{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:51:05Z","timestamp":1786650665385,"version":"build-2736575974"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Mol Immunol"],"DOI":"10.1038\/s41423-026-01439-2","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T09:25:44Z","timestamp":1782897944000},"page":"1038-1051","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["FAM234A acts as a switch between Th17 and Treg cell fate decisions that control inflammatory bowel disease"],"prefix":"10.1038","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1568-0857","authenticated-orcid":false,"given":"Zhaoqi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinglin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"1439_CR1","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/nri3661","volume":"14","author":"MF Neurath","year":"2014","unstructured":"Neurath MF. Cytokines in inflammatory bowel disease. Nat Rev Immunol. 2014;14:329\u201342.","journal-title":"Nat Rev Immunol"},{"key":"1439_CR2","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.autrev.2013.06.004","volume":"13","author":"A Geremia","year":"2014","unstructured":"Geremia A, Biancheri P, Allan P, Corazza GR, Di Sabatino A. Innate and adaptive immunity in inflammatory bowel disease. Autoimmun Rev. 2014;13:3\u201310.","journal-title":"Autoimmun Rev"},{"key":"1439_CR3","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1177\/1721727X15580902","volume":"13","author":"J Wen","year":"2015","unstructured":"Wen J, Yang P, Chen X, Fang Y, Chang Q, Li C, et al. The role of Th17\/Treg balance and Th22 cell in the pathogenesis of DSS-induced colitis in mice. Eur J Inflamm. 2015;13:101\u20138.","journal-title":"Eur J Inflamm"},{"key":"1439_CR4","doi-asserted-by":"publisher","first-page":"1952","DOI":"10.3389\/fimmu.2020.01952","volume":"11","author":"H Peng","year":"2020","unstructured":"Peng H, Ning H, Wang Q, Lai J, Wei L, Stumpo DJ, et al. Tristetraprolin regulates TH17 cell function and ameliorates DSS-induced colitis in mice. Front Immunol. 2020;11:1952.","journal-title":"Front Immunol"},{"key":"1439_CR5","volume":"2014","author":"J G\u00e1lvez","year":"2014","unstructured":"G\u00e1lvez J. Role of Th17 Cells in the pathogenesis of human IBD. ISRN Inflamm. 2014;2014:928461.","journal-title":"ISRN Inflamm"},{"key":"1439_CR6","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1016\/j.cell.2006.07.035","volume":"126","author":"II Ivanov","year":"2006","unstructured":"Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, Lafaille JJ, et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell. 2006;126:1121\u201333.","journal-title":"Cell"},{"key":"1439_CR7","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1038\/ni1488","volume":"8","author":"Zhou","year":"2007","unstructured":"Zhou, Ivanov II LA, Spolski R, Min R, Shenderov K, Egawa T, et al. IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol. 2007;8:967\u201374.","journal-title":"Nat Immunol"},{"key":"1439_CR8","first-page":"73","volume":"53","author":"K Kond\u0115lkov\u00e1","year":"2010","unstructured":"Kond\u0115lkov\u00e1 K, Vokurkov\u00e1 D, Krejsek J, Borsk\u00e1 L, Fiala Z, Ctirad A. Regulatory T cells (TREG) and their roles in immune system with respect to immunopathological disorders. Acta Med. 2010;53:73\u20137.","journal-title":"Acta Med"},{"key":"1439_CR9","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/nature04753","volume":"441","author":"E Bettelli","year":"2006","unstructured":"Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 2006;441:235\u20138.","journal-title":"Nature"},{"key":"1439_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/rai2.12104","volume":"4","author":"Q Tan","year":"2024","unstructured":"Tan Q, Huang W, Zheng Y, Li M, Tao Y, Yu S. Unveiling the nexus: decoding interactions between regulated cell death and systemic lupus erythematosus pathogenesis for innovative therapeutic avenues. Rheumatol Autoimmune. 