{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:20:38Z","timestamp":1792812038681,"version":"4.5.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:00:00Z","timestamp":1792713600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:00:00Z","timestamp":1792713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Ewha Womans University Research Grant of 2025","award":["-"],"award-info":[{"award-number":["-"]}],"id":[{"id":"https:\/\/ror.org\/053fp5c05","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2023-00301702"],"award-info":[{"award-number":["RS-2023-00301702"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2021-NR060138"],"award-info":[{"award-number":["RS-2021-NR060138"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Antibiot"],"DOI":"10.1038\/s41429-026-00967-3","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T10:46:20Z","timestamp":1792752380000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pobacilamides A and B, two linear depsipeptides from a marine-derived Bacillus sp. ROA-056"],"prefix":"10.1038","author":[{"given":"Eun-Young","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da-Ae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Young","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihye","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byeongchan","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man-Jeong","family":"Paik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9977-4596","authenticated-orcid":false,"given":"Hiyoung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8788-6056","authenticated-orcid":false,"given":"Songyi","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1517-7680","authenticated-orcid":false,"given":"Kyung-Min","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Jip","family":"Nam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,23]]},"reference":[{"key":"967_CR1","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.3389\/fmicb.2019.01404","volume":"10","author":"JV Pham","year":"2019","unstructured":"Pham JV, Yilma MA, Feliz A, Majid MT, Maffetone N, Walker JR, et al. A review of the microbial production of bioactive natural products and biologics. Front Microbiol. 2019;10:1404.","journal-title":"Front Microbiol"},{"key":"967_CR2","doi-asserted-by":"publisher","first-page":"2673","DOI":"10.3390\/md8102673","volume":"8","author":"I Bhatnagar","year":"2010","unstructured":"Bhatnagar I, Kim S-K. Immense essence of excellence: marine microbial bioactive compounds. Mar Drugs. 2010;8:2673\u2013701.","journal-title":"Mar Drugs"},{"key":"967_CR3","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/S1389-1723(00)80049-3","volume":"89","author":"M Shoda","year":"2000","unstructured":"Shoda M. Bacterial control of plant diseases. J Biosci Bioeng. 2000;89:515\u201321.","journal-title":"J Biosci Bioeng"},{"key":"967_CR4","doi-asserted-by":"publisher","first-page":"2846","DOI":"10.3390\/md11082846","volume":"11","author":"MAM Mondol","year":"2013","unstructured":"Mondol MAM, Shin HJ, Islam MT. Diversity of secondary metabolites from marine Bacillus species: chemistry and biological activity. Mar Drugs. 2013;11:2846\u201372.","journal-title":"Mar Drugs"},{"key":"967_CR5","doi-asserted-by":"publisher","first-page":"120","DOI":"10.3390\/md21020120","volume":"21","author":"M Zeng","year":"2023","unstructured":"Zeng M, Tao J, Xu S, Bai X, Zhang H. Marine organisms as a prolific source of bioactive depsipeptides. Mar Drugs. 2023;21:120.","journal-title":"Mar Drugs"},{"key":"967_CR6","doi-asserted-by":"publisher","first-page":"132","DOI":"10.3390\/md15050132","volume":"15","author":"Y Mi","year":"2017","unstructured":"Mi Y, Zhang J, He S, Yan X. New peptides isolated from marine cyanobacteria, an overview over the past decade. Mar Drugs. 