{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T11:26:45Z","timestamp":1771327605933,"version":"3.50.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T00:00:00Z","timestamp":1603065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T00:00:00Z","timestamp":1603065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Antibiot"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1038\/s41429-020-00374-2","type":"journal-article","created":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T11:06:45Z","timestamp":1603105605000},"page":"143-151","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Comparison of solithromycin with erythromycin in Enterococcus faecalis and Enterococcus faecium from China: antibacterial activity, clonality, resistance mechanism, and inhibition of biofilm formation"],"prefix":"10.1038","volume":"74","author":[{"given":"Yu","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanpeng","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanwen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinxin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangjian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiwen","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zewen","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhijian","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,10,19]]},"reference":[{"key":"374_CR1","doi-asserted-by":"publisher","first-page":"e0171317","DOI":"10.1371\/journal.pone.0171317","volume":"12","author":"PE Akpaka","year":"2017","unstructured":"Akpaka PE, Kissoon S, Wilson C, et al. Molecular characterization of vancomycin-resistant Enterococcus faecium isolates from Bermuda. PLoS ONE. 2017;12:e0171317.","journal-title":"PLoS ONE"},{"key":"374_CR2","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1089\/fpd.2018.2528","volume":"16","author":"TA Ball","year":"2019","unstructured":"Ball TA, Monte DF, Aidara-Kane A, et al. Phenotypic and genotypic characterization of Escherichia coli and Salmonella enterica from dairy cattle farms in the Wakiso District, Uganda: a cross-sectional study. Foodborne Pathog Dis. 2019;16:54\u20139.","journal-title":"Foodborne Pathog Dis."},{"key":"374_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1086\/668770","volume":"34","author":"DM Sievert","year":"2013","unstructured":"Sievert DM, Ricks P, Edwards JR, et al. Antimicrobial-resistant pathogens associated with healthcare-associated infections: summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2009-2010. Infect Control Hosp Epidemiol. 2013;34:1\u201314.","journal-title":"Infect Control Hosp Epidemiol"},{"key":"374_CR4","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1086\/591861","volume":"29","author":"AI Hidron","year":"2008","unstructured":"Hidron AI, Edwards JR, Patel J, et al. NHSN annual update: antimicrobial-resistant pathogens associated with healthcare-associated infections: annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006\u20132007. Infect Control Hosp Epidemiol. 2008;29:996\u20131011.","journal-title":"Infect Control Hosp Epidemiol"},{"key":"374_CR5","doi-asserted-by":"publisher","first-page":"189","DOI":"10.3412\/jsb.72.189","volume":"72","author":"Y Ike","year":"2017","unstructured":"Ike Y. Pathogenicity of enterococci. Nihon SaikingakuZasshi. 2017;72:189\u2013211.","journal-title":"Nihon SaikingakuZasshi"},{"key":"374_CR6","doi-asserted-by":"publisher","first-page":"e00512","DOI":"10.1128\/IAI.00512-19","volume":"87","author":"M Al-Zubidi","year":"2019","unstructured":"Al-Zubidi M, Widziolek M, Court EK, et al. Identification of novel bacteriophages with therapeutic potential that target Enterococcus faecalis. Infect Immun. 2019;87:e00512\u201319.","journal-title":"Infect Immun"},{"key":"374_CR7","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1002\/lt.24328","volume":"22","author":"M Niebel","year":"2016","unstructured":"Niebel M, Thamara PR, Perera M, Shah T, et al. Emergence of linezolid resistance in hepatobiliary infections caused by Enterococcus faecium. Liver Transplant. 