{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T03:04:09Z","timestamp":1782529449255,"version":"3.54.5"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T00:00:00Z","timestamp":1597795200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T00:00:00Z","timestamp":1597795200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Nutr"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1038\/s41430-020-00705-4","type":"journal-article","created":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T16:04:42Z","timestamp":1597853082000},"page":"364-372","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Contribution of iron status at birth to infant iron status at 9 months: data from a prospective maternal-infant birth cohort in China"],"prefix":"10.1038","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5873-7230","authenticated-orcid":false,"given":"Jie","family":"Shao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blair","family":"Richards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niko","family":"Kaciroti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingquan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7024-0948","authenticated-orcid":false,"given":"Katy M.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betsy","family":"Lozoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,19]]},"reference":[{"key":"705_CR1","doi-asserted-by":"publisher","first-page":"S43","DOI":"10.1111\/j.1753-4887.2011.00432.x","volume":"69","author":"MK Georgieff","year":"2011","unstructured":"Georgieff MK. Long-term brain and behavioral consequences of early iron deficiency. Nutr Rev. 2011;69:S43\u20138.","journal-title":"Nutr Rev"},{"key":"705_CR2","unstructured":"World Health Organization. Guideline: Daily iron supplementation in infants and children. World Health Organization. 2016. Geneva."},{"key":"705_CR3","doi-asserted-by":"publisher","first-page":"e16","DOI":"10.1016\/S2214-109X(13)70001-9","volume":"1","author":"GA Stevens","year":"2013","unstructured":"Stevens GA, Finucane MM, De-Regil LM, Paciorek CJ, Flaxman SR, Branca F, et al. Global, regional, and national trends in haemoglobin concentration and prevalence of total and severe anaemia in children and pregnant and non-pregnant women for 1995\u20132011: a systematic analysis of population-representative data. Lancet Glob Health. 2013;1:e16\u201325.","journal-title":"Lancet Glob Health"},{"key":"705_CR4","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1177\/0379572115616001","volume":"36","author":"J Huo","year":"2015","unstructured":"Huo J, Sun J, Fang Z, Chang S, Zhao L, Fu P, et al. Effect of home-based complementary food fortification on prevalence of anemia among infants and young children aged 6 to 23 months in poor rural regions of China. Food Nutr Bull. 2015;36:405\u201314.","journal-title":"Food Nutr Bull"},{"key":"705_CR5","doi-asserted-by":"publisher","unstructured":"Gupta PM, Hamner HC, Suchdev PS, Flores-Ayala R, Mei Z. Iron status of toddlers, nonpregnant females, and pregnant females in the United States. Am J Clin Nutr. 2017;106(Suppl 6):1640S\u20136S. https:\/\/doi.org\/10.3945\/ajcn.117.155978.","DOI":"10.3945\/ajcn.117.155978."},{"key":"705_CR6","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1001\/archpedi.162.4.374","volume":"162","author":"JM Brotanek","year":"2008","unstructured":"Brotanek JM, Gosz J, Weitzman M, Flores G. Secular trends in the prevalence of iron deficiency among US toddlers, 1976-2002. Arch Pediatr Adolesc Med. 2008;162:374\u201381.","journal-title":"Arch Pediatr Adolesc Med"},{"key":"705_CR7","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1542\/peds.2010-2576","volume":"126","author":"RD Baker","year":"2010","unstructured":"Baker RD, Greer FR. Committee on nutrition. diagnosis and prevention of iron deficiency and iron-deficiency anemia in infants and young children (0\u20133 years of age). Pediatrics. 2010;126:1040\u201350.","journal-title":"Pediatrics."