2017;15:132.","journal-title":"Mar Drugs"},{"key":"967_CR7","doi-asserted-by":"crossref","unstructured":"Heath EI, Weise A, Vaishampayan U, Danforth D, Ungerleider RS, Urata Y. Phase Ia dose escalation study of OBP-801, a cyclic depsipeptide class I histone deacetylase inhibitor, in patients with advanced solid tumors. Invest New Drugs 2022;40:300\u2013307.","DOI":"10.1007\/s10637-021-01180-9"},{"key":"967_CR8","doi-asserted-by":"publisher","first-page":"72","DOI":"10.2174\/1389203717666160526122130","volume":"18","author":"M Rangel","year":"2017","unstructured":"Rangel M, Jos\u00e9 Correia de Santana C, Pinheiro A, Dos Anjos L, Barth T, Rodrigues Pires J\u00fanior O, et al. Marine depsipeptides as promising pharmacotherapeutic agents. Curr Protein Pept Sci. 2017;18:72\u201391.","journal-title":"Curr Protein Pept Sci"},{"key":"967_CR9","doi-asserted-by":"publisher","first-page":"2969","DOI":"10.1021\/acs.jnatprod.7b00551","volume":"80","author":"FH Al-Awadhi","year":"2017","unstructured":"Al-Awadhi FH, Law BK, Paul VJ, Luesch H. Grassystatins D\u2013F, potent aspartic protease inhibitors from marine Cyanobacteria as potential antimetastatic agents targeting invasive breast cancer. J Nat Products. 2017;80:2969\u201386.","journal-title":"J Nat Products"},{"key":"967_CR10","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1021\/np5007907","volume":"78","author":"OB Vining","year":"2015","unstructured":"Vining OB, Medina RA, Mitchell EA, Videau P, Li D, Serrill JD, et al. Depsipeptide companeramides from a panamanian marine cyanobacterium associated with the coibamide producer. J Nat Products. 2015;78:413\u201320.","journal-title":"J Nat Products"},{"key":"967_CR11","doi-asserted-by":"publisher","first-page":"7219","DOI":"10.1021\/jo00103a011","volume":"59","author":"K Stratmann","year":"1994","unstructured":"Stratmann K, Burgoyne DL, Moore RE, Patterson GM, Smith CD. Hapalosin, a cyanobacterial cyclic depsipeptide with multidrug-resistance reversing activity. J Org Chem. 1994;59:7219\u201326.","journal-title":"J Org Chem"},{"key":"967_CR12","doi-asserted-by":"publisher","first-page":"4213","DOI":"10.1016\/j.tetlet.2016.08.012","volume":"57","author":"Y Kanamori","year":"2016","unstructured":"Kanamori Y, Iwasaki A, Sumimoto S, Suenaga K. Urumamide, a novel chymotrypsin inhibitor with a \u03b2-amino acid from a marine cyanobacterium Okeania sp. Tetrahedron Lett. 2016;57:4213\u20136.","journal-title":"Tetrahedron Lett"},{"key":"967_CR13","doi-asserted-by":"publisher","first-page":"6202","DOI":"10.1021\/ja954287p","volume":"118","author":"A Zampella","year":"1996","unstructured":"Zampella A, D\u2019Auria MV, Paloma LG, Casapullo A, Minale L, Debitus C, et al. Callipeltin A, an anti-HIV cyclic depsipeptide from the New Caledonian Lithistida sponge Callipelta sp. J Am Chem Soc. 1996;118:6202\u20139.","journal-title":"J Am Chem Soc"},{"key":"967_CR14","doi-asserted-by":"publisher","first-page":"6929","DOI":"10.1016\/j.tet.2016.09.016","volume":"72","author":"M Stierhof","year":"2016","unstructured":"Stierhof M, Hansen K\u00d8, Sharma M, Feussner K, Subko K, D\u00edaz-Rullo FF, et al. New cytotoxic callipeltins from the Solomon Island marine sponge Asteropus sp. Tetrahedron. 2016;72:6929\u201334.","journal-title":"Tetrahedron"},{"key":"967_CR15","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1021\/np070094r","volume":"71","author":"Y Feng","year":"2008","unstructured":"Feng Y, Carroll AR, Pass DM, Archbold JK, Avery VM, Quinn RJ. Polydiscamides B\u2212 D from a marine sponge Ircinia sp. as potent human sensory neuron-specific G protein coupled receptor agonists. J Nat Products. 2008;71:8\u201311.","journal-title":"J Nat Products"},{"key":"967_CR16","doi-asserted-by":"publisher","first-page":"4215","DOI":"10.1016\/j.tetlet.2015.05.058","volume":"56","author":"HJ Shin","year":"2015","unstructured":"Shin HJ, Rashid MA, Cartner LK, Bokesch HR, Wilson JA, McMahon JB, et al. Stellettapeptins A and B, HIV-inhibitory cyclic depsipeptides from the marine sponge Stelletta sp. Tetrahedron Lett. 2015;56:4215\u20139.","journal-title":"Tetrahedron Lett"},{"key":"967_CR17","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1021\/np060229d","volume":"69","author":"AS Ratnayake","year":"2006","unstructured":"Ratnayake AS, Bugni TS, Feng X, Harper MK, Skalicky JJ, Mohammed KA, et al. Theopapuamide, a cyclic depsipeptide from a Papua New Guinea lithistid sponge Theonella swinhoei. J Nat Products. 