2016;22:201\u20138.","journal-title":"Liver Transplant"},{"key":"374_CR8","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1093\/jac\/dkz097","volume":"74","author":"M Sassi","year":"2019","unstructured":"Sassi M, Gu\u00e9rin F, Zouari A, et al. Emergence of optrA-mediated linezolid resistance in enterococci from France, 2019. J Antimicrob Chemother. 2019;74:1469\u201372.","journal-title":"J Antimicrob Chemother"},{"key":"374_CR9","doi-asserted-by":"publisher","first-page":"49","DOI":"10.3390\/antibiotics7020049","volume":"7","author":"aB Suay-Garc\u00ed","year":"2018","unstructured":"Suay-Garc\u00eda B, P\u00e9rez-Gracia MT. Future prospects for Neisseria gonorrhoeaetreatment. Antibiotics. 2018;7:49.","journal-title":"Antibiotics."},{"key":"374_CR10","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1002\/psp4.12252","volume":"6","author":"SN Salerno","year":"2017","unstructured":"Salerno SN, Edginton A, Cohen-Wolkowiez M, et al. Development of an Adult physiologically based pharmacokinetic model ofsolithromycin in plasma and epithelial lining fluid. CPT Pharmacomet Syst Pharmacol. 2017;6:814\u201322.","journal-title":"CPT Pharmacomet Syst Pharmacol"},{"key":"374_CR11","doi-asserted-by":"publisher","first-page":"6462","DOI":"10.1021\/acs.jmedchem.9b01159","volume":"63","author":"P Fernandes","year":"2020","unstructured":"Fernandes P, Pereira D, Watkins PB, Bertrand D. Differentiating the pharmacodynamics and toxicology of macrolide and ketolide antibiotics. J Med Chem. 2020;63:6462\u201373.","journal-title":"J Med Chem"},{"key":"374_CR12","doi-asserted-by":"publisher","first-page":"e02606","DOI":"10.1128\/AAC.02606-18","volume":"63","author":"OO Okusanya","year":"2019","unstructured":"Okusanya OO, Forrest A, Bhavnani SM, et al. Pharmacokinetic\/pharmacodynamic evaluation of solithromycin against Streptococcus pneumoniae using data from a neutropenic murine lung infection model. Antimicrob Agents Chemother. 2019;63:e02606\u201318.","journal-title":"Antimicrob Agents Chemother"},{"key":"374_CR13","first-page":"e00692","volume":"62","author":"D Gonzalez","year":"2018","unstructured":"Gonzalez D, James LP, Al-Uzri A, et al. Population pharmacokinetics and safety of solithromycin following intravenous and oral administration in infants, children, and adolescents. Antimicrob Agents Chemother. 2018;62:e00692\u201318.","journal-title":"Antimicrob Agents Chemother"},{"key":"374_CR14","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1128\/AAC.01743-13","volume":"58","author":"JA Keelan","year":"2014","unstructured":"Keelan JA, Kemp MW, Payne MS, et al. Maternal administration of solithromycin, a new, potent, broad-spectrum fluoroketolide antibiotic, achieves fetal and intra-amniotic antimicrobial protection in a pregnant sheep model. Antimicrob Agents Chemother. 2014;58:447\u201354.","journal-title":"Antimicrob Agents Chemother"},{"key":"374_CR15","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1093\/jac\/dkw428","volume":"72","author":"B Darpo","year":"2017","unstructured":"Darpo B, Sager PT, Fernandes P, et al. Solithromycin, a novel macrolide, does not prolong cardiac repolarization: a randomized, three-way cross over study in healthy subjects. J Antimicrob Chemother. 2017;72:515\u201321.","journal-title":"J Antimicrob Chemother"},{"key":"374_CR16","doi-asserted-by":"publisher","first-page":"e1004168","DOI":"10.1371\/journal.ppat.1004168","volume":"10","author":"Y Li","year":"2014","unstructured":"Li Y, Petrova OE, Su S, et al. BdlA, DipA and induced dispersion contribute to acute virulence and chronic persistence of Pseudomonas aeruginosa. PLoS Pathog. 