng","year":"2009","unstructured":"Feng J, Iwama A, Satake M, Kohu K. MicroRNA-27 enhances differentiation of myeloblasts into granulocytes by post-transcriptionally downregulating Runx1. Br J Haematol. 2009;145:412\u201323.","journal-title":"Br J Haematol"},{"key":"1174_CR27","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1126\/science.aam9690","volume":"358","author":"J Wang","year":"2017","unstructured":"Wang J, Hossain M, Thanabalasuriar A, Gunzer M, Meininger C, Kubes P. Visualizing the function and fate of neutrophils in sterile injury and repair. Science. 2017;358:111\u20136.","journal-title":"Science."},{"key":"1174_CR28","doi-asserted-by":"publisher","first-page":"10258","DOI":"10.1523\/JNEUROSCI.2085-17.2017","volume":"37","author":"JA Lindborg","year":"2017","unstructured":"Lindborg JA, Mack M, Zigmond RE. Neutrophils are critical for myelin removal in a peripheral nerve injury model of Wallerian degeneration. J Neurosci. 2017;37:10258\u201377.","journal-title":"J Neurosci"},{"key":"1174_CR29","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1084\/jem.20161238","volume":"214","author":"LL Reber","year":"2017","unstructured":"Reber LL, Gillis CM, Starkl P, Jonsson F, Sibilano R, Marichal T, et al. Neutrophil myeloperoxidase diminishes the toxic effects and mortality induced by lipopolysaccharide. J Exp Med. 2017;214:1249\u201358.","journal-title":"J Exp Med"},{"key":"1174_CR30","doi-asserted-by":"publisher","first-page":"e60","DOI":"10.1182\/blood-2012-04-423525","volume":"120","author":"J Dalli","year":"2012","unstructured":"Dalli J, Serhan CN. Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators. Blood. 2012;120:e60\u201372.","journal-title":"Blood."},{"key":"1174_CR31","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/j.imbio.2012.05.021","volume":"218","author":"C Eken","year":"2013","unstructured":"Eken C, Sadallah S, Martin PJ, Treves S, Schifferli JA. Ectosomes of polymorphonuclear neutrophils activate multiple signaling pathways in macrophages. Immunobiology. 2013;218:382\u201392.","journal-title":"Immunobiology."},{"key":"1174_CR32","doi-asserted-by":"publisher","first-page":"e140508","DOI":"10.1172\/JCI148548","volume":"132","author":"CG Peace","year":"2022","unstructured":"Peace CG, O\u2019neill LA. The role of itaconate in host defense and inflammation. J Clin Investig. 2022;132:e140508.","journal-title":"J Clin Investig"},{"key":"1174_CR33","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1007\/s10753-012-9443-8","volume":"35","author":"Y Cheng","year":"2012","unstructured":"Cheng Y, Kuang W, Hao Y, Zhang D, Lei M, Du L, et al. Downregulation of miR-27a* and miR-532-5p and upregulation of miR-146a and miR-155 in LPS-induced RAW264.7 macrophage cells. Inflammation. 2012;35:1308\u201313.","journal-title":"Inflammation."},{"key":"1174_CR34","first-page":"479","volume":"44","author":"Y Wang","year":"2019","unstructured":"Wang Y, Zhang X, Tian J, Liu G, Li X, Shen D. Sevoflurane alleviates LPS-induced acute lung injury via the microRNA-27a-3p\/TLR4\/MyD88\/NF-kappaB signaling pathway. Int J Mol Med. 2019;44:479\u201390.","journal-title":"Int J Mol Med"},{"key":"1174_CR35","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.1080\/15384101.2018.1509635","volume":"17","author":"M Ju","year":"2018","unstructured":"Ju M, Liu B, He H, Gu Z, Liu Y, Su Y, et al. MicroRNA-27a alleviates LPS-induced acute lung injury in mice via inhibiting in fl ammation and apoptosis through modulating TLR4\/MyD88\/NF-kappaB pathway. Cell Cycle. 2018;17:2001\u201318.","journal-title":"Cell Cycle"},{"key":"1174_CR36","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1038\/s41374-021-00620-7","volume":"101","author":"X Lv","year":"2021","unstructured":"Lv X, Zhang XY, Zhang Q, Nie YJ, Luo GH, Fan X, et al. lncRNA NEAT1 aggravates sepsis-induced lung injury by regulating the miR-27a\/PTEN axis. Lab Invest. 2021;101:1371\u201381.","journal-title":"Lab Invest"},{"key":"1174_CR37","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1146\/annurev-med-042921-112837","volume":"74","author":"RQ Cron","year":"2023","unstructured":"Cron RQ, Goyal G, Chatham WW. Cytokine storm syndrome. Annu Rev Med. 2023;74:321\u201337.","journal-title":"Annu Rev Med"},{"key":"1174_CR38","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1038\/s42255-022-00605-w","volume":"4","author":"EM Schuster","year":"2022","unstructured":"Schuster EM, Epple MW, Glaser KM, Mihlan M, Lucht K, Zimmermann JA, et al. TFEB induces mitochondrial itaconate synthesis to suppress bacterial growth in macrophages. Nat Metab. 2022;4:856\u201366.","journal-title":"Nat Metab"},{"key":"1174_CR39","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/978-1-4939-7163-3_16","volume":"1639","author":"M Aparicio-Vergara","year":"2017","unstructured":"Aparicio-Vergara M, Tencerova M, Morgantini C, Barreby E, Aouadi M. Isolation of Kupffer Cells and Hepatocytes from a Single Mouse Liver. Methods Mol Biol. 2017;1639:161\u201371.","journal-title":"Methods Mol Biol"},{"key":"1174_CR40","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1084\/jem.20141539","volume":"212","author":"D Dal-Secco","year":"2015","unstructured":"Dal-Secco D, Wang J, Zeng Z, Kolaczkowska E, Wong CH, Petri B, et al. A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2+ monocytes at a site of sterile injury. J Exp Med. 2015;212:447\u201356.","journal-title":"J Exp Med"}],"container-title":["Cellular & Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41423-024-01174-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41423-024-01174-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41423-024-01174-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T06:03:02Z","timestamp":1734069782000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41423-024-01174-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,14]]},"references-count":40,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["1174"],"URL":"https:\/\/doi.org\/10.1038\/s41423-024-01174-6","relation":{},"ISSN":["2042-0226"],"issn-type":[{"value":"2042-0226","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,14]]},"assertion":[{"value":"19 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}