},{"key":"705_CR8","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1542\/peds.2014-3979","volume":"135","author":"MS McDonagh","year":"2015","unstructured":"McDonagh MS, Blazina I, Dana T, Cantor A, Bougatsos C. Screening and routine supplementation for iron deficiency anemia: a systematic review. Pediatrics. 2015;135:723\u201333.","journal-title":"Pediatrics."},{"key":"705_CR9","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1093\/ajcn\/84.6.1412","volume":"84","author":"B Lozoff","year":"2006","unstructured":"Lozoff B, Walter T, Kaciroti N. Iron deficiency in infancy: applying a physiologic framework for prediction. Am J Clin Nutr. 2006;84:1412\u201321.","journal-title":"Am J Clin Nutr"},{"key":"705_CR10","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1067\/mpd.2002.127090","volume":"141","author":"MK Georgieff","year":"2002","unstructured":"Georgieff MK, Wewerka SW, Nelson CA, deRegnier RA. Iron status at 9 months of infants with low iron stores at birth. J Pediatr. 2002;141:405\u20139.","journal-title":"J Pediatr"},{"key":"705_CR11","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1172\/JCI100507","volume":"12","author":"MB Strauss","year":"1933","unstructured":"Strauss MB. Anemia of infancy from maternal iron deficiency in pregnancy. J Clin Invest. 1933;12:345\u201353.","journal-title":"J Clin Invest"},{"key":"705_CR12","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1093\/jn\/132.8.2215","volume":"132","author":"S de Pee","year":"2002","unstructured":"de Pee S, Bloem MW, Sari M, Kiess L, Yip R. The high prevalence of low hemoglobin concentration among Indonesian infants aged 3-5 months is related to maternal anemia. J Nutr. 2002;132:2215\u201321.","journal-title":"J Nutr"},{"key":"705_CR13","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1111\/j.1365-3016.1990.tb00638.x","volume":"4","author":"J Colomer","year":"1990","unstructured":"Colomer J, Colomer C, Gutierrez D, Jubert A, Nolasco A, Donat J, et al. Anaemia during pregnancy as a risk factor for infant iron deficiency: report from the Valencia Infant Anaemia Cohort (VIAC) study. Paediatr Perinat Epidemiol. 1990;4:196\u2013204.","journal-title":"Paediatr Perinat Epidemiol"},{"key":"705_CR14","doi-asserted-by":"publisher","first-page":"3461","DOI":"10.1093\/jn\/133.11.3461","volume":"133","author":"MF Miller","year":"2003","unstructured":"Miller MF, Stoltzfus RJ, Mbuya NV, Malaba LC, Iliff PJ, Humphrey JH, et al. Total body iron in HIV-positive and HIV-negative Zimbabwean newborns strongly predicts anemia throughout infancy and is predicted by maternal hemoglobin concentration. J Nutr. 2003;133:3461\u20138.","journal-title":"J Nutr"},{"key":"705_CR15","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1093\/ajcn\/86.1.64","volume":"86","author":"G Hay","year":"2007","unstructured":"Hay G, Refsum H, Whitelaw A, Melbye EL, Haug E, Borch-Iohnsen B. Predictors of serum ferritin and serum soluble transferrin receptor in newborns and their associations with iron status during the first 2 y of life. Am J Clin Nutr. 2007;86:64\u201373.","journal-title":"Am J Clin Nutr"},{"key":"705_CR16","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.jpeds.2016.10.041","volume":"181","author":"KM Clark","year":"2017","unstructured":"Clark KM, Li M, Shao J, Liang F, Zhang Y, Chai J, et al. Breastfeeding, mixed or formula feeding at 9 months and the prevalence of iron deficiency and iron deficiency anemia in two cohorts of infants in China. J Pediatr. 2017;181:56\u201361.","journal-title":"J Pediatr"},{"key":"705_CR17","doi-asserted-by":"publisher","first-page":"139","DOI":"10.3390\/nu12010139","volume":"12","author":"CM Chen","year":"2020","unstructured":"Chen CM, Mu SC, Shih CK, Chen YL, Tsai LY, Kuo YT, et al. Iron status of infants in the first year of life in Northern Taiwan. Nutrient. 2020;12:139\u201351. https:\/\/doi.org\/10.3390\/nu12010139","journal-title":"Nutrient"},{"key":"705_CR18","doi-asserted-by":"crossref","unstructured":"Armony-Sivan R, Zhu B, Clark KM, Ji C, Kaciroti N, Shao J et al. Iron deficiency(ID) at both birth and 9 months predicts right frontal EEG asymmetry in infancy. Dev Psychobiol. 