2024;4:1\u201310.","journal-title":"Rheumatol Autoimmune"},{"key":"1439_CR11","doi-asserted-by":"publisher","first-page":"348","DOI":"10.3389\/fimmu.2020.00348","volume":"11","author":"A Capone","year":"2020","unstructured":"Capone A, Volpe E. Transcriptional regulators of T helper 17 cell differentiation in health and autoimmune diseases. Front Immunol. 2020;11:348.","journal-title":"Front Immunol"},{"key":"1439_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/02770903.2016.1266494","volume":"55","author":"C Li","year":"2018","unstructured":"Li C, Sheng A, Jia X, Zeng Z, Zhang X, Zhao W, et al. Th17\/Treg dysregulation in allergic asthmatic children is associated with elevated notch expression. J Asthma. 2018;55:1\u20137.","journal-title":"J Asthma"},{"key":"1439_CR13","doi-asserted-by":"publisher","first-page":"639","DOI":"10.3389\/fimmu.2015.00639","volume":"6","author":"S Omenetti","year":"2015","unstructured":"Omenetti S, Pizarro TT. The Treg\/Th17 axis: a dynamic balance regulated by the gut microbiome. Front Immunol. 2015;6:639.","journal-title":"Front Immunol"},{"key":"1439_CR14","doi-asserted-by":"publisher","first-page":"730","DOI":"10.3390\/ijms19030730","volume":"19","author":"GR Lee","year":"2018","unstructured":"Lee GR. The balance of Th17 versus Treg cells in autoimmunity. Int J Mol Sci. 2018;19:730.","journal-title":"Int J Mol Sci"},{"key":"1439_CR15","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1038\/s42255-024-01140-6","volume":"6","author":"AL Madsen","year":"2024","unstructured":"Madsen AL, Bon\u00e0s-Guarch S, Gheibi S, Prasad R, Vangipurapu J, Ahuja V, et al. Genetic architecture of oral glucose-stimulated insulin release provides biological insights into type 2 diabetes etiology. Nat Metab. 2024;6:1897\u2013912.","journal-title":"Nat Metab"},{"key":"1439_CR16","doi-asserted-by":"publisher","first-page":"12457","DOI":"10.2147\/CMAR.S280009","volume":"12","author":"L Lyu","year":"2020","unstructured":"Lyu L, Wang M, Zheng Y, Tian T, Deng Y, Xu P, et al. Overexpression of FAM234B predicts poor prognosis in patients with luminal breast cancer. Cancer Manag Res. 2020;12:12457\u201371.","journal-title":"Cancer Manag Res"},{"key":"1439_CR17","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22164-6","volume":"12","author":"N Jaeger","year":"2021","unstructured":"Jaeger N, Gamini R, Cella M, Schettini JL, Bugatti M, Zhao S, et al. Single-cell analyses of Crohn\u2019s disease tissues reveal intestinal intraepithelial T cells heterogeneity and altered subset distributions. Nat Commun. 2021;12:1921.","journal-title":"Nat Commun"},{"key":"1439_CR18","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.625423","volume":"9","author":"X Han","year":"2021","unstructured":"Han X, Ding S, Jiang H, Liu G. Roles of macrophages in the development and treatment of gut inflammation. Front Cell Dev Biol. 2021;9:625423.","journal-title":"Front Cell Dev Biol"},{"key":"1439_CR19","doi-asserted-by":"publisher","first-page":"3900","DOI":"10.1016\/j.jmb.2019.07.023","volume":"431","author":"T Das","year":"2019","unstructured":"Das T, Kim EE, Song EJ. Phosphorylation of USP15 and USP4 regulates localization and spliceosomal deubiquitination. J Mol Biol. 2019;431:3900\u201312.","journal-title":"J Mol Biol"},{"key":"1439_CR20","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1038\/ncb2522","volume":"14","author":"L Zhang","year":"2012","unstructured":"Zhang L, Zhou F, Drabsch Y, Gao R, Snaar-Jagalska BE, Mickanin C, et al. USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-\u03b2 type I receptor. Nat Cell Biol. 2012;14:717\u201326.","journal-title":"Nat Cell Biol"},{"key":"1439_CR21","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1038\/s41422-018-0120-9","volume":"29","author":"L Deng","year":"2019","unstructured":"Deng L, Chen L, Zhao L, Xu Y, Peng X, Wang X, et al. Ubiquitination of Rheb governs growth factor-induced mTORC1 activation. Cell Res. 2019;29:136\u201350.","journal-title":"Cell Res"},{"key":"1439_CR22","doi-asserted-by":"publisher","first-page":"4094","DOI":"10.4049\/jimmunol.1401451","volume":"194","author":"J Yang","year":"2015","unstructured":"Yang J, Xu P, Han L, Guo Z, Wang X, Chen Z, et al. Cutting edge: ubiquitin-specific protease 4 promotes Th17 Cell function under inflammation by deubiquitinating and stabilizing ROR\u03b3t. J Immunol. 