{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T19:35:15Z","timestamp":1785267315056,"version":"3.55.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T00:00:00Z","timestamp":1638230400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T00:00:00Z","timestamp":1638230400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K14794"],"award-info":[{"award-number":["21K14794"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Antibiot"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1038\/s41429-021-00489-0","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T17:05:46Z","timestamp":1638291946000},"page":"86-91","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Rausuquinone, a non-glycosylated pluramycin-class antibiotic from Rhodococcus"],"prefix":"10.1038","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8726-0865","authenticated-orcid":false,"given":"Enjuro","family":"Harunari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maho","family":"Bando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5114-1389","authenticated-orcid":false,"given":"Yasuhiro","family":"Igarashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,30]]},"reference":[{"key":"489_CR1","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1021\/ar950167a","volume":"29","author":"MR Hansen","year":"1996","unstructured":"Hansen MR, Hurley LH. Pluramycins. Old drugs having modern friends in structural biology. Acc Chem Res. 1996;29:249\u201358.","journal-title":"Acc Chem Res"},{"key":"489_CR2","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.7164\/antibiotics.30.1143","volume":"30","author":"S Kondo","year":"1997","unstructured":"Kondo S, Miyamoto M, Naganawa H, Takeuchi T, Umezawa H. Structures of pluramycin A and neopluramycin. J Antibiot. 1997;30:1143\u20135.","journal-title":"J Antibiot"},{"key":"489_CR3","doi-asserted-by":"publisher","first-page":"485","DOI":"10.7164\/antibiotics.43.485","volume":"43","author":"T Yasuzawa","year":"1989","unstructured":"Yasuzawa T, Saitoh Y, Sano H. Structures of the novel anthraquinone antitumor antibiotics, DC-92B and DC92-D. J Antibiot. 1989;43:485\u201391.","journal-title":"J Antibiot"},{"key":"489_CR4","doi-asserted-by":"publisher","first-page":"718","DOI":"10.7164\/antibiotics.54.718","volume":"54","author":"L V\u00e9rtesy","year":"2001","unstructured":"V\u00e9rtesy L, Barbone FP, Cashmen E, Decker H, Ehrlich K, Jordan B, et al. Potent antitumor antibiotics from Saccharothrix sp. DSM12931. J Antibiot. 2001;54:718\u201329.","journal-title":"J Antibiot"},{"key":"489_CR5","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1071\/CH10068","volume":"63","author":"BT Murphy","year":"2010","unstructured":"Murphy BT, Narender T, Kauffman CA, Woolery M, Jensen PR, Fenical W. Saliniquinones A-F, new members of the highly cytotoxic anthraquinone- \u03b3-pyrones from the marine actinomycete salinispora arenicola. Aust J Chem. 2010;63:929\u201334.","journal-title":"Aust J Chem"},{"key":"489_CR6","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1128\/AEM.01891-06","volume":"73","author":"PR Jensen","year":"2007","unstructured":"Jensen PR, Williams PG, Oh DC, Zeigler L, Fenical W. Species-specific secondary metabolite production in marine actinomycetes of the genus Salinispora. Appl Environ Microbiol. 2007;73:1146\u201352.","journal-title":"Appl Environ Microbiol"},{"key":"489_CR7","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1039\/C4NP00167B","volume":"32","author":"PR Jensen","year":"2015","unstructured":"Jensen PR, Moore BS, Fenical W. The marine actinomycete genus Salinispora: A model organism for secondary metabolite discovery. Nat Prod Rep. 2015;32:738\u201351.","journal-title":"Nat Prod Rep"},{"key":"489_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-018-24921-y","volume":"8","author":"H Komaki","year":"2018","unstructured":"Komaki H, Sakurai K, Hosoyama A, Kimura A, Igarashi Y, Tamura T. Diversity of nonribosomal peptide synthetase and polyketide synthase gene clusters among taxonomically close Streptomyces strains. Sci Rep. 2018;8:1\u201311.","journal-title":"Sci Rep"},{"key":"489_CR9","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/s41429-019-0261-1","volume":"73","author":"H Komaki","year":"2020","unstructured":"Komaki H, Sakurai K, Hosoyama A, Kimura A, Trujilo ME, Igarashi Y, et al. Diversity of PKS and NRPS gene clusters between Streptomyces abyssomicinicus sp. nov. and its taxonomic neighbor. J Antibiot. 2020;73:141\u201351.","journal-title":"J Antibiot"},{"key":"489_CR10","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1038\/s41429-018-0139-7","volume":"72","author":"T Yang","year":"2019","unstructured":"Yang T, Yamada K, Zhou T, Harunari E, Igarashi Y, Terahara T, et al. Akazamicin, a cytotoxic aromatic polyketide from marine-derived Nonomuraea sp. J Antibiot. 2019;72:202\u20139.","journal-title":"J Antibiot"},{"key":"489_CR11","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.1021\/acs.orglett.1c00210","volume":"23","author":"MRU Karim","year":"2021","unstructured":"Karim MRU, In Y, Zhou T, Harunari E, Oku N, Igarashi Y. Nyuzenamides A and B: bicyclic peptides with antifungal and cytotoxic activity from a marine-derived Streptomyces sp. Org Lett. 2021;23:2109\u201313.","journal-title":"Org Lett"},{"key":"489_CR12","first-page":"6528","volume":"86","author":"Y Igarashi","year":"2021","unstructured":"Igarashi Y, Matsuyuki Y, Yamada M, Fujihara N, Harunari E, Oku N, et al. Structure determination, biosynthetic origin, and total synthesis of akazaoxime, an enteromycin-class metabolite from a marine-derived actinomycete of the genus Micromonospora 2021;86:6528\u201337.","journal-title":"Micromonospora"},{"key":"489_CR13","doi-asserted-by":"publisher","first-page":"780","DOI":"10.7164\/antibiotics.39.780","volume":"39","author":"J Itoh","year":"1986","unstructured":"Itoh J, Tsuyuki T, Fujita K, Sezaki M. Studies on a new antibiotic SF-2330 II. The structural elucidation. J Antibiot. 