2014;10:e1004168.","journal-title":"PLoS Pathog"},{"key":"374_CR17","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1128\/CMR.00059-12","volume":"26","author":"A Beceiro","year":"2013","unstructured":"Beceiro A, Tom\u00e1s M, Bou G. Antimicrobial resistance and virulence: a successful or deleterious association in the bacterial world? Clin Microbiol Rev. 2013;26:185\u2013230.","journal-title":"Clin Microbiol Rev"},{"key":"374_CR18","doi-asserted-by":"publisher","first-page":"2815279","DOI":"10.1155\/2019\/2815279","volume":"2019","author":"M Golob","year":"2019","unstructured":"Golob M, Pate M, Ku\u0161ar D, et al. Antimicrobial resistance and virulence genes in Enterococcus faecium and Enterococcus faecalis from humans and retail red meat. Biomed Res Int. 2019;2019:2815279.","journal-title":"Biomed Res Int"},{"key":"374_CR19","doi-asserted-by":"publisher","first-page":"e03284","DOI":"10.1128\/mBio.03284-19","volume":"11","author":"S Arredondo-Alonso","year":"2020","unstructured":"Arredondo-Alonso S, Top J, McNally A, et al. Plasmids shaped the recent emergence of the major nosocomial pathogen Enterococcus faecium. mBio. 2020;11:e03284\u201319.","journal-title":"mBio."},{"key":"374_CR20","doi-asserted-by":"publisher","first-page":"3562","DOI":"10.3748\/wjg.v19.i23.3562","volume":"19","author":"E Goli\u0144ska","year":"2013","unstructured":"Goli\u0144ska E, Tomusiak A, Gosiewski T, et al. Virulence factors of Enterococcus strains isolated from patients with inflammatory bowel disease. World J Gastroenterol. 2013;19:3562\u201372.","journal-title":"World J Gastroenterol"},{"key":"374_CR21","first-page":"e01182","volume":"83","author":"K Lee","year":"2017","unstructured":"Lee K, Lee KM, Kim D, Yoon SS. Molecular determinants of the thickened matrix in a dual-species pseudomonas aeruginosa and Enterococcus faecalis biofilm. Appl Environ Microbiol. 2017;83:e01182\u201317.","journal-title":"Appl Environ Microbiol"},{"key":"374_CR22","doi-asserted-by":"publisher","first-page":"3521","DOI":"10.1007\/s00253-019-09618-0","volume":"103","author":"SAKS Ahmed","year":"2019","unstructured":"Ahmed SAKS, Rudden M, Smyth TJ, Dooley JSG, Marchant R, Banat IM. Natural quorum sensing inhibitors effectively downregulate gene expression of Pseudomonas aeruginosa virulence factors. Appl Microbiol Biotechnol. 2019;103:3521\u201335.","journal-title":"Appl Microbiol Biotechnol"},{"key":"374_CR23","doi-asserted-by":"publisher","first-page":"e02097","DOI":"10.1128\/AAC.00174-20","volume":"64","author":"Z Lin","year":"2020","unstructured":"Lin Z, Pu Z, Xu G, et al. Omadacycline efficacy against Enterococcus faecalis isolated in China: in vitro activity, Heteroresistance, and Resistance Mechanisms. Antimicrob Agents Chemother. 2020;64:e02097\u201319.","journal-title":"Antimicrob Agents Chemother"},{"key":"374_CR24","doi-asserted-by":"crossref","unstructured":"Bai B, Hu K, Li H, et al. Effect of tedizolid on clinical Enterococcus isolates: in vitro activity, distribution of virulence factor, resistance genes and multilocus sequence typing. FEMS Microbiol Lett. 2018;365.","DOI":"10.1093\/femsle\/fnx284"},{"key":"374_CR25","doi-asserted-by":"crossref","unstructured":"Yao W, Xu G, Bai B, et al. In vitro-induced erythromycin resistance facilitates cross-resistance to the novel fluoroketolide, solithromycin, in Staphylococcus aureus. FEMS Microbiol Lett. 2018;365.","DOI":"10.1093\/femsle\/fny116"},{"key":"374_CR26","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-019-3779-8","volume":"19","author":"W Yao","year":"2019","unstructured":"Yao W, Xu G, Li D, et al. Staphylococcus aureus with an erm-mediated constitutive macrolide-lincosamide-streptogramin B resistance phenotype has reduced susceptibility to the new ketolide, solithromycin. BMC Infect Dis. 2019;19:175.","journal-title":"BMC Infect Dis"},{"key":"374_CR27","doi-asserted-by":"publisher","first-page":"14","DOI":"10.14715\/cmb\/2019.65.2.3","volume":"65","author":"US Say Coskun","year":"2019","unstructured":"Say Coskun US. Investigation of the relationship between virulence factors and antibiotic resistance of Enterococci isolates. Cell Mol Biol (Noisy-le-Gd). 2019;65:14\u20137.","journal-title":"Cell Mol Biol (Noisy-le-Gd)"},{"key":"374_CR28","doi-asserted-by":"publisher","first-page":"2338","DOI":"10.3389\/fmicb.2017.02338","volume":"8","author":"JX Zheng","year":"2017","unstructured":"Zheng JX, Wu Y, Lin ZW, et al. Characteristics of and virulence factors associated with biofilm formation in clinical Enterococcus faecalis isolates in China. Front Microbiol. 