2015;194:4094.","journal-title":"J Immunol"},{"key":"1439_CR23","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.celrep.2019.03.029","volume":"27","author":"J Miska","year":"2019","unstructured":"Miska J, Lee-Chang C, Rashidi A, Muroski ME, Chang AL, Lopez-Rosas A, et al. HIF-1\u03b1 is a metabolic switch between glycolytic-driven migration and oxidative phosphorylation-driven immunosuppression of tregs in glioblastoma. Cell Rep. 2019;27:226\u201337.e4.","journal-title":"Cell Rep"},{"key":"1439_CR24","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/s41586-018-0846-z","volume":"565","author":"SE Weinberg","year":"2019","unstructured":"Weinberg SE, Singer BD, Steinert EM, Martinez CA, Mehta MM, Mart\u00ednez-Reyes I, et al. Mitochondrial complex III is essential for suppressive function of regulatory T cells. Nature. 2019;565:495\u20139.","journal-title":"Nature"},{"key":"1439_CR25","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1007\/s00432-022-03918-1","volume":"148","author":"S P\u00e9rez Regalado","year":"2022","unstructured":"P\u00e9rez Regalado S, Le\u00f3n J, Feriche B. Therapeutic approach for digestive system cancers and potential implications of exercise under hypoxia condition: what little is known? a narrative review. J Cancer Res Clin Oncol. 2022;148:1107\u201321.","journal-title":"J Cancer Res Clin Oncol"},{"key":"1439_CR26","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1037341","volume":"13","author":"JQ Xu","year":"2022","unstructured":"Xu JQ, Fu YL, Zhang J, Zhang KY, Ma J, Tang JY, et al. Targeting glycolysis in non-small cell lung cancer: Promises and challenges. Front Pharmacol. 2022;13:1037341.","journal-title":"Front Pharmacol"},{"key":"1439_CR27","doi-asserted-by":"publisher","DOI":"10.1126\/science.1250684","volume":"345","author":"S-C Cheng","year":"2014","unstructured":"Cheng S-C, Quintin J, Cramer RA, Shepardson KM, Saeed S, Kumar V, et al. mTOR- and HIF-1\u03b1\u2013mediated aerobic glycolysis as metabolic basis for trained immunity. Science. 2014;345:1250684.","journal-title":"Science"},{"key":"1439_CR28","doi-asserted-by":"publisher","DOI":"10.1002\/cpz1.1092","volume":"4","author":"CF Pearson","year":"2024","unstructured":"Pearson CF, Maloy KJ. Update: induction of inflammatory bowel disease in immunodeficient mice by injection of naive CD4(+) T cells (T-cell transfer model of colitis). Curr Protoc. 2024;4:e1092.","journal-title":"Curr Protoc"},{"key":"1439_CR29","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/j.chembiol.2022.02.006","volume":"29","author":"Y Zhong","year":"2022","unstructured":"Zhong Y, Zhou X, Guan KL, Zhang J. Rheb regulates nuclear mTORC1 activity independent of farnesylation. Cell Chem Biol. 2022;29:1037\u201345.e4.","journal-title":"Cell Chem Biol"},{"key":"1439_CR30","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1016\/j.cell.2017.02.004","volume":"168","author":"RA Saxton","year":"2017","unstructured":"Saxton RA, Sabatini DM. mTOR signaling in growth, metabolism, and disease. Cell. 2017;168:960\u201376.","journal-title":"Cell"},{"key":"1439_CR31","doi-asserted-by":"crossref","unstructured":"Li H, Zhou L, Zhou W, Zhang X, Shang J, Feng X, et al. Mitochondrial aberrations in systemic lupus erythematosus pathogenesis: Insights and therapeutic implications. Rheumatol Autoimmun. 