{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T23:36:02Z","timestamp":1777505762313,"version":"3.51.4"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T00:00:00Z","timestamp":1611619200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T00:00:00Z","timestamp":1611619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Antibiot"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1038\/s41429-021-00407-4","type":"journal-article","created":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T11:04:04Z","timestamp":1611659044000},"page":"330-336","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Study on the mechanisms of the cross-resistance to TET, PIP, and GEN in Staphylococcus aureus mediated by the Rhizoma Coptidis extracts"],"prefix":"10.1038","volume":"74","author":[{"given":"Sugui","family":"Lan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhirong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiqiu","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhong","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanke","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuemei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,1,26]]},"reference":[{"key":"407_CR1","first-page":"97","volume":"352","author":"PV Tishler","year":"2005","unstructured":"Tishler PV. Production of penicillin. N Engl J Med. 2005;352:97.","journal-title":"N Engl J Med"},{"key":"407_CR2","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1016\/S1473-3099(03)00833-8","volume":"3","author":"AD Russell","year":"2003","unstructured":"Russell AD. Biocide use and antibiotic resistance: the relevance of laboratory findings to clinical and environmental situations. Lancet Infect Dis. 2003;3:794\u2013803.","journal-title":"Lancet Infect Dis"},{"key":"407_CR3","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1111\/j.1365-2672.2004.02402.x","volume":"98","author":"L Thomas","year":"2005","unstructured":"Thomas L, Russell AD, Maillard J-Y. Antimicrobial activity of chlorhexidine diacetate and benzalkonium chloride against Pseudomonas aeruginosa and its response to biocide residues. J Appl Microbiol. 2005;98:533\u201343.","journal-title":"J Appl Microbiol"},{"key":"407_CR4","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/S0924-8579(03)00209-7","volume":"22","author":"P Fernandes","year":"2003","unstructured":"Fernandes P, Ferreira BS, Cabral JM. Solvent tolerance in bacteria: role of efflux pumps and cross-resistance with antibiotics. Int J Antimicrob Agents. 2003;22:211\u20136.","journal-title":"Int J Antimicrob Agents"},{"key":"407_CR5","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1111\/j.1365-2672.2004.02402.x","volume":"98","author":"L Thomas","year":"2005","unstructured":"Thomas L, Russell AD, Maillard J-Y. Antimicrobial activity of chlorhexidine diacetate and benzalkonium chloride against Pseudomonas aeruginosa and its response to biocide residues. J Appl Microbiol. 2005;98:533\u201343.","journal-title":"J Appl Microbiol"},{"key":"407_CR6","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/S0964-8305(03)00039-8","volume":"51","author":"S Langsrud","year":"2003","unstructured":"Langsrud S, Sidhu MS, Heir E, Askild LH. Bacterial disinfectant resistance a challenge for the food industry. Int Biodeterior Biodegrad. 2003;51:283\u201390.","journal-title":"Int Biodeterior Biodegrad"},{"key":"407_CR7","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1517\/14656566.2015.993381","volume":"16","author":"AK Thabit","year":"2015","unstructured":"Thabit AK, Crandon JL, Nicolau DP. Antimicrobial resistance: impact on clinical and economic outcomes and the need for new antimicrobials. Expert Opin Pharmacother. 