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Addressing this challenge requires the development of novel antimicrobial agents. Previously, we identified a blue 1,4-benzoquinone isolated from the venom of the Mexican scorpion <jats:italic>Diplocentrus melici<\/jats:italic> as a potent antimicrobial compound effective against <jats:italic>Staphylococcus aureus<\/jats:italic> and <jats:italic>Mycobacterium tuberculosis<\/jats:italic>. Moreover, we devised a cost-effective synthetic route for its production. In this study, we demonstrate that the blue benzoquinone exhibits antibacterial activity against additional pathogens, including the priority pathogen <jats:italic>Acinetobacter baumannii<\/jats:italic>. Notably, the compound effectively killed clinical strains of <jats:italic>A. baumannii<\/jats:italic> resistant to multiple antibiotics, including carbapenem and colistin. Furthermore<jats:italic>, A. baumannii<\/jats:italic> did not develop resistance to the benzoquinone even after multiple growth cycles under sub-inhibitory concentrations, unlike the tested antibiotics. These findings underscore the potential of this blue benzoquinone as a lead compound for the development of a new class of antibiotics targeting multidrug-resistant bacteria.<\/jats:p>","DOI":"10.1038\/s41429-025-00809-8","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T12:28:46Z","timestamp":1739881726000},"page":"235-245","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Blue benzoquinone from scorpion venom shows bactericidal activity against drug-resistant strains of the priority pathogen Acinetobacter baumannii"],"prefix":"10.1038","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2366-0912","authenticated-orcid":false,"given":"Ramses","family":"Gallegos-Monterrosa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jimena I.","family":"Cid-Uribe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo","family":"Delgado-Prudencio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deyanira","family":"P\u00e9rez-Morales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda M.","family":"Banda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis","family":"T\u00e9llez-Galv\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edson N.","family":"Carcamo-Noriega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5013-3050","authenticated-orcid":false,"given":"Ulises","family":"Garza-Ramos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard N.","family":"Zare","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lourival D.","family":"Possani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8852-150X","authenticated-orcid":false,"given":"V\u00edctor H.","family":"Bustamante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,2,18]]},"reference":[{"key":"809_CR1","doi-asserted-by":"publisher","unstructured":"Murray CJ, Ikuta KS, Sharara F, Swetschinski L, Robles Aguilar G, Gray A et al. 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