2024;4:69\u201380.","DOI":"10.1002\/rai2.12119"},{"key":"1439_CR32","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1084\/jem.20110278","volume":"208","author":"LZ Shi","year":"2011","unstructured":"Shi LZ, Wang R, Huang G, Vogel P, Neale G, Green DR, et al. HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J Exp Med. 2011;208:1367\u201376.","journal-title":"J Exp Med"},{"key":"1439_CR33","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.celrep.2012.02.007","volume":"1","author":"Y Kurebayashi","year":"2012","unstructured":"Kurebayashi Y, Nagai S, Ikejiri A, Ohtani M, Ichiyama K, Baba Y, et al. PI3K-Akt-mTORC1-S6K1\/2 axis controls Th17 differentiation by regulating Gfi1 expression and nuclear translocation of ROR\u03b3. Cell Rep. 2012;1:360\u201373.","journal-title":"Cell Rep"},{"key":"1439_CR34","doi-asserted-by":"publisher","first-page":"3939","DOI":"10.4049\/jimmunol.1601078","volume":"198","author":"O Chornoguz","year":"2017","unstructured":"Chornoguz O, Hagan RS, Haile A, Arwood ML, Gamper CJ, Banerjee A, et al. mTORC1 promotes T-bet phosphorylation to regulate Th1 differentiation. J Immunol. 2017;198:3939\u201348.","journal-title":"J Immunol"},{"key":"1439_CR35","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202350836","volume":"54","author":"Z Zhang","year":"2024","unstructured":"Zhang Z, Zhao C, Sun L, Cheng C, Tian Q, Wu C, et al. Trappc1 intrinsically prevents ferroptosis of naive T cells to avoid spontaneous autoinflammatory disease in mice. Eur J Immunol. 2024;54:e2350836.","journal-title":"Eur J Immunol"},{"key":"1439_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111668","volume":"41","author":"Y Hou","year":"2022","unstructured":"Hou Y, Wei D, Zhang Z, Guo H, Li S, Zhang J, et al. FABP5 controls macrophage alternative activation and allergic asthma by selectively programming long-chain unsaturated fatty acid metabolism. Cell Rep. 2022;41:111668.","journal-title":"Cell Rep"},{"key":"1439_CR37","doi-asserted-by":"publisher","first-page":"2168","DOI":"10.1016\/j.jaci.2017.06.026","volume":"141","author":"P Wang","year":"2018","unstructured":"Wang P, Su H, Zhang L, Chen H, Hu X, Yang F, et al. Phosphatase wild-type p53-induced phosphatase 1 controls the development of T(H)9 cells and allergic airway inflammation. J Allergy Clin Immunol. 2018;141:2168\u201381.","journal-title":"J Allergy Clin Immunol"},{"key":"1439_CR38","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1111\/all.16430","volume":"80","author":"H Guo","year":"2025","unstructured":"Guo H, Zhao Y, Zhang Z, Xu Y, Chen Y, Lei T, et al. The presence and pathogenic roles of M(IL-33 + IL-2) macrophages in allergic airway inflammation. Allergy. 2025;80:1298\u2013308.","journal-title":"Allergy"},{"key":"1439_CR39","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1038\/s41423-023-01057-2","volume":"20","author":"Y Chen","year":"2023","unstructured":"Chen Y, Zhao C, Guo H, Zou W, Zhang Z, Wei D, et al. Wip1 inhibits neutrophil extracellular traps to promote abscess formation in mice by directly dephosphorylating Coronin-1a. Cell Mol Immunol. 2023;20:941\u201354.","journal-title":"Cell Mol Immunol"},{"key":"1439_CR40","doi-asserted-by":"crossref","unstructured":"Morris GM, Huey R, Olson AJ. Using AutoDock for ligand\u2012receptor docking. Curr Proto Bioinform. 2008;Chapter 8:Unit 8.14.","DOI":"10.1002\/0471250953.bi0814s24"},{"key":"1439_CR41","doi-asserted-by":"publisher","first-page":"2195","DOI":"10.1073\/pnas.89.6.2195","volume":"89","author":"E Katchalski-Katzir","year":"1992","unstructured":"Katchalski-Katzir E, Shariv I, Eisenstein M, Friesem AA, Aflalo C, Vakser IA. Molecular surface recognition: determination of geometric fit between proteins and their ligands by correlation techniques. Proc Natl Acad Sci USA. 1992;89:2195\u20139.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1439_CR42","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.softx.2015.06.001","volume":"1-2","author":"MJ Abraham","year":"2015","unstructured":"Abraham MJ, Murtola T, Schulz R, P\u00e1ll S, Smith JC, Hess B, et al. GROMACS: High performance molecular simulations through multilevel parallelism from laptops to supercomputers. SoftwareX. 