2015;16:159\u201377.","journal-title":"Expert Opin Pharmacother"},{"key":"407_CR8","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-016-2082-1","volume":"16","author":"N Moremi","year":"2016","unstructured":"Moremi N, Claus H, Mshana SE. Antimicrobial resistance pattern: a report of microbiological cultures at a tertiary hospital in Tanzania. BMC Infect Dis. 2016;16:756.","journal-title":"BMC Infect Dis"},{"key":"407_CR9","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.diagmicrobio.2008.02.012","volume":"61","author":"RC Owens Jr","year":"2008","unstructured":"Owens RC Jr. Antimicrobial stewardship: concepts and strategies in the 21st century. Diagn Microbiol Infect Dis. 2008;61:110\u201328.","journal-title":"Diagn Microbiol Infect Dis"},{"key":"407_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1086\/668770","volume":"34","author":"DM Sievert","year":"2013","unstructured":"Sievert DM, Ricks P, Edwards JR, Schneider A, Patel J, Srinivasan A, et al. Antimicrobial-resistant pathogens associated with healthcare-associated infections: summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2009\u201310. Infect Control Hosp Epidemiol. 2013;34:1\u201314.","journal-title":"Infect Control Hosp Epidemiol"},{"key":"407_CR11","first-page":"89","volume":"31","author":"A Davin-Regli","year":"2012","unstructured":"Davin-Regli A, Pag\u00e8s JM. Cross-resistance between biocides and antimicrobials: an emerging question. Rev Sci Tech. 2012;31:89\u2013104.","journal-title":"Rev Sci Tech"},{"key":"407_CR12","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.fm.2015.04.010","volume":"51","author":"L Lavilla Lerma","year":"2015","unstructured":"Lavilla Lerma L, Benomar N, Casado Mu\u00f1oz Mdel C, G\u00e1lvez A, Abriouel H. Correlation between antibiotic and biocide resistance in mesophilic and psychrotrophic Pseudomonas spp. isolated from slaughterhouse surfaces throughout meat chain production. Food Microbiol. 2015;51:33\u201344.","journal-title":"Food Microbiol"},{"key":"407_CR13","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1093\/jac\/dkf071","volume":"50","author":"P Gilbert","year":"2002","unstructured":"Gilbert P, McBain AJ, Bloomfield SF. Biocide abuse and antimicrobial resistance: being clear about the issues. J Antimicrob Chemother. 2002;50:137\u20139.","journal-title":"J Antimicrob Chemother"},{"key":"407_CR14","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/S0163-4453(01)90853-9","volume":"43","author":"P Gilbert","year":"2001","unstructured":"Gilbert P, McBain AJ. Biocide usage in the domestic setting and concern about antibacterial and antibiotic resistance. J Infect. 2001;43:85\u201391.","journal-title":"J Infect"},{"key":"407_CR15","first-page":"1617","volume":"8","author":"D Lau","year":"2013","unstructured":"Lau D, Plotkin BJ. Antimicrobial and biofilm effects of herbs used in traditional Chinese medicine. Nat Prod Commun. 2013;8:1617\u201320.","journal-title":"Nat Prod Commun"},{"key":"407_CR16","doi-asserted-by":"publisher","first-page":"5258","DOI":"10.1016\/j.ejmech.2010.08.045","volume":"45","author":"BL Zhang","year":"2010","unstructured":"Zhang BL, Fan CQ, Dong L, Wang FD, Yue JM. Structural modification of a specific antimicrobial lead against Helicobacter pylori discovered from traditional Chinese medicine and a structure-activity relationship study. Eur J Med Chem. 2010;45:5258\u201364.","journal-title":"Eur J Med Chem"},{"key":"407_CR17","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.ijom.2010.02.024","volume":"39","author":"RWK Wong","year":"2010","unstructured":"Wong RWK, Hagg U, Samaranayake L, Yuen MKZ, Seneviratne CJ, Kao R. Antimicrobial activity of Chinese medicine herbs against common bacteria in oral biofilm. A pilot study. Int J Oral Maxillofac Surg. 2010;39:599\u2013605.","journal-title":"Int J Oral Maxillofac Surg"},{"key":"407_CR18","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1073\/pnas.030540597","volume":"97","author":"FR Stermitz","year":"2000","unstructured":"Stermitz FR, Lorenz P, Tawara JN, Zenewicz LA, Lewis K. Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 50-methoxyhydno-carpin, a multidrug pump inhibitor. Proc Natl Acad Sci U S A. 2000;97:1433\u20137.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"407_CR19","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1590\/S0074-02762006000400007","volume":"101","author":"JE Betoni","year":"2006","unstructured":"Betoni JE, Mantovani RP, Barbosa LN, Stasi LC, Junior AF. Synergism between plant extract and antimicrobial drugs used on Staphylococcus aureus diseases. Mem Inst Oswaldo Cruz. 2006;101:387\u201390.","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"407_CR20","first-page":"2886","volume":"6","author":"T Sibanda","year":"2007","unstructured":"Sibanda T, Okoh AI. The challenges of overcoming antibiotic resistance: plant extracts as potential sources of antimicrobial and resistance modifying agents. Afr J Biotechnol. 2007;6:2886\u201396.","journal-title":"Afr J Biotechnol"},{"key":"407_CR21","first-page":"1880","volume":"17","author":"UK Choi","year":"2007","unstructured":"Choi UK, Kim MH, Lee NH. Optimization of antibacterial activity by Gold-Thread (Coptidis Rhizoma Franch) against Streptococcus mutans using evolutionary operation-factorial design technique. J Microbiol Biotechnol. 2007;17:1880\u20134.","journal-title":"J Microbiol Biotechnol"},{"key":"407_CR22","first-page":"393","volume":"12","author":"JY Luo","year":"2014","unstructured":"Luo JY, Yan D, Yang MH. Study of the anti-MRSA activity of Rhizoma coptidis by chemical fingerprinting and broth microdilution methods. Chin J Nat Med. 2014;12:393\u2013400.","journal-title":"Chin J Nat Med"},{"key":"407_CR23","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1002\/jms.727","volume":"39","author":"DW Wang","year":"2004","unstructured":"Wang DW, Liu ZQ, Guo MQ, Liu SY. Structural elucidation and identification of alkaloids in Rhizoma coptidis by electrospray ionization tandem mass spectrometry. J Mass Spectrom. 2004;39:1356\u201365.","journal-title":"J Mass Spectrom"},{"key":"407_CR24","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1211\/0022357023024","volume":"56","author":"T Yokozawa","year":"2004","unstructured":"Yokozawa T, Ishida A, Kashiwada Y, Cho EJ, Kim HY, Ikeshiro Y. Coptidis rhizoma: protective effects against peroxynitrite-induced oxidative damage and elucidation of its active components. J Pharm Pharm. 2004;56:547\u201356.","journal-title":"J Pharm Pharm"},{"key":"407_CR25","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.bbrc.2006.11.043","volume":"352","author":"M Asai","year":"2007","unstructured":"Asai M, Iwata N, Yoshikawa A, Aizaki Y, Ishiura S, Saido TC, et al. Berberine alters the processing of Alzheimer\u2019s amyloid precursor protein to decrease Abeta secretion. Biochem Biophys Res Commun. 2007;352:498\u2013502.","journal-title":"Biochem Biophys Res Commun"},{"key":"407_CR26","doi-asserted-by":"publisher","first-page":"2768","DOI":"10.1016\/j.bmcl.2016.04.070","volume":"26","author":"SQ Wen","year":"2016","unstructured":"Wen SQ, Jeyakkumar P, Avula SR, Zhang L, Zhou CH. Discovery of novel berberine imidazoles as safe antimicrobial agents by down regulating ROS generation. Bioorg Med Chem Lett. 2016;26:2768\u201373.","journal-title":"Bioorg Med Chem Lett"},{"key":"407_CR27","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.jgar.2016.07.011","volume":"7","author":"DM Wu","year":"2016","unstructured":"Wu DM, Lu RC, Chen YQ, Qiu J, Deng CC, Tan Q. Study of cross-resistance mediated by antibiotics, chlorhexidine and Rhizoma coptidis in Staphylococcus aureus. J Glob Antimicrob Resist. 2016;7:61\u20136.","journal-title":"J Glob Antimicrob Resist"},{"key":"407_CR28","unstructured":"Chinese Pharmacopoeia Commission. Pharmacopoeia of the People\u2019s Republic of China (Part 2). Beijing, China: China Medical Science Press; 2010, p. 213\u20134."