2017;8:2338.","journal-title":"Front Microbiol"},{"key":"374_CR29","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1007\/s12275-019-8538-4","volume":"57","author":"S Jung","year":"2019","unstructured":"Jung S, Park OJ, Kim AR, et al. Lipoteichoic acids of lactobacilli inhibit Enterococcus faecalis biofilm formation and disrupt the preformed biofilm. J Microbiol. 2019;57:310\u20135.","journal-title":"J Microbiol"},{"key":"374_CR30","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1099\/jmm.0.001122","volume":"69","author":"JX Zheng","year":"2020","unstructured":"Zheng JX, Tu HP, Sun X, et al. In vitro activities of telithromycin against Staphylococcus aureus biofilms compared with azithromycin, clindamycin, vancomycin and daptomycin. J Med Microbiol. 2020;69:120\u201331.","journal-title":"J Med Microbiol"},{"key":"374_CR31","doi-asserted-by":"publisher","first-page":"2269","DOI":"10.1093\/jac\/dkz173","volume":"74","author":"MP Lorenzo","year":"2019","unstructured":"Lorenzo MP, Kidd JM, Jenkins SG, Nicolau DP, Housman ST. In vitro activity of ampicillin and ceftriaxone against ampicillin-susceptible Enterococcus faecium. J Antimicrob Chemother. 2019;74:2269\u201373.","journal-title":"J Antimicrob Chemother"},{"key":"374_CR32","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/j.oret.2017.11.013","volume":"2","author":"L Ya-Han","year":"2018","unstructured":"Ya-Han L, Yi-Hua C, Kuan-Jen C, et al. Infectious sources, prognostic factors, and visual outcomes of endogenous klebsiella pneumoniae endophthalmitis. Ophthalmol Retina. 2018;2:771\u20138.","journal-title":"Ophthalmol Retina."},{"key":"374_CR33","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.jiac.2018.09.003","volume":"25","author":"H Kato","year":"2019","unstructured":"Kato H, Yamagishi Y, Hagihara M, et al. Antimicrobial activity of solithromycin and levofloxacin against a murine pneumonia mixed-infection model caused by Streptococcus pneumoniae and anaerobic bacteria. J Infect Chemother. 2019;25:311\u20133.","journal-title":"J Infect Chemother"},{"key":"374_CR34","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1128\/AAC.02210-13","volume":"58","author":"G Piccinelli","year":"2014","unstructured":"Piccinelli G, Fernandes P, Bonfanti C, Caccuri F, Caruso A, De, Francesco MA. In vitro activity of solithromycin against erythromycin-resistant Streptococcus agalactiae. Antimicrob Agents Chemother. 2014;58:1693\u20138.","journal-title":"Antimicrob Agents Chemother"},{"key":"374_CR35","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1128\/AAC.01639-13","volume":"58","author":"J Mallegol","year":"2014","unstructured":"Mallegol J, Fernandes P, Melano RG, Guyard C. Antimicrobial activity of solithromycin against clinical isolates of Legionella pneumophila serogroup 1. Antimicrob Agents Chemother. 2014;58:909\u201315.","journal-title":"Antimicrob Agents Chemother"}],"container-title":["The Journal of Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41429-020-00374-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41429-020-00374-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41429-020-00374-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T03:24:03Z","timestamp":1634613843000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41429-020-00374-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,19]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["374"],"URL":"https:\/\/doi.org\/10.1038\/s41429-020-00374-2","relation":{},"ISSN":["0021-8820","1881-1469"],"issn-type":[{"value":"0021-8820","type":"print"},{"value":"1881-1469","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,19]]},"assertion":[{"value":"20 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 August 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 August 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 October 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the Ethics Committee of Shenzhen Nanshan people\u2019s Hospital, the 6th Affiliated Hospital of Shenzhen University Health Science Center. For this type of study, formal consent is not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}