2006;69:1582\u20136.","journal-title":"J Nat Products"},{"key":"967_CR18","doi-asserted-by":"publisher","first-page":"8509","DOI":"10.1016\/j.tet.2004.06.125","volume":"60","author":"K Suenaga","year":"2004","unstructured":"Suenaga K, Mutou T, Shibata T, Itoh T, Fujita T, Takada N, et al. Aurilide, a cytotoxic depsipeptide from the sea hare Dolabella auricularia: Isolation, structure determination, synthesis, and biological activity. Tetrahedron. 2004;60:8509\u201327.","journal-title":"Tetrahedron"},{"key":"967_CR19","doi-asserted-by":"publisher","first-page":"8449","DOI":"10.1016\/S0040-4039(00)61356-4","volume":"34","author":"H Sone","year":"1993","unstructured":"Sone H, Nemoto T, Ishiwata H, Ojika M, Yamada K. Isolation, structure, and synthesis of dolastatin D, a cytotoxic cyclic depsipeptide from the sea gare Dolabella auricularia. Tetrahedron Lett. 1993;34:8449\u201352.","journal-title":"Tetrahedron Lett"},{"key":"967_CR20","doi-asserted-by":"publisher","first-page":"6340","DOI":"10.1021\/jo9608228","volume":"61","author":"T Mutou","year":"1996","unstructured":"Mutou T, Kondo T, Ojika M, Yamada K. Isolation and stereostructures of dolastatin G and nordolastatin G, cytotoxic 35-membered cyclodepsipeptides from the Japanese sea hare Dolabella auricularia. J Org Chem. 1996;61:6340\u20135.","journal-title":"J Org Chem"},{"key":"967_CR21","doi-asserted-by":"publisher","first-page":"2989","DOI":"10.1021\/jo00297a001","volume":"55","author":"GR Pettit","year":"1990","unstructured":"Pettit GR, Kamano Y, Herald CL, Dufresne C, Bates RB, Schmidt JM, et al. Antineoplastic agents. 190. Isolation and structure of the cyclodepsipeptide dolastatin 14. J Org Chem. 1990;55:2989\u201390.","journal-title":"J Org Chem"},{"key":"967_CR22","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1021\/np0002379","volume":"64","author":"MA Rashid","year":"2001","unstructured":"Rashid MA, Gustafson KR, Cartner LK, Shigematsu N, Pannell LK, Boyd MR. Microspinosamide, a new HIV-inhibitory cyclic depsipeptide from the marine sponge sidonops m icrospinosa. J Nat Products. 2001;64:117\u201321.","journal-title":"J Nat Products"},{"key":"967_CR23","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/ja.2008.103","volume":"61","author":"N Oku","year":"2008","unstructured":"Oku N, Kawabata K, Adachi K, Katsuta A, Shizuri Y. Unnarmicins A and C, new antibacterial depsipeptides produced by marine bacterium Photobacterium sp. MBIC06485. J Antib. 2008;61:11\u201317.","journal-title":"J Antib"},{"key":"967_CR24","doi-asserted-by":"publisher","first-page":"5732","DOI":"10.1021\/jm9009394","volume":"52","author":"JC Kwan","year":"2009","unstructured":"Kwan JC, Eksioglu EA, Liu C, Paul VJ, Luesch H. Grassystatins A\u2212 C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. J Med Chem. 2009;52:5732\u201347.","journal-title":"J Med Chem"},{"key":"967_CR25","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1021\/np8003529","volume":"72","author":"RG Linington","year":"2009","unstructured":"Linington RG, Clark BR, Trimble EE, Almanza A, Ure\u00f1a L-D, Kyle DE, et al. Antimalarial peptides from marine cyanobacteria: isolation and structural elucidation of gallinamide A. J Nat Products. 2009;72:14\u20137.","journal-title":"J Nat Products"},{"key":"967_CR26","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1021\/np800110e","volume":"71","author":"TL Simmons","year":"2008","unstructured":"Simmons TL, Engene N, Ure\u00f1a LD, Romero LI, Ortega-Barr\u00eda E, Gerwick L, et al. Viridamides A and B, lipodepsipeptides with antiprotozoal activity from the marine cyanobacterium Oscillatoria nigro-viridis. J Nat Products. 2008;71:1544\u201350.","journal-title":"J Nat Products"},{"key":"967_CR27","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/s00726-004-0118-0","volume":"27","author":"R Bhushan","year":"2004","unstructured":"Bhushan R, Br\u00fcckner H. Marfey\u2019s reagent for chiral amino acid analysis: a review. Amino Acids. 