2016;58:462\u201370.","DOI":"10.1002\/dev.21388"},{"key":"705_CR19","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1159\/000353161","volume":"104","author":"L Lorenz","year":"2013","unstructured":"Lorenz L, Peter A, Poets CF, Franz AR. A review of cord blood concentrations of iron status parameters to define reference ranges for preterm infants. Neonatology. 2013;104:194\u2013202.","journal-title":"Neonatology."},{"key":"705_CR20","doi-asserted-by":"publisher","first-page":"2004","DOI":"10.3945\/jn.112.162362","volume":"142","author":"J Shao","year":"2012","unstructured":"Shao J, Lou J, Rao R, Georgieff MK, Kaciroti N, Felt BT, et al. Maternal serum ferritin concentration is positively associated with newborn iron stores in women with low ferritin status in late pregnancy. J Nutr. 2012;142:2004\u20139.","journal-title":"J Nutr"},{"key":"705_CR21","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1067\/mpd.2002.120688","volume":"140","author":"T Tamura","year":"2002","unstructured":"Tamura T, Goldenberg RL, Hou J, Johnston KE, Cliver SP, Ramey SL, et al. Cord serum ferritin concentrations and mental and psychomotor development of children at five years of age. J Pediatr. 2002;140:165\u201370.","journal-title":"J Pediatr."},{"key":"705_CR22","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.jpeds.2009.09.049","volume":"156","author":"SB Amin","year":"2010","unstructured":"Amin SB, Orlando M, Eddins A, MacDonald M, Monczynski C, Wang H. In utero iron status and auditory neural maturation in premature infants as evaluated by auditory brainstem response. J Pediatr. 2010;156:377\u201381.","journal-title":"J Pediatr."},{"key":"705_CR23","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1016\/j.jpeds.2013.06.020","volume":"163","author":"SB Amin","year":"2013","unstructured":"Amin SB, Orlando M, Wang H. Latent iron deficiency in utero is associated with abnormal auditory neural myelination in >= 35 weeks gestational age infants. J Pediatr. 2013;163:1267\u201371.","journal-title":"J Pediatr."},{"key":"705_CR24","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1038\/sj.jp.7211178","volume":"24","author":"R Armony-Sivan","year":"2004","unstructured":"Armony-Sivan R, Eidelman AI, Lanir A, Sredni D, Yehuda S. Iron status and neurobehavioral development of premature infants. J Perinatol. 2004;24:757\u201362.","journal-title":"J Perinatol"},{"key":"705_CR25","unstructured":"World Health Organization. Worldwide Prevalence of Anaemia 1993-2005: WHO Global Database on Anaemia. 2008; Geneva, Switzerland: WHO Press."},{"key":"705_CR26","unstructured":"Centers for Disease Control. Healthy People - 2000 National Health Promotion and Disease Prevention Objectives Final Review. 2001. Hyattsville, MD, Department of Health and Human Services."},{"key":"705_CR27","first-page":"1","volume":"47","author":"Centers for Disease Control and Prevention.","year":"1998","unstructured":"Centers for Disease Control and Prevention. Recommendations to prevent and control iron deficiency in the United States. MMWR. 1998;47:1\u201329.","journal-title":"MMWR"},{"key":"705_CR28","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1111\/j.1651-2227.1978.tb16254.x","volume":"67","author":"UM Saarinen","year":"1978","unstructured":"Saarinen UM, Siimes MA. Serum ferritin in assessment of iron nutrition in healthy infants. Acta Pediatr. 1978;67:745\u201351.","journal-title":"Acta Pediatr."},{"key":"705_CR29","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/S0009-9120(02)00405-8","volume":"36","author":"OP Soldin","year":"2003","unstructured":"Soldin OP, Miller M, Soldin SJ. Pediatric reference ranges for zinc protoporphyrin. Clin Biochem. 2003;36:21\u201325.","journal-title":"Clin Biochem."},{"key":"705_CR30","doi-asserted-by":"publisher","first-page":"3359","DOI":"10.1182\/blood-2002-10-3071","volume":"101","author":"JD Cook","year":"2003","unstructured":"Cook JD, Flowers CH, Skikne BS. The quantitative assessment of body iron. Blood. 2003;101:3359\u201364.","journal-title":"Blood."