2015;1-2:19\u201325.","journal-title":"SoftwareX"},{"key":"1439_CR43","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1002\/jcc.23354","volume":"34","author":"J Huang","year":"2013","unstructured":"Huang J, MacKerell AD Jr. CHARMM36 all-atom additive protein force field: validation based on comparison to NMR data. J Comput Chem. 2013;34:2135\u201345.","journal-title":"J Comput Chem"},{"key":"1439_CR44","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/j.ejmech.2016.05.058","volume":"121","author":"R Dolezal","year":"2016","unstructured":"Dolezal R, Soukup O, Malinak D, Savedra RML, Marek J, Dolezalova M, et al. Toward understanding the mechanism of action of antibacterial N-alkyl-3-hydroxypyridinium salts: biological activities, molecular modeling and QSAR studies. Eur J Med Chem. 2016;121:699\u2013711.","journal-title":"Eur J Med Chem"},{"key":"1439_CR45","doi-asserted-by":"publisher","first-page":"6673","DOI":"10.1021\/acs.jpcb.8b02144","volume":"122","author":"MC Childers","year":"2018","unstructured":"Childers MC, Daggett V. Validating molecular dynamics simulations against experimental observables in light of underlying conformational ensembles. J Phys Chem B. 2018;122:6673\u201389.","journal-title":"J Phys Chem B"},{"key":"1439_CR46","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202255503","volume":"24","author":"Y Xu","year":"2023","unstructured":"Xu Y, Zhang Z, Zhao Y, Zhao C, Shi M, Dong X, et al. TRAPPC1 is essential for the maintenance and differentiation of common myeloid progenitors in mice. EMBO Rep. 2023;24:e55503.","journal-title":"EMBO Rep"},{"key":"1439_CR47","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1011279","volume":"13","author":"Z Zhang","year":"2022","unstructured":"Zhang Z, Bossila EA, Li L, Hu S, Zhao Y. Central gene transcriptional regulatory networks shaping monocyte development in bone marrow. Front Immunol. 2022;13:1011279.","journal-title":"Front Immunol"},{"key":"1439_CR48","doi-asserted-by":"publisher","first-page":"W317","DOI":"10.1093\/nar\/gkab447","volume":"49","author":"D Bu","year":"2021","unstructured":"Bu D, Luo H, Huo P, Wang Z, Zhang S, He Z, et al. KOBAS-i: intelligent prioritization and exploratory visualization of biological functions for gene enrichment analysis. Nucleic Acids Res. 2021;49:W317\u2013W25.","journal-title":"Nucleic Acids Res"},{"key":"1439_CR49","doi-asserted-by":"publisher","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","volume":"51","author":"D Szklarczyk","year":"2023","unstructured":"Szklarczyk D, Kirsch R, Koutrouli M, Nastou K, Mehryary F, Hachilif R, et al. The STRING database in 2023: protein\u2012protein association networks and functional enrichment analyses for any sequenced genome of interest. Nucleic Acids Res. 2023;51:D638\u2013d46.","journal-title":"Nucleic Acids Res"},{"key":"1439_CR50","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13:2498\u2013504.","journal-title":"Genome Res"},{"key":"1439_CR51","doi-asserted-by":"publisher","DOI":"10.1002\/imo2.70034","volume":"2","author":"Z Zhang","year":"2025","unstructured":"Zhang Z, Xu Y, Pang K, Wu C, Zhao C, Lei T, et al. Microbiota humanization drives human-like metabolic and immune transcriptomic shifts in pigs. IMetaOmics. 2025;2:e70034.","journal-title":"IMetaOmics"}],"container-title":["Cellular &amp; Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41423-026-01439-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41423-026-01439-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41423-026-01439-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T08:16:12Z","timestamp":1786608972000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41423-026-01439-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":51,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["1439"],"URL":"https:\/\/doi.org\/10.1038\/s41423-026-01439-2","relation":{},"ISSN":["2042-0226"],"issn-type":[{"value":"2042-0226","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,1]]},"assertion":[{"value":"19 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests. YZ is an editorial board member of Cellular & Molecular Immunology, but he has not been involved in the peer review or the decision-making of the article.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}]}}