2004;27:231\u201347.","journal-title":"Amino Acids"},{"key":"967_CR28","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/S0021-9673(00)00072-8","volume":"874","author":"K-R Kim","year":"2000","unstructured":"Kim K-R, Lee J, Ha D, Jeon J, Park H-G, Kim JH. Enantiomeric separation and discrimination of 2-hydroxy acids as O-trifluoroacetylated (S)-(+)-3-methyl-2-butyl esters by achiral dual-capillary column gas chromatography. J Chromatogr A. 2000;874:91\u2013100.","journal-title":"J Chromatogr A"},{"key":"967_CR29","doi-asserted-by":"publisher","first-page":"2316","DOI":"10.1002\/pro.3979","volume":"29","author":"DA Alonzo","year":"2020","unstructured":"Alonzo DA, Schmeing TM. Biosynthesis of depsipeptides, or Depsi: The peptides with varied generations. Protein Sci. 2020;29:2316\u201347.","journal-title":"Protein Sci"},{"key":"967_CR30","doi-asserted-by":"publisher","first-page":"780","DOI":"10.3390\/microorganisms9040780","volume":"9","author":"S Huang","year":"2021","unstructured":"Huang S, Liu Y, Liu W-Q, Neubauer P, Li J. The nonribosomal peptide valinomycin: From discovery to bioactivity and biosynthesis. Microorganisms. 2021;9:780.","journal-title":"Microorganisms"},{"key":"967_CR31","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/BF01573860","volume":"5","author":"RE Schwartz","year":"1990","unstructured":"Schwartz RE, Hirsch CF, Sesin DF, Flor JE, Chartrain M, Fromtling RE, et al. Pharmaceuticals from cultured algae. J Ind Microbiol Biotechnol. 1990;5:113\u201323.","journal-title":"J Ind Microbiol Biotechnol"},{"key":"967_CR32","first-page":"17","volume":"129","author":"N Agata","year":"1995","unstructured":"Agata N, Ohta M, Mori M, Isobe M. A novel dodecadepsipeptide, cereulide, is an emetic toxin of Bacillus cereus. FEMS Microbiol Lett. 1995;129:17\u20139.","journal-title":"FEMS Microbiol Lett"},{"key":"967_CR33","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1126\/science.282.5386.63","volume":"282","author":"DE Cane","year":"1998","unstructured":"Cane DE, Walsh CT, Khosla C. Harnessing the biosynthetic code: combinations, permutations, and mutations. Science. 1998;282:63\u20138.","journal-title":"Science"},{"key":"967_CR34","doi-asserted-by":"publisher","first-page":"3468","DOI":"10.1021\/cr0503097","volume":"106","author":"MA Fischbach","year":"2006","unstructured":"Fischbach MA, Walsh CT. Assembly-line enzymology for polyketide and nonribosomal peptide antibiotics: logic, machinery, and mechanisms. Chem Rev. 2006;106:3468\u201396.","journal-title":"Chem Rev"},{"key":"967_CR35","doi-asserted-by":"publisher","first-page":"6707","DOI":"10.1016\/j.tet.2011.04.051","volume":"67","author":"S-J Nam","year":"2011","unstructured":"Nam S-J, Kauffman CA, Jensen PR, Fenical W. Isolation and characterization of actinoramides A\u2013C, highly modified peptides from a marine Streptomyces sp. Tetrahedron. 2011;67:6707\u201312.","journal-title":"Tetrahedron"},{"key":"967_CR36","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/S0021-9673(00)96823-7","volume":"195","author":"WA K\u00f6nig","year":"1980","unstructured":"K\u00f6nig WA, Benecke I. Gas chromatographic separation of chiral 2-hydroxy acids and 2-alkyl-substituted carboxylic acids. J Chromatogr A. 1980;195:292\u20136.","journal-title":"J Chromatogr A"},{"key":"967_CR37","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1002\/bmc.2703","volume":"26","author":"DT Nguyen","year":"2012","unstructured":"Nguyen DT, Kim KR, Lee G, Paik MJ. Chiral separation of N-methyl-dl-aspartic acid in rat brain tissue as N-ethoxycarbonylated (S)-(+)-2-octyl ester derivatives by GC-MS. Biomed Chromatogr. 2012;26:1353\u20136.","journal-title":"Biomed Chromatogr"}],"container-title":["The Journal of Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41429-026-00967-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41429-026-00967-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41429-026-00967-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:03:40Z","timestamp":1792796620000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41429-026-00967-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,23]]},"references-count":37,"alternative-id":["967"],"URL":"https:\/\/doi.org\/10.1038\/s41429-026-00967-3","relation":{},"ISSN":["0021-8820","1881-1469"],"issn-type":[{"value":"0021-8820","type":"print"},{"value":"1881-1469","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,23]]},"assertion":[{"value":"18 August 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 September 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 October 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}}]}}