},{"key":"705_CR31","first-page":"368","volume":"114","author":"CH Flowers","year":"1989","unstructured":"Flowers CH, Skikne BS, Covell AM, Cook JD. The clinical measurement of serum transferrin receptor. J Lab Clin Med. 1989;114:368\u201377.","journal-title":"J Lab Clin Med"},{"key":"705_CR32","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.cca.2007.04.008","volume":"382","author":"CM Pfeiffer","year":"2007","unstructured":"Pfeiffer CM, Cook JD, Mei Z, Cogswell ME, Looker AC, Lacher DA. Evaluation of an automated soluble transferrin receptor (sTfR) assay on the Roche Hitachi analyzer and its comparison to two ELISA assays. Clin Chim Acta. 2007;382:112\u20136.","journal-title":"Clin Chim Acta"},{"key":"705_CR33","unstructured":"World Health Organization. Child growth standards. WHO Anthro (version 3.2.2, January 2011) and macros [Internet]. Available from: http:\/\/www.who.int\/childgrowth\/software\/en\/. 2011. Geneva, World Health Organization."},{"key":"705_CR34","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1542\/peds.110.3.545","volume":"110","author":"M Domellof","year":"2002","unstructured":"Domellof M, Lonnerdal B, Dewey KG, Cohen RJ, Rivera LL, Hernell O. Sex differences in iron status during infancy. Pediatrics. 2002;110:545\u201352.","journal-title":"Pediatrics."},{"key":"705_CR35","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.1093\/clinchem\/45.12.2060","volume":"45","author":"RF Labb\u00e9","year":"1999","unstructured":"Labb\u00e9 RF, Vreman HJ, Stevenson DK. Zinc protoporphyrin: a metabolite with a mission. Clin Chem. 1999;45:2060\u201372.","journal-title":"Clin Chem"},{"key":"705_CR36","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1097\/MPH.0b013e3182707f2e","volume":"35","author":"HM McLimore","year":"2013","unstructured":"McLimore HM, Phillips AK, Blohowiak SE, Pham DQ, Coe CL, Fischer B, et al. Impact of multiple risk factors on newborn iron status. J Pediatr Hematol Oncol. 2013;35:473\u20137.","journal-title":"J Pediatr Hematol Oncol"},{"key":"705_CR37","doi-asserted-by":"publisher","DOI":"10.1542\/peds.104.3.e37","volume":"104","author":"RL Rettmer","year":"1999","unstructured":"Rettmer RL, Carlson TH, Maurice L, Origenes ML, Jack RM, Labbe\u00b4 RF. Zinc protoporphyrin\/Heme Ratio diagnosis preanemic iron deficiency. Pediatrics.1999;104:e37 https:\/\/doi.org\/10.1542\/peds.104.3.e37.","journal-title":"Pediatrics."},{"key":"705_CR38","doi-asserted-by":"publisher","first-page":"40","DOI":"10.4162\/nrp.2011.5.1.40","volume":"5","author":"KH Yu","year":"2011","unstructured":"Yu KH. Effectiveness of zinc protoporphyrin\/heme ratio for screening iron deficiency in preschool-aged children. Nutr. Res Pract. 2011;5:40\u201345. https:\/\/doi.org\/10.4162\/nrp.2011.5.1.40","journal-title":"Nutr. Res Pract"},{"key":"705_CR39","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10776.","volume":"17","author":"G Hennig","year":"2016","unstructured":"Hennig G, Homann C, Teksan I, Hasbargen U, Hasmuller S, Holdt LM, et al. Non-invasive detection of iron deficiency by fluorescence measurement of erythrocyte zinc protoporphyrin in the lip. Nat Commun. 2016;17:10776 https:\/\/doi.org\/10.1038\/ncomms10776.","journal-title":"Nat Commun."}],"container-title":["European Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41430-020-00705-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41430-020-00705-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41430-020-00705-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T23:28:15Z","timestamp":1629329295000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41430-020-00705-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,19]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["705"],"URL":"https:\/\/doi.org\/10.1038\/s41430-020-00705-4","relation":{},"ISSN":["0954-3007","1476-5640"],"issn-type":[{"value":"0954-3007","type":"print"},{"value":"1476-5640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,19]]},"assertion":[{"value":"7 February 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 August 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict ofinterest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}