1986;39:780\u20133.","journal-title":"J Antibiot"},{"key":"489_CR14","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1021\/np50118a024","volume":"58","author":"RW Schumacher","year":"1985","unstructured":"Schumacher RW, Davidson BS, Montenegro DA, Bernan VS. \u03b3-Indomycinone, a new pluramycin metabolite from a deep-sea derived actinomycete. J Nat Prod. 1985;58:613\u20137.","journal-title":"J Nat Prod"},{"key":"489_CR15","doi-asserted-by":"publisher","first-page":"874","DOI":"10.7164\/antibiotics.50.874","volume":"50","author":"MAF Biabani","year":"1997","unstructured":"Biabani MAF, Laatsch H, Helmke E, Weyland H. \u03b4-Indomycinone: a new member of pluramycin class of antibiotics isolated from marine Streptomyces sp. J Antibiot. 1997;50:874\u20137.","journal-title":"J Antibiot"},{"key":"489_CR16","unstructured":"Matsumoto M, Nagaoka K, Ishizeki S, Yokoi K, Nakajima T. Manufacture of antibiotic ss43405e by Streptomyces. Jpn Kokai Tokkyo Koho. 1986;JP 6118928."},{"key":"489_CR17","unstructured":"Konishi M, Shimizu K, Ohbayashi M, Tomita K, Miyaki T, Oki T. BU-3839T antibiotic isolation and use as antibacterial agent and neoplasm inhibitor. 1990;U.S. patent 4927848."},{"key":"489_CR18","doi-asserted-by":"publisher","first-page":"824","DOI":"10.7164\/antibiotics.44.824","volume":"44","author":"M Hanada","year":"1991","unstructured":"Hanada M, kaneta K, Nishiyama Y, Hoshino Y, Konishi M, Oki T. Hydramycin, a new antitumor antibiotic. Taxonomy, isolation, physico-chemical properties, structure and biological activity. J Antibiot. 1991;44:824\u201331.","journal-title":"J Antibiot"},{"key":"489_CR19","doi-asserted-by":"publisher","first-page":"828","DOI":"10.7164\/antibiotics.50.828","volume":"50","author":"M Uyeda","year":"1997","unstructured":"Uyeda M, Yokomizo K, Ito A, Nakayama K, Watanabe H, Kido Y. A new antiherpetic agent, AH-1763 IIa, produced by Streptomyces cyaneus strain No. 1763. J Antibiot. 1997;50:828\u201332.","journal-title":"J Antibiot"},{"key":"489_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12864-017-3966-1","volume":"18","author":"A Ceniceros","year":"2017","unstructured":"Ceniceros A, Dijkhuizen L, Petrusma M, Medema MH. Genome-based exploration of the specialized metabolic capacities of the genus Rhodococcus. BMC Genomics. 2017;18:1\u201316.","journal-title":"BMC Genomics"},{"key":"489_CR21","doi-asserted-by":"publisher","first-page":"W81","DOI":"10.1093\/nar\/gkz310","volume":"47","author":"K Blin","year":"2019","unstructured":"Blin K, Shaw S, Steinke K, Villebro R, Ziemert N, Lee SY, et al. AntiSMASH 5.0: updates to the secondary metabolite genome mining pipeline. Nucleic Acids Res. 2019;47:W81\u20137.","journal-title":"Nucleic Acids Res"},{"key":"489_CR22","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1038\/ja.2010.79","volume":"63","author":"J Nachtigall","year":"2010","unstructured":"Nachtigall J, Schneider K, Nicholson G, Goodfellow M, Zinecker H, Imhoff JF, et al. Two new aurachins from Rhodococcus sp. Acta 2259. J Antibiot. 2010;63:567\u20139.","journal-title":"J Antibiot"},{"key":"489_CR23","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1021\/ja077821p","volume":"130","author":"K Kurosawa","year":"2008","unstructured":"Kurosawa K, Ghiviriga I, Sambandan TG, Lessard PA, Barbara JE, Rha C, et al. Rhodostreptomycins, antibiotics biosynthesized following horizontal gene transfer from Streptomyces padanus to Rhodococcus fascians. J Am Chem Soc. 2008;130:1126\u20137.","journal-title":"J Am Chem Soc"},{"key":"489_CR24","doi-asserted-by":"publisher","first-page":"297","DOI":"10.3762\/bjoc.16.29","volume":"16","author":"AR Sharma","year":"2020","unstructured":"Sharma AR, Harunari E, Oku N, Matsuura N, Trianto A, Igarashi Y. Two antibacterial and PPAR\u03b1\/\u03b3-agonistic unsaturated keto fatty acids from a coral-associated actinomycete of the genus Micrococcus. Beilstein J Org Chem. 2020;16:297\u2013304.","journal-title":"Beilstein J Org Chem"}],"container-title":["The Journal of Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41429-021-00489-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41429-021-00489-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41429-021-00489-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T11:04:01Z","timestamp":1643022241000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41429-021-00489-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,30]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["489"],"URL":"https:\/\/doi.org\/10.1038\/s41429-021-00489-0","relation":{},"ISSN":["0021-8820","1881-1469"],"issn-type":[{"value":"0021-8820","type":"print"},{"value":"1881-1469","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,30]]},"assertion":[{"value":"30 August 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 October 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 November 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}