{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:48:56Z","timestamp":1790779736351,"version":"4.1.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T00:00:00Z","timestamp":1610928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T00:00:00Z","timestamp":1610928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Antibiot"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1038\/s41429-020-00401-2","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T04:24:27Z","timestamp":1610943867000},"page":"324-329","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A small molecule interacts with pMAC-derived hydroperoxide reductase and enhances the activity of aminoglycosides"],"prefix":"10.1038","volume":"74","author":[{"given":"Zhen","family":"Hui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiqin","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxia","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyang","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shumin","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutian","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaisheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinsong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuemei","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyun","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8569-5184","authenticated-orcid":false,"given":"Wei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,18]]},"reference":[{"key":"401_CR1","unstructured":"US Department of Health and Human Services: Centers for Disease Control and Prevention. Antibiotic Resistant Threats In The United States. Centers for Disease Control and Prevention; 2019. https:\/\/www.cdc.gov\/drugresistance\/biggest-threats.html."},{"key":"401_CR2","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1056\/NEJMoa1306801","volume":"370","author":"SS Magill","year":"2014","unstructured":"Magill SS, et al. Multistate point-prevalence survey of health care-associated infections. N. Engl J Med. 2014;370:1198\u2013208.","journal-title":"N. Engl J Med."},{"key":"401_CR3","doi-asserted-by":"publisher","first-page":"2057","DOI":"10.1007\/s00134-015-4079-4","volume":"41","author":"J Garnacho-Montero","year":"2015","unstructured":"Garnacho-Montero J, et al. Task force on management and prevention of Acinetobacter baumannii infections in the ICU. Intensive Care Med. 2015;41:2057\u201375.","journal-title":"Intensive Care Med."},{"key":"401_CR4","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1517\/17425255.2011.623126","volume":"7","author":"H Giamarellou","year":"2011","unstructured":"Giamarellou H, Poulakou G. Pharmacokinetic and pharmacodynamic evaluation of tigecycline. Expert Opin Drug Metab Toxicol. 2011;7:1459\u201370.","journal-title":"Expert Opin Drug Metab Toxicol."},{"key":"401_CR5","doi-asserted-by":"publisher","DOI":"10.1038\/s41426-018-0038-9","volume":"7","author":"R Xie","year":"2018","unstructured":"Xie R, Zhang XD, Zhao Q, Peng B, Zheng J. Analysis of global prevalence of antibiotic resistance in Acinetobacter baumannii infections disclosed a faster increase in OECD countries. Emerg Microbes Infect. 2018;7:31.","journal-title":"Emerg Microbes Infect."},{"key":"401_CR6","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1093\/cid\/civ048","volume":"60","author":"ZA Qureshi","year":"2015","unstructured":"Qureshi ZA, et al. Colistin-resistant Acinetobacter baumannii: beyond carbapenem resistance. Clin Infect Dis. 2015;60:1295\u2013303.","journal-title":"Clin Infect Dis."},{"key":"401_CR7","doi-asserted-by":"publisher","first-page":"1724","DOI":"10.1086\/599225","volume":"48","author":"JD Hartzell","year":"2009","unstructured":"Hartzell JD, et al. Nephrotoxicity associated with intravenous colistin (colistimethate sodium) treatment at a tertiary care medical center. Clin Infect Dis. 2009;48:1724\u20138.","journal-title":"Clin Infect Dis."},{"key":"401_CR8","doi-asserted-by":"publisher","first-page":"2113","DOI":"10.1128\/AAC.02036-13","volume":"58","author":"KP Connors","year":"2014","unstructured":"Connors KP, et al. Phase I, open-label, safety and pharmacokinetic study to assess bronchopulmonary disposition of intravenous eravacycline in healthy men and women. Antimicrob Agents Chemother. 2014;58:2113\u20138.","journal-title":"Antimicrob Agents Chemother."},{"key":"401_CR9","doi-asserted-by":"publisher","first-page":"423","DOI":"10.21037\/atm.2018.10.29","volume":"6","author":"G Poulakou","year":"2018","unstructured":"Poulakou G, Lagou S, Karageorgopoulos DE, Dimopoulos G. New treatments of multidrug-resistant Gram-negative ventilator-associated pneumonia. Ann Transl Med. 2018;6:423.","journal-title":"Ann Transl Med."},{"key":"401_CR10","unstructured":"World Health Organization. Antibacterial agents in clinical development: an analysis of the antibacterial clinical development pipeline, including tuberculosis. World Health Organization; 2017. https:\/\/apps.who.int\/iris\/handle\/10665\/258965."