{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:51:14Z","timestamp":1791582674173,"version":"4.3.4"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22H04922"],"award-info":[{"award-number":["22H04922"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23H04885"],"award-info":[{"award-number":["23H04885"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Antibiot"],"DOI":"10.1038\/s41429-026-00962-8","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T08:11:11Z","timestamp":1791533471000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Inhibition of vasculogenic mimicry by 22-benzyloxydaphlongaminone via glycolysis suppression"],"prefix":"10.1038","author":[{"given":"Yuma","family":"Tanaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akari","family":"Murase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4323-9527","authenticated-orcid":false,"given":"Makoto","family":"Muroi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sora","family":"Iwamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Kawahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaaki","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Osada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2949-2427","authenticated-orcid":false,"given":"Siro","family":"Simizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"962_CR1","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1055\/s-0033-1351024","volume":"79","author":"H Wu","year":"2013","unstructured":"Wu H, Zhang X, Ding L, Chen S, Yang J, Xu X. Daphniphyllum alkaloids: recent findings on chemistry and pharmacology. Planta Med. 2013;79:1589\u201398.","journal-title":"Planta Med"},{"key":"962_CR2","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1002\/hlca.200800358","volume":"92","author":"CS Li","year":"2009","unstructured":"Li CS, Di YT, Zhang Q, Zhang Y, Tan CJ, Hao XJ. Alkaloids from the leaves of Daphniphyllum longeracemosum ROSENTH. Helv Chim Acta. 2009;92:653\u20139.","journal-title":"Helv Chim Acta"},{"key":"962_CR3","doi-asserted-by":"publisher","first-page":"2623","DOI":"10.1002\/ange.201510861","volume":"128","author":"AK Chattopadhyay","year":"2016","unstructured":"Chattopadhyay AK, Ly VL, Jakkepally S, Berger G, Hanessian S. Total synthesis of isodaphlongamine H: a possible biogenetic conundrum. Angew Chem Int Ed. 2016;128:2623.","journal-title":"Angew Chem Int Ed"},{"key":"962_CR4","doi-asserted-by":"publisher","first-page":"8431","DOI":"10.1021\/jacs.9b03576","volume":"141","author":"CL Hugelshofer","year":"2019","unstructured":"Hugelshofer CL, Palani V, Sarpong R. Calyciphylline B-type alkaloids: total syntheses of (\u2013)-daphlongamine H and (\u2013)-isodaphlongamine H. J Am Chem Soc. 2019;141:8431\u20135.","journal-title":"J Am Chem Soc"},{"key":"962_CR5","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202508062","volume":"64","author":"S Iwamoto","year":"2025","unstructured":"Iwamoto S, Nakano R, Sasaki K, Kobayashi S, Taira Y, Takei K, et al. Total synthesis of isodaphlongamine H by iridium-catalyzed reductive [3 + 2] cycloaddition of N-hydroxylactam. Angew Chem Int Ed. 2025;64:e202508062.","journal-title":"Angew Chem Int Ed"},{"key":"962_CR6","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/S0002-9440(10)65173-5","volume":"155","author":"AJ Maniotis","year":"1999","unstructured":"Maniotis AJ, Folberg R, Hess A, Seftor EA, Gardner LM, Pe\u2019er J, et al. Vascular channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicry. Am J Pathol. 1999;155:739\u201352.","journal-title":"Am J Pathol"},{"key":"962_CR7","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s10456-016-9500-2","volume":"19","author":"JP Yang","year":"2016","unstructured":"Yang JP, Liao YD, Mai DM, Xie P, Qiang YY, Zheng LS, et al. Tumor vasculogenic mimicry predicts poor prognosis in cancer patients: a meta-analysis. Angiogenesis. 2016;19:191\u2013200.","journal-title":"Angiogenesis"},{"key":"962_CR8","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.cmet.2006.02.002","volume":"3","author":"JW Kim","year":"2006","unstructured":"Kim JW, Tchernyshyov I, Semenza GL, Dang CV. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab. 2006;3:177\u201385.","journal-title":"Cell Metab"},{"key":"962_CR9","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03682-z","volume":"12","author":"R Fu","year":"2021","unstructured":"Fu R, Du W, Ding Z, Wang Y, Li Y, Zhu J, et al. HIF-1\u03b1 promoted vasculogenic mimicry formation in lung adenocarcinoma through NRP1 upregulation in the hypoxic tumor microenvironment. Cell Death Dis. 2021;12:394.","journal-title":"Cell Death Dis"},{"key":"962_CR10","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-12-152","volume":"12","author":"S Ganapathy-Kanniappan","year":"2013","unstructured":"Ganapathy-Kanniappan S, Geschwind JF. Tumor glycolysis as a target for cancer therapy: Progress and Prospects. Mol Cancer. 