{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T17:59:38Z","timestamp":1762711178483,"version":"3.37.3"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T00:00:00Z","timestamp":1727222400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T00:00:00Z","timestamp":1727222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Antibiot"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1038\/s41429-024-00775-7","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T15:02:16Z","timestamp":1727276536000},"page":"842-846","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Aldgamycins Q1 and Q2, two novel 16-membered macrolides from the rare actinomycete Saccharothrix sp. 16Sb2-4"],"prefix":"10.1038","volume":"77","author":[{"given":"Keke","family":"Luo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6813-8274","authenticated-orcid":false,"given":"Chenghang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaowei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,9,25]]},"reference":[{"key":"775_CR1","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.ijantimicag.2017.05.020","volume":"51","author":"B Arsic","year":"2018","unstructured":"Arsic B, et al. 16-membered macrolide antibiotics: a review. Int J Antimicrob Agents. 2018;51:283\u201398.","journal-title":"Int J Antimicrob Agents"},{"key":"775_CR2","doi-asserted-by":"publisher","first-page":"241","DOI":"10.3390\/md17040241","volume":"17","author":"TM Karpi\u0144ski","year":"2019","unstructured":"Karpi\u0144ski TM. Marine macrolides with antibacterial and\/or antifungal activity. Mar Drugs. 2019;17:241.","journal-title":"Mar Drugs"},{"key":"775_CR3","first-page":"87","volume":"10","author":"MP Kunstmann","year":"1964","unstructured":"Kunstmann MP, Mitscher LA, Patterson EL. Aldgamycin E, a new neutral macrolide antibiotic. Antimicrob Agents Chemother. 1964;10:87\u201390.","journal-title":"Antimicrob Agents Chemother"},{"key":"775_CR4","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1002\/cber.19751080311","volume":"108","author":"H Achenbach","year":"1975","unstructured":"Achenbach H, Karl W. Metabolites of microorganisms. VIII. Aldgamycin F, in a new antibiotic from Streptomyces lavendulae. Chem Ber 1975;108:780\u20139.","journal-title":"Chem Ber"},{"key":"775_CR5","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.7164\/antibiotics.39.1776","volume":"39","author":"S Mizobuchi","year":"1986","unstructured":"Mizobuchi S, Mochizuki J, Soga H, Tanba H, Inoue H. Aldgamycin G, a new macrolide antibiotic. J Antibiot. 1986;39:1776\u20138.","journal-title":"J Antibiot"},{"key":"775_CR6","unstructured":"Zitouni A, Sabaou N, Mathieu F, Lebrihi A. Novel saccharothrix strain and antibiotics derived therefrom, i.e. mutactimycins and aldgamycins. Patent US 20070202574A1. 2007."},{"key":"775_CR7","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1038\/ja.2009.6","volume":"62","author":"JS Park","year":"2009","unstructured":"Park JS, Yang HO, Kwon HC. Aldgamycin I, an antibacterial 16-membered macrolide from the abandoned mine bacterium, Streptomyces sp. KMA-001. J Antibiot. 2009;62:171\u20135.","journal-title":"J Antibiot"},{"key":"775_CR8","doi-asserted-by":"publisher","first-page":"2446","DOI":"10.1021\/acs.jnatprod.6b00200","volume":"79","author":"CX Wang","year":"2016","unstructured":"Wang CX, et al. Aldgamycins J\u2013O, 16-membered macrolides with a branched octose unit from Streptomycetes sp. and their antibacterial activities. J Nat Prod. 2016;79:2446\u201354.","journal-title":"J Nat Prod"},{"key":"775_CR9","doi-asserted-by":"publisher","first-page":"7979","DOI":"10.1002\/ange.202016477","volume":"133","author":"G Sp\u00e4th","year":"2021","unstructured":"Sp\u00e4th G, F\u00fcrstner A. Scalable de novo synthesis of aldgarose and total synthesis of aldgamycin N. Angew Chem Int Ed Engl. 2021;133:7979\u201384.","journal-title":"Angew Chem Int Ed Engl"},{"key":"775_CR10","doi-asserted-by":"publisher","first-page":"3002","DOI":"10.1002\/slct.201803591","volume":"4","author":"K Muralikrishna","year":"2019","unstructured":"Muralikrishna K, Satyanarayana V, Kumar GC, Yadav JS. Studies towards the synthesis of aldgamycin\u2013M. ChemistrySelect. 