},{"key":"401_CR11","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1089\/cmb.2012.0021","volume":"19","author":"A Bankevich","year":"2012","unstructured":"Bankevich A, et al. SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing. J Comput Biol. 2012;19:455\u201377.","journal-title":"J Comput Biol"},{"key":"401_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/jac\/dkg301","volume":"52","author":"FC Odds","year":"2003","unstructured":"Odds FC. Synergy, antagonism, and what the chequerboard puts between them. J Antimicrob Chemother. 2003;52:1.","journal-title":"J Antimicrob Chemother."},{"key":"401_CR13","doi-asserted-by":"publisher","first-page":"e0196918","DOI":"10.1371\/journal.pone.0196918","volume":"13","author":"E Piccirillo","year":"2018","unstructured":"Piccirillo E, et al. Structural insights on the efficient catalysis of hydroperoxide reduction by Ohr: Crystallographic and molecular dynamics approaches. PLoS One. 2018;13:e0196918.","journal-title":"PLoS One."},{"key":"401_CR14","doi-asserted-by":"publisher","first-page":"2636","DOI":"10.1128\/JB.180.10.2636-2643.1998","volume":"180","author":"S Mongkolsuk","year":"1998","unstructured":"Mongkolsuk S, Praituan W, Loprasert S, Fuangthong M, Chamnongpol S. Identification and characterization of a new organic hydroperoxide resistance (ohr) gene with a novel pattern of oxidative stress regulation from Xanthomonas campestris pv. phaseoli. J Bacteriol. 1998;180:2636\u201343.","journal-title":"J Bacteriol."},{"key":"401_CR15","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1099\/00221287-147-7-1775","volume":"147","author":"S Atichartpongkul","year":"2001","unstructured":"Atichartpongkul S, et al. Bacterial Ohr and OsmC paralogues define two protein families with distinct functions and patterns of expression. Microbiology. 2001;147:1775\u201382.","journal-title":"Microbiology."},{"key":"401_CR16","doi-asserted-by":"publisher","first-page":"E132","DOI":"10.1073\/pnas.1619659114","volume":"114","author":"TG Alegria","year":"2017","unstructured":"Alegria TG, et al. Ohr plays a central role in bacterial responses against fatty acid hydroperoxides and peroxynitrite. Proc Natl Acad Sci USA. 2017;114:E132\u201341.","journal-title":"Proc Natl Acad Sci USA."},{"key":"401_CR17","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.plasmid.2006.01.004","volume":"56","author":"CW Dorsey","year":"2006","unstructured":"Dorsey CW, Tomaras AP, Actis LA. Sequence and organization of pMAC, an Acinetobacter baumannii plasmid harboring genes involved in organic peroxide resistance. Plasmid. 2006;56:112\u201323.","journal-title":"Plasmid."},{"key":"401_CR18","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1111\/j.1365-2672.1990.tb01551.x","volume":"69","author":"PJ C\u00f3llier","year":"1990","unstructured":"C\u00f3llier PJ, et al. Chemical reactivity of some isothiazolone biocides. J Appl Bacteriol. 1990;69:578\u201384.","journal-title":"J Appl Bacteriol."},{"key":"401_CR19","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/0223-5234(94)90132-5","volume":"29","author":"ML Carmellino","year":"1994","unstructured":"Carmellino ML, Pagani G, Pregnolato M, Terreni M, Pastoni F. Antimicrobial activity of fluorinated 1,2-benzisothiazol-3(2H)-ones and 2,2\u2019-dithiobis(benzamides). Eur J Med Chem. 1994;29:743\u201351.","journal-title":"Eur J Med Chem."},{"key":"401_CR20","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1016\/j.tim.2016.06.009","volume":"24","author":"GD Wright","year":"2016","unstructured":"Wright GD. Antibiotic adjuvants: rescuing antibiotics from resistance. Trends Microbiol. 2016;24:862\u201371.","journal-title":"Trends Microbiol."},{"key":"401_CR21","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/j.cell.2007.06.049","volume":"130","author":"MA Kohanski","year":"2007","unstructured":"Kohanski MA, Dwyer DJ, Hayete B, Lawrence CA, Collins JJ. A common mechanism of cellular death induced by bactericidal antibiotics. Cell. 2007;130:797\u2013810.","journal-title":"Cell."},{"key":"401_CR22","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1089\/mdr.2018.0398","volume":"26","author":"L Lin","year":"2020","unstructured":"Lin L, Xiao X, Wang X, Xia M, Liu S. In vitro antimicrobial susceptibility differences between carbapenem-resistant KPC-2-producing and NDM-1-producing Klebsiella pneumoniae in a Teaching hospital in Northeast China. Micro Drug Resist. 2020;26:94\u201399.","journal-title":"Micro Drug Resist."}],"container-title":["The Journal of Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41429-020-00401-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41429-020-00401-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41429-020-00401-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T06:23:48Z","timestamp":1744179828000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41429-020-00401-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,18]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["401"],"URL":"https:\/\/doi.org\/10.1038\/s41429-020-00401-2","relation":{},"ISSN":["0021-8820","1881-1469"],"issn-type":[{"value":"0021-8820","type":"print"},{"value":"1881-1469","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,18]]},"assertion":[{"value":"24 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 December 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 January 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}