2013;12:152.","journal-title":"Mol Cancer"},{"key":"962_CR11","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1126\/science.123.3191.309","volume":"123","author":"O Warburg","year":"1956","unstructured":"Warburg O. On the origin of cancer cells. Science. 1956;123:309\u201314.","journal-title":"Science"},{"key":"962_CR12","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1126\/science.124.3215.269","volume":"124","author":"SW House","year":"1956","unstructured":"House SW, Warburg O, Burk D, Schade AL. On respiratory impairment in cancer cells. Science. 1956;124:269\u201370.","journal-title":"Science"},{"key":"962_CR13","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.chembiol.2010.03.016","volume":"17","author":"M Muroi","year":"2010","unstructured":"Muroi M, Kazami S, Noda K, Kondo H, Takayama H, Kawatani M, et al. Application of proteomic profiling based on 2D-DIGE for classification of compounds according to the mechanism of action. Chem Biol. 2010;17:460\u201370.","journal-title":"Chem Biol"},{"key":"962_CR14","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.bbapap.2018.06.001","volume":"1867","author":"Y Futamura","year":"2019","unstructured":"Futamura Y, Muroi M, Aono H, Kawatani M, Hayashida M, Sekine T, et al. Bioenergetic and proteomic profiling to screen small molecule inhibitors that target cancer metabolisms. Biochim Biophys Acta. 2019;1867:28\u201337.","journal-title":"Biochim Biophys Acta"},{"key":"962_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2023.130397","volume":"1867","author":"YS Tamayo-Molina","year":"2023","unstructured":"Tamayo-Molina YS, Velilla PA, Hern\u00e1ndez-Sarmiento LJ, Urcuqui-Inchima S. Multitranscript analysis reveals an effect of 2-deoxy-D-glucose on gene expression linked to unfolded protein response and integrated stress response in primary human monocytes and monocyte-derived macrophages. Biochim Biophys Acta. 2023;1867:130397.","journal-title":"Biochim Biophys Acta"},{"key":"962_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellin.2024.100186","volume":"3","author":"Q Hu","year":"2024","unstructured":"Hu Q, Sun L, Cheng Z, Wang L, Wan X, Xu J, et al. Deacetylation of GLUD1 maintains the survival of lung adenocarcinoma cells under glucose starvation by inhibiting autophagic cell death. Cell Insight. 2024;3:100186.","journal-title":"Cell Insight"},{"key":"962_CR17","doi-asserted-by":"publisher","first-page":"8316","DOI":"10.3390\/ijms26178316","volume":"26","author":"I Zwolak","year":"2025","unstructured":"Zwolak I. Exogenous pyruvate in defense against human-exposure toxicants: a review of in vitro and in vivo evidence. Int J Mol Sci. 2025;26:8316.","journal-title":"Int J Mol Sci"},{"key":"962_CR18","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/s41388-021-02079-8","volume":"41","author":"X Jiang","year":"2022","unstructured":"Jiang X, Deng X, Wang J, Mo Y, Shi L, Wei F, et al. BPIFB1 inhibits vasculogenic mimicry via downregulation of GLUT1-mediated H3K27 acetylation in nasopharyngeal carcinoma. Oncogene. 2022;41:233\u201345.","journal-title":"Oncogene"},{"key":"962_CR19","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1111\/cas.15258","volume":"113","author":"R Kawahara","year":"2022","unstructured":"Kawahara R, Simizu S. ErbB4-mediated regulation of vasculogenic mimicry capability in breast cancer cells. Cancer Sci. 2022;113:950\u20139.","journal-title":"Cancer Sci"},{"key":"962_CR20","doi-asserted-by":"publisher","first-page":"169","DOI":"10.3892\/ol.2022.13289","volume":"23","author":"H Kamo","year":"2022","unstructured":"Kamo H, Kawahara R, Simizu S. Tyrosinase suppresses vasculogenic mimicry in human melanoma cells. Oncol Lett. 2022;23:169.","journal-title":"Oncol Lett"}],"container-title":["The Journal of Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41429-026-00962-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41429-026-00962-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41429-026-00962-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:03:17Z","timestamp":1791579797000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41429-026-00962-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,9]]},"references-count":20,"alternative-id":["962"],"URL":"https:\/\/doi.org\/10.1038\/s41429-026-00962-8","relation":{},"ISSN":["0021-8820","1881-1469"],"issn-type":[{"value":"0021-8820","type":"print"},{"value":"1881-1469","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,9]]},"assertion":[{"value":"10 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}}]}}