2019;4:3002\u20135.","journal-title":"ChemistrySelect"},{"key":"775_CR11","first-page":"1764","volume":"31","author":"L Wang","year":"2019","unstructured":"Wang L, et al. Marcolides from soil-derived Streptomyces sp. KIB-K1 and their antimicrobial activities. Nat Prod Res Dev. 2019;31:1764\u201371.","journal-title":"Nat Prod Res Dev"},{"key":"775_CR12","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.7164\/antibiotics.40.1368","volume":"40","author":"S Chatterjee","year":"1987","unstructured":"Chatterjee S, Reddy GCS, Franco CMM, Rupp RH, Ganguli BN. Swalpamycin, a new macrolide antibiotic II. Structure elucidation. J Antibiot. 1987;40:1368\u201374.","journal-title":"J Antibiot"},{"key":"775_CR13","doi-asserted-by":"publisher","first-page":"6060","DOI":"10.1016\/j.tet.2013.05.094","volume":"69","author":"X Wang","year":"2013","unstructured":"Wang X, Tabudravu J, Jaspars M, Deng H. Tianchimycins A\u2013B, 16-membered macrolides from the rare actinomycete Saccharothrix xinjiangensis. Tetrahedron. 2013;69:6060\u20134.","journal-title":"Tetrahedron"},{"key":"775_CR14","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.604999","volume":"12","author":"S Liu","year":"2021","unstructured":"Liu S, et al. Bioprospecting of soil-derived actinobacteria along the Alar-Hotan desert highway in the Taklamakan desert. Front Microbiol. 2021;12:604999.","journal-title":"Front Microbiol"},{"key":"775_CR15","doi-asserted-by":"publisher","first-page":"3857","DOI":"10.1016\/S0040-4020(96)00052-X","volume":"52","author":"PWK Woo","year":"1996","unstructured":"Woo PWK, Rubin JR. Chalcomycin: single-crystal X-ray crystallographic analysis; biosynthetic and stereochemical correlations with other polyoxo macrolide antibiotics. Tetrahedron. 1996;52:3857\u201372.","journal-title":"Tetrahedron"},{"key":"775_CR16","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1128\/jcm.29.6.1089-1094.1991","volume":"29","author":"A Espinel-Ingroff","year":"1991","unstructured":"Espinel-Ingroff A, Kerkering TM, Goldson PR, Shadomy S. Comparison study of broth macrodilution and microdilution antifungal susceptibility tests. J Clin Microbiol. 1991;29:1089\u201394.","journal-title":"J Clin Microbiol"},{"key":"775_CR17","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1002\/cbic.201700216","volume":"18","author":"P Dai","year":"2017","unstructured":"Dai P, et al. Characterization of methyltransferase AlmCII in chalcomycin biosynthesis: the first TylF family O\u2010methyltransferase works on a 4\u2032\u2010deoxysugar. Chembiochem. 2017;18:1510\u20137.","journal-title":"Chembiochem"},{"key":"775_CR18","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1021\/cb5009348","volume":"10","author":"SM Bernard","year":"2015","unstructured":"Bernard SM, et al. Structural basis of substrate specificity and regiochemistry in the MycF\/TylF family of sugar O-methyltransferases. ACS Chem Biol. 2015;10:1340\u201351.","journal-title":"ACS Chem Biol"}],"container-title":["The Journal of Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41429-024-00775-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41429-024-00775-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41429-024-00775-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:03:21Z","timestamp":1732665801000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41429-024-00775-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,25]]},"references-count":18,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["775"],"URL":"https:\/\/doi.org\/10.1038\/s41429-024-00775-7","relation":{},"ISSN":["0021-8820","1881-1469"],"issn-type":[{"type":"print","value":"0021-8820"},{"type":"electronic","value":"1881-1469"}],"subject":[],"published":{"date-parts":[[2024,9,25]]},"assertion":[{"value":"22 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 September 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 September 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}