},{"key":"407_CR29","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1002\/(SICI)1099-1573(200005)14:3<210::AID-PTR591>3.0.CO;2-7","volume":"14","author":"T Blaszczyk","year":"2000","unstructured":"Blaszczyk T, Krzyzanowska J, Lamer-Zarawska E. Screening for antimycotic properties of 56 traditional Chinese drugs. Phytother Res. 2000;14:210\u20132.","journal-title":"Phytother Res"},{"key":"407_CR30","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.aca.2009.01.005","volume":"634","author":"WJ Kong","year":"2009","unstructured":"Kong WJ, Zhao YL, Xiao XH, Wang JB, Li HB, Li ZL, et al. Spectrum\u2013effect relationships between ultra-performance liquid chromatography fingerprints and antibacterial activities of Rhizoma coptidis. Anal Chim Acta. 2009;634:279\u201385.","journal-title":"Anal Chim Acta"},{"key":"407_CR31","unstructured":"European Committee on Antimicrobial Susceptibility Testing. Breakpoint tables for interpretation of MICs and zone diameters. Version 9.0, 2019. http:\/\/www.eucast.org."},{"key":"407_CR32","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/s12866-019-1446-2","volume":"19","author":"HRM Dos Santos","year":"2019","unstructured":"Dos Santos HRM, Argolo CS, Argolo-Filho RC, Loguercio LL. A 16S rDNA PCR-based theoretical to actual delta approach on culturable mock communities revealed severe losses of diversity information. BMC Microbiol. 2019;19:74.","journal-title":"BMC Microbiol"},{"key":"407_CR33","doi-asserted-by":"crossref","unstructured":"Kanehisa M. The KEGG database. Novartis Found Symp. 2002;247:91\u2013101.","DOI":"10.1002\/0470857897.ch8"},{"key":"407_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fmicb.2019.00001","volume":"10","author":"Y Qian","year":"2019","unstructured":"Qian Y, Linglin G, Teng X, Yun C, Xin Y, Mengmeng H, et al. Amoxicillin administration regimen and resistance mechanisms of staphylococcus aureus established in tissue cage infection model. Front Microbiol. 2019;10:1\u20139.","journal-title":"Front Microbiol"},{"key":"407_CR35","doi-asserted-by":"publisher","unstructured":"Grossman TH. Tetracycline antibiotics and resistance. Cold Spring Harb Perspect Med. 2016. https:\/\/doi.org\/10.1101\/cshperspect.a025387.","DOI":"10.1101\/cshperspect.a025387"},{"key":"407_CR36","doi-asserted-by":"publisher","first-page":"3370","DOI":"10.1016\/j.jmb.2019.06.033","volume":"431","author":"TA Wencewicz","year":"2019","unstructured":"Wencewicz TA. Crossroads of antibiotic resistance and biosynthesis. J Mol Biol. 2019;431:3370\u201399.","journal-title":"J Mol Biol"},{"key":"407_CR37","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1021\/acs.biochem.5b01269","volume":"55","author":"L Favrot","year":"2016","unstructured":"Favrot L, Blanchard JS, Vergnolle O. Bacterial GCN5-related N-acetyltransferases: from resistance to regulation. Biochemistry. 2016;55:989\u20131002.","journal-title":"Biochemistry"}],"container-title":["The Journal of Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41429-021-00407-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41429-021-00407-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41429-021-00407-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:34:32Z","timestamp":1684618472000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41429-021-00407-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,26]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["407"],"URL":"https:\/\/doi.org\/10.1038\/s41429-021-00407-4","relation":{},"ISSN":["0021-8820","1881-1469"],"issn-type":[{"value":"0021-8820","type":"print"},{"value":"1881-1469","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,26]]},"assertion":[{"value":"19 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 December 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 December 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 January 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}